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Profiles of interferon-gamma and interleukin-2 in patients after allogeneic hematopoietic stem cell transplantation

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World Journal of Biological Chemistry 2022年第4期13卷 72-82页

作者： Malwina Rybicka-Ramos Mirosław Markiewicz Aleksandra Suszka-Świtek Ryszard Wiaderkiewicz Sylwia Mizia monika Dzierżak-Mietła Krzysztof Białas Department of Hematology Specialist Hospital No.1 in BytomBytom 41-902Poland Department of Hematology University of RzeszowCollege of Medical SciencesInstitute of Medical SciencesRzeszów 35-315Poland Department of Histology and Embryology School of Medicine in KatowiceMedical University of SilesiaKatowice 40-752Poland Department of Population Health Division of Epidemiology and Health EducationWroclaw Medical UniversityWrocław 51-618Poland Department of Bone Marrow Transplantation and Hematooncology Maria Sklodowska-Curie National Research Institute of OncologyGliwice 44-102Poland Department of Hematology and Bone Marrow Transplantation SPSK-M HospitalKatowice 40-027Poland

BACKGROUND Allogeneic hematopoietic stem cell transplantation(allo-HSCT)may be related to the occurrence of complications,including graft-versus-host disease(GvHD)and *** pathogenesis of acute GvHD is connected with T lymphocytes,which identify alloantigens on host's antigen-presenting cells,activate production of interferon-gamma(IFN-gamma)and interleukin-2(IL-2),and act on the immune effector cells and damage tissues and *** The aim of the study was to investigate and distinguish serum concentration profiles of IFN-gamma and IL-2 within a 30-d period after *** We enrolled 62 patients,i.e.,30(48%)male and 32(52%)female subjects[median age 49.5(19-68)years],after allo-HSCT from siblings(n=12)or unrelated donors(n=50)due to acute myeloid leukemia with myeloablative conditioning(n=26;42%)and with non-myeloablative conditioning(n=36;58%).All patients were given standard immunosuppressive therapy with cyclosporin-A and methotrexate and pre-transplant antithymocyte globulin in the unrelated *** samples were collected pre-transplant before and after(on day-1)the conditioning therapy and on days+2,+4,+6,+10,+20,and+30 after *** levels of IL-2 and IFNgamma were determined using *** Patients were divided into four groups depending on the presence of acute GvHD and clinical manifestations of *** I included patients with neither acute GvHD nor infections[n=15(24%)],group II consisted of patients with infections without acute GvHD[n=17(27%)],group III was comprised of patients with acute GvHD without infections[n=9(15%)],and group IV included patients with both acute GvHD and infections[n=21(34%)].IFN-gamma concentrations were higher in Group II than in other groups on days+20(P=0.014)and+30(P=0.008).Post-hoc tests showed lower concentrations of IFN-gamma on day+30 in groups I(P=0.039)and IV(P=0.017)compared to group *** levels of IL-2 were mostly *** Serum levels of IFN-gamma fol

关键词： Interleukin-2 Interferon-gamma Cytokine profiles Acute myeloid leukemia Allogeneic hematopoietic stem cell transplantation Acute graft-versus-host disease

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软件工程环境概况

计算机科学 1984年第1期 11-23页

作者： Hans-Ludwig Hausen monika Müllerburg 朱宗元

本文讨论软件工程环境的诸多方面,即动机,生存期模式,概念,方法,描述手段和工具。就这些方面和软件工程环境领域引出某些一般结论。本文的基础是对精选的软件工程环境的研究。

关键词：软件工程生存期软件研制概念思维形式规格说明语言 SE 语言环境言语环境描述手段

用固定化链霉菌细胞产生泰乐菌素和Nikkomycin

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国外医药(抗生素分册) 1983年第5期 384-387页

作者： monika Veelken Hermann Pape 宋友礼

过去几年已开始集中研究细胞固定化,在各个领域中应用,已被几位作者综述(Ab-bott 1976,1977;Jack 和 Zajic1977;Ken-katasubramanian 和 Vieth 1979)报道。尽管一些报告有关固定化细胞应用于次级代谢物产生,如抗生素方面已有发表,代谢... 详细信息

过去几年已开始集中研究细胞固定化,在各个领域中应用,已被几位作者综述(Ab-bott 1976,1977;Jack 和 Zajic1977;Ken-katasubramanian 和 Vieth 1979)报道。尽管一些报告有关固定化细胞应用于次级代谢物产生,如抗生素方面已有发表,代谢产物是由共同中间体化合物经过多步途径合成

关键词：泰乐菌素链霉菌菌丝体相对产量兽用药固定化细胞 Nikkomycin

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悉尼PetSure宠物主题办公室

现代装饰 2016年第7期 112-115页

作者： Ali McShane monika Branagan 姜敏华 The Bold Collective

项目地址澳大利亚悉尼设计单位The Bold CollectivePetSure宠物保险公司是南非最大的私营保险集团Hollard Insurance旗下的子公司,占据坐落在悉尼Chatswood区维多利亚大道的Hollard总部的9至12层。PetSure力邀悉尼当地设计风格极为大胆... 详细信息

