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In situ measurement of ECM rheology and microheterogeneity in embedded and overlaid 3D pancreatic tumor stroma co-cultures via passive particle tracking

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Journal of Innovative Optical Health Sciences 2017年第6期10卷 26-34页

作者： Dustin p.jones William Hanna Gwendolyn M.Cramer Jonathan p.Celli Department of physics University of Massachusetts Boston Boston MA 02215USA

Tumor growth is regulated by a diverse set of extraellular infuences,including paracrine crosstalk with stromal partners,and biophysical interactions with surrounding cells and *** elucidating the role of physical force and the mechanical properties of the extracellular matrix(ECM)itself as regulators of tumor growth and invasion have been greatly catalyzed by the use of in ritro three-dimensional(3D)tumor *** systems provide the ability to systematically isolate,manipulate,and evaluate impact of stromal components and extracellular mechanics in a platform that is both conducive to imaging and biologically ***,recognizing that mechanoregulatory crosstalk is bi-directional and fully utilizing these models requires complementary methods for in situ measurements of the local mechanical ***,in 3D tumor/fbroblast co-culture models of pancreatic canocer,a discase characterized by its prominent stromal involvement,we evaluate the use of particle-tracking microrhoology to probe dynamic mechanical *** videos of fuorescently labeled polystyrene micro-spheres embedded in ollagen I ECM,we measure spatiotemporal changes in the Brownian motion of probes to report local ECM shear modulus and *** approach reveals st ffening of collagen in fibroblast co-cultures relative to cultures with cancer cells only,which exhibit degraded ECM with heterogeneous *** further show that these effects are dependent on culture geometry with contrast ing behavior for embedded and overlay *** addition to potential application to screening stroma targeted therapeutics,this work also provides insight into how the compoition and plating geometry impact the mechanical propertios of 3D cell cultures that are increasingly widey used in cancer biology.

关键词： Microrheology 3D tumor models matrix remodeling mechanobiology stromal depletion

Influence of biological sex and exercise on murine cardiac metabolism

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Journal of Sport and Health Science 2022年第4期11卷 479-494页

作者： Kyle Fulghum Helen E.Collins Steven p.jones Bradford G.Hill Diabetes and Obesity Center Department of MedicineDivision of Environmental MedicineChristina Lee Brown Envirome InstituteUniversity of LouisvilleLouisvilleKY 40202USA Department of physiology University of LouisvilleLouisvilleKY 40202USA

Although the structural and functional effects of exercise on the heart are well established,the metabolic changes that occur in the heart during and after exercise remain *** this study,we used metabolomics to assess time-dependent changes in the murine cardiac metabolome following 1 session of treadmill *** the exercise bout,we also recorded blood lactate,glucose,and ketone body levels and measured cardiac mitochondrial *** both male and female mice,moderate-and high-intensity exercise acutely increased blood lactate *** both sexes,low-and moderate-intensity exercise augmented circulating 3-hydroxybutryrate levels immediately after the exercise bout;however,only in female mice did high-intensity exercise increase 3-hydroxybutyrate levels,with significant increases occurring 1 h after the exercise *** metabolomics analyses of sedentary female and male hearts suggest considerable sex-dependent differences in basal cardiac metabolite levels,with female hearts characterized by higher levels of pantothenate,pyridoxamine,homoarginine,tryptophan,and several glycerophospholipid and sphingomyelin species and lower levels of numerous metabolites,including acetyl coenzyme A,glucuronate,gulonate,hydroxyproline,prolyl-hydroxyproline,carnosine,anserine,and carnitinylated and glycinated species,as compared with male *** after a bout of treadmill exercise,both male and female hearts had higher levels of corticosterone;however,female mice showed more extensive exercise-induced changes in the cardiac metabolome,characterized by significant,time-dependent changes in amino acids(e.g.,serine,alanine,tyrosine,tryptophan,branched-chain amino acids)and the ketone body *** from experiments using isolated cardiac mitochondria suggest that high-intensity treadmill exercise does not acutely affect respiration or mitochondrial coupling;however,female cardiac mitochondria demonstrate generally higher adenosi

