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The DUF579 proteins GhIRX15s regulate cotton fiber development by interacting with proteins involved in xylan synthesis

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The Crop Journal 2024年第4期12卷 1112-1125页

作者： Mengyun Li Feng Chen Jingwen Luo Yanan Gao Jinglong Cai Wei Zeng monika S.Doblin Gengqing Huang Wenliang Xu Hubei Key Laboratory of Genetic Regulation and Integrative Biology School of Life SciencesCentral China Normal UniversityWuhan 430079HubeiChina Zhejiang Provincial Key Laboratory of Plant Evolutionary Ecology and Conservation School of Life SciencesTaizhou UniversityTaizhou 318000ZhejiangChina La Trobe Institute for Sustainable Agriculture&Food School of AgricultureBiomedicine and EnvironmentLa Trobe UniversityBundooraVIC 3086Australia

Cotton provides the most abundant natural fiber for the textile *** mature cotton fiber largely consists of secondary cell walls with the highest proportion of cellulose and a small amount of hemicellulose and *** dissect the roles of hemicellulosic polysaccharides during fiber development,four IRREGULAR XYLEM 15(IRX15)genes,GhIRX15-1/-2/-3/-4,were functionally characterized in *** genes encode DUF579 domain-containing proteins,which are homologs of AtIRX15 involved in xylan *** four GhIRX15 genes were predominantly expressed during fiber secondary wall thickening,and the encoded proteins were localized to the Golgi *** GhIRX15 gene could restore the xylan deficient phenotype in the Arabidopsis irx15irx15l double *** of GhIRX15s in cotton resulted in shorter mature fibers with a thinner cell wall and reduced cellulose content as compared to the wild ***,GhIRX15-2 and GhIRX15-4 formed homodimers and *** addition,the GhIRX15s showed physical interaction with glycosyltransferases GhGT43C,GhGT47A and GhGT47B,which are responsible for synthesis of the xylan backbone and reducing end ***,the GhIRX15s can form heterocomplexes with enzymes involved in xylan modification and side chain synthesis,such as GhGUX1/2,GhGXM1/2 and *** findings suggest that GhIRX15s participate in fiber xylan biosynthesis and modulate fiber development via forming large multiprotein complexes.

关键词： Cotton fiber Xylan biosynthesis GhIRX15s Protein-protein interaction Protein complexes

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畅游德国名城

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2024年

主讲人： monika

本期课程适合德语零基础的同学；热爱德语、对德语各领域文化感兴趣的同学；热爱德语文化，想去德语国家留学、工作和生活的学员。

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Outcome of patients with traumatic cranial nerve palsy admitted to a university hospital in Nepal

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中华神经外科杂志(英文) 2024年第2期10卷 1-7页

作者： Kumari Khusbu Gautam Naveen Parajuli monika Singh Shreejana Pradhananga Amit Sedai Gopal Shilpakar Sushil Sharma Mohan Raj Maharajgunj Medical Campus Institute of Medicine Tribhuvan University Maharajgunj Kathmandu Nepal Department of Research Institute of Medicine Maharajgunj Kathmandu Nepal Department of Neurosurgery Tribhuvan University Teaching Hospital Maharajgunj Kathmandu Nepal

Background Cranial nerve palsy (CNP) is a common complication of traumatic brain injury (TBI). Despite a high incidence of TBI in Nepal (382 per 100,000), literature on the specific management and outcome of CNP is lacking. This study aimed to examine the outcomes of TBI patients involving single versus multiple *** A retrospective chart review of 170 consecutive TBI patients admitted to the tertiary neurosurgical center in Nepal between April 2020 and April 2022 was conducted. Demographic, clinical, and etiological characteristics; imaging findings; and management strategies were recorded, compared, and analyzed using descriptive statistics. The Glasgow Outcome Scale Extended (GOSE) was used to measure the outcomes in two groups of patients (single and multiple CNP) at 3 *** Out of 250 eligible patients, 80 were excluded and CNP was noted in 29 (17.1%) of the remaining 170. The median age was 34.9 years, and falls (60.6%) were the most common cause of trauma. TBI severity was categorized based on GCS: mild (82.4%), moderate (15.9%), and severe (1.8%). Cranial nerve involvement was seen in 29 (17.05%) patients: single cranial nerve involvement in 26 (89.65%) and multiple nerve involvement in 3 (10.34%). The most common isolated cranial nerve involved was the oculomotor nerve (37.9%). CT findings revealed a maximum of skull fractures with no significant association between CNP and CT *** CNP is a common consequence of TBI with the most common etiology being falls followed by RTA. Single CNP was more common than multiple CNP with no significant difference in the outcome in the 3-month GOSE score. Further research is needed to determine the burden of traumatic CNP and establish specific management guidelines for different types of CNP.

