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Evaluation of effects of 1,3-dinitrobenzene on sperm motility of hamster using computer assisted semen analysis (CASA)

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Asian Journal of Andrology 2001年第2期3卷 109-114页

作者： L.D.C.Peiris H.D.m.moore Dept. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S 10 2TN UK

Aim: To evaluate the effects of 1,3-dinitrobenznene (mDNB) on sperm motility of hamster and to correlate the re-sults with the fertility. methods: Adult male hamsters were gavaged with one of the 3 dose regimes of mDNB(1.5 mg daily for 4 weeks ,1.5 mg one day a week for 4 weeks and 1.0 mg 3 days a week for 4 weeks). Computerassisted semen analysis (CASA) was used to analyse the sperm motility parameters, curvilinear velocity (VCL) andstraight line velocity (VSL) of sperm in distal corpus epididymides and distal cauda epididymides. In vitro fertilisationwas carried out only for 1.5 mg mDNB daily group to determine the sperm fertilising capacity. Results: There wasa significant reduction in sperm velocity parameters at weeks 3 and 4 after treatment, which was correlated with a de-cline in sperm fertility. Conclusion; Sperm velocity parameters may be used to determine the effect of a toxic insulton the sperm function.

关键词： mDNB sperm motility CASA sperm fertility

Effects of acut and chronic doses of methoxy acetic acid on hamster sperm fertilising ability

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Asian Journal of Andrology 2001年第3期3卷 209-216页

作者： L.D.C.Peiris H.D.m.moore Dept. of Zoology University of Colombo Colombo 03 Sri LankaDept. of Molecular Biology and Biotechnology University of Sheffield Sheffield S10 2TN UK

Aim: To evaluate the effects of acute and chronic doses of methoxy acetic acid (mAA) on in vitro fertilisation byhamster sperm and to correlate the data with the testicular damage. methods: Adult male hamsters were gavagedwith 3 single doses (0, 80, 160 and 650 mg/kg) and 3 chronic doses (0, 8, 32 and 64 mg/kg daily for 5 weeks) ofmAA in distilled water. After treatment hamsters were killed at weekly intervals and spermatozoa recovered from thedistal cauda epididymides were used to assess the fertilising capacity in vitro. The testes were processed for histologicalexamination. Results; Acute doses showed a significant reduction in sperm fertilising ability from week 3 and 4 af-ter treatment and with the chronic doses, the effects were more extensive and persistent. The results were in correpon-dence with the testicular damages observed. Conclusion: It is evident that both acute and chronic doses of mAAcan impair the sperm function by damaging one or more cell populations in the testis.(Asian J Androl 2001 Sep; 3: 209- 216)

关键词： methoxy acetic acid fertilisation in vitro testis spermatozoa fertility

Cirrhotic ascites review: Pathophysiology, diagnosis and management

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World Journal of Hepatology 2013年第5期5卷 251-263页

作者： Christopher m moore David H Van Thiel Section of Hepatology Department of MedicineRush University Medical CenterChicagoIL 60612United States

Ascites is a pathologic accumulation of peritoneal fluidcommonly observed in decompensated cirrhotic states. Its causes are multi-factorial, but principally involve significant volume and hormonal dysregulation in the setting of portal hypertension. The diagnosis of ascites is considered in cirrhotic patients given a constellation of clinical and laboratory findings, and ultimately confirmed, with insight into etiology, by imaging and paracentesis procedures. Treatment for ascites is multimodal including dietary sodium restriction, pharmacologic therapies, diagnostic and therapeutic paracentesis, and in certain cases transjugular intra-hepatic portosystemic shunt. Ascites is associated with numerous complications including spontaneous bacterial peritonitis, hepato-hydrothorax and hepatorenal syndrome. Given the complex nature of ascites and associatedcomplications, it is not surprising that it heralds increased morbidity and mortality in cirrhotic patients and increased cost-utilization upon the health-care system. This review will detail the pathophysiology of cirrhotic ascites, common complications derived from it, and pertinent treatment modalities.