关键词： Ketone bodies Metabolomics Mitochondria physical activity Sex difference

perspectives for the recovery of rare earths from end-of-life fluorescent lamps

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Journal of Rare Earths 2014年第3期32卷 195-200页

作者： K.Binnemans p.T.jones Department of Chemistry KU Leuven – University of LeuvenCelestijnenlaan 200F- box 2404 B-3001 Heverlee Belgium Department of Metallurgy and Materials Engineering KU Leuven – University of LeuvenKasteelpark Arenberg 44 - box 2450 B-3001 Heverlee Belgium

This vision paper discusses the advantages and disadvantages of the three main options for the recycling of rare-earth ele- ments from end-of-life fluorescent lamps：（1） direct re-use of the lamp phosphor mixture; （2） separation of the lamp phosphor mixture into the different phosphor components; （3） recovery of the rare-earth content. An overview is given of commercial activities in Europe in the domain of recycling of materials from end-of-life fluorescent lamps and the recovery of rare earths from these lamps. The collection of end-of-life fluorescent lamps is currently driven by a legal framework that prohibited the release of mercury to the environment. The contaminations of the lamp phosphor powders by mercury and by small glass particles of crushed fluorescent lamps are limiting factors in the recycling process. Research should be directed to an advanced clean-up of the reclaimed lamp phosphor fraction, and in particular to the removal of mercury and glass fragments. The recovery of rare earths from the lamp phosphors could be facilitated by taking advantage of the differences in resistance of the different lamp phosphors by chemical attack by inorganic ac- ids and bases.

关键词： balance problem fluorescence lamps lamp phosphors lanthanides rare-earth elements recycling urban mining

用键合相硅胶的离子色谱法测定铂族金属和金的氯络合物

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湿法冶金 1990年第3期9卷 74-79页

作者： p.jones 巫忆陵

采用硅基相的阴离子交换和离子相互作用法,研究了Au(Ⅲ)、Ir(Ⅳ)、Ir(Ⅲ)、Os(Ⅳ)、pd(Ⅱ)、pt(Ⅳ)、Rh(Ⅲ)和Ru(Ⅲ)氯络合物的离子色谱。体系中不存在氯化物或其浓度很低,且其pH值高,则能够使用钢制液相色谱设备。采用阴离子交换法时,... 详细信息

采用硅基相的阴离子交换和离子相互作用法,研究了Au(Ⅲ)、Ir(Ⅳ)、Ir(Ⅲ)、Os(Ⅳ)、pd(Ⅱ)、pt(Ⅳ)、Rh(Ⅲ)和Ru(Ⅲ)氯络合物的离子色谱。体系中不存在氯化物或其浓度很低,且其pH值高,则能够使用钢制液相色谱设备。采用阴离子交换法时,Ir(Ⅳ)、Ir(Ⅲ)、Os(Ⅳ)和pt(Ⅳ)具有好的稳定的色谱图,除Ir(Ⅳ)由于样品溶液不稳定外,其它离子有线性的校正曲线。检测限分别为Ir(Ⅲ)5ng/mL、Os(Ⅳ)10ng/mL和pt(Ⅳ)2ng/mL。采用离子相互作用法不是很成功的,仅Au(Ⅲ)和pd(Ⅱ)能得到稳定的色谱图。虽然校正曲线稍有弯曲,但尚能接受。Au(Ⅲ)和pd(Ⅱ)的检测限分别为10和30ng/mL。

关键词：铂族金属色谱法测定金氯络合物

Oxidative damages to DNA by indoor pM10s: Their relationships with trace element compositions

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progress in Natural Science:Materials International 2005年第8期15卷 694-699页

