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Asian Pacific Journal of Tropical Medicine 2014年第8期7卷 602-608页

作者： Vivek K.Bajpai Jung In Yoon monika Bhardwaj Sun Chul Kang Department of Applied Microbiology and Biotechnology Yeungnam UniversityGyeongsanGyeongbuk 712-749Republic of Korea Department of Biotechnology Daegu UniversityGyeongsanGyeongbuk 712-714Republic of Korea

Objective:To examine the individual and synergistic anti-listcrial effect of nisin and leaf essential oil of Metasequoia glyptostroboides(***) against one of the leading foodhorne pathogens Listeria monocytogenes(***) ATCC 19116 in milk ***:The whole(8%),low(1%) and skim(no fat content) milk samples were inoculated with *** ATCC 19116 along with leaf essential oil of *** or nisin alone as well in ***:In this study,the leaf essential oil at the concentrations of 2% and 5% revealed strong anti-listerial effect against *** ATCC 19116 in all categories of milk *** at the concentrations of 250 and 500 IU/mL displayed a strong inhibitory effect against ATCC 19116 as compared to the control ***,synergistic combinations of leaf essential oil(1%) and nisin(62.5,125.250 and 500 IU/mL) also had a remarkable anti-listerial synergism in all the tested milk samples including whole,low and skim milk after 14 ***:As a major finding,the leaf essential oil of *** might he a useful candidate for using in food industry to control the growth of foodhorne pathogenic bacteria as confirmed by its potent anti-listerial Synergistic effect with nisin against *** ATCC 19116 in different milk samples.

关键词： Anti-listerial effect Synergism Metasequoia glyptostroboides Leaf essential oil Nisin,Milk samples

Plant Small RNAs: Biogenesis, Mode of Action and Their Roles in Abiotic Stresses

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Genomics, Proteomics & Bioinformatics 2011年第6期9卷 183-199页

作者： Praveen Guleria monika Mahajan Jyoti Bhardwaj Sudesh Kumar Yadav Plant Metabolic Engineering Biotechnology Division CSIR-Institute of Himalayan Bioresource TechnologyCSIR Palampur 176061 (HP) India

Small RNAs （sRNAs） are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. With the development of new and improved technologies, sRNAs have also been identified and characterized in plant systems. Among them, micro RNAs （miRNAs） and small interfering RNAs （siRNAs） are found to be very important riboregulators in plants. Various types of sRNAs differ in their mode of biogenesis and in their function of gene regulation, sRNAs are involved in gene regulation at both transcriptional and post-transcriptional levels. They are known to regulate growth and development of plants. Furthermore, sRNAs especially plant miRNAs have been found to be involved in various stress responses, such as oxidative, mineral nutrient deficiency, dehydration, and even mechanical stimulus. Therefore, in the present review, we focus on the current understanding of biogenesis and regulatory mechanisms of plant sRNAs and their responses to various abiotic stresses.

关键词： plants abiotic stress small RNA microRNA siRNA

Malignant insulinoma:Can we predict the long-term outcomes?

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World Journal of Clinical Cases 2022年第16期10卷 5124-5132页

作者： Maja Cigrovski Berkovic monika Ulamec Sonja Marinovic Ivan Balen Anna Mrzljak Department of Endocrinology DiabetesMetabolism and Clinical PharmacologyClinical Hospital DubravaZagreb 10000Croatia Department of Kinesiological Anthropology and Methodology Faculty of KinesiologyUniversity of ZagrebZagreb 10000Croatia Department of Pathology and Cytology“Ljudevit Jurak” University Hospital Center“Sestre milosrdnice”Zagreb 10000Croatia Scientific Group for Research on Epigenetic Biomarkers and Department of Pathology School of MedicineUniversity of ZagrebZagreb 10000Croatia Laboratory for Personalized Medicine Division of Molecular MedicineRudjer Boskovic InstituteZagreb 10000Croatia Department of Gastroenterology and Endocrinology General Hospital“Dr.Josip Bencevic”Slavonski Brod 35000Croatia Department of Gastroenterology and Hepatology UHC ZagrebZagreb 10000Croatia School of Medicine University of ZagrebZagreb 10000Croatia

Insulinomas are the most frequent type of functional pancreatic neuroendocrine tumors with a variety of neuroglycopenic and autonomic symptoms and welldefined diagnostic criteria;however,prediction of their clinical behavior and early differentiation between benign and malignant lesions remain a *** comparative studies between benign and malignant cases are limited,suggesting that short clinical history,early hypoglycemia during fasting,high proinsulin,insulin,and C-peptide concentrations raise suspicion of ***,malignant tumors are larger with higher mitotic count and Ki-67 proliferative activity,but there are no accurate histological criteria to distinguish benign from malignant *** signaling pathways have been suggested to affect the pathophysiology and behavior of insulinomas;however,our knowledge is limited,urging a further understanding of molecular ***,there is a need for the identification of reliable markers of metastatic disease that could also serve as therapeutic targets in patients with malignant *** opinion review reflects on current gaps in diagnostic and clinical aspects related to the malignant behavior of insulinoma.

