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Preservation of aberrant right hepatic arteries does not affect safety and oncological radicality of pancreaticoduodenectomy-own results and a systematic review of the literature

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Hepatobiliary Surgery and Nutrition 2022年第1期11卷 25-37页

作者： Cedrik Pyras Carsten Lukas monika Janot-Matuschek Torsten Herzog Andrea Tannapfel Waldemar Uhl Orlin Belyaev Department of Surgery St.Josef HospitalRuhr University BochumBochumGermany Institute of Radiology St.Josef HospitalRuhr University BochumBochumGermany Institute of Pathology Ruhr University BochumBochumGermany

Background:Aberrant right hepatic arteries(aRHA)are frequently encountered during pancreaticoduodenectomy(PD).Their effects on surgical morbidity and resection margin are still *** study aimed to compare the short term and long term outcomes in patients with and without ***:A single-center retrospective analysis of 353 consecutive PD during a 5-year period was *** type of arterial supply was determined preoperatively by CT and confirmed at *** types III-VI included some type of aRHA and comprised the study *** types I and II were considered irrelevant for PD and used as *** endpoints were the rates of major postoperative complications and the rate of R0-resection in cases of malignant *** endpoints included duration of surgery,postoperative stay,number of harvested lymph nodes and survival in patients with pancreatic *** results were compared to existent data using a systematic review of the ***:No aRHA had to be sacrificed or *** morbidity and specific complications such as post-pancreatectomy hemorrhage(PPH),pancreatic fistula and bile leak were the same in patients with and without *** was no significant difference in operative time,blood loss,length of ICU-and hospital *** with malignancy had similar high rates of R0-resection and identical number of harvested lymph *** of patients with pancreatic cancer was not affected by ***:aRHA may be preserved in virtually all cases of PD for resectable pancreatic head lesions without increasing surgical morbidity and without compromising oncological radicality in patients with cancer,provided the variant anatomy is being recognised on preoperative CT and a meticulous surgical technique is used.

关键词： Replaced hepatic artery accessory hepatic artery pancreatic cancer pancreatic surgery resection margin complications vascular anomalies

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Missed colorectal cancers in a fecal immunochemical test-based screening program: Molecular profiling of interval carcinomas

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World Journal of Gastrointestinal Oncology 2022年第11期14卷 2195-2207页

作者： Manon van der Vlugt Beatriz Carvalho Joelle Fliers Nahid Montazeri Christian rausch Esmée J Grobbee Manon van Engeland Manon C W Spaander Gerrit A Meijer Evelien Dekker Department of Gastroenterology and Hepatology Amsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Pathology Netherlands Cancer InstituteAmsterdam 1066 CXNetherlands Biostatistics Unit Department of Gastroenterology and HepatologyAmsterdam University Medical CenterAmsterdam 1105 AZNetherlands Department of Gastroenterology and Hepatology Erasmus MC University Medical CenterRotterdam 3015 CNNetherlands Department of Pathology GROW-School for Oncology and Developmental BiologyMaastricht University Medical CenterMaastricht 6202 AZNetherlands

BACKGROUND For optimizing fecal immunochemical test(FIT)-based screening programs,reducing the rate of missed colorectal cancers(CRCs)by FIT(FIT-interval CRCs)is an important *** of the molecular make-up of these missed lesions could facilitate more accurate detection of all(precursor)*** To compare the molecular make-up of FIT-interval CRCs to lesions that are detected by FIT[screen-detected CRCs(SD-CRCs)].METHODS FIT-interval CRCs observed in a Dutch pilot-program of FIT-based screening were compared to a control group of SD-CRCs in a 1:2 ratio,resulting in 27 FIT-interval CRC and 54 *** analyses included microsatellite instability(MSI),CpG island methylator phenotype(CIMP),DNA sequence mutations and copy number alterations(CNAs).RESULTS Although no significant differences were reached,FIT-interval CRCs were more often CIMP positive and MSI positive(33%CIMP in FIT-interval CRCs vs 21%in SD-CRCs(P=0.274);19%MSI in FIT-interval CRCs vs 12%in SD-CRCs(P=0.469)),and showed more often serrated pathway associated features such as BRAF(30%vs 12%,P=0.090)and PTEN(15%vs 2.4%,P=0.063)*** mutations,a classic feature of the adenoma-carcinoma-sequence,were more abundant in SD-CRCs(68%vs 40%in FIT-interval CRCs P=0.035).Regarding CNAs differences between the two groups;FIT-interval CRCs less often showed gains at the regions 8p11.22-q24.3(P=0.009),and more often gains at 20p13-p12.1(P=0.039).CONCLUSION Serrated pathway associated molecular features seem to be more common in FIT-interval CRCs,while classic adenoma carcinoma pathway associated molecular features seem to be more common in *** indicates that proximal serrated lesions may be overrepresented among FITinterval CRCs.

