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Feasibility of progressive strength training shortly after hip fracture surgery

World Journal of Orthopedics 2013年第4期4卷 248-258页

作者： Jan Overgaard morten t kristensen Department of Rehabilitation Municipality of Lolland Physical Medicine and Rehabilitation Research-Copen-hagen (PMR-C)DK-4930 Maribo Denmark Physical Medicine and Rehabilitation Research-Copenhagen (PMR-C) Departments of Physiotherapy and Orthopaedic Surgery Copenhagen University Hospital HvidovreDK-2650 Hvidovre Denmark

AIM: to investigate the feasibility of a 6-wk progressive strength-training programme commenced shortly after hip fracture surgery in community-dwelling ***: this prospective, single-blinded cohort study evaluated 31 community-dwelling patients from four outpatient geriatric health centres aged 60 years or older, who started a 6-wk programme at a mean of 17.5 ± 5.7 d after hip fracture surgery. the intervention consisted primarily of progressive fractured kneeextension and bilateral leg press strength training(twice weekly), with relative loads commencing at 15 and increasing to 10 repetitions maximum(RM), with three sets in each session. the main measurements included progression in weight loads, hip fracture-related pain during training, maximal isometric knee-extension strength, new mobility score, the timed up and go test, the 6-min walk test and the 10-meter fast speed walk test, assessed before and after the ***: Weight loads in kilograms in the fractured limb knee-extension strength training increased from 3.3 ± 1.5 to 5.7 ± 1.7 and from 6.8 ± 2.4 to 7.7 ± 2.6, respectively, in the first and last 2 wk(P the weight loads increased from 50.3 ± 1.9 to 90.8 ± 40 kg and from 108.9 ± 47.7 to 121.9 ± 54 kg in the bilateral leg press exercise(P ture-related pain was reduced, and large improvements were observed in the functional outcome measurements, e.g., the 6-min walk test improved from 200.6 ± 79.5 to 322.8 ± 68.5 m(P the fractured limb knee-extension strength deficit was reduced from 40% to 17%, compared with the non-fractured limb. ten patients reported knee pain as a minor restricting factor during the last 10 RM knee-extension strength-training sessions, but with no significant influences on performance. CONCLUSION: Progressive strength training, initiated shortly after hip fracture surgery, seems feasible and does not increase hip fracture-related pain. Progressive strength tra

关键词： Hip fracture Resistance training Feasibility Repetition maximum Pain

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Surgical apgar score predicts early complication in transfemoral amputees:Retrospective study of 170 major amputations

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World Journal of Orthopedics 2016年第12期7卷 832-838页

作者： Christian Wied Nicolai B Foss morten t kristensen Gitte Holm thomas Kallemose Anders troelsen Department of Orthopedic Surgery Copenhagen University Hospital Hvidovre Department of Anesthesiology and Intensive Care Copenhagen University Hospital Hvidovre Physical Medicine and Rehabilitation Research-Copenhagen Department of Physical TherapyCopenhagen University Hospital Hvidovre Clinical Research Centre Copenhagen University Hospital Hvidovre

AIM to assess whether the surgical apgar score(SAS) is a prognostic tool capable of identifying patients at risk of major complications following lower extremity amputations *** this was a single-center,retrospective observational cohort study conducted between January 2013 and April 2015. All patients who had either a primary transtibial amputation(ttA) or transfemoral amputation(tFA) conducted at our institution during the study period were assessed for inclusion. All ttA patients underwent a standardized one-stage operative procedure(ad modum Persson amputation) performed approximately 10 cm below the knee joint. All ttA procedures were performedwith sagittal flaps. tFA procedures were performed in one stage with amputation approximately 10 cm above the knee joint,performed with anterior/posterior flaps. trained residents or senior consultants performed the surgical procedures. the SAS is based on intraoperative heart rate,blood pressure and blood loss. Intraoperative parameters of interest were collected by revising electronic health records. the first author of this study calculated the SAS. Data regarding major complications were not revealed to the author until after the calculation of SAS. the SAS results were arranged into four groups(SAS 0-4,SAS 5-6,SAS 7-8 and SAS 9-10). the cohort was then divided into two groups representing low-risk(SAS ≥ 7) and highrisk patients(SAS tablished threshold. the outcome of interest was the occurrence of major complications and death within 30-d of *** A logistic regression model with SAS 9-10 as a reference showed a significant linear association between lower SAS and more postoperative complications [all patients: OR = 2.00(1.33-3.03),P = 0.001]. this effect was pronounced for tFA [OR = 2.61(1.52-4.47),P t increase was observed for the high-risk group compared to the low-risk group for all patients [OR = 2.80(1.40-5.61),P = 0.004] and for the tFA sub-

关键词： Surgical apgar score Mortality transfemoral amputation Post-operative complication Lower extremity amputation

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tourniquets do not increase the total blood loss or reamputation risk in transtibial amputations

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World Journal of Orthopedics 2017年第1期8卷 62-67页