关键词： Pancreatic neuroendocrine tumor Malignant insulinoma Resection Liver Transplantation

Toxicity studies of elemental sulfur in marine sediments

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International Journal of Sediment Research 2018年第2期33卷 191-197页

作者： monika Cieszynska-Semenowicz Justyna Rogowska Wojciech Ratajczyk Joanna Ratajczyk Lidia Wolska Department of Environmental Toxicology Faculty of Health Sciences Medical University of Gdansk

Elemental sulfur(ES) is a component essential for proper development of animals, but it can be toxic for aquatic organisms. The objectives of the study reported here included determination of ES concentrations in sediment collected in the area of the Gulf of Gdansk(Baltic Sea) and search for the possible correlations with the ecotoxicity results. Sediment samples were collected from four locations: the Vistula River mouth, in the Port Basin, in the area of discharge of the treated wastewater from the Wastewater Treatment Plant(WWTP) and in the area of the sunken World War Ⅱ s/s 'Stuttgart' shipwreck. The levels of elemental sulfur were determined using a gas chromatograph coupled with a mass spectrometer(GC-MS). Toxicity of marine sediment samples was estimated for three biotest organisms-bioluminescent bacteria Vibrio fischeri, crustacean Heterocypris incongruens, and Synapis alba plant. The highest toxicity of sediments for all indicator organisms was observed in samples taken at the place of the shipwreck(2-100%). The same samples had a high sulfur content(16.7-143.2 μg/g dry weight(d.w.))therefore, it was decided to investigate whether the presence of ES in the sediment in the studied area can have an impact on the results of the ecotoxicity determination in real samples. However, the removal of sulfur from the samples resulted in no significant changes in the level of toxicity of the samples. In this research it could not be confirmed that the presence of elemental sulfur is the only factor responsible for the observed sediment toxicity. It seems that other compounds or their mixtures present in the sediment may have a significant influence on the results obtained.

关键词： Elemental sulfur(ES) Ecotoxicity Sediment Aquatic environment

Techno-economic comparison of three technologies for precombustion CO2 capture from a lignite-fired IGCC

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Frontiers of Chemical Science and Engineering 2020年第3期14卷 436-452页

作者： Simon Roussanaly monika Vitvarova Rahul Anantharaman David Berstad Brede Hagen Jana Jakobsen Vaclav Novotny Geir Skaugen SINTEF Energy Research NO-7465 TrondheimNorway Faculty of Mechanical Engineering Czech Technical University in Prague16607 Prague 6Czech Republic

This paper compares the techno-economic performances of three technologies for CO2 capture from a lignite-based IGCC power plant located in the Czech Republic:(1)Physical absorption with a Rectisol-based process;(2)Polymeric CO2-selective membrane-based capture;(3)Low-temperature *** evaluations show that the IGCC plant with CO2 capture leads to costs of electricity between 91 and 120€·MWh−1,depending on the capture technology employed,compared to 65€·MWh−1 for the power plant without *** results in CO2 avoidance costs ranging from 42 to 84€·tCO2,avoided−1,mainly linked to the losses in net power *** both energy and cost points of view,the low-temperature and Rectisol based CO2 capture processes are the most efficient capture ***,partial CO2 capture appears as a good mean to ensure early implementation due to the limited increase in CO2 avoidance cost when considering partial *** go beyond the two specific CO2-selective membranes considered,a cost/membrane property map for CO2-selective membranes was *** map emphasise the need to develop high performance membrane to compete with solvent ***,the cost of the whole CCS chain was estimated at 54€·tCO2,avoided−1 once pipeline transport and storage are taken into consideration.

