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Optimal management for alcoholic liver disease: Conventional medications, natural therapy or combination?

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World journal of Gastroenterology 2016年第1期22卷 8-23页

作者： moon-Sun kim Madeleine Ong Xianqin Qu School of Medical and Molecular Biosciences University of Technology Sydney Faculty of Pharmacy University of Sydney

Alcohol consumption is the principal factor in thepathogenesis of chronic liver *** liver disease(ALD)is defined by histological lesions on the liver that can range from simple hepatic steatosis to more advanced stages such as alcoholic steatohepatitis,cirrhosis,hepatocellular carcinoma and liver *** one of the oldest forms of liver injury known to humans,ALD is still a leading cause of liver-related morbidity and mortality and the burden is exerting on medical systems with hospitalization and management costs rising constantly *** the biological mechanisms,including increasing of acetaldehyde,oxidative stress with induction of cytochrome p4502E1,inflammatory cytokine release,abnormal lipid metabolism and induction of hepatocyte apoptosis,by which chronic alcohol consumption triggers serious complex progression of ALD is well established,there is no universally accepted therapy to prevent or *** this article,we have briefly reviewed the pathogenesis of ALD and the molecular targets for development of novel *** review is focused on current therapeutic strategies for ALD,including lifestyle modification with nutrition supplements,available pharmacological drugs and new agents that are under development,liver transplantation,application of complementary medicines,and their *** relevant molecular mechanisms of each conventional medication and natural agent have been reviewed according to current available knowledge in the *** also summarized efficacy vs safety on conventional and herbal medicines which are specifically used for the prevention and treatment of *** a system review,this article highlighted that the combination of pharmaceutical drugs with naturally occurring agents may offer an optimal management for ALD and its *** is worthwhile to conduct large-scale,multiple centre clinical trials to further prove the safety and benefits for the integrative therapy on ALD.

关键词： Alcoholic liver disease Alcohol hepatitis Conventional medicines Natural medicines Hepaticlipid metabolism Hepatic inflammation Combinationtherapy

Parametric study on hydraulic performance of an inlet plenum in a printed-circuit heat exchanger

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Science China(Technological Sciences) 2013年第9期56卷 2137-2142页

作者： LEE Sang-moon KOO Gyoung-Wan kim Kwang-Yong Department of Mechanical Engineering Inha University

Hydraulic performance of an inlet plenum in a printed-circuit heat exchanger has been analyzed using three-dimensional Reynolds-Averaged Navier-Stokes equations. The numerical model of the inlet plenum was constructed through grid dependency test, calculation domain tests, and turbulence model and numerical scheme selections. Shear stress transport turbulence model was used for analysis of turbulence. Non-uniformity of the flow in zigzag flow channels was evaluated for the reference case. Parametric studies have been performed with the angle of the inlet plenum wall, radius of curvature of the inlet plenum wall, and width of the inlet pipes. The effects of these parameters on the flow uniformity and friction performance were evaluated.

关键词： printed-circuit heat exchanger inlet plenum Reynolds-averaged Navier-Stokes equations flow uniformity friction

Evaluation of lubrication performance of crank pin bearing in a marine diesel engine

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Friction 2018年第4期6卷 464-471页

作者： Suk Man moon Yong joo CHO Tae Wan kim School of Mechanical Engineering Pusan National University Department of Mechanical Engineering Pukyong National University

In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact.