关键词： Fecal immunochemical test-interval colorectal cancer Mutation analysis Colorectal cancer screening Serrated pathway Adenoma-carcinoma pathway

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Long non-coding RNA Databases in Cardiovascular Research

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Genomics, Proteomics & Bioinformatics 2016年第4期14卷 191-199页

作者： Frank Rühle monika Stoll Institute of Human Genetics Genetic EpidemiologyUniversity of Muenster48149 MuensterGermany Carmany Cardiovascular Research Institute Maastricht(CARIM) Genetic Epidemiology and Statistical GeneticsMaastricht Center for Systems Biology(MaCSBio)Maastricht University6211 LK MaastrichtThe Netherlands

With the rising interest in the regulatory functions of long non-coding RNAs （IncRNAs） in complex human diseases such as cardiovascular diseases, there is an increasing need in public databases offering comprehensive and integrative data for all aspects of these versatile molecules. Recently, a variety of public data repositories that specialized in lncRNAs have been developed, which make use of huge high-throughput data particularly from next-generation sequencing （NGS） approaches. Here, we provide an overview of current IncRNA databases covering basic and functional annotation, IncRNA expression and regulation, interactions with other biomolecules, and genomic variants influencing the structure and function of lncRNAs. The prominent IncRNA antisense noncoding RNA in the INK4 locus （ANRIL）, which has been unequivocally associated with coronary artery disease through genome-wide association studies （GWAS）, serves as an example to demonstrate the features of each individual database.

关键词： Database Non-coding IncRNA Gene regulation Cardiovascular disease ANRIL

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Immunomodulatory properties of dental tissue-derived mesenchymal stem cells: Implication in disease and tissue regeneration

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World Journal of Stem Cells 2019年第9期11卷 604-617页

作者： Oleh Andrukhov Christian Behm Alice Blufstein Xiaohui rausch-Fan Division of Conservative Dentistry and Periodontology University Clinic of Dentistry Medical University of Vienna

Mesenchymal stem cells(MSCs)are considered as an attractive tool for tissue regeneration and possess a strong immunomodulatory *** tissuederived MSCs can be isolated from different sources,such as the dental pulp,periodontal ligament,deciduous teeth,apical papilla,dental follicles and *** to numerous in vitro studies,the effect of dental MSCs on immune cells might depend on several factors,such as the experimental setting,MSC tissue source and type of immune cell *** studies have shown that the immunomodulatory activity of dental MSCs is strongly upregulated by activated immune *** exert mostly immunosuppressive effects,leading to the dampening of immune cell ***,the reciprocal interaction between dental MSCs and immune cells represents an elegant mechanism that potentially contributes to tissue homeostasis and inflammatory disease *** the immunomodulatory potential of dental MSCs has been extensively investigated in vitro,its role in vivo remains obscure.A few studies have reported that the MSCs isolated from inflamed dental tissues have a compromised immunomodulatory ***,the expression of some immunomodulatory proteins is enhanced in periodontal disease and even shows some correlation with disease ***-based immunomodulation may play an essential role in the regeneration of different dental ***,immunomodulation-based strategies may be a very promising tool in regenerative dentistry.

关键词： Mesenchymal stem cells Dental tissue Immunomodulation Peripheral blood mononuclear cells Oral diseases Tissue regeneration

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Photoluminescence and electrochemiluminescence studies of chosen rare earths systems

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Journal of Rare Earths 2008年第2期26卷 192-197页

作者： Stefan Lis Slawomir But Krzysztof Staninski monika Jesiolowska Department of Rare Earths Faculty of Chemistry Adam Mickiewicz University Grunwaldzka 6