作者： T. p. jones,L. MEROLLA School of Earth Ocean and planetary Sciences Cardiff University Cardiff CF10 3YE UK School of Biosciences Cardiff University Cardiff CF10 3US UK

plasmid DNA assay and ICp-MS analysis were conducted in order to investigate the bioreactivity of inhalable particles （pM_ 10） and the relationship between bioreactivity and trace element compositions of pM_ 10 in Beijing air. A total of four pM_ 10 samples were carefully selected to represent the indoor and corresponding outdoor environments: one from urban smoker's home, two from non-smoker's homes, and the other from the outdoor. In general, the oxidative damage by indoor pM_ 10 was slightly higher than that of outdoor. Among the four sets of samples, the pM_ 10 from the smoker's home had a lowest TD50 （toxic dose of pM_ 10 causing 50% DNA to be damaged）, being 100 μg·mL -1, suggesting the highest bioreactivity. The heavy metals are believed to be the main reason for oxidative damage to plasmid DNA. The ICp-MS analysis combined with the DNA assay showed that the water-soluble zinc levels had better relationship with TD50 values than other elements, implying that water-soluble zinc might play an important role in the damage of DNA. It is concluded that the pM_ 10 in smoker's home had the highest level of water-soluble zinc as well as the lowest TD50 （highest bioreactivity）. Iron is considered to be one of the most bioreactive elements, but it will cause little damage to plasmid DNA, probably because iron is mainly in water-insoluble state in Beijing pM_ 10.

关键词： plasmid DNA assay oxidative capacity trace element indoor air pM_ 10.

Dim artificial light at night reduces the cellular immune response of the black field cricket, Teleogryllus commodus

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Insect Science 2020年第3期27卷 571-582页

作者： Joanna Durrant Mark p.Green Theresa M.jones The School of BioSciences Faculty of ScienceUniversity of MelbourneVictoria3010Australia

A functioning immune system is crucial for protection against disease and illness,yet increasing evidence suggests that species living in urban areas could be suffering from immune suppression,due to the presence of artificial light at night(ALAN).This study examined the effects of ecologically relevant levels of ALAN on three key measures of immune function(haemocyte concentration,lytic activity,and phenoloxidase activity)using a model invertebrate species,the Australian black field cricket,Teleogryllus *** reared crickets under an ecologically relevant daily light‐cycle consisting of 12 hr bright daylight(2600 lx)followed by either 12 h darkness(0 lx)or dim environmentally relevant ALAN(1,10,100 lx),and then assessed immune function at multiple time points throughout adult life using haemolymph *** found that the presence of ALAN had a clear negative effect on haemocytes,while the effects on lytic activity and phenoloxidase activity were more complex or largely unaffected by ***,the effects of lifelong exposure to ALAN of 1 lx were comparable to those of 10 and 100 *** data suggest that the effects of ALAN could be large and widespread,and such reductions in the core immune response of individuals will likely have greater consequences for fitness and survival under more malign conditions,such as those of the natural environment.

关键词： circadian rhythm ecophysiology immune function immunomodulation invertebrate light pollution melatonin urbanization

Integrated Approach to Detect Cyberbullying Text:Mobile Device Forensics Data

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Computer Systems Science & Engineering 2022年第3期40卷 963-978页

作者： G.Maria jones S.Godfrey Winster p.Valarmathie Department of Computer Science and Engineering Saveetha Engineering CollegeChennai602105India Department of Computer Science and Engineering School of ComputingSRM Institute of Science and TechnologyChengalpattu603203India Department of Information Technology Saveetha Engineering CollegeChennai602105India

