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Dyslipidemia modulates Müller glial sensing and transduction of ambient information

Neural Regeneration Research 2018年第2期13卷 207-210页

作者： monika Lakk Felix Vazquez-Chona Oleg Yarishkin David Krizaj Department of Ophthalmology&Visual Sciences University of UtahSalt Lake CityUTUSA Department of Bioengineering University of UtahSalt Lake CityUTUSA Department of Neurobiology&Anatomy University of UtahSalt Lake CityUTUSA

Unesterified cholesterol controls the fluidity, permeability and electrical properties of eukaryotic cell mem- branes. Consequently, cholesterol levels in the retina and the brain are tightly regulated whereas depletion or oversupply caused by diet or heredity contribute to neurodegenerative diseases and vision loss. Astrog- lia play a central role in the biosynthesis, uptake and transport of cholesterol and also drive inflammatory signaling under hypercholesterolemic conditions associated with high-fat diet （diabetes） and neurodegen- erative disease. A growing body of evidence shows that unesterified membrane cholesterol modulates the ability of glia to sense and transduce ambient information. Cholesterol-dependence of Mfiller glia - which function as retinal sentinels for metabolic, mechanical, osmotic and inflammatory signals - is mediated in part by transient receptor potential V4 （TRPV4） channels. Cholesterol supplementation facilitates, where- as depletion suppresses, TRPV4-mediated transduction of temperature and lipid agonists in Mfiller cells. Acute effects of cholesterol supplementation/depletion on plasma membrane ion channels and calcium ho- meostasis differ markedly from the effects of chronic dyslipidemia, possibly due to differential modulation of modality-dependent energy barriers associated with the functionality of polymodal channels embedded within lipid rafts. Understanding of cholesterol-dependence of TRP channels is thus providing insight into dyslipidemic pathologies associated with diabetic retinopathy, glaucoma and macular degeneration.

关键词： dyslipidemia cholesterol Muller glia transient receptor potential V4 cyclodextrin calcium retina

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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

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Journal of Pharmaceutical Analysis 2021年第3期11卷 364-373页

作者： monika Zielinska Ewa Chmielewska Tomasz Buchwald Adam Voelkel PawełKafarski Poznan University of Technology Institute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and Technology Faculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of Technology Institute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland

There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.

关键词： Monolithic column Polymer composites Bisphosphonates Hydroxyapatite coatings Hydroxyapatite composite

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Structure and corrosion resistance of Al–Cu–Fe alloys

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Progress in Natural Science:Materials International 2020年第3期30卷 393-401页

作者： Rafa? Babilas Anna Bajorek monika Spilka Adrian Radoń Wojciech ?oński Department of Engineering Materials and Biomaterials Silesian University of Technology Institute of Physics University of Silesia in Katowice ?ukasiewicz Research Network-Institute of Non-Ferrous Metals

The microstructure and electrochemical properties of Al–Cu–Fe alloys with the atomic compositions of Al65Cu20Fe15,Al78Cu7Fe15and Al80Cu5Fe14Si1have been *** alloys were produced by induction melting of pure elements with copper mold *** microstructure of the alloys was analyzed by X-ray diffraction and high-resolution transmission electron *** formation of quasicrystalline phases in the Al–Cu–Fe alloys was *** presence of intermetallic phases was observed in the alloys after crystallization in a form of ingots and *** electrochemical measurements were conducted in 3.5%NaCl *** electronic structure of the alloys was determined by X-ray photoelectron *** post corrosion surface of the samples was checked using a scanning electron microscope equipped with the energydispersive X-ray *** was observed that the Al65Cu20Fe15alloy had the highest corrosion *** improved corrosion resistance parameters were noted for the plate samples rather than those in the as-cast *** the hardness of the Al65Cu20Fe15alloy was significantly higher than the other alloy samples.

