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Pathologic tumor response to neoadjuvant therapy in borderline resectable pancreatic cancer

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Hepatobiliary & Pancreatic Diseases International 2019年第4期18卷 373-378页

作者： june s Peng jane Wey sricharan Chalikonda Daniela s Allende R Matthew Walsh Gareth morris-stiff Department of General surgery Digestive Disease and Surgery InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA Department of Pathology Pathology and Laboratory Medicine InstituteCleveland Clinic Foundation9500 Euclid AvenueClevelandOHUSA

Background:Previous studies have demonstrated the prognostic significance of pathologic tumor response in pancreatic adenocarcinoma following neoadjuvant therapy(NAT).The aim of this study was to determine the incidence of significant pathologic response to NAT in borderline resectable pancreatic cancer(BRPC),and association of NAT regimen and other clinico-pathologic characteristics with pathologic ***:Patients with BRPC who underwent NAT and pancreatic resection between january 2012 and june 2017 were *** response was assessed on a qualitative scale based on the College of American Pathologists grading *** and baseline characteristics,oncologic treatment,pathology,and survival outcomes were ***:seventy-one patients were included for *** patients had complete pathologic responses(tumor regression score 0),12 patients had marked responses(score 1),42 had moderate responses(score 2),and 13 had minimal responses(score 3).Patients with complete or marked responses were more likely to have received neoadjuvant gemcitabine chemoradiation(62.5%,38.1%,and 23.1%of the complete/marked,moderate,and minimal response groups,respectively;P=0.04).Of the complete/marked,moderate,and minimal response groups,margins were negative in 75.0%,78.6%,and 46.2%(P=0.16);node negative disease was observed in 87.5%,54.8%,and 15.4%(Psurvival was 50.0 months,31.7 months,and 23.2 months(P=0.563).Of the four patients with pathologic complete responses,three were disease-free at 66.1,41.7 and 31.4 months,and one was deceased with metastatic liver disease at 16.9 ***:A more pronounced pathologic tumor response to NAT in BRPC is correlated with node negative disease,but was not associated with a statistically significant survival benefit in this study.

关键词： Pancreatic cancer Borderline resectable Neoadjuvant therapy Pathologic response

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环境教育

世界社会科学 2004年第3期 102-103页

作者： j.s.肖,霓美

20世纪90年代初期以来，环境教育失败的现象越来越严重。父母们开始注意到，他们的孩子将一些有关自然界的莫名其妙的想法带回家中。家长甚至因为就业于石油、化学工业或因驾驶汽车而受到孩子的谴责。

关键词：环境教育学校董事会成员经济学环境主义教育资料

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土木工程

土木工程

Relief of osteoarthritis with a herbal-amino acid supplement: A randomized double-blind placebo controlled trial

作者： j.s.·斯科特(j.s. scott)撰

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Advances in Bioscience and Biotechnology 2012年第4期3卷 504-510页

作者： Mark j.s. Miller Ross Butler University of south Australia School of Pharmacy & Medical Sciences

A redox active medicinal plant and L-leucine mixture (HLM) was investigated in subjects with established osteoarthritis of the knee in a multi-center, rando- m-ized, placebo-controlled, double-blind clinical trial. A total of 96 subjects with osteoarthritis were enrolled and randomized to either placebo (n = 38) or HLM treatment group (n = 38). The HLM group re- ceived a combination of Uncaria tomentosa (300 mg), Boswellia serrata (200 mg), Lepidium meyenii (1000 mg) and L-Leucine (700 mg) given as 3 capsules once a day. The placebo group received matching capsules with carboxymethylcellulose. The treatment period was 8 weeks, with assessments made at days 7, 14, 28 and 56. The primary outcome was reduction in total WOMAC score. VAs pain, tolerability, investigator assessments, use of rescue medication (acetominophen), and safety assessments of vital signs and laboratory assessments were included. subject randomization was effective for age, gender and disease severity. In the placebo group 32/38 subjects completed the trial and for HLM 35/38. WOMAC scores (pain, stiffness, physical performance and total) steadily declined over the course of the 8 week study in both groups, but the magnitude was significantly greater for HLM (P s reduced 46.5% for HLM and 25.4 % for placebo. VAs pain was reduced 21.8% in the placebo group (p s were significantly greater (37.8% p stigator’s global assessment rating of good-excellent was 24/35 (69%) for HLM and 14/32 (44%) for placebo (P = 0.05). Rescue medication consumption and tolerability were comparable for HLM and placebo. No safety issues were evident with either group. As expected a placebo effect was observed, nevertheless HLM was clearly more effective in relieving the symptoms of osteoarthritis. This HLM represents a safe and effective new approach to the management of osteoarthritis symptoms.