关键词： Cranial nerve palsy Nepal Outcome Traumatic brain injury

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Mammal-bearing Pleistocene deposits,Vranic,southwestern Pannonian Basin System

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Journal of Palaeogeography 2024年第3期13卷 430-452页

作者： Adriano Banak Zsòfia Ruszkiczay-Rüdiger Anita Grizelj Martina Đuras Kresimir Petrinjak ASTER Team Alexander Wieser monika Milosevic Davor Pavelic Department of Geology Croatian Geological SurveyMilana Sachsa 2HR-10000 ZagrebCroatia Institute for Geological and Geochemical Research HUN-REN Research Centre for Astronomy and Earth Sciences(MTA Centre of Excellence)Budaorsi Street 451112 BudapestHungary The Faculty of Veterinary Medicine University of ZagrebHeinzelova 55HR-10000 ZagrebCroatia CEREGE CNRS-IRD-College de France-INRAE UM34Aix-Marseille UniversiteAix-en-ProvenceFrance Faculty of Physics-Isotope Physics University of ViennaWahringer Straße 171090 ViennaAustria Faculty of Mining Geology and Petroleum EngineeringUniversity of ZagrebPierottijeva 6HR-10000 ZagrebCroatia

Vranic site is a sand quarry that is located on the southern foothills of Papuk *** bottom to top of the succession,three sedimentary units have been recognized as:Unit 1 containing massive sand with scattered gravel-sized clasts,marl cobbles and boulders,and abundant marine mammal and fish fossils;Unit 2 consisting of sand intercalated with silt,clay and gravel,which may be horizontally bedded;and Unit 3,which is an erosionally-based lenticular matrix to clast-supported structureless *** basal part of Unit 1 shows numerous reworked skeletal remains of Miocene marine *** radionuclides constrain the age of burial of Unit 1 to 895±211 ka,while the source area of Unit 1 had a quick *** massive sands deposited on the slopes of Papuk Mountain were vulnerable to erosion due to the absence of *** rainfall or water from snow melting created flash floods that infiltrated the sands,thereby causing slope destabilization and *** process led to slumps that were transformed into a sandy debris *** sediment was probably deposited during the interglacial marine isotope age(MIS)21 period when the scarce vegetation and a warmer climate favored the melting of permafrost ice and consequently triggered slope movements during MIS *** reworked skeletal material sampled at the Vranic site comprises fossilized fish along with mammal bones and ***,the Vranic site represents an important site for cetacean fossil remains and serves as an important data source for marine life in the Central Paratethys.

关键词： Miocene marine mammals Alluvial slope deposit Pleistocene Cosmogenic nuclides Pannonian Basin System

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基于人地关系的东北农村空心化测度及其整治路径研究——以黑龙江省拜泉县为例

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地理科学进展 2024年第3期43卷 488-503页

作者：张茹杜国明李玉恒王玲 monika Stanny Alexey Naumov 东北农业大学公共管理与法学院哈尔滨150030 中国科学院地理科学与资源研究所区域可持续发展分析与模拟重点实验室北京100101 中国科学院大学资源与环境学院北京100049 黑龙江省自然资源权益调查监测院哈尔滨150030 波兰科学院农村与农业发展研究所波兰华沙00-3306 罗蒙诺索夫莫斯科国立大学俄罗斯莫斯科119991

快速城镇化进程中,人口大规模流失引发乡村人地关系失衡,加剧了村庄空心化问题。科学测度乡村空心化、提出以乡村振兴为导向的空心村整治策略,具有重要的现实意义。论文以黑龙江省拜泉县为例,基于人口转移率测度了乡村空心化水平,运用熵... 详细信息

