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Incidental biliary dilation in the era of the opiate epidemic:High prevalence of biliary dilation in opiate users evaluated in the Emergency Department

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World Journal of Hepatology 2020年第12期12卷 1289-1298页

作者： monique T Barakat Subhas Banerjee Divisions of Adult and Pediatric Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94305United States Division of Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94304United States

BACKGROUND Biliary dilation is frequently related to obstruction;however,non-obstructive factors such as age and previous cholecystectomy have also been *** the past two decades there has been a dramatic increase in opiate use/dependence and utilization of cross-sectional abdominal imaging,with increased detection of biliary dilation,particularly in patients who use *** To evaluate associations between opiate use,age,cholecystectomy status,ethnicity,gender,and body mass index utilizing our institution’s integrated informatics *** One thousand six hundred and eighty-five patients(20%sample)presenting to our Emergency Department for all causes over a 5-year period(2011-2016)who had undergone cross-sectional abdominal imaging and had normal total bilirubin were included and *** Common bile duct(CBD)diameter was significantly higher in opiate users compared to non-opiate users(8.67 mm vs 7.24 mm,P<0.001)and in patients with a history of cholecystectomy compared to those with an intact gallbladder(8.98 vs 6.72,P<0.001).For patients with an intact gallbladder who did not use opiates(n=432),increasing age did not predict CBD diameter(r^2=0.159,P=0.873).Height weakly predicted CBD diameter(r^2=0.561,P=0.018),but weight,body mass index,ethnicity and gender did *** Opiate use and a history of cholecystectomy are associated with CBD dilation in the absence of an obstructive *** alone is not associated with increased CBD *** findings suggest that factors such as opiate use and history of cholecystectomy may underlie the previously-reported association of advancing age with increased CBD *** prospective study is warranted.

关键词： Biliary dilation Opiate Narcotic Endoscopic ultrasound Endoscopic retrograde cholangiopancreatography Bile duct

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Biofilm architecture: An emerging synthetic biology target

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Synthetic and Systems Biotechnology 2020年第1期5卷 1-10页

作者： Stephen J.Kassinger monique L.van Hoek George Mason University School of Systems BiologyGeorge Mason University10920 George Mason CircleManassasVA20110USA

Synthetic biologists are exploiting biofilms as an effective mechanism for producing various *** optimization has become commonplace as a method of maximizing system *** addition to production pathways,the biofilm itself contributes to the efficacy of *** purpose of this review is to highlight opportunities that might be leveraged to further enhance production in preexisting biofilm production *** opportunities may be used with previously established production systems as a method of improving system efficiency *** may be accomplished through the reduction in the cost of establishing and maintaining biofilms,and maintenance of the enhancement of product yield per unit of time,per unit of area,or per unit of required input.

关键词： Synthetic biology Tunable Biofilm engineering

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In Memoriam: Matthias Kuhle

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山地科学学报（英文） 2015年第5期12卷 1065-1067页

作者： Lasafam ITURRIZAGA Hermann KREUTZMANN Kenneth HEWITT LIU Shiyin monique FORT Section of Geography and High Mountain Geomorphology Institute of Geography University of Goettingen Centre for Development Studies Geographic Sciences Freie Universitaet Berlin Cold Regions Research Centre Wilfrid Laurier University Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Department of Geography CNRS PRODIG University Paris Diderot SPC

Matthias Kuhle,an internationally renowned physical geographer and highly respected geomorphologist,died tragically on the 25th of April,*** was in the Manaslu Himalaya,close to the epicentre of April 2015 Nepal earth... 详细信息

关键词：埃及地理学家喜马拉雅科学家尼泊尔十五地震

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Characterization of the voltage-gated sodium channel of the Asian citrus psyllid, Diaphorina citri

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Insect Science 2017年第1期24卷 47-59页

作者： Bin Liu monique R. Coy Jin-Jun Wang Lukasz L. Stelinski Entomology and Nematology Department Citrus Research and Education Center University of Florida Florida USA Key Laboratory of Entomology and Pest Control Engineering College of Plant Protection Southwest University Chongqing China

