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An index for evaluating distance of a healthy heart from Sino-Atrial blocking arrhythmia

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Journal of Biomedical Science and Engineering 2010年第3期3卷 308-316页

作者： Hossein Gholizade-Narm morteza khademi Asad Azemi Masoud Karimi-Ghartemani Electronic & Robotic Engineering Shahrood University Technology Ferdowsi University of Mashhad College of Engineering Penn State University Sharif University of Technology

In this paper, an index for evaluating Distance of a healthy heart from Sino-Atrial Blocking Arrhythmia (SABA) is presented. After definition of the main pacemakers' model of heart, Sino-Atrial (SA) and Atrio-Ventricular nodes (AV), the boundary of synchronization, which demonstrates the boundary of blocking arrhythmia, is obtained using perturbation method. In order to estimate of healthy heart characteristics, a parameter estimator is introduced. The distance from SABA is calculated using Lagrange method and Kohn-Tucker conditions. In addition, the maximum admissible decrease in the coupling intensity and the maximum admissible increase in the discrepancy between the natural frequencies of two pacemakers are determined in order to maintain the synchronization between the two pacemakers.

关键词： Healthy Heart Blocking Arrhythmia Perturbation method Synchronization Boundary Optimization Bifurcation

Numerical study of flow and thermal characteristics of pulsed impinging jet on a dimpled surface

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Theoretical & Applied Mechanics Letters 2024年第2期14卷 106-117页

作者： Amin Bagheri Kazem Esmailpour morteza Heydari Renewable Energy Research Center Damavand BranchIslamic Azad UniversityDamavandIran

This research comprehensively investigates the flow and thermal characteristics of a pulsating impinging jet over a dimpled *** analyzes the impact of key parameters(e.g.,inlet velocity pulsation functions,pulsation frequency,amplitude,dimple pitch,dimple depth,Reynolds number)on flow patterns and heat *** computational fluid dynamics and the Re-normalization group turbulence model are employed to accurately simulate complex turbulent flow *** and average heat transfer coefficients are calculated and compared to steady impingement cases,revealing the potential benefits of pulsation for heat transfer *** study also examines how pulsation-induced flow modulation and thermal mixing affect heat transfer *** indicate that combining fluctuating flow with a dimpled surface can improve heat transfer *** summary,increasing pulsation amplitude consistently enhances heat transfer,while the effect of frequency varies between impinging and wall jet zones.

关键词： Pulsating impinging jet Dimpled surface Heat transfer enhancement Pulsation frequency and amplitude Coherent structures

Optimal site selection for geothermal heated greenhouses in cold climates: a fuzzy logic and geographic information system approach

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CLEAN ENERGY 2024年第2期8卷 8-26页

作者： Mirabadi, Amirhossein Minaei, Saeid Noorollahi, Younes Almasi, morteza Islamic Azad Univ Dept Agr Syst Sci & Res Branch Tehran Iran Tarbiat Modares Univ Fac Agr Biosyst Engn Dept Tehran Iran Univ Tehran Fac New Sci & Technol Energy Modelling & Sustainable Energy Syst METSAP Tehran Iran

This paper presents a comprehensive model for selecting optimal sites for geothermal heated greenhouses in the agricultural industry. The research involves two main componentsf: assessing the geothermal energy resource using geological, geochemical and geophysical indicators; and developing a siting model based on fuzzy logic that considers technical, environmental and socio-economic factors. The study focuses on East Azerbaijan province in Iran-a cold region. The results indicate that similar to 3.24% of the total area of the province is suitable for constructing geothermal greenhouses, resulting in potential savings of similar to 148 000 and 745 978 m(3) of natural gas in areas with high and very high suitability, respectively. [GRAPHICS] .

关键词： geothermal energy site selection GIS fuzzy logic resource assessment ENERGY PROVINCE

Revealing connectivity in residential Architecture: An algorithmic approach to extracting adjacency matrices from floor plans

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Frontiers of Architectural Research 2024年第2期13卷 370-386页

作者： Mohammad Amin Moradi Omid Mohammadrashidi Navid Niazkar morteza Rahbar School of Architecture and Engineering University College of RouzbahanMazandaranIran School of Architecture Islamic Azad UniversitySafaDasht CampusTehranIran A.James Clark School of Engineering University of MarylandCollege ParkMDUSA School of Architecture and Environmental Design Iran University of Science and TechnologyTehranIran

In today's world, various approaches and parameters exist for designing a plan and determining its spatial, placement. Hence, various modes for identifying crucial locations can be explored when an architectural plan is designed in different dimensions. While designing all these modes takes considerable time, there are numerous potential applications for artificial intelligence (AI) in this domain. This study aims to compute and use an adjacency matrix to generate architectural residential plans. Additionally, it develops a plan generation algorithm in Rhinoceros software, utilizing the Grasshopper plugin to create a dataset of architectural plans. In the following step, the data was entered into a neural network to identify the architectural plan's type, furniture, icons, and use of spaces, which was achieved using YOLOv4, EfficientDet, YOLOv5, DetectoRS, and RetinaNet. The algorithm's execution, testing, and training were conducted using Darknet and PyTorch. The research dataset comprises 12,000 plans, with 70% employed in the training phase and 30% in the testing phase. The network was appropriately trained practically and precisely in relation to an average precision (AP) resulting of 91.50%. After detecting the types of space use, the main research algorithm has been designed and coded, which includes determining the adjacency matrix of architectural plan spaces in seven stages. All research processes were conducted in Python, including dataset preparation, network object detection, and adjacency matrix algorithm design. Finally, the adjacency matrix is given to the input of the proposed plan generator network, which consequently, based on the resulting adjacency, obtains different placement modes for spaces and furniture.