关键词： Al-Cu-Fe alloys Copper mold casting X-ray diffraction High-resolution transmission electron microscopy X-ray photon spectroscopy Electrochemical impedance spectroscopy

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Prematurity and the burden of influenza and respiratory syncytial virus disease

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World Journal of Pediatrics 2016年第1期12卷 8-18页

作者： Bernhard Resch Stefan Kurath-Koller monika Eibisberger Werner Zenz Research Unit for Neonatal Infectious Diseases and Epidemiology Division of NeonatologyDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria Research Unit for Neonatal Infectious Diseases and Epidemiology Medical University of GrazAustria Research Unit for Infectious Diseases and Vaccinology Division of General PediatricsDepartment of Pediatrics and Adolescent MedicineMedical University of GrazAustria

Background:Respiratory morbidity of former preterm infants and especially those with bronchopulmonary dysplasia(BPD)is high during infancy and early *** sources:We performed a review based on a literature search including EMBASE,MEDLINE,and CINAHL databases to identify all relevant papers published in the English and German literature on influenza and respiratory syncytial virus infection associated with preterm infant,prematurity,and BPD between 1980 and ***:Recurrent respiratory symptoms remain common at preschool age,school age and even into young *** viral respiratory tract infections due to different pathogens cause significant morbidity and necessitate rehospitalizations during the fi rst years of *** uenza virus infection plays a minor role compared to respiratory syncytial virus(RSV)associated respiratory tract infection during infancy and early ***,particular morbidity to both viruses is ***:The particular burden of both viral diseases in preterm infants is dominated by RSV and its associated rehospitalizations during the fi rst two years of *** measures include vaccination against influenza virus of family members and caregivers and active immunization starting at the age of 6 months,and monthly injections of palivizumab during the cold season to avoid severe RSV disease and its sequelae.

关键词： bronchopulmonary dysplasia infl uenza preterm infant respiratory infectious disease respiratory syncytial virus

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Fungal genus Hypocrea/Trichoderma:from barcodes to biodiversity

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2008年第10期9卷 753-763页

作者： Christian P.KUBICEK monika KOMON-ZELAZOWSKA Irina S.DRUZHININA Institute of Chemical Engineering Research Area Gene Technology and Applied Biochemistry Vienna University of TechnologyGetreidemarkt 9/E1665A-1060 ViennaAustria Institute of Chemical Engineering Research Area Gene Technology and Applied BiochemistryVienna University of TechnologyGetreidemarkt 9/E1665A-1060 ViennaAustria

Hypocrea/Trichoderma is a genus of soil-borne or wood-decaying fungi containing members important to mankind as producers of industrial enzymes and biocontrol agents against plant pathogens, but also as opportunistic pathogens of immuno- compromised humans and animals, while others can cause damage to cultivated mushroom. With the recent advent of a reliable, BarCode-aided identification system for all known taxa of Trichoderma and Hypocrea, it became now possible to study some of the biological fundamentals of the diversity in this fungal genus in more detail. In this article, we will therefore review recent progress in (1) the understanding of the geographic distribution of individual taxa; (2) mechanisms of speciation leading to development of mushroom diseases and facultative human mycoses; and (3) the possible correlation of specific traits of secondary metabolism and molecular phylogeny.

关键词： Hypocrea/Trichoderma Biogeography Biodiversity Facultative human opportunists Peptaibols Mushroom pathogens

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Do older patients get takotsubo syndrome differently?

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Journal of Geriatric Cardiology 2019年第12期16卷 909-910页

作者： monika Budnik Janusz Kochanowski Martyna Zaleska Grzegorz Opolski Department of Cardiology Medical University of Warsaw

We read with great interest case report of 99-year-old patient with takotsubo syndrome(TTS)presented by Yenerçağ,et al.,[1]especially because four years ago,we described the oldest so far person diagnosed with TTS:a 98-year old woman.[2]During analysis of your article a few comments and questions occurred to *** is usually preceded with a stress factor.[3]Do you know,or can you suspect the TTS cause in this patient?Was she diagnosed with primary or secondary TTS?TTS often occurs in people with ongoing or previous neurological or psychiatric disorder.[4]The patient had history of Alzheimer’s *** she have any new neurological symptoms during described hospitalization?A very good diagnostic test for TTS is NT-proBNP to troponin I ratio.[5]

关键词： Takotsubo syndrome

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One-pot glycerol conversion to acrylic acid catalyzed by Cu modified HY zeolite synthesized from natural resources and pro-analytical precursor

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Carbon Resources Conversion 2024年第1期7卷 61-70页

作者： monika Lumongga Putri Tambunan Iman Abdullah Yuni Krisyuningsih Krisnandi Department of Chemistry Faculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok 16424Indonesia Solid Inorganic Framework Laboratory Department of ChemistryFaculty of Mathematics and Natural SciencesUniversitas IndonesiaDepok 16424Indonesia