关键词： Ascites Cirrhosis Hepato-hydrothorax Hepatorenal syndrome Spontaneous bacterial peritonitis

The role of emergency incident type in identifying first responders' health exposure risks

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Journal of Safety Science and Resilience 2023年第2期4卷 167-173页

作者： Emily J.Haas Katherine N.Yoon Alexa Furek megan Casey Susan m.moore National Personal Protective Technology Laboratory(NPPTL) National Institute for Ocupational Safety and Health(NIOSH)PittsburghPA 15236United States National Personal Protective Technology Laboratory(NPPTL) National Institute forOccupational Safety and Health(NIOSH)MorgantownWV2605United States

Fire-based emergency management service(EmS)personnel are dispatched to various incidents daily,many of which have unique occupational *** fully understand the variability of incident types and how to best pre-pare and respond,an exploration of the *** system of incident types is *** study uses potential exposure to SARS-CoV-2 as a case example to understand if and how coding categories for incident call types may be updated to improve data standardization and emergency response decision *** received emergency response incident data generated by three fire department computer-aided dispatch(CAD)systems between march and September *** incident was labeled EmS,Fire,or *** the 162,766 incidents,approximately 8.1%(n=13,144)noted potential SARS-CoV-2 exposure within their narrative descriptions of which 86.3%were coded as EmS,9.9%as Fire,and 3.9%as *** assess coding variability across incident types,researchers used the original 3-incident type variable and a new 5-incident type variable reassigned by researchers into EmS,Fire,Other,Hazmat,and motor *** regressions compared differences in potential exposure using the 3-and 5-incident type *** evaluating the 3-incident type variable,those respond-ing to a Fire versus an EmS incident were 84%less likely to be associated with potential exposure to *** the 5-incident type variable,those responding to Fire incidents were 77%less likely to be associated with a potential exposure than those responding to EmS *** in potential exposure between the 3-and 5-incident type models show the need to understand how incident types are *** demonstrates the need for data standardization to accurately categorize incident types to improve emergency preparedness and *** have implications for incident type coding at fire department municipality and national levels.

关键词： Emergencymedical se Firefighter Incident type Surveillance Telecommunicator

The proteome of distal nerves: implication in delayed repair and poor functional recovery

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Neural Regeneration Research 2022年第9期17卷 1998-2006页

作者： Song Guo Raymond m.moore m.Cristine Charlesworth Kenneth L.Johnson Robert J.Spinner Anthony J.Windebank Huan Wang Department of Neurologic Surgery Mayo ClinicRochesterMNUSA Biomedical Statistics and Informatics Mayo ClinicRochesterMNUSA Proteomics Core Mayo ClinicRochesterMNUSA Department of Neurology Mayo ClinicRochesterMNUSA

Chronic denervation is one of the key factors that affect nerve *** axotomy deteriorates the distal nerve stump,causes protein changes,and renders the microenvironment less permissive for *** of these factors/proteins have been individually *** better delineate the comprehensive protein expression profiles and identify proteins that contribute to or are associated with this detrimental effect,we carried out a proteomic analysis of the distal nerve using an established delayed rat sciatic nerve repair *** rats that received immediate repair after sciatic nerve transection served as control,whereas four rats in the experimental group(chronic denervation)had their sciatic nerve repaired after a 12-week *** the rats were sacrificed after 16 weeks to harvest the distal nerves for extracting ***-five micrograms of protein from each sample were fractionated in SDS-PAGE ***-mS/mS analysis was applied to the *** expression levels of nerves on the surgery side were compared to those on the contralateral *** protein with a P value of less than 0.05 and a fold change of 4 or higher was deemed differentially *** the differentially expressed proteins in both groups were further stratified according to the biological processes.A Pubmed search was also conducted to identify the differentially expressed proteins that have been reported to be either beneficial or detrimental to nerve *** Pathway Analysis(IPA)software was used for pathway *** results showed that 709 differentially expressed proteins were identified in the delayed repair group,with a bigger proportion of immune and inflammatory process-related proteins and a smaller proportion of proteins related to axon regeneration and lipid metabolism in comparison to the control group where 478 differentially expressed proteins were *** experimental group also had more beneficial proteins that were d

关键词： chronic axotomy chronic denervation delayed repair distal nerve functional recovery nerve regeneration peripheral nerve prolonged denervation proteome sciatic nerve sciatic nerve transection

Procalcitonin,and cytokines document a dynamic inflammatory state in non-infected cirrhotic patients with ascites

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World Journal of Gastroenterology 2014年第9期20卷 2374-2382页