关键词： Algorithm design Adjacency matrix Generate floor plan Detection plan

Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi Farzad Dastaviz Mehdi Sheikh Arabi Ayyoob Khosravi morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh Arabi Abouzar Bagheri Mohsen Rashidi morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

Visualizing traumatic brain injury:ocular clues for diagnosis and assessment

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Neural Regeneration Research 2025年第5期20卷 1399-1400页

作者： morteza Abyadeh Vivek Gupta Yuyi You Joao A.Paulo Mehdi Mirzaei ProGene Technologies Pty Ltd SydneyNSWAustralia Department of Clinical Medicine Faculty of MedicineHealth and Human SciencesMacquarie Medical SchoolMacquarie UniversityMacquarie ParkNorth RydeSydneyNSWAustralia Department of Cell Biology Harvard Medical SchoolBostonMAUSA

Traumatic brain injury (TBI) is defined as damage to the brain resulting from an external sudden physical force or shock to the *** is considered a silent public health epidemic causing significant death and disability *** were 64,000 TBI related deaths reported in the USA in 2020,with about US$76 billion in direct and indirect medical costs annually.

关键词： diagnosis ocular injury

Mid-term outcomes of a kinematically designed cruciate retaining total knee arthroplasty

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World Journal of Orthopedics 2024年第2期15卷 118-128页

作者： Jonathan L Katzman Akram A Habibi Muhammad A Haider Casey Cardillo Ivan Fernandez-Madrid morteza Meftah Ran Schwarzkopf Department of Orthopedic Surgery Division of Adult Reconstructive SurgeryNYU Langone Orthopedic HospitalNYU Langone HealthNew YorkNY 10010United States

BACKGROUND Advances in implant material and design have allowed for improvements in total knee arthroplasty(TKA)outcomes.A cruciate retaining(CR)TKA provides the least constraint of TKA designs by preserving the native posterior cruciate *** research exists that has examined clinical outcomes or patient reported outcome measures(PROMs)of a large cohort of patients undergoing a CR TKA utilizing a kinematically designed *** was hypothesized that the studied CR Knee System would demonstrate favorable outcomes and a clinically significant improvement in pain and functional *** To assess both short-term and mid-term clinical outcomes and PROMs of a novel CR TKA *** A retrospective,multi-surgeon study identified 255 knees undergoing a TKA utilizing a kinematically designed CR Knee System(JOURNEY™II CR;Smith and Nephew,Inc.,Memphis,TN)at an urban,academic medical institution between March 2015 and July 2021 with a minimum of two-years of clinical follow-up with an orthopedic *** demographics,surgical information,clinical outcomes,and PROMs data were collected via query of electronic medical *** PROMs collected in the present study included the Knee Injury and Osteoarthritis Outcome Score for Joint Replacement(KOOS JR)and Patient-Reported Outcomes Measurement Information System(PROMIS■)*** significance of improvements in mean PROM scores from preoperative scores to scores collected at six months and two-years postoperatively was analyzed using Independent Samples *** Of the 255 patients,65.5%were female,43.8%were White,and patients had an average age of 60.6 *** osteoarthritis(96.9%)was the most common primary *** mean surgical time was 105.3 minutes and mean length of stay was 2.1 d with most patients discharged home(92.5%).There were 18 emergency department(ED)visits within 90 d of surgery resulting in a 90 d ED visit rate of 7.1%,including a 2.4%orthopedic-related ED visit ra

关键词： Total knee arthroplasty Cruciate retaining Kinematic design Survivorship Bearing material Prosthetic design Clinical outcomes Patient-reported outcome measures

Assessment of rehabilitation strategies for lakes affected by anthropogenic and climatic changes: A case study of the Urmia Lake, Iran

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Journal of Arid Land 2024年第6期16卷 752-767页

作者： Seyed morteza MOUSAVI Hossein BABAZADEH Mahdi SARAI-TABRIZI Amir KHOSROJERDI Department of Water Science and Engineering Science and Research BranchIslamic Azad UniversityTehran 147789-3855Iran

Over the last three decades,more than half of the world's large lakes and wetlands have experienced significant shrinkage,primarily due to climate change and extensive water consumption for agriculture and other human *** desiccation of lakes leads to severe environmental,economic,and social *** Lake,located in northwestern Iran and representing a vital natural ecosystem,has experienced a volume reduction of over 90.0%.Our research evaluated diverse water management strategies within the Urmia Lake basin and prospects of inter-basin water *** study focused on strategies to safeguard the environmental water rights of the Urmia Lake by utilizing the modeling and simulating(MODSIM)*** model simulated changes in the lake's water volume under various *** included diverting water from incoming rivers,cutting agricultural water use by 40.0%,releasing dam water in non-agricultural seasons,treated wastewater utilization,and inter-basin *** hierarchy process(AHP)was utilized to analyze the simulation *** opinions with AHP analysis,acted as a multi-criteria decision-making tool to evaluate the simulation and determine the optimal water supply source priority for the Urmia *** findings underscore the critical importance of reducing agricultural water consumption as the foremost step in preserving the *** this,inter-basin water transfers are suggested,with a detailed consideration of the inherent challenges and limitations faced by the source *** is imperative to conduct assessments on the impacts of these transfers on the downstream users and the potential environmental risks,advocating for a diplomatic and cooperative approach with adjacent *** study also aims to forecast the volumes of water that can be transferred under different climatic conditions—drought,normal,and wet years—to inform strategic water management planning for the Urmia *** to our proj

关键词： climate change drought lake ecological level agricultural water demand inter-basin water transfer