Eu（Ⅲ） complexes with chosen Keggin polyoxomatalates, POM, containing organic counter cations （tetrabutylarnmonium, tetrabutylphosphonium, triphenylethylphosphonium）, were synthesized, and their photophysical properties were studied. The synthesized complexes had the general formula of XnH5-n[EuSiW11O39], formulated based on the results of elemental and thermogravimetric analysis and FTIR spectroscopy. The photophysical properties of the obtained compounds were investigated using photoluminescence and electrochemiluminescence, ECL, methods in solutions and solids. The most intense luminescence of Eu（Ⅲ） was observed for the complexes with tetrabutylarnmonium cations. After the addition of phenanthroline to the XnH5-n[EuSiW11O39] solutions, a large increase in the Eu（Ⅲ） luminescence intensity and a lengthening of its luminescence lifetime were observed as a result of the formation of ternary complexes. Attempts to apply ECL as a method of light emission by generating species capable of forming excited states in Ln/POMs, i.e., Tb（Ⅲ） and Eu（Ⅲ） in the Na9EuW10O36 and Na9TbW10O36 complexes, were made. The influence of the POM complexes on the ECL was also tested using the Tb/EDDHA （EDDA=ethylenediamine di（o-hydroxyphenylacetic acid）） complex, which is effective in generating ECL.

关键词： Ln(Ⅲ) luminescence electrochemiluminescence polyoxometalates complexes rare earths

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Impact of environmental factors on the sampling rate ofβ-blockers and sulfonamides from water by a carbon nanotube-passive sampler

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Journal of Environmental Sciences 2021年第3期33卷 413-427页

作者： Klaudia Godlewska Aleksandra Jakubus Piotr Stepnowski monika Paszkiewicz Department of Environmental Analysis Faculty of ChemistryUniversity of Gdanskul.Wita Stwosza 63Gdansk 80-308Poland

Passive techniques are a constantly evolving approach to the long-term monitoring of micropollutants,including pharmaceuticals,in the aquatic *** paper presents,for the first time,the calibration results of a new CNTs-PSDs(carbon nanotubes used as a sorbent in passive sampling devices)with an examination of the effect of donor phase salinity,water pH and the concentration of dissolved humic acids(DHAs),using both ultrapure and environmental *** rates(R_(s))were determined for the developed kinetic *** has been observed that the impact of the examined environmental factors on the R_(s) values strictly depends on the type of the *** the case ofβ-blockers,the only environmental parameter affecting their uptake rate was the salinity of water.A certain relationship was noted,namely the higher the salt concentration in water,the lower the Rs values ofβ-*** the case of sulfonamides,water salinity,water pH 7-9 and DHAs concentration decreased the uptake rate of these compounds by *** determined Rs values differed in particular when the values obtained from the experiments carried out using ultrapure water and environmental waters were *** general conclusion is that the calibration of novel CNTs-PSDs should be carried out under physicochemical conditions of the aquatic phase that are similar to the environmental matrix.

关键词： Carbon nanotubes Passive sampling Pharmaceuticals Sampling rates(R_s)

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Trajectory analysis at intersections for traffic rule identification

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Geo-Spatial Information Science 2021年第1期24卷 75-84,I0010页

作者： Chenxi Wang Stefania Zourlidou Jens Golze monika Sester Institute of Cartography and Geoinformatics Leibniz University HannoverHannoverGermany

In this paper,we focus on trajectories at intersections regulated by various regulation types such as traffic lights,priority/yield signs,and right-of-way *** test some methods to detect and recognize movement patterns from GPS trajectories,in terms of their geometrical and spatio-temporal *** particular,we first find out the main paths that vehicles follow at such *** then investigate the way that vehicles follow these geometric paths(how do they move along them).For these scopes,machine learning methods are used and the performance of some known methods for trajectory similarity measurement(DTW,Hausdorff,and Fréchet distance)and clustering(Affinity propagation and Agglomerative clustering)are compared based on clustering ***,the movement behavior observed at six different intersections is analyzed by identifying certain movement patterns in the speed-and time-profiles of *** show that depending on the regulation type,different movement patterns are observed at *** finding can be useful for intersection categorization according to traffic *** practicality of automatically identifying traffic rules from GPS tracks is the enrichment of modern maps with additional navigation-related information(traffic signs,traffic lights,etc.).

