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Blood concentration of aminothiols in children with relapse of nephrotic syndrome

世界儿科杂志:英文版 2016年第3期12卷 353-359页

作者： Marcin Tkaczyk monika Miklaszewska Jolanta Lukamowicz Wojciech Fendler Division of Nephrology Polish Mother's Memorial Hospital Research Institute of lodz281/289 Rzgowska st.93-338lodzPoland Department of Pediatric Nephrology Collegium Medicum of Jagiellonian UniversityWielicka 26530-663 KrakowPoland Center of Medical Diagnostics Polish Mother's Memorial Hospital Research Institute of lodzPoland281/289 Rzgowska st.93-338 lodzPoland Medical University of lodz al.Kosciuszki 4lodzPoland

Background:The role of idiopathic nephrotic syndrome(INS)in the pathogenesis of atherosclerosis in childhood has not been clearly ***,antioxidative defense in INS is thought to be *** study aimed to assess the changes of plasma concentration of selected aminothiols in the blood of children with INS at various stages of the ***:This cross-sectional study was conducted in 125 children aged 2-18 *** children were divided into 4 groups:group A,early relapse(n=37);group B,early remission for 4-6 weeks from the onset(n=37);group C,late steroid-free remission(n=31);and group D,long-term remission for 2-5 years(n=20).Control group(E)consisted of 30 age-and gender-matched healthy *** study protocol comprised an analysis of plasma concentrations of glutathione,homocysteine,cysteine and cysteinylglycine by high-performance liquid *** of protein-bound and free aminothiols were *** injury was assessed by thrombomodulin,PAI-1 concentration,and von Willebrand factor ***:The children with INS had unbalanced aminothiol metabolism only in relapse and early remission,that shifted towards increased oxidative *** of cyclosporine A caused a significant increase in homocysteine and cysteine *** in aminothiol metabolism were significantly related to endothelial ***:The fi ndings of this study may be helpful in elucidating the pathogenesis of premature atherosclerosis in patients with INS refractory to the treatment or in the case of frequent relapse.

关键词： aminothiols children cyclosporine A homocysteine nephrotic syndrome

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Luminescence properties of dysprosium doped YVO_4 phosphor

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Journal of Rare Earths 2018年第12期36卷 1245-1249页

作者： H.J.Rajendra C.PANDurangappa D.L.monika Department of Physics RNS Institute of TechnologyChannasandra Department of Physics SJB Institute of Technology

Trivalent dysprosium(Dy) activated nanocrystalline yttrium vanadate(YVO) phosphor was synthesized via co-precipitation method. The prepared samples were characterized by X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FTIR), scanning electron microscopy(SEM), optical absorption and photo luminescence(PL) techniques. The XRD patterns reveal the tetragonal crystalline phase. SEM images reveal that Dy doped YVOnanocrystals are agglomerated. EDAX confirms the formation of YVO:Dy. FTIR spectrum shows two strong absorption bands at 459 and 761 cm. Optical absorption spectrum showed the surface defects in the as-prepared samples. The PL emission spectrum shows two characteristic emission bands at 485 and 575 nm. The strong yellow emission peak at 575 nm is assigned to ~4 F→~6 Hhyper sensitive transition of Dyions, Study of CIE chromaticity diagram indicates the suitability of the phosphor for the development of yellow-green LEDs.

关键词： Precipitation Yttrium vanadate Dysprosium X-ray diffraction Photoluminescence Rare earths

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当代城市空间的沉思

当代城市空间的沉思

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作者： monika Strzelec 湖南农业大学

学位级别：硕士

这篇论文的目的是为了创建现代城市的冥想空间设计导则。冥想被公认是减轻社会压力的一种方法。在这项工作的最初期间,冥想和压力的定义就被解释为理解基础的问题。之所以选择这种自然的方法来减轻压力,是基于环境心理学领域的研究出版... 详细信息

这篇论文的目的是为了创建现代城市的冥想空间设计导则。冥想被公认是减轻社会压力的一种方法。在这项工作的最初期间,冥想和压力的定义就被解释为理解基础的问题。之所以选择这种自然的方法来减轻压力,是基于环境心理学领域的研究出版物进一步分析之上的。而由于绿化对于个人的影响,这是有可能达到的。在下一节中便会讨论关于欧洲和亚洲的部分国家的冥想空间塑造历史的重要方面。之后是对有利于放松的地方进行民意调查。在调查中,人们被要求现场投票,主要是针对城市空间。论文中的照片就是根据几个变量来进行分类的,因此调查结果表明了大众的偏好。根据调查结果,创建了一个有助于冥想的空间模型,这也是设计工作的其中一部分内容。接下来,便用弗罗茨瓦夫的几个主要空间作为冥想空间概念的示范来进行分析。这些分析有助于在Daliowa岛上选择最合适的地方来创建冥想空间概念的范例。

关键词：冥想现代城市放松压力

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Neuroinflammation after acute ischemic stroke:a volcano hard to contain

