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Effects of aqueous extract from red Liriope platyphylla on phthalic-anhydride-induced atopic dermatitis in Interleukin-4/Luciferase/Consensus non-coding sequence-1 transgenic mice evaluated in terms of luciferase signal and general phenotype biomarkers

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Journal of Traditional Chinese Medicine 2017年第4期37卷 475-485页

作者： moon Hwa kwak Ji Eun Kim Jun Go Hong Joo Son Hee Seob Lee Jin Tae Hong Dae Youn Hwang College of Natural Resources and Life Science/Life and Industry Convergence Research Institute Pusan National UniversityMiryang 627-706South of Korea College of Human Ecology Pusan National UniversityBusan 609-735south of Korea College of Pharmacy and Medical Research Center Chungbuk National UniversityChungju 361-763south of Korea College of Pharmacology Chungbuk National UniversityChungju 361-763south of Korea

OBJECTIVE: To quantitatively evaluate the therapeutic effects of Red Liriope platyphylla(RLP) on atopic dermatitis(AD), alterations in the luciferase(Luc) signal and general phenotype biomarkers were compared in phthalic anhydride(PA) treated Interleukin-4(IL-4)/Luc/Consensus non-coding sequence-1(CNS-1) transgenic(Tg) mice following treatment with aqueous extract of RLP(AEt RLP) for4 ***: Alterations in AD phenotypes were measured in IL-4/Luc/CNS-1 Tg mice following treatment with AEt RLP using inflammation parameter analysis, bioluminescence imaging analysis, histological analysis, reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay and Western blot ***: RLP contained high concentrations of total phenolic compounds, total flavonoid compounds and 5-HNE related to AD therapy. The Luc signal was only detected in the abdominal region and the submandibular lymph node(SL), mesenteric lymph node(ML), thymus and pancreas of the PA treated group. This signal was significantly decreased by 28%-73% throughout the body and in the four organs in PA + AEt RLP treated group. Furthermore, the lymph node weight, immunoglobulin E concentration and dermal thickness were decreased by 37%-67% in the PA + AEt RLP treated ***: Our findings suggest that the therapeutic effect of AEt RLP on PA induced AD could be successfully quantified by comparison of Luc signals and AD phenotype markers in IL-4/Luc/CNS-1Tg mice, and that the Luc signal was as sensitive as the general AD phenotypes, enabling detection of effects without euthanasia.

关键词： Dermatitis, Atopic Liriope plant Interleukin-4 Luciferases Mice, transgenic Phthalic anhydrides Immunoglobulin E

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Tailoring strength-ductility balance of caliber-rolled AZ31 Mg alloy through subsequent annealing

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Journal of Magnesium and Alloys 2020年第1期8卷 163-171页

作者： Taein Kong Byung Je kwak Jonghyun Kim Jeong Hun Lee Sung Hyuk Park Ji Hoon Kim Young Hoon moon Hyun Sik Yoon Taekyung Lee School of Mechanical Engineering Pusan National UniversityBusan 46241Republic of Korea Advanced Forming Process R&D Group Korea Institute of Industrial TechnologyUlsan 44413Republic of Korea College of Materials Science and Engineering Chongqing UniversityChongqing 400044China School of Materials Science and Engineering Kyungpook National UniversityDaegu 41566Republic of Korea Department of Naval Architecture and Ocean Engineering Pusan National UniversityBusan 46241Republic of Korea

Recently,multi-pass caliber rolling has been shown to be effective for Mg *** study investigated the effect of subsequent annealing on the mechanical properties of a caliber-rolled AZ31 Mg alloy to modulate the strength-ductility *** annealing gave rise to different trends in mechanical properties depending on the temperature ***-temperature annealing(T≤473 K)exhibited a typical trade-off relationship,where an increase in annealing temperature resulted in increased ductility but decreased strength and *** a heat treatment did not degrade the high strength-ductility balance of the caliber-rolled alloy,suggesting that the mechanical properties could be tailored for different potential *** contrast,high-temperature annealing(T>473 K)caused a simultaneous deterioration in strength,hardness,and ductility with increasing annealing *** differences are discussed in terms of the varying microstructural features under the different investigated annealing regimes.