The Asian citrus psyllid, Diaphorina citri Kuwayama （Hemiptera： Liviidae）, is an important insect pest of citrus. It is the vector of ＇Candidatus＇ Liberibacter asiaticus, a phloem-limited bacterium that infects citrus, resulting in the disease Huanglongbing （HLB）. Disease management relies heavily on suppression of D. cirri populations with insecticides, including pyrethroids. In recent annual surveys to monitor insecticide resistance, reduced susceptibility to fenpropathrin was identified in several field populations olD. citri. The primary target ofpyrethroids is the voltage-gated sodium channel （VGSC）. The VGSC is prone to target-site insensitivity because of mutations that either reduce pyrethroid binding and/or alter gating kinetics. These mutations, known as knockdown resistance or kdr, have been reported in a wide diversity of arthropod species. Alternative splicing, in combination with kdr mutations, has been also associated with reduced pyrethroid efficacy. Here we report the molecular characterization of the VGSC in D. citri along with a survey of alternative splicing across developmental stages of this species. Previous studies demonstrated that D. citri has an exquisite enzymatic arsenal to detoxify insecticides resulting in reduced efficacy. The results from the current investigation demonstrate that target-site insensitivity is also a potential basis for insecticide resistance to pyrethroids in D. citri. The VGSC sequence and its molecular characterization should facilitate early elucidation of the underlying cause of an established case of resistance to pyrethroids. This is the first characterization of a VGSC from a hemipteran to this level of detail, with the majority of the previous studies on dipterans and lepidopterans.

关键词： citrusgreening diseasemanagement knockdownresistance(kdr) target-site insensitivity

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Escalating complexity of endoscopic retrograde cholangiopancreatography over the last decade with increasing reliance on advanced cannulation techniques

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World Journal of Gastroenterology 2020年第41期26卷 6391-6401页

作者： monique T Barakat Mohit Girotra Nirav Thosani Shivangi Kothari Subhas Banerjee Divisions of Adult and Pediatric Gastroenterology and Hepatology Stanford University Medical CenterCupertinoCA 95014United States Division of Gastroenterology and Hepatology University of Miami Miller School of MedicineMiamiFL 33136United States Department of Internal Medicine Division of GastroenterologyHepatology&NutritionUniversity of Texas Health Science Center HoustonHoustonTX 77030United States Division of Gastroenterology and Hepatology University of Rochester Medical CenterRochesterNY 14627United States Division of Gastroenterology and Hepatology Stanford University Medical CenterStanfordCA 94304United States

BACKGROUND At our academic tertiary care medical center, we have noted patients referred for endoscopic retrograde cholangiopancreatography(ERCP) who increasingly require advanced cannulation techniques. This trend is noted despite increased endoscopist experience and annual ERCP volume over the same *** To evaluate this phenomenon of perceived escalation in complexity of cannulation at ERCP and assessed potential underlying *** Demographic/clinical variables and records of ERCP patients at the beginning(2008), middle(2013) and end(2018) of the last decade were reviewed retrospectively. Cannulation approaches were classified as "standard" or "advanced" and duodenoscope position was labeled as "standard"(short position) or "non-standard"(e.g., long, semi-long).RESULTS Patients undergoing ERCP were older in 2018 compared to 2008(69.7 ± 15.2 years vs 55.1 ± 14.7, P 4 cm, pancreatic uncinate mass, and bilirubin > 10 mg/d L predicted use of advanced cannulation techniques(P < 0.03 for each).CONCLUSION Complexity of cannulation at ERCP has sharply increased over the past 5 years, with an increased proportion of elderly patients and those with malignancy requiring advanced cannulation approaches. These data suggest that complexity of cannulation at ERCP may be predicted based on patient/ampulla characteristics. This may inform selection of experienced, high-volume endoscopists to perform these complex procedures.