The conversion of glycerol to acrylic acid was carried out by the one-pot process *** catalyst used in this conversion is Cu-modified HY zeolite synthesized using pro-analytical precursors and alternative precursors from natural resources i.e.,Indonesian natural zeolite and *** crystal structure and physicochemical properties of catalysts were determined by various characterization techniques such as XRD,FTIR,SEM-EDX,TEM,SAA,and TPD-NH_(3).Based on XRD analysis,it shows that HY and CuHY,both from synthetic and alternative precursors,are confirmed to have typical peaks of Y *** mapping images show a uniform distribution of Cu on the HY *** addition,the TEM analysis also shows uniform particle size *** results of catalytic glycerol conversion show that Cu-modified HY catalysts give a higher acrylic acid yield than *** results also show that the highest yield of acrylic acid was obtained in 27.5%and 25.8%at a dehydration time of 3 h using pro-analytical and natural resources CuHY catalyst,*** Cu-modified HY catalysts having weak acid sites show the best catalytic activity in the conversion of glycerol to acrylic acid.

关键词： Glycerol Acrylic acid HY zeolite Copper Dehydration and oxidation

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Oral rehabilitation of a Parkinson's patient:A case report

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World Journal of Clinical Cases 2013年第1期1卷 67-70页

作者： Yashpal Singh monika Saini Neha Garg Department of Prosthodontics Subharti Dental College Meerut UP 250005India

Parkinson's disease is an idiopathic disorder of the central nervous system, characterized by resting tremors, muscular rigidity, slow and decreased movements. Oral rehabilitation of these patients requires special care, especially in those cases where the patient's socioeconomic status is not good and patient cannot come several times for fabrication of a complete denture. This clinical report presents a case of a Parkinson's patient who was completely rehabilitated in 3 appointments using special techniques. Border molding, f inal impression and jaw relation procedures were done in one appointment by using a custom tray with detachable handles and occlusal rims.

关键词： Parkinson’s disease Tich buttons Detachable handles and occlusal rims Monoplane teeth

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Kinematic Analysis of Leaf Growth in Grasses:A Comment on Spatial and Temporal Quantitative Analysis of Cell Division and Elongation Rate in Growing Wheat Leaves under Saline Conditions

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Journal of Integrative Plant Biology 2009年第5期51卷 433-436页

作者： Hans Schnyder monika Kavanova C.Jerry Nelson Lehrstuhl für Grünlandlehre Technische Universitt München85350 Freising-WeihenstephanGermany Department of Cell & Developmental Biology John Innes Centre Division of Plant Sciences University of Missouri

Hu and Schmidhalter （2008） conducted a study with wheat seedlings growing in saline and non-stressed （control） conditions with the aim of identifying and quantifying the cellular basis for the reduction in leaf growth. We applaud their goals as salinity is an important issue for plant ecology and food production; however, we have concerns about the methodology used and the subsequent conclusJons that are drawn.

关键词： Kinematic Analysis of Leaf Growth in Grasses cell length

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Evolutionary History of the Non-Specific Lipid Transfer Proteins

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Molecular Plant 2011年第6期4卷 947-964页

作者： monika M. Edstam Lenita Viitanen Tiina A. Salminen Johan Edqvist IFM Molecular Genetics Link6ping University 581 83 LinkSping Swedenb Structural Bioinformatics Laboratory Department of Biosciences Abo Akademi University Artillerigatan 6 A III FIN-20520 Turku Finland

The non-specific lipid transfer proteins （nsLTPs） are small, basic proteins characterized by a tunnel-like hydrophobic cavity, capable of transferring various lipid molecules between lipid bilayers. Most nsLTPs are synthesized with an N-terminal signal peptide that localizes the protein to the apoplastic space. The nsLTPs have only been identified in seed plants, where they are encoded by large gene families. We have initiated an analysis of the evolutionary history of the nsLTP family using genomic and EST information from non-seed land plants and green algae to determine：（1） when the nsLTP family arose, （2） how often new nsLTP subfamilies have been created, and （3） how subfamilies differ in their patterns of expansion and loss in different plant lineages. In this study, we searched sequence databases and found that genes and transcripts encoding nsLTPs are abundant in liverworts, mosses, and all other investigated land plants, but not present in any algae. The tertiary structures of representative liverwort and moss nsLTPs were further studied with homology modeling. The results indicate that the nsLTP family has evolved after plants conquered land. Only two of the four major subfamilies of nsLTPs found in flowering plants are present in mosses and liverworts. The additional subfamilies have arisen later, during land plant evolution. In this report, we also introduce a modified nsLTP classification system.

关键词： Lipids evolutionary genetics molecular biology molecular evolution bryophytes ferns.

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