项目地址澳大利亚悉尼设计单位The Bold CollectivePetSure宠物保险公司是南非最大的私营保险集团Hollard Insurance旗下的子公司,占据坐落在悉尼Chatswood区维多利亚大道的Hollard总部的9至12层。PetSure力邀悉尼当地设计风格极为大胆的The Bold Collective设计公司担纲其中两层空间的室内设计。通常说来,工作场所一般很少会专门为猫或其他宠物设置休息区,

关键词： PetSure 项目地址私营保险设计单位层空间室内设计休息区计部非正式会议区中

维普期刊数据库博看期刊

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南非制定《初级医疗卫生系统处方集》的经验

中国执业药师 2009年第9期6卷 52-53页

作者： monika Zweygarth Robert S.Summers 国家食品药品监督管理局药品评价中心

2002年10月，WHO公布了纸质和电子版《示范处方集》，它包括WHO基本药物示范日录中全部325种药品的信息，这成为各个国家或医疗机构制定处方集的基础。例如，以诚信为宗旨的非政府组织“慈善之船”就在WHO示范处方集的基础上，形成了自... 详细信息

2002年10月，WHO公布了纸质和电子版《示范处方集》，它包括WHO基本药物示范日录中全部325种药品的信息，这成为各个国家或医疗机构制定处方集的基础。例如，以诚信为宗旨的非政府组织“慈善之船”就在WHO示范处方集的基础上，形成了自己的药品信息厍，并将其用于该组织在发展中国家服务的医疗船上。该处方集强调用药剂量和适应证，可以免费从网上以MS Word文档的格式获得。本文介绍了南非以《WHO示范处方集》为基础编制初级医疗卫生用处方集的经验。

关键词：医疗卫生系统处方集南非非政府组织药品信息发展中国家 WHO 基本药物

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Photo Acoustic Energy Applications for the Detection of Human Arterial Blockages via Multiple Skin/Bone Layers, a Non-Invasive Approach

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World Journal of Cardiovascular Diseases 2017年第8期7卷 251-270页

作者： monika Kakani Neeraj Rathi Ahdy Helmy Ashok Kumar Thella M. D. James Rizkalla Paul Salama Maher E. Rizkalla Department of Electrical and Computer Engineering Indiana University Purdue University Indianapolis (IUPUI) Indianapolis USA VA Hospital Indiana University School of Medicine Indianapolis USA Baylor University Medical Center (BUMC) Dallas USA Integrated Nanosystems Development Institute IUPUI Indianapolis USA Richard G. Lugar Center for Renewable Energy IUPUI Indianapolis USA

The impact of arterial narrowing/blocking caused by plaque buildup in arteries leads to many life-threatening consequences. This is recognized as a cause in heart attacks and peripheral vascular disease. Diagnosing the illness is only feasible after symptoms have presented to the patient. Currently, the standard for visualizing coronary arteries is through angiography, which may have complications, and impact on the healthcare system. Furthermore, cardiac catheterization may also places high health risks, given its overall invasiveness. Cardiac arrhythmias, infection, and contrast dye nephrotoxicity are recognized complications within this process. Therefore, a noninvasive approach may have potentials to reduce patient complications, finances surrounding healthcare, and more efficient patient care through earlier screening and diagnosing. This research addresses a new approach using photoacoustic (PA) imaging. The transmission properties of atherosclerosis within walls of arteries, can be exploited using photo acoustics, to better visualize and characterize the degree and severity of atherosclerosis. The delivered energy is absorbed by components of the vascular tissue converted into heat, leading to transient thermos elastic expansion, which creates an acoustic emission. The thermal response was analyzed for its fall and recovery times that are attributed to the artery fat type. The control parameters, including the frequency, penetration depth, energy levels, and tissue layer sizes, for multilayered structures were considered. The structures investigated were fatty infiltrate within the artery, blood, bones, and skin, within frequency range from 1 MHz to 3 MHz, and typical tissue sizes in the milli to centimeter range. As high as 14 MPas in the acoustic pressure at 1 MHz, resulted in temperature difference of up to 3.4 K. When the operating frequency was altered to 2 MHz, the temperature changed to 23 K. Furthermore, when the frequency was changed to 3 MHz, the te

关键词： Acoustic Thermal Cardiovascular Diagnosis MEMS/NEMS COMSOL Multilayers Non-Invasive

Control of Canine Endoparasites,Especially Isospora spp.,with Procox^(■) in Naturally Infected Puppies:Parasitological,Bacteriological and Health Parameters

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Open Journal of Veterinary Medicine 2013年第2期3卷 121-130页