作者： Christian Wied Peter t tengberg Gitte Holm thomas Kallemose Nicolai B Foss Anders troelsen morten t kristensen Depart-ment of Orthopedic Surgery Copenhagen University Hospital Hvidovre Clinical Research Centre Copenhagen University Hospital Hvidovre Department of Anesthesiology and Intensive Care Copenhagen University Hospital Hvidovre Physical Medicine and Rehabilita-tion Research--Copenhagen Department of Physical TherapyCopenhagen University Hospital Hvidovre

AIM to investigate the total blood loss(tBL) and the safety with respect to the re-amputation rate after transtibial amputation(ttA) conducted with and without a tourniquet. MEtHODS the study was a single-centre retrospective cohort study of patients with a primary ttA admitted between January 2013 and April 2015. All patients with a primary ttA were assessed for inclusion if the amputation was performed because of arteriosclerosis or diabetic complications. All patients underwent a standardized ttA procedure that was performed approximately 10 cm below the knee joint and performed with sagittalflaps. the pneumatic tourniquet, when used, was inflated around the femur to a pressure of 100 mmH g above the systolic blood pressure. the number of blood transfusions within the first four postoperative days was recorded. the intraoperative blood loss(OBL), which is defined as the volume of blood lost during surgery, was determined from the suction volume and by the weight difference of the surgical dressings. the trigger for a blood transfusion was set at a decrease in the Hgb level transfusions were performed with pooled red blood cells containing 245 m L per portion, which equals 55 g/L of haemoglobin. the tBL during the first four postoperative days was calculated based on the haemoglobin level and the estimated blood volume. the re-amputation rate was evaluated within 30 d. RESULtS Seventy-four out of 86 consecutive patients who underwent ttA within the two-year study period were included in the analysis. Of these, 38 were operated on using a tourniquet and 36 were operated on without using a tourniquet. there were no significant preoperative differences between the groups. the patients in both groups had a postoperative decrease in their Hgb level compared with preoperative baseline values. the patients operated on using a tourniquet received approximately three millilitres less blood transfusion per kilogram body weight compared with patients o

关键词： total blood loss Intraoperative blood loss transtibial amputation Lower extremity amputation Pneumatic tourniquet Re-amputation

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Vortex lattices in type-II superconductors studied by small-angle neutron scattering

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Frontiers of physics 2011年第4期6卷 398-409页

作者： morten Ring Eskildsen Department of Physics University of Notre Dame Notre Dame IN 46556 USA

Here we review recent small-angle scattering studies of the vortex lattice in a range of type-II superconductors carried out by our group. Emphasis is placed on providing examples of the kind of information which can be obtained by such measurements, focusing in particular on studies of the vortex lattice structure and form factor in LuNi2B2C, tmNi2B2C, CeCoIn5 and Ba（Fe0.93Co0.07）2As2.

关键词： superconductivity vortex lattice small-angle neutron scattering borocarbides pnic-tides CeCoIn5

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Characterization of tGFβ-specific CD4+t cells through the modulation of tGFβexpression in malignant myeloid cells

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Cellular & Molecular Immunology 2021年第11期18卷 2575-2577页

作者： Rasmus Erik Johansson mortensen morten Orebo Holmström Mads Hald Andersen National Center for Cancer Immune therapy Department of OncologyCopenhagen University HospitalHerlevDenmark Institute for Immunology and Microbiology Copenhagen UniversityCopenhagenDenmark

transforming growth factor beta(tGFβ)is a pleiotropic cytokine with functions related to angiogenesis,tumor suppression,and immune tolerance[1].tGFβis involved in tumor immune escape and is a target for cancer immune therapy[1].We have reported that healthy donors and cancer patients harbor CD8^(+)cytotoxic t lymphocytes(CtLs)that are specific to tGFβ-derived epitopes and that these CD8^(+)CtLs kill malignant myeloid cells in a tGFβ-dependent manner[2].

关键词： tGFβ malignant myeloid

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transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEED M.IMRAN t.ASGHAR Z.ABBAS Department of Mathematics Division of Science and TechnologyUniversity of Education Department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PDEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

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Fecal microbiota transplantation in allergic diseases

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World Journal of Methodology 2025年第2期15卷 83-91页

作者： Ece tüsüzÖnata ÖnerÖzdemir Division of Pediatric Allergy and Immunology Medical FacultySakarya UniversityAdapazarı54100SakaryaTürkiye

Microorganisms such as bacteria,fungi,viruses,parasites living in the human intestine constitute the human intestinal *** refers to composi-tional and quantitative changes that negatively affect healthy gut *** recent years,with the demonstration that many diseases are associated with dysbiosis,treatment strategies targeting the correction of dysbiosis in the treat-ment of these diseases have begun to be *** microbiota trans-plantation(FMt)is the process of transferring faeces from a healthy donor to another recipient in order to restore the gut microbiota and provide a therapeutic *** studies have gained popularity after probiotic,prebiotic,symbiotic studies in the treatment of dysbiosis and related *** has emerged as a potential new therapy in the treatment of allergic diseases as it is associated with the maintenance of intestinal microbiota and immunological balance(t helper 1/t helper 2 cells)and thus suppression of allergic *** this article,the definition,application,safety and use of FMt in allergic diseases will be discussed with current data.