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中国现代神经疾病杂志 2013年第11期13卷 964-970页

作者： monika Mishra Vishnumurthy Shushrutha Hedna Department of Neurology College of Medicine University of Florida

各种内源性、外源性和系统性因素均可影响脑血流的神经血管内单位,但又互为导致血管闭塞的独立因素。无论何种机制引起的脑缺血,其结局均相同,包括血管因素、星形胶质细胞、神经元和诱发神经炎症疾病谱的周围小胶质细胞。而神经炎症反... 详细信息

各种内源性、外源性和系统性因素均可影响脑血流的神经血管内单位,但又互为导致血管闭塞的独立因素。无论何种机制引起的脑缺血,其结局均相同,包括血管因素、星形胶质细胞、神经元和诱发神经炎症疾病谱的周围小胶质细胞。而神经炎症反应则为缺血级联反应中的重要环节,可引起神经细胞去极化和炎性细胞因子前体激活,继而细胞死亡。神经炎症反应可引起中枢神经系统急性能量衰竭、兴奋性毒性反应、电解质紊乱、离子通道功能障碍和氧自由基分泌增多等一系列反应,而又可以是其后果。若在阈值期内缺血状态不能得到改善,则可激活基质金属蛋白酶,导致脑组织广泛损害,而即早基因激活将致使神经体液微内环境和血脑脊液屏障破坏。脱氧和复氧均可造成卒中相关性损伤。缺血性脑损伤级联反应的病理过程还包括小胶质细胞和星形胶质细胞活化,释放细胞因子、氧自由基、神经毒性因子和神经营养因子等化学介质,进一步加重脑损伤。与此同时,中性粒细胞活化并通过细胞内黏附因子结合到内皮细胞表面,然后移行至缺血核心区,加剧脑组织损伤。单核细胞和巨噬细胞通过释放炎性细胞因子和转化为吞噬细胞而在缺血性脑损伤过程中发挥作用。针对神经炎症不同环节的治疗原则,是停止或减轻脑损伤程度,如抑制细胞内黏附分子(ICAMs)、血管细胞黏附分子(VCAMs)、中性粒细胞、小胶质细胞、主要组织相容性复合物(MHC)、细胞因子、趋化因子和自由基活性。上述针对脑缺血后神经炎症的各种治疗方法,动物实验已有可喜的结果,但临床试验未见成效,目前正在做进一步研究。然而,了解神经炎症的病理学机制,对今后开发新型神经保护治疗方法的开拓脑缺血治疗领域至关重要。本文旨在阐述缺血性卒中相关神经炎症反应的不同病理学机制。

关键词：脑缺血炎症中枢神经系统免疫,细胞神经免疫调节综述

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Dyslipidemia modulates Müller glial sensing and transduction of ambient information

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Neural Regeneration Research 2018年第2期13卷 207-210页

作者： monika Lakk Felix Vazquez-Chona Oleg Yarishkin David Krizaj Department of Ophthalmology&Visual Sciences University of UtahSalt Lake CityUTUSA Department of Bioengineering University of UtahSalt Lake CityUTUSA Department of Neurobiology&Anatomy University of UtahSalt Lake CityUTUSA

Unesterified cholesterol controls the fluidity, permeability and electrical properties of eukaryotic cell mem- branes. Consequently, cholesterol levels in the retina and the brain are tightly regulated whereas depletion or oversupply caused by diet or heredity contribute to neurodegenerative diseases and vision loss. Astrog- lia play a central role in the biosynthesis, uptake and transport of cholesterol and also drive inflammatory signaling under hypercholesterolemic conditions associated with high-fat diet （diabetes） and neurodegen- erative disease. A growing body of evidence shows that unesterified membrane cholesterol modulates the ability of glia to sense and transduce ambient information. Cholesterol-dependence of Mfiller glia - which function as retinal sentinels for metabolic, mechanical, osmotic and inflammatory signals - is mediated in part by transient receptor potential V4 （TRPV4） channels. Cholesterol supplementation facilitates, where- as depletion suppresses, TRPV4-mediated transduction of temperature and lipid agonists in Mfiller cells. Acute effects of cholesterol supplementation/depletion on plasma membrane ion channels and calcium ho- meostasis differ markedly from the effects of chronic dyslipidemia, possibly due to differential modulation of modality-dependent energy barriers associated with the functionality of polymodal channels embedded within lipid rafts. Understanding of cholesterol-dependence of TRP channels is thus providing insight into dyslipidemic pathologies associated with diabetic retinopathy, glaucoma and macular degeneration.