关键词： carbon capture and storage(CCS) techno-economic comparison pre-combustion capture physical solvent low-temperature capture

Surveilling Russell body Helicobacter pylori-negative gastritis: A case report and review of literature

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World Journal of Gastroenterology 2020年第33期26卷 5050-5059页

作者： Milena Peruhova monika Peshevska-Sekulovska Viktoriya Georgieva Gabriela Panayotova Dorian Dikov Department of Gastroenterology University Hospital LozenetzSofia 1407Bulgaria Department of General and Clinical pathology Grand Hôpital de l'Est FrancilienJossigny 77600France

BACKGROUND Russell body gastritis(RBG)is very rare type of chronic inflammation of gastric *** pathologic hallmark of the disease is Russell bodies(RB)which represent accumulation of eosinophilic cytoplasmic inclusions in endoplasmic reticulum of mature plasma cells(Mott cells).Most published cases are associated with Helicobacter pylori(***)infection because of correlation between plasma cell activation and antigenic *** are insufficient data about ***-negative RBG and very little is known about the natural course of the *** SUMMARY A 51-year-old male patient underwent endoscopic screening for mild iron deficiency *** revealed diffuse hyperemia,edema and nodularity of the fundic and corpus *** to non-specific endoscopic findings and iron-deficiency anemia our preliminary diagnosis was diffuse type of gastric carcinoma or gastric *** specimens of gastric mucosa showed inflammatory infiltrate rich in Mott cells,consisting entirely of cytoplasmic *** of nuclear atypia and mitosis of the plasma cells,polyclonal pattern of the Mott cells and negative staining for cytokeratins favored diagnosis of *** patient was treated with proton-pump inhibitor for 8 ***-term clinical and endoscopic surveillance was ***,there was no improvement in endoscopic features of the gastric mucosa in three consecutive gastroscopies,histopathological findings demonstrated that the chronic inflammatory infiltrate in the fundic mucosa is less pronounced,rich in plasma cells,with almost absent RB and Mott *** The prognosis of this entity is uncertain,that is why these patients are subjects of continuous follow up.

关键词： Russell body gastritis Helicobacter pylori-negative Treatment Mature plasma cells Case report

The mRNA Binding Proteome of Proliferating and Differentiated Muscle Cells

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Genomics, Proteomics & Bioinformatics 2020年第4期18卷 384-396页

作者： monika Hiller Miriam Geissler George Janssen Peter van Veelen Annemieke Aartsma-Rus Pietro Spitali Department of Human Genetics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands Center for Proteomics and Metabolomics Leiden University Medical CenterLeiden 2333 ZCthe Netherlands

Muscle formation is a coordinated process driven by extensive gene expression changes where single cells fuse together to form multinucleated muscle fibers. Newly synthesized m RNAs are then regulated by RNA binding proteins(RBPs), affecting post-transcriptional transcript metabolism. Here, we determined how large-scale gene expression changes affect the catalog of RBPs by studying proliferating and differentiated muscle cells in healthy and dystrophic conditions. Transcriptomic analysis showed that the expression of more than 7000 genes was affected during myogenesis. We identified 769 RBPs, of which 294 were muscle-specific and 49 were uniquely shared with cardiomyocytes. A subset of 32 RBPs(half of which were muscle-specific) was found to be preferentially associated with target mRNAs in either myoblasts(MBs) or myotubes(MTs). A large proportion of catalytic proteins were bound to mRNAs even though they lack classical RNA binding domains. Finally, we showed how the identification of cell-specific RBPs enabled the identification of biomarkers that can separate healthy individuals from dystrophic patients. Our data show how interactome data can shed light on new basic RNA biology as well as provide cell-specific data that can be used for diagnostic purposes.

关键词： RNA binding protein Interactome Duchenne muscular dystrophy Proteomics Skeletal muscle

Numerical approach for modeling particle transport phenomena in a closed loop of a circulating fluidized bed

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Particuology 2016年第6期14卷 69-79页

作者： Wojciech P. Adamczyk Pawel Kozolub Grzegorz Kruczek monika Pilorz Adam Klimanek Tomasz Czakiert Gabriel Wecel Institute of Thermal Technology Silesian University of Technology Gliwice Poland AMEC Foster Wheeler Staszica 31 41-200 Sosnowiee Poland Institute of Advanced Energy Technologies Czestochowa University of Technology Czestochowa Poland