快速城镇化进程中,人口大规模流失引发乡村人地关系失衡,加剧了村庄空心化问题。科学测度乡村空心化、提出以乡村振兴为导向的空心村整治策略,具有重要的现实意义。论文以黑龙江省拜泉县为例,基于人口转移率测度了乡村空心化水平,运用熵权TOPSIS法评价了村庄发展潜力水平,将二者结合识别了村庄发展类型,提出差异化的空心村整治策略。研究结果显示:(1)拜泉县乡村空心化水平均值为0.6529,空心化程度明显。乡镇层面的空心化处于中度和高度水平,村庄以高度和重度空心化为主。农村人口流失主要归因于城乡建设不均衡、农村就业机会少、农村社会保障水平偏低等。(2)村庄发展潜力均值为0.2279,整体水平偏低且空间分布差异明显,县城周边、沿主要交通干线以及主要河流的村庄发展潜力水平普遍高于偏远地区的村庄。产业兴旺(0.5026)水平显著高于乡风文明(0.2703)、生态宜居(0.1472),治理有效(0.0317)、生活富裕(0.0482)水平较低,成为村庄发展潜力的短板。(3)拜泉县村庄类型划分为Ⅰ类——高潜力低空心化、Ⅱ类——高潜力高空心化、Ⅲ类——低潜力低空心化、Ⅳ类——低潜力高空心化4类,整体以Ⅱ类——高潜力高空心化为主,且县域南部村庄发展状态好于北部地区。未来村庄发展应以乡村振兴战略为指引,重心向Ⅰ类、Ⅱ类以及南部村镇转移,并完善宅基地、生态用地、耕地等相关制度体系,促进村庄内部结构调整;培育合作社、家庭农场等新型经营主体,探索特色产业规划与升级道路;构建“中心镇—中心村—农民社区—村庄”的新型村镇体系,加强城乡互动,促进要素聚集、资源共享;同时加大环境整治,增强社会保障,吸引人才回归,实现空心化治理与县域乡村振兴。

关键词：乡村振兴人地关系村庄空心化潜力评价村庄发展黑龙江省拜泉县

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The transcriptional landscape of the developmental switch from regular pollen maturation towards microspore-derived plant regeneration in barley

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The Crop Journal 2024年第4期12卷 1064-1080页

作者： Anna Nowicka Martin Kovacik Anna Maksylewicz Przemysław Kopec Ewa Dubas monika Krzewska Agnieszka Springer Robert E.Hoffie Diaaeldin S.Daghma Zbynek Milec Ales Pecinka Jochen Kumlehn Iwona Zur The Franciszek Górski Institute of Plant Physiology Polish Academy of Sciences Niezapominajek 2130-239 KrakówPoland Institute of Experimental Botany of the Czech Academy of Sciences Centre of Plant Structural and Functional GenomicsŠlechtitelu3177900 OlomoucCzech Republic Department of Cell Biology and Genetics Faculty of SciencePalacky UniversityŠlechtitelu°2777900 OlomoucCzech Republic Malopolska Centre of Biotechnology Jagiellonian University30-387 KrakówPoland Leibniz Institute of Plant Genetics and Crop Plant Research(IPK)Gatersleben Corrensstraße 306466 Stadt SeelandGermany Institute for Breeding Research on Horticultural Crops Julius Kühn Institute(JKI)-Federal Research Centre for Cultivated PlantsErwin-Baur Straße 2706484 QuedlinburgGermany Global Change Research Institute Czech Academy of Sciences Beˇlidla 986/4a60300 BrnoCzech Republic

Plant formation from in vitro-cultivated microspores involves a complex network of internal and environmental ***/doubled haploids(DHs)derived from in vitro-cultured microspores are widely used in plant breeding and genetic ***,the mechanism underlying the developmental switch from regular pollen maturation towards microspore-derived plant regeneration remains poorly ***,RNA-sequencing was employed to elucidate the transcriptional landscapes of four early stages of microspore embryogenesis(ME)in barley cultivars Golden Promise and Igri,which exhibit contrasting responsiveness to microspore-derived plant *** experiments revealed fundamental regulatory networks,specific groups of genes,and transcription factor(TF)families potentially regulating the developmental *** identified a set of candidate genes crucial for genotype-dependent responsiveness/recalcitrance to *** high-resolution temporal transcriptome atlas provides an important resource for future functional studies on the genetic control of microspore developmental transition.