关键词： AZ31 Mg alloy Caliber rolling Annealing Grain growth Mechanical improvement Twinning

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Expression of protein S100A4 is a predictor of recurrence in colorectal cancer

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World Journal of Gastroenterology 2010年第31期16卷 3897-3904页

作者： Jung Myun kwak Hyun Joo Lee Seon Hahn Kim Han Kyeom Kim Young Jae Mok Young Tae Park Jong Sang Choi Hong Young moon Department of Surgery Korea University Anam Hospital Department of Pathology Korea University Guro Hospital Department of Surgery Korea University Guro Hospital Department of Gastroenterology Korea Uni-versity Guro Hospital

AIM: To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53. METHODS: A cohort of archival formalin-fixed paraff inembedded specimens was selected from 127 patients with colorectal cancer who underwent surgical resection between April 2000 and March 2004 at the Department of Surgery, Korea University Guro Hospital. The expression of protein S100A4 was evaluated according to the proportion of positively stained cancer cells. In each case, three core biopsies with a diameter of 2 mm were punched out and positioned in a recipient paraff in array block. Four-μm sections of these tissue array blocks were used for immunohistochemical analysis of protein S100A4, E-cadherin, and p53. Clinicopathological data were based on the original histopathologic reports and clinical records of patients. RESULTS: In normal colorectal mucosa, protein S100A4 immunoreactivity was clearly absent in both cytoplasm and nucleus. However, positive immunoreactivity of protein S100A4 was detected in 45 (35.4%) of the tumor cases. There was no significant association between positive immunoreactivity of protein S100A4 and clinicopathological parameters such as tumor differentiation or TNM stage, and also no correlation between the reactivity and E-cadherin or p53 expression. However, positive immunoreactivity of protein S100A4 was found to be associated with tumor recurrence (P = 0.004), and was also associated with significantly worse overall survival in the Kaplan-Meyer survival analysis (P = 0.044). After adjustment for tumor differentiation, tumor depth and nodal status, however, it failed to achieve statistical significance (P = 0.067). CONCLUSION: The expression of protein S100A4 is associated with tumor recurrence and poor overall survival in patients with colorectal cancer.

关键词： S100A4 E-cadherin p53 Prognostic factor Colorectal cancer

Serum prostate-specific antigen value adjusted for non-cancerous prostate tissue volume in patients undergoing radical prostatectomy： a new predictor of biochemical recurrence in localized or locally advanced prostate cancer

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Asian Journal of Andrology 2011年第2期13卷 248-253页

作者： Ja Hyeon Ku kyung Chul moon Sung Yong Cho Cheol kwak Hyeon Hoe Kim Department of Urology Seoul National University College of Medicine Seoul 1 10-744 Korea Department of Pathology Seeul National University College of Medicine Seoul110-744 Korea

The aim of this study was to investigate the significance of serum prostate-specific antigen （PSA） value adjusted for total tumor volume （PSA/tumor volume） and serum PSA value adjusted for non-cancerous prostate tissue volume （NCPV）（PSA/NCPV） as a predictor of pathological findings and clinical outcome after radical prostatectomy. Clinical and pathological data of 407 patients （median age： 66.5 years; range： 41.8--85.7 years） were reviewed retrospectively. The median follow-up period was 18. I months （range： 1.0- 107.8 months）. Biochemical recurrence was defined as detectable PSA levels （greater than 0.2 ng ml-1） and the time of biochemical recurrence was taken to be the first time PSA became detectable. In the multivariate model, PSA/NCPV was an independent predictor of extracapsular extension and positive surgical margin （P〈O.05）, but PSA/tumor volume was not. Kaplan-Meier curves revealed that PSA/NCPV correlated with biochemical recurrence-free survival （P〈O.O01; log-rank test） but PSA/tumor volume did not （P=0.275; log-rank test）. PSA/NCPV was also a significant independent prognostic factor for biochemical recurrence-free survival on multivariate Cox proportional hazard analysis （P=0.004, relative risk=2.42）. Our findings suggest that PSA/NCPV is associated independently with extracapsular extension and surgical margin status and may be an independent prognostic variable of PSA recurrence after radical prostatectomy.