关键词： Traffic rules traffic regulators GPS trajectories intersection classification speed-profiles clustering similarity measures

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Circulating tumor cells and their role in prostate cancer

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Asian Journal of Andrology 2019年第1期21卷 24-31页

作者： Moritz Maas Miriam Hegemann Steffen rausch Jens Bedke Arnulf Stenzl Tilman Todenhofer Department of Urology University Hospital TuebingenHoppe-Seyler-Strabe 3Tuebingen 72076Germany.

Circulating tumor cells (CTC)have become an important biomarker in patients with advanced prostate *** count has been demonstrated to be a prognostic factor for overall survival in patients with metastatic castration-resistant prostate cancer (mCRPC). In localized prostate cancer,a clear correlation between CTC counts and clinicopathological risk parameters and outcome has not been ***,the focus of research is shifting from CTC enumeration towards molecular characterization of CTC leading to the discovery of markers predicting treatment *** role of androgen receptor splice variants expressed by CTC as markers of resistance to abiraterone and enzalutamide has been assessed by various *** identification of CTC markers predicting treatment response represents a key step to guide the selection of treatment (e.g.,abiraterone/enzalutamide vs taxanes), particularly in patients with *** an alternative to CTC,the analysis of circulating tumor DNA has been shown to enable a noninvasive disease characterization having high potential to promote precision oncology.

关键词： AR-V7 biomarker cell-free DNA cfDNA circulating tumor cells ctDNA liquid biopsy prostate cancer

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The value of testicular ＇mapping＇ in men with non-obstructive azoospermia

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Asian Journal of Andrology 2011年第2期13卷 225-230页

作者： monika E Beliveau Paul J Turek The Turek Clinic 55 Francisco St. Suite 300 San Francisco CA 94010 USA

As the field of assisted reproduction has advanced, many previously untreatable men are now biological fathers. Although finding sperm in men with obstructive azoospermia is not difficult, locating and retrieving spermatozoa in men with non-obstructive azoospermia remains a clinical challenge, largely because sperm production in these men can be patchy or focal in nature. In response to this challenge, strategies such as fine-needle aspiration （FNA） mapping have been developed to find spermatozoa. This review discusses the history, evolution and current clinical utility and findings with FNA mapping for male infertility）. Review of the current literature in the English language on FNA （diagnostic or therapeutic） with a keyword focuses on sperm detection, retrieval, safety and complications. FNA was described in human medicine over 100 years ago. Testis FNA was described 45 years ago and FNA ＇mapping＇ of spermatozoa was described in 1997. This comparative review of the literature on sperm detection and complication rates with FNA and open testis biopsy or microdissection procedures suggests that FNA is highly informative, minimally invasive and is associated with fewer complications than other commonly used approaches to sperm detection in non-obstructive azoospermic patients. FNA mapping has gained considerable traction as an informative, ＇testis sparing＇ technique for sperm detection in non-obstructive azoospermia. With knowledge of sperm presence and location prior to sperm retrieval, FNA maps can help clinicians tailor sperm retrieval to optimize time, effort and extent of procedures needed to procure spermatozoa in these difficult cases.

关键词： azoospermia fine-needle aspiration hypogonadism sperm mapping sperm retrieval

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Corrosion Resistance of AZ91 Magnesium Alloy after Laser Remelting Treatment

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Journal of Wuhan University of Technology(Materials Science) 2016年第5期31卷 1075-1080页

作者： STRZELECKA monika IWASZKO Jozef MALIK Marcin A Czestochowa University of Technology 42-200 Czestochowa Poland

The main objective of the study was the modification of the surface layer of magnesium alloy by the COlaser. The studied material was the commercial AZ91 magnesium alloy. The effectiveness of the alternations caused by the remelting process was verified on the basis of microscopic observation and corrosion investigations, i e, recording of potentiodynamic polarization curves, electrochemical noise measurements and hydrogen evolution rate measurements. For the adopted range of the treatment parameters, favourable changes were observed in the surface layer such as the refinement of structure and more uniform arrangement of individual phases. As a consequence of those favourable structural changes the improvement of the corrosion resistance of the alloy was achieved in comparison to its non-remelted equivalent. For the treated material corrosion rates expressed as corrosion current densities were at least three times lower than the appropriate values for the untreated alloy comparing them for the same period of samples immersion in the test solution. The obtained results have confirmed the effectiveness of the applied surface treatment resulting in favourable changes in the structure and corrosion properties of the AZ91 magnesium alloy.

关键词： magnesium alloy CO_2 laser surface layer modification corrosion

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