关键词： Osteoarthritis Dietary supplement Cat’s Claw L-Leucine Boswellia serrata Maca Uncaria Tomentosa Lepidium Meyenii Inflammation Cartilage Flexibility Pain Quality of Life stiffness Arthritis Nutraceutical Natural Product

sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi sun shiqian shen Robert j.Thomas M.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

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巴赫《六首帕蒂塔》

2005年

作者：（德）j.s.巴赫曲

《巴赫六首帕蒂塔》介绍了：维也纳原始出版社向来以出版最具权威性的依据作曲家手稿及第一次出版（俗称“原版”）的版本而著称，这种“净版本”（或称“原始版本”），即URTEXT，对每个细节做出详细而殷实的考证，对多种有据可查的最... 详细信息

ISBN: (纸本)7544402037

《巴赫六首帕蒂塔》介绍了：维也纳原始出版社向来以出版最具权威性的依据作曲家手稿及第一次出版（俗称“原版”）的版本而著称，这种“净版本”（或称“原始版本”），即URTEXT，对每个细节做出详细而殷实的考证，对多种有据可查的最初来源进行比较分析，以最接近作曲家原始意图为其追求目标。因此，“维也纳原始版本”在世界音乐界享有盛誉，业已成为一切严肃的音乐学家、乐器演奏家、作曲家、音乐教育家研究音乐作品本来面貌的最可靠出发点。

关键词：钢琴谱德国

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外国人眼里的新中国文化人类学

贵州民族研究 1998年第2期18卷 170-180页

作者： j.s.艾迪思覃敏笑贵州省民族研究所

THE CHARACTERIsTICs OF OXIDE sCALE FORMED ON LOW PREssURE PLAsMA sPRAYED NiCrAlY COATING IN THE PREsENCE OF 5% WATER VAPOR

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Acta Metallurgica sinica(English Letters) 2002年第1期15卷 123-126页

作者： j.s. Yu C.G. Zhou H.B. Xu s.K. Gong Department of Materials science and Engineering Beijing University of Aeronautics and AstronauticsBeijing 100083 China

The oxidations of low pressure plasma sprayed (LPPs) NiCrAlY coating on nickel base superalloy were studied at 1050℃ in flows of O2, and mixture of O2 and 5%H2O under atmospheric pressure. Oxide formed on the surface of LPPs NiCrAlY coating after oxidation at 1050℃ in pure O2 consisted of NiCr2O4, whereas oxide formed on the surface of LPPs NiCrAlY coating after oxidation at 1050℃ in a mixture of O2 and 5%H2O is mainly composed of NiO. The effect of water vapor on the characteristics of the oxide scale is attributed to the increase in Ni cation transport.

关键词： oxidation water vapor coating

Dominant species of mid-elevation grasslands of the uKhahlamba-Drakensberg Park are predicted to be largely immune to climate change

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journal of Mountain science 2023年第9期20卷 2468-2486页

作者： Debbie jEWITT Craig D.morris Tim G.O’CONNOR Michelle j.TEDDER Ezemvelo KZN Wildlife Scientific ServicesPO Box 13053Cascades 3202South Africa school of Animal Plant and Environmental SciencesUniversity of the WitwatersrandJohannesburgPrivate Bag X3WITS 2050South Africa Agricultural Research Council-Animal Production(ARC-AP) ℅School of Life Sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa school of Life sciences University of KwaZulu-NatalPrivate Bag X01Scottsville 3209PietermaritzburgSouth Africa

Anticipating global change impact on natural vegetation,especially in poorly researched systems,requires an understanding of the environmental factors that most strongly influence the organisation of plant communities at different *** environmental relations of plant communities in the Drakensberg mountains of south Africa remain poorly *** study investigated the influence of selected environmental determinants on the dominant species of plant community organisation in this *** order to provide an overview of the influence of the environment on botanical composition and plant diversity,this study,conducted as four discrete exercises,investigated the interplay of altitude,aspect and slope on the abundance of selected species,and to examine the influence of latitude,geological substrate and local topography on species *** diversity showed no pattern of response to investigated environmental *** composition was related to temperature and solarradiation *** altitude sites facing east were distinct for non-graminoid *** and latitude exerted a pronounced effect on species composition,confounded by longitude and precipitation *** substrate,in concert with slope steepness and orientation,influenced composition,restricting the abundance but not distribution of some *** individualistic responses were found for C_3,C_4,and non-graminoid species in relation to altitude,slope and *** and aspect mediate the effects of altitude and hence temperature for some *** study has demonstrated the complexity of drivers influencing species and compositional distribution in the Drakensberg and permits a preliminary consideration of potential changes in the composition and dominance structure of mid-elevation grasslands in response to climate *** dominant grass species were widespread across environmental gradients,occupying currently warm,cool,moist and dry habitats

关键词： Drakensberg Environmental gradients Grasslands Mountain biodiversity Vegetation