关键词： Endoscopic retrograde cholangiopancreatography Biliary cannulation Goff trans-pancreatic septotomy Needle knife precut sphincterotomy Endoscopy Complexity

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Dietary modification in the treatment of schizophrenia spectrum disorders: A systematic review

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World Journal of Psychiatry 2020年第8期10卷 187-201页

作者： monique Aucoin Laura LaChance Sam N Clouthier Kieran Cooley Department of Research and Clinical Epidemiology Canadian College of Naturopathic MedicineToronto M2K 1E2Canada Department of Psychiatry McGill UniversityMontreal H3A 0G4Canada Centre for Addiction and Mental Health Toronto M6R 1A1Canada Department of Doctoral Acupuncture and Chinese Medicine Pacific College of Health ScienceSan DiegoCA 92108United States

BACKGROUND Schizophrenia spectrum disorders impact functioning,reduce quality of life and increase the risk of physical illness and premature *** intervention studies aimed at decreasing body weight have demonstrated efficacy in improving metabolic outcomes;however,few studies have explored the impact of interventions designed to modify diet on mental health *** To synthesize the existing experimental studies of adjunctive diet modification as an intervention in the treatment of psychotic disorders,analyze findings related to effectiveness and safety,highlight knowledge gaps and limitations,and set forward recommendations for future research *** An extensive a priori search strategy was developed and the databases Embase,Embase Classic,Ovid MEDLINE were *** and data extraction were completed in *** included in this analysis were experimental studies of an adjunctive dietary intervention(overall dietary pattern or education on dietary change)for treatment of schizophrenia spectrum *** restrictions were placed on control groups or *** studies were required to report a mental health *** Twenty-five clinical trials were identified,along with two additional protocols and two *** of the clinical trials reported improvement in one or more mental health domain including psychosis symptoms,cognition,and quality of life.A high level of heterogeneity was found with respect to patient population,intervention,and study *** of the studies included lifestyle or psychosocial components in addition to dietary *** nutrition advice provided to participants was poorly described overall and compliance was not *** studies that showed benefit tended to have a smaller sample size and were less likely to be randomized but were more likely to use a group delivery *** Further research assessing effectiveness and efficacy of clear

关键词： Nutrition Psychosis Schizophrenia Diet

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Adverse events with bismuth salts for Helicobacter pylori eradication:Systematic review and meta-analysis

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World Journal of Gastroenterology 2008年第48期14卷 7361-7370页

作者： Alexander C Ford Peter Malfertheiner monique Giguère José Santana Mostafizur Khan Paul Moayyedi Gastroenterology Division McMaster University Health Sciences Centre Klinic fur Gastroenterologie Hepatologie and Infektiologie Otto-v.-Guerike Universitat Magdeburg Germany AxCan Pharma Inc.

AIM： To assess the safety of bismuth used in Helicobacter pylori （H pylorl） eradication therapy regimens. METHODS： We conducted a systematic review and meta-analysis. MEDLINE and EMBASE were searched （up to October 2007） to identify randomised controlled tri- als comparing bismuth with placebo or no treatment, or bismuth salts in combination with antibiotics as part of eradication therapy with the same dose and duration of antibiotics alone or, in combination, with acid suppresion. Total numbers of adverse events were recorded. Data were pooled and expressed as relative risks with 95% confidence intervals （CI）.RESULTS： We identified 35 randomised controlled trials containing 4763 patients. There were no serious adverse events occurring with bismuth therapy. There was no statistically significant difference detected in total adverse events with bismuth rrelative risk （RR） = 1.01; 95% CI： 0.87-1.16], specific individual adverse events, with the exception of dark stools （RR = 5.06; 95% CI： 1.59-16.12）, or adverse events leading to withdrawal of therapy （RR = 0.86; 95% CI： 0.54-1.37）. CONCLUSION： Bismuth for the treatment of H py/ori is safe and well-tolerated. The only adverse event occurring significantly more commonly was dark stools.