Numerical modeling of a large scale circulating fiuidized bed （CFB） imposes many complexities and difficulties. Presence of a dense solid phase, a variety of spatial and time scales as well as complex model geometries requires advanced numerical techniques. Moreover, the appropriate selection of a numerical model capable of solving granular flow, and geometrical model simplification can have a huge impact on the predicted flow field within the CFB boiler. In order to reduce the cost of the numerical simulations, the complex CFB boiler geometry is reduced to that of the combustion chamber. However, a question arises as to bow much one can simplify the geometrical model without losing accuracy of numerical simulations. To accurately predict the gas-solid and solid-solid mixing processes within subsequent sections of the CFB boiler （combustion chamber, solid separator, drain section）, a complete 3D geometrical model should be used. Nevertheless, because of the presence of various spatial and temporal scales within subsequent boiler sections, the complete model of the 3D CFB boiler is practically unrealizable in numerical simulations. To resolve the aforementioned problems, this paper describes a new approach that can be applied for complete boiler modeling. The proposed approach enables complex particle transport and gas flow problems within each of the boiler sections to be accurately resolved, It has been achieved by dividing the CFB boiler geometry into several submodels, where different numerical approaches can be used to resolve gas-solid transport. The interactions between computational domains were taken into account by connecting the inlets/outlets of each section using a set of user-defined functions implemented into the solution procedure. The proposed approach ensures stable and accurate solution within the separated boiler zones.

关键词： Fluidization CFB Numerical modeling Multiphase flow Particle transport Cyclone

Propolis modulates cellular biochemistry, antioxidants, cytokine profile, histological and ultra-morphological status against antituberculosis drugs induced hepatic injury

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Asian Pacific Journal of Tropical Medicine 2018年第11期11卷 609-620页

作者： Nisha Sahu Gita Mishra Hemeshwer Kumar Chandra Satendra Kumar Nirala monika Bhadauria Toxicology and Pharmacology Laboratory Department of Zoology Guru Ghasidas University Laboratory of Natural Products Department of Rural Technology and Social development Guru Ghasidas University

To evaluate hepatic injury induced by antituberculosis drugs(ATDs) when administered orally for 2, 4, 6 and 8 weeks and the therapeutic potential of propolis(bee hive product) against ATDs induced hepatic injury. Methods: The ATDs were administered for 8 weeks as well as propolis extract at three different doses(100, 200, 400 mg/kg) conjointly for 8 weeks in rats. Silymarin(50 mg/kg) was given as positive control. Animals were euthanized after 8 weeks; blood and liver samples were collected to perform various biochemicals, serological and histopathological and ultramorphological studies. Results: Significant increase(P < 0.05) in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, triglyceride and cholesterol along with reduction in glucose and albumin level were noted after ATDs induced hepatic injury. Significant increase(P < 0.05) in lipid peroxidation, triglyceride, cholesterol and CYP2E1 activity; decline in reduced glutathione, catalase, superoxide dismutase, glutathione reductase, glutathione peroxidase, glucose-6-phosphatase dehydrogenase activity were observed after ATDs intoxication. Due to presence of a wide range of flavonoids and polyphenols in propolis extract, its administration reduced hepatic injury and maintained biochemical indices towards control. Histopathological and electron microscopic observations indicated hepatoprotective potential of propolis at cellular level whereas, TNF-α, IL-6 and IGF-1 confirmed therapeutic potential of propolis at molecular level. Conclusions: It can be concluded that propolis possess hepatoprotective potential against ATDs induced hepatic injury that may prove itself as a clinically useful natural product in management of drug induced liver injury.

关键词： Antituberculosis drugs Propolis Biochemical Hepatic injury

Effect of exposure to chlorpyrifos on the cuticular and internal lipid composition of Blattella germanica males

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Insect Science 2016年第1期23卷 94-104页

作者： monika Paszkiewicz Agata Sikora Mieczystawa I. Bogus Emilia Wloka Piotr Stepnowski Marek Golebiowski Laboratory of Natural Products Analysis Department of Environmental Analysis Institute for Environmental and Human Health ProtectionFaculty of Chemistry University of Gdansk ul. Wita Stwosza 63 80-308 Gdansk Institute of Parasitology Polish Academy ofSciences Twarda 51155 00-818 Warszawa Poland

The results of our research on the cuticular and internal lipids of Blattella germanica males provide new information on variation in the composition of the cuticular and internal lipids ofB. germanica males after exposure to the presence of the insecticide. gas chromatography and gas chromatography-mass spectrometry analyses were used to identify and quantify the cuticular and internal lipid composition in males and males exposed to insecticide. There were significantly more acids having an even number of carbon atoms in the molecule, and these were also generally in higher concentrations. The following acids were in a higher concentration： C16：0 and C18：1, C18：2, C18：0. In both males and males exposed to insecticide, 24 fatty acids ranging from C6 to C22 were determined. However, there was a significantly higher content of fatty acids in the surface lipids of B. germanica males after exposure to insecticide. Our results indicate a higher content of n-alkanes, sterols, particularly cholesterol, fatty acids, and fatty acid methyl esters in the B. germanica surface after exposure to chlorpyrifos than in males that were not exposed.

关键词： Blattella germanica chlorpyrifos cockroach cuticular and internal lipid GC-MS