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Distinct patterns of mucosal apoptosis in H pylori-associated gastric ulcer are associated with altered FasL and perforin cytotoxic pathways

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World Journal of Gastroenterology 2006年第38期12卷 6133-6141页

作者： Heitor SP Souza Marcelo S Neves Celeste CS Elia Claudio JA Tortori Ilana Dines Cesonia A Martinusso Kalil Madi Leonardo Andrade morgana tl castelo-branco Departamento de Clínica Médica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório Multidisciplinar de Pesquisa e Departamento de Anatomia Patologica Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Hospital Universitário Clementino Fraga Filho Departamento de Histologia e Embriologia Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil Laboratório de Imunologia Celular Instituto de Ciências Biomédicas Universidade Federal do Rio de Janeiro 21941-590 Brazil

AIM: To analyze the level of apoptosis in different mucosal compartments and the differential expression of Fas/Fas-ligand and perforin in H pylori-associated gastric ulcer. METHODS: Antral specimens from patients with H pylori-related active gastric ulcer (GU), H pylori-related gastritis, and non-infected controls were analysed for densities and distribution of apoptotic cells determined by the TdT-mediated dUDP-biotin nick-end-labelling method. GU patients were submitted to eradication therapy with follow-up biopsy after 60 d. Fas, FasL, and perforin-expressing cells were assessed by immunoper- oxidase, and with anti-CD3, anti-CD20 and anti-CD68 by double immunofluorescence and confocal microscopy. Quantitative analysis was performed using a computer- assisted image analyser. RESULTS: H pylori-infected antrum showed greater surface epithelial apoptosis which decreased after eradi- cation therapy. In the lamina propria, higher rates of mononuclear cell apoptosis were observed in H pylori- gastritis. Co-expression of Fas with T-cell and macro- phage markers was reduced in GU. FasL- and perforin-expressing cells were increased in H pylori-infection and correlated with epithelial apoptosis. Perforin-expressing cells were also increased in GU compared with H pylori- gastritis. CONCLUSION: Epithelial apoptosis is increased in H pylori-infection and correlates to FasL- and perforin- expression by T cells. Expression of perforin is correlated with the tissue damage, and may represent the enhance- ment of a distinct cytotoxic pathway in GU. Increased expression of FasL not paralleled by Fas on T-cells and macrophages may indicate a reduced susceptibility to the Fas/FasL-mediated apoptosis of lymphoid cells in H pylori-infection.

关键词： Gastric ulcer H pylori Apoptosis Fas receptor Fas ligand Perforin

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Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis

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World Journal of Gastroenterology 2012年第32期18卷 4278-4287页

作者： Rodrigo Goulart Pacheco Christiano Costa Esposito Lucas CM Müller morgana tl castelo-branco Leonardo Pereira Quintella Vera Lucia A Chagas Heitor Siffert P de Souza Alberto Schanaider Department of Surgery Experimental Surgery CenterSurgical Sciences Postgraduate ProgramMedical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Laboratory of Cellular Immunology Department of Histology and EmbryologyInstitute of Biomedical SciencesFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Pathology Medical SchoolFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil Department of Internal Medicine Hospital Universitario Clementino Fraga FilhoFederal University of Rio de JaneiroRio de JaneiroRJ 21941-913Brazil

AIM:To investigate whether butyrate or glutamine enemas could diminish inflammation in experimental diversion ***:Wistar specific pathogen-free rats were submitted to a Hartmann's end colostomy and treated with enemas containing glutamine,butyrate,or *** were administered twice a week in the excluded segment of the colon from 4 to 12 wk after the surgical ***-up colonoscopy was performed every 4 wk for 12 *** effect of treatment was evaluated using video-endoscopic and histologic scores and measuring interleukin-1β,tumor necrosis factor-alpha,and transforming growth factor beta production in organ cultures by enzyme linked immunosorbent ***:Colonoscopies of the diverted segment showed mucosa with hyperemia,increased number of vessels,bleeding and mucus *** with either glutamine or butyrate induced significant reductions in both colonoscopic(P tly decreased to normal values after treatment with butyrate or ***:The improvement of experimental diversion colitis following glutamine or butyrate enemas highlights the importance of specific luminal nutrients in the homeostasis of the colonic mucosa and supports their utilization for the treatment of human diversion colitis.

关键词： Diversion colitis Butyrate Glutamine Shortchain fatty acids Cytokines

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Determination of the Atomic Weight of Samarium

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Chinese Chemical Letters 1997年第1期8卷 91-94页

作者： Chang, tl Qiao, GS BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA CHINESE ACAD SCI INST GEOLBEIJING 100029PEOPLES R CHINA

The atomic weight of samarium was redetermined as A(r)(Sm) = 150. 3661(2). Application of substitute calibration using the true isotopic ratio of Eu-151/153 results in A(r)(Sm) = 150. 3740(10). A summary is given incl... 详细信息

关键词： Determination of the Atomic Weight of Samarium

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The Atomic Weight of Gadolinium, Dysprosium and Erbium

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Chinese Chemical Letters 1996年第10期7卷 969-972页

作者： Chang, tl Gao, DS BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA BEIJING GEOL RES INST NUCL IND BEIJING 100029PEOPLES R CHINA

Isotopic ratio measurement was made for gadolinium, utilizing the bias correction facor df cerium and europium for the same mass spectrometer. The atomic weight found from the raw data is A(r)(Gd)=157.2473(2). However, the application of the method of doable substitute calibration results in A(r)(Gd) = 157.2526(10), both on 2 sigma basis. For dysprosium and erbium the same method yields A(r)(Dy)=162.4993(10) and A(r)(Er)=167.2611(12).

