Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap

作     者：Iliya D.Stoev Benjamin Seelbinder Elena Erben Nicola Maghelli Moritz Kreysing 

作者机构：Max Planck Institute of Molecular Cell Biology and GeneticsPfotenhauerstraße 10801307 DresdenGermany. Centre for Systems BiologyPfotenhauerstraße 10801307 DresdenGermany. Cluster of Excellence Physics of LifeTU DresdenDresdenGermany. 

出 版 物：《eLight》 (e光学（英文）)

年 卷 期：2021年第1卷第1期

页      面：69-77页

学科分类：07[理学] 0701[理学-数学] 0702[理学-物理学] 070101[理学-基础数学] 

基　　金：We thank Iain Patten for valuable discussions on the structure and layout of the manuscript.IDS kindly acknowledges funding from the Life grant by Volkswagen Foundation(Grant No.92772) 

主　　题：Force measurements Optofluidics Hydrodynamic trap Thermoviscous flows 

摘      要：The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell ***,despite optical control capabilities,this technology is highly constrained by the material properties of the probe,and its use may be limited due to concerns about the effect on biological *** we present a novel,optically controlled trapping method based on light-induced hydrodynamic ***,we leverage optical control capabilities to convert a translationally invariant topological defect of a flow field into an attractor for colloids in an effectively one-dimensional harmonic,yet freely rotatable *** the need to stabilise particle dynamics along an unstable axis,this novel trap closely resembles the isotropic dynamics of optical *** magnetic beads,we explicitly show the existence of a linear force-extension relationship that can be used to detect femtoNewton-range forces with sensitivity close to the thermal *** force measurements remove the need for laser-particle contact,while also lifting material constraints,which renders them a particu-larly interesting tool for the life sciences and engineering.