作者： Bashar m Attar Christopher m moore magdalena George Nicolae Ion-Nedelcu Rafael Turbay Annamma Zachariah Guiliano Ramadori Jawed Fareed David H Van Thiel Division of Gastroenterology and Hepatology John H Stroger Hospital of Cook County Chicago IL 60612 United States David H Van Thiel Division of Gastroenterology and HepatologyRush University Medical Center Chicago IL 60612 United States Division of Gastroenterology and Hepatology Victor Babes Infectious Clinic 050094 Bucharest Romania Division of Gastroenterology and Hepatology August Georg University D-37075 Gottingen Germany Division of Gastroenterology and Hepatology Loyola University Medical Center Maywood IL 60153 United States

AIm: To quantitate the simultaneous serum and ascitic fluid levels of procalcitonin and inflammatory markers in cirrhotics with and without ascites.

关键词： Ascites Bacterial translocation Inflammatory markers Procalcitonin Cirrhosis

Investigating drivers of microbial activity and respiration in a forested bog

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Pedosphere 2020年第1期30卷 135-145页

作者： Kenna E.REWCASTLE Jessica A.m.moore Jeremiah A.HENNING melanie A.mAYES Courtney m.PATTERSON Gangsheng WANG Daniel B.mETCALFE Aimée T.CLASSEN Rubenstein School of Environment and Natural Resources University of VermontBurlington VT 05405(USA) Ecology&Evolutionary Biology University of TennesseeKnoxville TN 37996(USA) The Gund Institute for Environment University of VermontBurlington VT 05405(USA) Department of Biology University of South AlabamaMobile AL 36688(USA) Climate Change Science Institute and Environmental Sciences Division Oak Ridge National LaboratoryOak Ridge TN 37830(USA) Institute for Environmental Genomics&Department of microbiology and Plant Biology University of OklahomaNorman OK 73019(USA) The Department of Physical Geography and Ecosystem Science Lund UniversityLund 22362(Sweden)

Northern peatlands store nearly one-third of terrestrial carbon(C)stocks while covering only 3%of the global landmass;nevertheless,the drivers of C cycling in these often-waterlogged ecosystems are different from those that control C dynamics in upland forested *** explore how multiple abiotic and biotic characteristics of bogs interact to shape microbial activity in a northern,forested bog,we added a labile C tracer(13C-labeled starch)to in situ peat mesocosms and correlated heterotrophic respiration with natural variation in several microbial predictor variables,such as enzyme activity and microbial biomass,as well as with a suite of abiotic variables and proximity to vascular plants *** found that peat moisture content was positively correlated with respiration and microbial activity,even when moisture levels exceeded total saturation,suggesting that access to organic matter substrates in drier environments may be limiting for microbial *** to black spruce trees decreased total and labile heterotrophic *** negative relationship may reflect the influence of tree evapotranspiration and peat shading effects;i.e.,microbial activity may decline as peat dries and cools near ***,we isolated the response of heterotrophic respiration to explore the variation in,and interactions among,multiple abiotic and biotic drivers that influence microbial *** approach allowed us to reveal the relative influence of individual drivers on C respiration in these globally important C sinks.

关键词： carbon cycling enzyme activity heterotrophic respiration labile carbon respiration ombrotrophic bog peat moisture plant proximity soil carbon sink

EVALUATION OF THE APPLICABILITY OF STANDARD ASSAYS FOR ASSESSING THE GENOTOXICITY OF NANOmATERIALS

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Regulation of Shear-Dependent Vascular Smooth muscle Cell migration by Tyrosine Kinase Signaling Pathways

3rd Asian Conference on Environmental mutagens & 15th Conference of Chinese Environmental mutagen Society

作者： martha m. moore Division of Genetic and molecular Toxicology National Center for Toxicological ResearchFDA

The unique properties of nanomaterials may cause adverse biological effects that are different from their bulk *** is important to evaluate whether the currently used genotoxicity tests are adequate to detect the potential genotoxicity of nanomaterials. Genotoxicity of titanium dioxide nanoparticles(Ti02NPs) and silver nanoparticles(AgNPs) were evaluated using the Ames test,the in vivo and in vitro Comet assay,the mouse lymphoma gene mutation assay,the mouse Pig-a mutation assay,and the in vivo and in vitro

关键词： EVALUATION OF THE APPLICABILITY OF STANDARD ASSAYS FOR ASSESSING THE GENOTOXICITY OF NANOmATERIALS

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Regulation of Shear-Dependent Vascular Smooth Muscle Cell Mi...