关键词： Dysprosium and Erbium The Atomic Weight of Gadolinium

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Determination of the Atomic Weight of Germanium

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Chinese Chemical Letters 1997年第9期8卷 837-840页

作者： Chang, tl Qiao, GS BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA ACAD SINICA INST GEOLBEIJING 100029PEOPLES R CHINA

The atomic weight of germanium was determined as A(r)(Ge) = 72.6284(22). Application of substitute calibration using the true isotopic ratio of Ga-69/71 results in A(r)(Ge) = 72.6389(29), both on 2 sigma basis.

关键词： Determination of the Atomic Weight of Germanium Rev Res

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NUMERICAL SIMULATION OF ELASTIC WAVE PROPAGATION IN ANISOTROPIC MEDIA

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Acta Mechanica Solida Sinica 2000年第1期13卷 50-59页

作者： Zhang, JF Liu, tl Dalian Univ Technol State Key Lab Struct Anal Ind Equipment Dalian 116024 Peoples R China

A new numerical simulation algorithm is presented for the elastic wave propagation in heterogeneous anisotropic media. We make discretization of the computational domain by using triangular and quadrangular grids. The scheme is based on integral equilibrium at each node to simulate the elastic wave propagation in heterogeneous anisotropic media. The scheme is very flexible in dealing with arbitrary surface topography, inner openings, liquid-solid boundaries and irregular interfaces. Moreover, tho free-surface condition of complex geometrical boundaries can be satisfied naturally. This work is an extension of the grid method for the elastic wave propagation in heterogeneous isotropic media, and a quadrangular grid with low computational cost is also introduced.

关键词： numerical modeling anisotropy finite difference grid method

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Infrared Isotopic Shift of Lithium Carbonate and Sulfate

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Chinese Chemical Letters 1996年第10期7卷 967-968页

作者： Tian, W Wu, JG Chang, tl BEIJING UNIV DEPT CHEMBEIJING 100871PEOPLES R CHINA

The infrared spectra of (Li2CO3)-Li-6, (Li2CO3)-Li-7, (Li2SO4)-Li-6, and (Li2SO4)-Li-7 were studied. The isotopic shift of the vibrational frequency for Li-6 - O and Li-7 - O bonds amounts to 4.5-7.8 % for the carbona... 详细信息

关键词： Infrared Isotopic Shift of Lithium Carbonate and Sulfate

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Modeling of Reversibleγ/αTransformations of Low Carbon Steels in the Intercritical Temperature Range

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材料热处理学报 2004年第05B期25卷 702-705页

作者： Tamás Rtl Imre FELDE Hakan GR Budapest Polytechnic Budapest HungaryBay Zoltdn Institute for Materials Science and Technology Budapest HungaryMetallurgical and Materials Eng. Dept. Middle East Technical University Ankara Turkey

A phenomenological kinetic model has been developed for the prediction of non-isothermal reversible incomplete transformations in low-carbon hypoeutectoid steels. The theoretical basis of the proposed method has its origin in a possible extension of the traditional Austin-Rickett kinetic differential equation. To critically assess the applicability of the model, a number of experiments based on computer simulations have been performed to predict the austenite/ferrite proeutectoid transformation in the temperature range of Aei to Ae3 on plain carbon hypoeutectoid steels. A comparison with published experimental data has verified that the model developed is reasonable both quantitatively and with respect to well-established trends. Extension of the method of prediction appears promising when the non-isothermal reactions occurring during heat treatment (such as carbide precipitation and dissolution) can be assumed to proceed in a reversible manner.

关键词：奥氏体转变动力学低碳钢临界温度

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Influence of intrinsic magnetic field on the distribution of O^+ in Martian magnetosphere

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Chinese Science Bulletin 1997年第22期42卷 1898-1901页

作者： Shi, JK Liu, ZX Zhang, tl Torkar, K Chinese Acad Sci Ctr Space Sci & Appl Res Beijing 100080 Peoples R China

SO far, the observation data on Martian magnetosphere have been obtained only in some specialtime and special situation, and there have been no systematic data. In the field of theoreticstudy, there are only some papers on Martian magnetopause. The question of the structureof the Martian magnetosphere, the Martian magnetic moment and its role on the

关键词： Mars magnetosphere ion distribution intrinsic magnetic field.

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Effects of Zr on Microstructure and Short-TermStrength in GH586

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Journal of Materials Science & Technology 1999年第5期15卷 415-418页

作者： Xie, SS Wang, tl Lu, JY Yang, HC Zhao, GP Northeastern Univ Sch Met & Mat Shenyang 110006 Peoples R China Gen Inst Iron & Steels Beijing 100081 Peoples R China

0.020, 0.045 and 0.075 wt pct Zr were added to a Ni-base superalloy GH586 to investigate their effects on the microstructure and the short-term strengths at 850 degrees C. The results showed that proper Zr addition could improve the alloy tensile strength at 850 degrees C and short-term rupture life at 850 degrees C, 580 MPa. Zr exists in both gamma' phase and gamma matrix, which caused Zr to distribute in grain instead of segregating in grain boundaries, therefore increased both of their lattice parameters but decreased the mismatch between them. Meanwhile, it also increased the amount of grain-boundary carbides and decreased their size markedly. These contributed to the improvement of short-term rupture life. However, further addition of Zr resulted in forming Zr4C2S2, a plate-like stable sulphurocarbides in grain boundaries, which decreased short-term strength at high temperature, and led to a worse hot workability. According to the experimental results, the optimum content of Zr should be 0.020 wt pct.

关键词： Superalloys

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