关键词： Bismuth Eradication therapy Helicobacterpylori Adverse events Systematic review Meta-analysis

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Bilateral uveitis associated with nivolumab therapy for metastatic melanoma: a case report

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International Journal of Ophthalmology(English edition) 2017年第7期10卷 1183-1186页

作者： Daniel Russell Richardson Brian Ellis Inderjit Mehmi monique Leys West Virginia University Eye Institute West Virginia University Cancer Institute

Dear Editor,I am *** Russell Richardson from the West Virginia University Eye Institute in Morgantown,West Virginia,United States.I write to present a case of uveitis associated with nivolumab,which is a promising new immune checkpoint inhibitor（ICI）for metastatic melanoma and non-small cell lung carcinoma with expanding *** the use of nivolumab continues to increase,ophthalmologists must be aware of uveitis as an adverse event.

关键词： melanoma metastatic Virginia checkpoint expanding Richardson aware write presentation Russell

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工业和农业废弃物在混凝土中的本地资源化利用:可持续解决方案（英文）

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硅酸盐学报 2015年第10期43卷 1372-1384页

作者： Arezki TAGNIT-HAMOU monique T TOGNONVI Department of Civil Engineering Universite de Sherbrooke 2500 Boulevard de l'Universite Sherbrooke (Qu6bec) J1K 2R1 Canada Department of Civil Engineering Universite de Sherbrooke 2500 Boulevard de l'Universite Sherbrooke (Qu6bec) J1K 2RI Canada

全球变暖是当今社会面临的主要环境问题，是由过量二氧化碳排放造成的。水泥生产过程中石灰石的分解和燃料的燃烧排放的CO2量占据了总排放的5％～8％。随着民用基础设施建设的快速发展，特别是在中国、印度、中东等发展中国家，水泥和... 详细信息

全球变暖是当今社会面临的主要环境问题，是由过量二氧化碳排放造成的。水泥生产过程中石灰石的分解和燃料的燃烧排放的CO2量占据了总排放的5％～8％。随着民用基础设施建设的快速发展，特别是在中国、印度、中东等发展中国家，水泥和混凝土使用量飞速增长。采用辅助胶凝材料替代混凝土中水泥的使用量，尤其是工业废弃物，能够显著降低了混凝土生产过程中的碳排放。普通的工业废弃物，如硅灰、粉煤灰、矿粉等并不是全部可以利用的，较远距离运输会造成CO2总排放量的增加。然而，铝生产工业的其他副产物和废弃纸泥灰也可以作为辅助胶凝材料进行循环利用的。农业生产中的废弃物，如甘蔗灰、棕榈油灰、椰子壳灰、稻壳灰等也有火山灰特性，能够将其作为辅助胶凝材料使用。此外，一些天然掺合料，如硅藻土含有丰富的火山灰活性组分。近年来，玻璃粉作为辅助胶凝材料在很多国家广泛应用。上述辅助胶凝材料的循环利用能够降低混凝土对环境影响，且能有效减少相关生产费用。

关键词：全球变暖工业废弃物农业废弃物可持续混凝土火山灰特性

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Understanding Factors of Bias in the Way Information Is Processed Through a Metamemetic and Multilogical Approach

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Intelligent Information Management 2022年第2期14卷 80-91页

作者： monique Cardinal Library and Information Services Kingston USA

Training in complex thinking is required in fields like computer science and discussing sensitive topics that can easily polarize internet users’ propensities. Multilogicality and Metamemetic reasoning are strongly suggested as an approach to identifying and analyzing factors related to AI Bias and human biases. This approach entails identifying problems and deducting invalid premises, distinguishing them from valid premises or those we are uncertain about. The theme of this paper focuses on four groups of people: curators, developers, businesses, and users (the fourth group being the main focus). This approach offers a new way to apply critical thinking strategies in the context of living in a digital age.

关键词： Information Ecology Algorithms Memetics Bias Reduction

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