关键词： Microbiota Dysbiosis Faecal microbiota transplantation Allergic diseases

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Free vibration and transient response of double curved beams connected by intermediate straight beams

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 37-62页

作者： R.A.JAFARI-tALOOKOLAEI H.GHANDVAR E.JUMAEV S.KHAtIR t.CUONG-LE School of Mechanical Engineering Babol Noshirvani University of Technology Department of Mechanical Engineering Faculty of Engineering New Uzbekistan University University of Business and Science Center for Engineering Application and technology Solutions Ho Chi Minh City Open University

this paper investigates the free vibration and transient response of interconnected structures including double curved beams and intermediate straight beams,which are all constructed from functionally graded porous(FGP) materials. the strain potential and kinetic energies of each beam along with the work done by the external force are calculated. Additionally, a higher-order beam element is introduced to derive stiffness and mass matrices, along with the force vector. the curved and straight beams are discretized, and their assembled stiffness, mass matrices, and force vectors, are *** conditions at the joints are used to derive the total matrices of the entire structure. Subsequently, the natural frequencies and transient response of the system are determined. the accuracy of the mathematical model and the self-developed computer program is validated through the comparison of the obtained results with those of the existing literature and commercial software ANSYS, demonstrating excellent ***, a comprehensive study is conducted to investigate the effects of various parameters on the free vibration and transient response of the considered structure.

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target-Oriented Inversion of time-Lapse Seismic Waveform Data

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Communications in Computational Physics 2020年第6期28卷 249-275页

作者： Xingguo Huang morten Jakobsen Kjersti Solberg Eikrem Geir Nævdal Department of Earth Science University of BergenP.O.Box 78035020 BergenNorway NORCE Norwegian Research Centre Postboks 225838 BergenNorway

Full waveform inversion of time-lapse seismic data can be used as a means of estimating the reservoir changes due to the *** the repeated computa-tions for the monitor surveys lead to a large computational cost,time-lapse full wave-form inversion is still considered to be a challenging *** address this problem,we present an efficient target-oriented inversion scheme for time-lapse seismic data using an integral equation formulation with Gaussian beam based Green’s function *** proposed time-lapse approach allows one to perform a local inversion within a small region of interest(e.g.a reservoir under production)for the monitor *** have verified that the t-matrix approach is indeed naturally target-oriented,which was mentioned by Jakobsen and Ursin[24]and allows one to reduce the compu-tational cost of time-lapse inversion by focusing the inversion on the target-area *** method is based on a new version of the distorted Born iterative t-matrix inverse scattering *** Gaussian beam and t-matrix are used in this approach to perform the wavefield computation for the time-lapse inversion in the baseline model from the survey surface to the target *** have provided target-oriented inversion results of the synthetic time-lapse waveform data,which shows that the proposed scheme reduces the computational cost significantly.

关键词： Waveform inversion time-lapse seismic seismic inverse scattering target-oriented inversion Gaussian beam based Green’s function

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transition Operator Approach to Seismic Full-Waveform Inversion in Arbitrary Anisotropic Elastic Media

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Communications in Computational Physics 2020年第6期28卷 297-327页

作者： morten Jakobsen Ivan Psencık Einar Iversen Bjørn Ursin Department of Earth Science University of BergenNorway Institute of Geophysics Czech Academy of SciencesCzech Republic Department of Geoscience and Petroleum NTNU and F.University of BahiaBrazil

We generalize the existing distorted Born iterative t-matrix(DBIt)method to seismic full-waveform inversion(FWI)based on the scalar wave equation,so that it can be used for seismic FWI in arbitrary anisotropic elastic media with variable mass densities and elastic stiffness *** elastodynamic wave equation for an ar-bitrary anisotropic heterogeneous medium is represented by an integral equation of the Lippmann-Schwinger type,with a 9-dimensional wave state(displacement-strain)*** solve this higher-dimensional Lippmann-Schwinger equation using a transition operator formalism used in quantum scattering *** allows for domain decomposition and novel variational *** tensorial nonlinear inverse scat-tering problem is solved iteratively by using an expression for the Fŕechet derivatives of the scattered wavefield with respect to elastic stiffness tensor fields in terms of modified Green’s functions and wave state vectors that are updated after each *** the generalized DBIt method is consistent with the Gauss-Newton method,it incorporates approximate Hessian information that is essential for the reduction of multi-parameter cross-talk *** DBIt method is implemented efficiently using a variant of the Levenberg-Marquard method,with adaptive selection of the regularization parameter after each *** a series of numerical experiments based on synthetic waveform data for transversely isotropic media with vertical symmetry axes,we obtained a very good match between the true and inverted models when using the traditional Voigt *** suggests that the effects of cross-talk can be sufficiently reduced by the incorporation of Hessian information and the use of suitable regularization *** the generalized DBIt method for FWI in anisotropic elastic media is naturally target-oriented,it may be particularly suitable for applications to seismic reservoir characterization and ***,the theory a

关键词： Waveform inversion time-lapse seismic seismic inverse scattering target-oriented inversion Green’s function

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