关键词： Hordeum vulgare Marker gene Microspore embryogenesis Stress response Transcriptome analysis

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Harnessing immunity:Immunomodulatory therapies in COVID-19

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World Journal of Virology 2024年第2期13卷 34-47页

作者： Tsvetelina Velikova Hristo Valkov Anita Aleksandrova monika Peshevska-Sekulovska Metodija Sekulovski Russka Shumnalieva Medical Faculty Sofia University St.Kliment OhridskiSofia 1407Bulgaria Department of Gastroenterology University Hospital“Tsaritsa Yoanna-ISUL”Medical University of SofiaSofia 1527Bulgaria Department of Immunology SMDL RamusSimitli 6000Bulgaria Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Department of Anesthesiology and Intensive Care University Hospital LozenetzSofia 1407Bulgaria Department of Rheumatology Clinic of RheumatologyUniversity Hospital"St.Ivan Rilski"Medical University-SofiaSofia 1612Bulgaria

An overly exuberant immune response,characterized by a cytokine storm and uncontrolled inflammation,has been identified as a significant driver of severe coronavirus disease 2019(COVID-19)***,deciphering the intricacies of immune dysregulation in COVID-19 is imperative to identify specific targets for intervention and *** these delicate dynamics in mind,immunomodulatory therapies have emerged as a promising avenue for miti-gating the challenges posed by *** in manipulating immune pathways presents an opportunity to alter the host response,optimizing antiviral defenses while curbing deleterious *** review article compre-hensively analyzes immunomodulatory interventions in managing *** explore diverse approaches to mitigating the hyperactive immune response and its impact,from corticosteroids and non-steroidal drugs to targeted biologics,including anti-viral drugs,cytokine inhibitors,JAK inhibitors,convalescent plasma,monoclonal antibodies(mAbs)to severe acute respiratory syndrome coronavirus 2,cell-based therapies(i.e.,CAR T,etc.).By summarizing the current evidence,we aim to provide a clear roadmap for clinicians and researchers navigating the complex landscape of immunomodulation in COVID-19 *** Glucocorticoids are among the most widely prescribed drugs with their immune-suppressive and anti-inflammatory effect[84].The current guidelines for the treatment of COVID-19 recommend against the use of dexamethasone or other systemic CS in non-hospitalized patients in the absence of another indication[70].The RECOVERY trial demonstrates the reduced 28-d mortality among hospitalized patients with COVID-19 using dexamethasone compared to the usual standard of care,along with other investigators,such as Ahmed and Hassan[85].The benefit of dexamethasone was seen only among participants receiving either oxygen alone or invasive mechanical ventilation at randomization but not among those receiving no respi

关键词： Immunomodulation COVID-19 SARS-CoV-2 Immunotherapy Antiviral immune response Cytokine storm Adaptive immunity Therapeutic strategies Immune modulators Viral infection Host immune response

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Acute coalescent mastoiditis in a 16-month-old child due to Streptococcus pneumoniae infection

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Journal of Acute Disease 2024年第1期13卷 36-39页

作者： Magdalena Pszczołowska monika Morawska-Kochman Katarzyna Resler Katarzyna Pękalska Tomasz Zatoński Department and Clinic of Otolaryngology Head and Neck SurgeryWrocław Medical UniversityBorowska 213WrocławPoland Department of General Radiology Interventional Radiology and NeuroradiologyWrocław Medical UniversityBorowska 213WrocławPoland