关键词： prostatectomy prostatic neoplasm PSA treatment outcome tumor volume

细胞学检查不能确诊的甲状腺结节的恶性危险分级:结合甲状腺影像报告和数据系统及Bethesda系统的综合分析

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国际医学放射学杂志 2015年第2期 173-174页

作者： H.J.moon E.K.Kim J.H.Yoon J.Y.kwak 郭凌飞 Department of Radiology Research Institute of Radiological Science Severance Hospital Yonsei University College of Medicine 50 Yonse-ro Seodaemun-gu 120-752 Seoul Kore

摘要目的依据经超声引导细针抽吸活检(FNAB)不能确诊的甲状腺结节的恶性风险进行评估,并且根据甲状腺报告与数据系统(TIRADS)评估需重复进行经超声引导FNAB

关键词：结节甲状腺粒子肉内分泌腺数据系统

超声随访中可能良性乳腺病灶的间歇生长：怎样处理这些病灶？

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国际医学放射学杂志 2011年第4期34卷 392-408页

作者： H.J.moon E.K.Kim J.Y.kwak J.H.Yoon M.J.Kim 余华君 Department of Radiology Research Institute of Radiological ScienceYonsei University College of Medicine

目的调查在随访超声（US）中间隔生长的可能良性病灶的恶性率,以及预测恶性病灶的临界值。方法回顾性复习被评估为可能良性病灶的19432例US检查资料,199例病人中共有214个间隔生长的病灶被纳入该研究。

关键词：乳腺肿瘤不确定肿块超声监测活检

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甲状腺小结节的诊断与管理:甲状腺结节6项指南的比较研究

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国际医学放射学杂志 2017年第4期 467-468页

作者： J.H.Yoon K.Han E.K.Kim H.J.moon J.Y.kwak 赵智勇 Department of Radiology Severance HospitalResearch Institute of Radiological Science Yonsei UniversityCollege of Medicine

摘要目的探讨6项指南的诊断效果,以便用于评估甲状腺结节并确定这些指南中是否可辨别出人群中的恶性甲状腺癌。材料与方法纳入2007年3月—2010年2月共4 696个甲状腺结节。基于细胞学结果为基础,4 585例病人共4 696个1;cm的甲状腺结节被...

摘要目的探讨6项指南的诊断效果,以便用于评估甲状腺结节并确定这些指南中是否可辨别出人群中的恶性甲状腺癌。材料与方法纳入2007年3月—2010年2月共4 696个甲状腺结节。基于细胞学结果为基础,4 585例病人共4 696个1;cm的甲状腺结节被明确诊断为良性或恶性。回顾性分析甲状腺结节的超声检查及以先前发布的甲状腺

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灰阶超声和弹性成像在实性甲状腺结节中的诊断表现

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国际医学放射学杂志 2012年第3期 276-277页

作者： H.J.moon J.M.Sung E.K.Kim J.H.Yoon J.H.Youk J.Y.kwak 乔辉 Department of Radiology Research Institute of Radiological ScienceYonsei University College of Medicine250 SeongsannoSeodaemun-gu120-752 SeoulKorea

目的评价灰阶超声(US)和弹性成像在鉴别甲状腺良、恶性结节中的诊断表现。材料与方法这是一个经机构审查委员会批准的有知情同意放弃的回顾性研究。总共包括676例病人的703个实性甲状腺结节(年龄18～79岁,平均49.7岁),其中女性556例(年... 详细信息

目的评价灰阶超声(US)和弹性成像在鉴别甲状腺良、恶性结节中的诊断表现。材料与方法这是一个经机构审查委员会批准的有知情同意放弃的回顾性研究。总共包括676例病人的703个实性甲状腺结节(年龄18～79岁,平均49.7岁),其中女性556例(年龄20～74岁,平均49.5岁),男

关键词：灰阶超声弹性成像结节甲状腺粒子肉内分泌腺实性

基于超声征象建立甲状腺结节恶性度分级的影像报告与数据系统

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国际医学放射学杂志 2011年第6期 586-586页

作者： J.Y.kwak J.H.Yoon H.J.moon E.J.Son S.H.Park 洪桂洵 Department of Radiology Research Institute of Radiological ScienceYonsei University College of Medicine250 SeongsannoSeodaemun-guSeoul 120-752Korea

目的建立一种实用的甲状腺影像报告与数据系统,对甲状腺结节进行分类并对其恶性度进行分级。方法本研究获得了伦理审查委员会批准,回顾性分析影像资料的研究,免除病人的知情同意。2008年5月—12月间对连续的3414例共3674个局灶性甲状腺... 详细信息

目的建立一种实用的甲状腺影像报告与数据系统,对甲状腺结节进行分类并对其恶性度进行分级。方法本研究获得了伦理审查委员会批准,回顾性分析影像资料的研究,免除病人的知情同意。2008年5月—12月间对连续的3414例共3674个局灶性甲状腺结节行超声引导下细针抽吸活检(FNAB),其中病理及随访资料齐全的1638例(女性

关键词：甲状腺恶性度粒子肉内分泌腺结节数据系统超声征象