作者： Barbara Anna Rauscher Sabine Schafer-Somi monika Ehling-Schulz Karin Mostl Stefanie Handl Barbara Hinney Joachim Spergser Roland Schaper Anja Joachim Institute of Parasitology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Centre for Artificial Insemination and Embryo Transfer Department for Small Animals and HorsesUniversity of Veterinary Medicine ViennaViennaAustria Functional Microbiology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Virology Department of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Institute of Animal Nutrition Department for Farm Animals and Veterinary Public HealthUniversity of Veterinary Medicine ViennaViennaAustria Clinical Microbiology and Infection Biology IBMHDepartment of PathobiologyUniversity of Veterinary Medicine ViennaViennaAustria Bayer Animal Health GmbH MonheimGermany

The effect of Procox? (Bayer, emodepside/toltrazuril suspension for dogs) against natural infections with Isospora spp. was investigated. Two groups were treated either with 0.5 ml suspension/kg of body weight (0.45 mg emodepside and 9 mg toltrazuril/kg of body weight) in the 3rd, 5th and 7th week of life (w.o.l.) (Procox? group;n = 28) or with a control anthelminthic (Dewormed Control group;n = 26). Animals were surveyed weekly from the 3rd w.o.l. by coproscopy and clinical examination. Faecal samples were examined microbiologically from the 4th to the 8th w.o.l. and faecal inflammatory markers canine calprotectin and canine S100A12 were measured in the 8th w.o.l. Specific antibody titres were evaluated in serum samples from five litters before and after vaccination against canine distemper virus and canine parvovirus 2. The prevalence of Isospora-positive animals increased to 67% in the Dewormed Control group (n = 15 puppies from four parasite-positive litters), while in the Procox? group (n = 15 puppies) it was less than 34% with significantly lower excretion (p ? was easily applied and effective;adverse effects did not occur. The level of seroconversion or titre increase upon vaccination was higher in parasite-free animals (91%) compared to Procox?-treated puppies (30%) and the Control animals (10%). Animals from parasite-free litters showed significantly different excretion patterns for haemolytic Escherichia coli and Clostridium perfringens, while there was no difference between Procox?-treated and Control animals. In some animals kept under poor hygienic conditions diarrhoea was noted in association with C. perfringens, E. coli or Salmonella. Concentrations of inflammatory markers in the faeces did not significantly differ between the Procox? and the Control group. Adequate control of parasitic and bacterial infections in suckling puppies requires both antiparasitic treatment and hygiene. Even when parasites do not cause overt effects treatment is recommended

关键词： Dog Emodepside Gut Health Isospora Toltrazuril Toxocara Vaccination

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《管锥编》与杜甫新解 2版

丛书名：钱锺书研究丛书

1997年

作者：（德）莫芝宜佳（monika Motsch）马树德译

本书的第一部分论述的是《管维编》，这一部分起的是定向作用：除了介绍钱锺书的生平与著作，还将综述《管维编》的“中西法”。“文体”、“母题”以及“宇宙观”三章将由近而远地铺出三条能使我们较易进入这片“丛林”的“通道”。本... 详细信息

ISBN: (纸本)7543430916

本书的第一部分论述的是《管维编》，这一部分起的是定向作用：除了介绍钱锺书的生平与著作，还将综述《管维编》的“中西法”。“文体”、“母题”以及“宇宙观”三章将由近而远地铺出三条能使我们较易进入这片“丛林”的“通道”。本书第二部分论述的是唐代诗人杜。在这里作者告别了钱锺书的《管维编》，为的是把第一部分中形成的理念验证于实践。在中国，杜甫被尊崇为最伟大的诗人，但在西方却很少有人研究，且没有给予他应有的评价。作者选择了25首杜诗并加以诠释，为的是探求中西方存在差异的原因并试图对杜甫作一新解。

关键词：文学研究地点:中国杜诗

来源：汇雅图书（南通市图书馆... 评论

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花语者女人与植物的神秘对话

摄影之友 2015年第4期 98-105页

作者： Carsten Witte monika Mohr Gallery Hamburg 汤淑娟

关于女人的题材屡见不鲜,关于花的创作也是数不胜数,而将两者结合的作品也比比皆是。但是能将两者表现得出神入化的却是少之又少,而摄影师Carsten Witte的作品就是其一,因为他呈现的是女人与植物的心灵对话。心灵与自然相结合才能产生智... 详细信息

关于女人的题材屡见不鲜,关于花的创作也是数不胜数,而将两者结合的作品也比比皆是。但是能将两者表现得出神入化的却是少之又少,而摄影师Carsten Witte的作品就是其一,因为他呈现的是女人与植物的心灵对话。心灵与自然相结合才能产生智慧,才能产生想象力。——梭洛当在形容自然界生物的时候,我们常有拟人一说,这其实是人类将一种自己不熟悉的生物用自己熟悉的物体去解释。其实人类的种种都可以在自然界中找到对照物,就像女人与花,这个一直被世人所拟比的两个生物,"她们"同样的美丽与神秘。

关键词：自然界生物 Witte 花语自然相能将对照物品色藤蔓自然地表令人