Rationale:Acute otitis media is a common disease in early childhood,and is usually caused by Streptococcus pneumoniae(***).Acute mastoiditis is a complication of acute otitis media and can involve not only the mucoperiosteum of the middle ear but can also spread to the periosteum by destroying the mastoid bone(acute coalescent mastoiditis).In addition,the infection can extend through the surrounding bones or the emissary veins beyond the mastoid’s air cells,leading to subperiosteal ***’s Concern:A 16-month-old female patient was hospitalized due to the purulent discharge of the left ear and the symptoms of right mastoiditis(swelling and redness of the skin).Diagnosis:Bilateral acute coalescent mastoiditis caused by *** *** computer tomography revealed bilateral bone destruction of the mastoid and abscesses found behind the auricle on both ***:The patient underwent intravenous antibiotic therapy and surgical ***:The patient was discharged 14 days after hospitalization with an improved ***:Improperly treated acute coalescent mastoiditis can lead to extracranial and intracranial complications,sometimes serious and even *** are prevalent in children under 2 years,in whom the disease progresses more rapidly and *** vaccination with a 13-valent vaccine may not result in sufficient immunity against ***,a predominant pathogen in children affected by acute coalescent mastoiditis.

关键词： Acute otitis media Acute coalescent mastoiditis Streptococcus pneumoniae Children Case report

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Low-grade myofibrosarcoma of the maxillary sinus:Two case reports

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World Journal of Clinical Oncology 2024年第4期15卷 566-575页

作者： Anna Mydlak ŁukaszŚcibik monika Durzynska Jakub Zwoliński Karolina Buchajska Olga Lenartowicz Jakub Kucharz Department of Head and Neck Cancer Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland Department of Otolaryngology and Head and Neck Oncological Surgery The 5th Military Clinical Hospital with PolyclinicKrakow 30-901Poland Department of Pathology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland Department of Genitourinary Oncology Maria Sklodowska-Curie National Research Institute of OncologyWarsaw 02-781Poland

BACKGROUND Low-grade myofibroblastic sarcoma(LGMS)is an extremely rare tumor characterized by the malignant proliferation of *** most commonly develops in adults,predominantly in males,in the head and neck region,oral cavity,especially on the tongue,mandible,and *** article presents 2 cases of LGMS localized to the maxillary sinus and provides an overview of the available *** SUMMARY Two patients with LGMS located in the maxillary sinus underwent surgery at the Department of Head and Neck *** 1:A 46-year-old patient was admitted to the clinic with suspected LGMS recurrence in the right maxillary sinus(rT4aN0M0),with symptoms of pain in the suborbital area,watering of the right eye,thick discharge from the right nostril,and augmented facial *** open biopsy-confirmed LGMS,the patient underwent expanded maxillectomy of the right side with immediate palate reconstruction using a microvascular skin flap harvested surgically from the middle *** patient qualified for adjuvant radiotherapy for the postoperative bed,with an additional ***,the patient is under 1.5 years of observation with no evidence of *** 2:A 45-year-old man was admitted to our clinic with facial asymmetry,strabismus,exophthalmos,and visual impairment in the right *** months earlier,the patient had undergone partial jaw resection at another hospital for fibromatosis.A contrast-enhanced computed tomography scan revealed a tumor mass in the postoperative log after an earlier *** open biopsy confirmed lowgrade fibrosarcoma(rT4aN0M0).The patient qualified for an extended total right maxillectomy with orbital excision and right hemimandibulectomy with immediate microvascular reconstruction using an anterolateral thigh *** patient subsequently underwent adjuvant radiotherapy to the postoperative *** 9 months,recurrence occurred in the right mandibular arch below the irradiated *** lesion infiltrated t

关键词： Head and neck cancer Paranasal sinuses Maxillary sinus Sarcoma Low-grade myofibroblastic sarcoma Case report

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Analysis of mobility data-A focus on Mobile Mapping Systems

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Geo-Spatial Information Science 2020年第1期23卷 68-74页

作者： monika Sester Institute of Cartography and Geoinformatics Leibniz Universitat HannoverHannoverGermany

The increasing availability of devices to capture the position of moving objects(and other environmental information)leads to a very large amount and variety of mobility *** order to obtain important information about the objects,their behavior or the environment of the objects,an automatic analysis is *** article highlights current research questions in the context of the analysis of mobility data and presents them on the basis of work carried out at the Institute of Cartography and Geoinformatics(ikg)at Leibniz University of Hannover,Germany.A focus is put on the analysis and exploitation of information from Mobile Mapping vehicles.

关键词： Trajectories Lidar data automatic analysis traffic applications

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