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Opto-fluidically multiplexed assembly and micro-robotics

Light(Science & Applications) 2024年第3期13卷 544-554页

作者： Elena Erben Weida Liao Antonio Minopoli Nicola Maghelli Eric Lauga moritz kreysing Max Planck Institute of Molecular Cell Biology and Genetics Dresden 01307Germany Center for Systems Biology Dresden 01307Germany Institute of Biological and Chemical Systems–Biological Information Processing.Karlsruhe Institute of Technology(KIT) Eggenstein-Leopoldshafen 76344Germany Department of Applied Mathematics and Theoretical Physics University of CambridgeCambridge CB30WAUK

Techniques for high-definition micromanipulations,such as optical tweezers,hold substantial interest across a wide range of ***,their applicability remains constrained by material properties and laser *** while microfluidic manipulations have been suggested as an alternative,their inherent capabilities are limited and further hindered by practical challenges of implementation and *** we show that the iterative application of laser-induced,localized flow fields can be used for the relative positioning of multiple micro-particles,irrespectively of their material *** to the standing theoretical proposal,our method keeps particles mobile,and we show that their precision manipulation is non-linearly accelerated via the multiplexing of temperature stimuli below the heat diffusion *** resulting flow fields are topologically rich and mathematically *** represent unprecedented microfluidic control capabilities that are illustrated by the actuation of humanoid micro-robots with up to 30 degrees of freedom,whose motions are sufficiently well-defined to reliably communicate personal characteristics such as gender,happiness and *** results constitute high-definition micro-fluidic manipulations with transformative potential for assembly,micro-manufacturing,the life sciences,robotics and optohydraulically actuated micro-factories.

关键词： manipulation fluid assembly

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Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

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eLight 2021年第1期1卷 69-77页

作者： Iliya D.Stoev Benjamin Seelbinder Elena Erben Nicola Maghelli moritz kreysing Max Planck Institute of Molecular Cell Biology and Genetics Pfotenhauerstraße 10801307 DresdenGermany. Centre for Systems Biology Pfotenhauerstraße 10801307 DresdenGermany. Cluster of Excellence Physics of Life TU DresdenDresdenGermany.

The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell ***,despite optical control capabilities,this technology is highly constrained by the material properties of the probe,and its use may be limited due to concerns about the effect on biological *** we present a novel,optically controlled trapping method based on light-induced hydrodynamic ***,we leverage optical control capabilities to convert a translationally invariant topological defect of a flow field into an attractor for colloids in an effectively one-dimensional harmonic,yet freely rotatable *** the need to stabilise particle dynamics along an unstable axis,this novel trap closely resembles the isotropic dynamics of optical *** magnetic beads,we explicitly show the existence of a linear force-extension relationship that can be used to detect femtoNewton-range forces with sensitivity close to the thermal *** force measurements remove the need for laser-particle contact,while also lifting material constraints,which renders them a particu-larly interesting tool for the life sciences and engineering.

关键词： Force measurements Optofluidics Hydrodynamic trap Thermoviscous flows

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