关键词： crank pin bearing film thickness lubricant film parameter diesel engine

Wind response of high-rise building in diversified inlets to construct wind turbine system on roof

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journal of Central South University 2014年第11期21卷 4395-4403页

作者： YOU Ki-pyo YOU jang-youl kim Young-moon Department of Architecture Engineering Long-Span Steel Frame System Research Center Chonbuk National UniversityChonju 561-756 Korea KOCED Wind Tunnel Center Chonbuk National UniversityChonju 561-756 Korea

Many skyscrapers have installed wind turbine systems to use new renewable energy. In particular, building an integrated wind power generation system by installing a wind power generator inside a building is an attractive method to secure safe energy. However, most studies have dealt with the efficiency of wind turbines and the response effects of wind induced vibration; space preparation for wind turbine installations has not been sufficiently considered. This work reviewed the shapes of openings where wind turbines can be installed in skyscrapers, and the characteristics of wind induced vibration responses occurring in the building with changes in cross sectional area. Nine wind power models were constructed to carry out the experiment. According to the experimental results, wind speed varies with shape of opening in the order of C-type>S-type>R-type. Moreover, wind speed increases as the area is reduced.

关键词： wind induced vibration tall building shapes of opening wind turbine

High-temperature Oxidation Behavior of Zircaloy-4 and Zirlo in Steam Ambient

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journal of Materials Science & Technology 2010年第9期26卷 827-832页

作者： Hyung Hoon kim jun Ho kim jin Young moon Ho Seong Lee jeong joo kim Young Suck Chai School of Materials Science and Engineering Kyungpook National University School of Mechanical Engineering Yeungnam University214-1 Dae-dongGyeongsan-si

The oxidation characteristics for Zircaloy-4 and Zirlo in the temperature range of 700-1200°C under steam supply condition were investigated by using a modified thermo-gravimetric *** specimens were oxidized for 3600 s at each temperature and then quenched in a *** oxidation rate constants were measured from the weight gains to evaluate the oxidation behavior in Zircaloy-4 and *** weight gain rates of Zirlo were lower than those of Zircaloy-4,leading to the low rate *** different oxidation behaviors between both cladding materials were considered to be due to the difference in their chemical compositions.

关键词： Zircaloy-4 Zirlo Oxidation

Nucleus-Encoded Thylakoid Protein,OsY3IP1,Confers Enhanced Tolerance to Saline and Alkaline Stresses in Rice

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Rice science 2022年第3期29卷 225-236页

作者： Hyeran moon Young-Ah kim Ryoung SHIN Chang-jin PARK Department of Molecular Biology Sejong University Department of Bioresources Engineering Sejong University RIKEN Center for Sustainable Resource Science Plant Engineering Research Institute Sejong University

Abiotic stress confers serious damage to the photosynthetic machinery,often resulting in plant growth *** chloroplast open reading frame 3(Ycf3)-interacting protein 1(Y3IP1)is a nucleus-encoded thylakoid protein and plays an essential role in the assembly of photosystem *** full-length cDNA over-expresser(FOX)gene-hunting system is an approach using systemically generated gain-of-function *** the FOX-rice lines,a line CE175 overexpressing rice Y3IP1gene(Os Y3IP1)displayed less inhibition of root growth under saline(NaCl)*** expression of Os Y3IP1 was up-regulated under saline and alkaline(Na2CO3)stresses in the rice variety *** saline and alkaline treatments,transgenic Kitaake overexpressing OsY3IP1-GFP(OsY3IP1-GFPox/Kit)displayed higher levels of chlorophyll content compared to *** the stress conditions,the maximum quantum yield of photosystem II photochemistry levels was higher in OsY3IP1-GFPox/Kit than in *** increased tolerance conferred by OsY3IP1 overexpression correlated with reduced reactive oxygen species *** data provide new insights into the possible role of OsY3IP1 in the pathway suppressing photooxidative damage under stress *** features can be further exploited to improve saline and alkaline tolerances of rice plants in future.