Mobile devices and social networks provide communication opportunities among the young generation,which increases vulnerability and cybercrimes activities.A recent survey reports that cyberbullying and cyberstalking constitute a developing issue among *** paper focuses on cyberbullying detection in mobile phone text by retrieving with the help of an oxygen forensics *** describe the data collection using forensics technique and a corpus of suspicious activities like cyberbullying annotation from mobile phones and carry out a sequence of binary classification experiments to determine cyberbullying *** use forensics techniques,Machine Learning(ML),and Deep Learning(DL)algorithms to exploit suspicious patterns to help the forensics investigation where every evidence contributes to the *** on a real-time dataset reveal better results for the detection of cyberbullying *** Random Forest in ML approach produces 87%of accuracy without SMOTE technique,whereas the value of F1Score produces a good result with SMOTE *** LSTM has 92%of validation accuracy in the DL algorithm compared with Dense and BiLSTM algorithms.

关键词： Mobile forensics cyberbullying machine learning investigation model suspicious pattern

Flame Structure of Methane and Kerosene Combustion with a Compact Concave Flame-Holder using the LES-pdf Method

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Journal of Thermal Science 2024年第1期33卷 222-234页

作者： WANG Fang WANG Yunfan WEI Guanyi LIU Denghuan JIN Jie jones p.William School of Energy and power Engineering Beihang UniversityBeijingBeijing 100191China Department of Mechanical Engineering Imperial College LondonLondon SW72AZUK

Compact flame-holders for afterburners are an increasing requirement for modern aero ***,flame-holder design is non-trivial since high inlet temperatures,velocities,and elaborate structures induce complex turbulence,combustion,and spray coupling in modern *** this work,the LES-pdf and stochastic fields-Lagrangian particle spray methods are used to investigate methane and aviation kerosene combustion structures formed by new-type concave *** flow pattern,combustion mode,and flame structure of gaseous and liquid fuel around a concave flame-holder are analyzed,discussed,and compared with experimental *** reveal that the flame stability of a concave flame-holder is better than that of the non-concave ***,when using liquid fuel,the concave flame-holder forms a stable and compact *** results suggest concave flame-holders are a promising design for compact afterburners.

关键词： concave structure flame-holder LES-pdf spray combustion flame structure AECSC

恢复红树林:热带发展中国家沿海管理的一种潜在手段

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人类环境杂志 1998年第8期27卷 654-659页

作者： Ursula L.Kaly Geoffrey p.jones 王燕澳大利亚昆士兰詹姆斯库克大学海洋生物系昆士兰詹姆斯库克大学大学海洋生物系

红树林生态系统是热带地区沿海的主要生境,它直接或间接地为人们提供了生活物资和商业鱼产品。然而,发展中国家红树林生态系统正在受到威胁,那里的红树林正为了满足人类各种活动而被砍伐。据估计,现在亚太地区每年损失1%的红树林面积,... 详细信息

红树林生态系统是热带地区沿海的主要生境,它直接或间接地为人们提供了生活物资和商业鱼产品。然而,发展中国家红树林生态系统正在受到威胁,那里的红树林正为了满足人类各种活动而被砍伐。据估计,现在亚太地区每年损失1%的红树林面积,有些地区已经失去了70%的原始红树林生境。由于不断的干扰、土地条件的改变和有限的扩种,自然恢复过程很缓慢。本文讨论了把恢复红树林作为管理沿海生态系统的一个潜在手段问题。我们简要地分析了红树林和渔业的关系,概述了评价恢复红树林行动的生态系统方法。过去发展中国家有关恢复红树林的项目只是着重再植树的各种方法,几乎不注重评价生态系统功能是否恢复。然而,恢复红树林项目的目的应该是积极地促进其自然群体的结构和自我维持的功能恢复(在自然变动范围内)。这个目标需要:①明确自然状态,包括维持自然基础的关键生物、维持鱼种的群落结构和食物网;②发展恢复关键生物的生物技术;③对项目能否长期保持成功进行评价。由于恢复被看作是维持发展中国家沿海生态系统健康的重要手段,所以应该优先考虑如何把恢复项目和对它的评价与沿海管理计划结合起来。

关键词：红树林热带沿海管理发展中国家潜在手段