关键词： alkaline reactive oxygen species rice saline stress tolerance

Environmentally friendly hybrid coating prepared by electro-deposition method at various seawater conditions

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中国有色金属学会会刊：英文版 2009年第B09期19卷 110-113页

作者： Myeong-Hoon LEE Kyung-Man moon jong-Do kim Kang jUN Kwang-Ho kim Division of Marine System Engineering Korea Maritime University Dongsam-Dong Youngdo Busan 606-791 Korea National Core Research Center for Hybrid Materials Solution Pusan National University Busan 609-735 Korea

The formation mechanism of calcareous deposit films in seawater involves an increase in pH at the metal/solution interface due to cathodic reactions, a raised carbonate ion concentration at the interface and precipitation of inorganic deposits such as CaCO3, Mg(OH)2. Environmentally friendly hybrid calcareous deposit films were formed by an electrochemical technique on steel substrates in various solution environments. And the influence of dissolved gas on formation of calcareous deposit films was investigated by scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and X-ray diffractometry(XRD). Consequently, these results showed that formation of good overall calcareous deposited films by dissolved gas in seawater environments can be achieved by controlling the material composition and structure through effective use of electrochemical method.

关键词：海水混合环保电沉积扫描电子显微镜涂层制备溶液界面

Fingerprint inspired advanced end-effector and its applications

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Friction 2022年第10期10卷 1739-1750页

作者： Sung Ho LEE Hyo Sung kim Han jun PARK moon Kyu KWAK Department of Electrical Engineering and Computer Science University of MichiganAnn Arbor 48109USA Department of Mechanical Engineering Kyungpook National UniversityDaegu 41566Republic of Korea

The human fingertip consists of a fingerprint with many micro-grating *** main roles of the fingerprint could be divided into two purposes,namely,the enhancement of the frictional force and the effective transmittance of the *** this study,we present the fingerprint-inspired end-effector that has not only admirable frictional force but also electric *** end-effector is composed of fluorocarbon rubber,one of the famous materials to achieve high frictional force and *** various experiments,the novel performance of micro structured fluorocarbon rubber end-effector(MSFE)is characterized by comparing with a macroscale patterned sample(MPS),which has been already used in real industrial *** results are analyzed ***,as feasible applications,we suggest two applications based on the role of the *** is the conductive astronaut glove with high frictional force,and the other one is a non-slip pad for the next-generation glass transfer *** these experiments,we successfully observe the enhanced system performance and confirm the possibility of using the MSFE as feasible *** believe that the MSFE could be a useful and powerful alternative as an end-effector,not only in the aerospace industry but also in display manufacturing processes.

关键词： fingerprint end-effector fluorocarbon rubber(FKM) glass transfer system spacesuit

Ultrasensitive and Highly Stretchable Multiple‑Crosslinked Ionic Hydrogel Sensors with Long‑Term Stability

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Nano-Micro Letters 2023年第4期15卷 85-96页

作者： jin‑Young Yu Seung Eon moon jeong Hun kim Seong Min Kang Department of Mechanical Engineering Chungnam National UniversityDaejeon 34134Korea Emerging Nano‑Materials Research Section Electronics and Telecommunications Research InstituteDaejeon 305‑700Republic of Korea

Flexible hydrogels are receiving significant attention for their application in wearable ***,most hydrogel materials exhibit weak and one-time adhesion,low sensitivity,ice crystallization,water evaporation,and poor self-recovery,thereby limiting their application as *** issues are only partly addressed in previous ***,a multiplecrosslinked poly(2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide-co-acrylamide)(P(SBMA-co-AAm))multifunctional hydrogel is prepared via a one-pot synthesis method to overcome the aforementioned ***,ions,glycerol,and 2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide are incorporated to reduce the freezing point and improve the moisture retention *** proposed hydrogel is superior to existing hydrogels because it exhibits good stretchability(a strain of 2900%),self-healing properties,and transparency through effective energy dissipation in its dynamic crosslinked ***,2-(methacryloyloxy)ethyl)dimethyl-(3-sulfopropyl)ammonium hydroxide as a zwitterion monomer results in an excellent gauge factor of 43.4 at strains of 1300-1600%by improving the ion transportability and achieving a strong adhesion of 20.9 kPa owing to the dipole-dipole *** proposed hydrogel is promising for next-generation biomedical applications,such as soft robots,and health monitoring.

关键词： Hydrogel sensors Biocompatibility Multifunction High-sensitivity sensors Multiple-crosslink association