关键词： dyslipidemia cholesterol Muller glia transient receptor potential V4 cyclodextrin calcium retina

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Determination of bisphosphonates anti-resorptive properties based on three forms of ceramic materials: Sorption and release process evaluation

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Journal of Pharmaceutical Analysis 2021年第3期11卷 364-373页

作者： monika Zielinska Ewa Chmielewska Tomasz Buchwald Adam Voelkel PawełKafarski Poznan University of Technology Institute of Chemical Technology and EngineeringUl.Berdychowo 460-965PoznanPoland Wrocław University of Science and Technology Faculty of ChemistryDepartment of Bioorganic ChemistryWybrzeze Wyspia_nskiego 2750-370WrocławPoland Poznan University of Technology Institute of Materials Research and Quantum EngineeringPiotrowo 360-965PoznanPoland

There is a strong need to search for more effective compounds with bone anti-resorptive properties,which will cause fewer complications than commonly used bisphosphonates. To achieve this goal, it is necessary to search for new techniques to characterize the interactions between bone and drug. By studying their interaction with hydroxyapatite(HA), this study used three forms of ceramic materials,two of which are bone-stimulating materials, to assess the suitability of new active substances with antiresorptive properties. In this study, three methods based on HA in loose form, polycaprolactone/HA(a polymer-ceramic materials containing HA), and polymer-ceramic monolithic in-needle extraction(MINE) device(a polymer inert skeleton), respectively, were used. The affinity of risedronate(a standard compound) and sixteen aminomethylenebisphosphonates(new compounds with potential antiresorptive properties) to HA was defined according to the above-mentioned methods. Ten monolithic materials based on 2-hydroxyethyl methacrylate/ethylene dimethacrylate are prepared and studied, of which one was selected for more-detailed further research. Simulated body fluids containing bisphosphonates were passed through the MINE device. In this way, sorptionedesorption of bisphosphonates was evaluated using this MINE device. The paper presents the advantages and disadvantages of each technique and its suitability for assessing new active substances. All three methods allow for the selection of several compounds with potentially higher anti-resorptive properties than risedronate, in hope that it reflects their higher bone affinity and release ability.

关键词： Monolithic column Polymer composites Bisphosphonates Hydroxyapatite coatings Hydroxyapatite composite

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Point-based tool representations for modeling complex tool shapes and runout for the simulation of process forces and chatter vibrations

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Advances in Manufacturing 2018年第3期6卷 301-307页

作者： P. Wiederkehr T. Siebrecht J. baumann D. Biermann Institute of Machining Technology TU Dortmund University Dortmund Germany Virtual Machining Department of Computer Science TU Dortmund University Dortmund Germany

Geometric physically-based simulation systemscan be used for analyzing and optimizing complex millingprocesses, for example in the automotive or aerospaceindustry, where the surface quality and process efficiencyare limited due to chatter vibrations. Process simulationsusing tool models based on the constructive solid geometry（CSG） technique allow the analysis of process forces, tooldeflections, and surface location errors resulting from five-axis machining operations. However, modeling complextool shapes and effects like runout is difficult using CSGmodels due to the increasing complexity of the shapedescriptions. Therefore, a point-based method for modelingthe rotating tool considering its deflections is presented inthis paper. With this method, tools with complex shapesand runout can be simulated in an efficient and flexibleway. The new modeling approach is applied to exemplarymilling processes and the simulation results are validatedbased on machining experiments.

关键词： Modeling Tool geometry Milling

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Structure and corrosion resistance of Al–Cu–Fe alloys

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Progress in Natural Science:Materials International 2020年第3期30卷 393-401页

作者： Rafa? Babilas Anna Bajorek monika Spilka Adrian Radoń Wojciech ?oński Department of Engineering Materials and Biomaterials Silesian University of Technology Institute of Physics University of Silesia in Katowice ?ukasiewicz Research Network-Institute of Non-Ferrous Metals

The microstructure and electrochemical properties of Al–Cu–Fe alloys with the atomic compositions of Al65Cu20Fe15,Al78Cu7Fe15and Al80Cu5Fe14Si1have been *** alloys were produced by induction melting of pure elements with copper mold *** microstructure of the alloys was analyzed by X-ray diffraction and high-resolution transmission electron *** formation of quasicrystalline phases in the Al–Cu–Fe alloys was *** presence of intermetallic phases was observed in the alloys after crystallization in a form of ingots and *** electrochemical measurements were conducted in 3.5%NaCl *** electronic structure of the alloys was determined by X-ray photoelectron *** post corrosion surface of the samples was checked using a scanning electron microscope equipped with the energydispersive X-ray *** was observed that the Al65Cu20Fe15alloy had the highest corrosion *** improved corrosion resistance parameters were noted for the plate samples rather than those in the as-cast *** the hardness of the Al65Cu20Fe15alloy was significantly higher than the other alloy samples.

关键词： Al-Cu-Fe alloys Copper mold casting X-ray diffraction High-resolution transmission electron microscopy X-ray photon spectroscopy Electrochemical impedance spectroscopy

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The Impact of Willow Flowering Time on Species Composition and the Number of Apoidea Pollinators

The Impact of Willow Flowering Time on Species Composition a...

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作者： monika Konatowska Pawe? Rutkowski Jacek Wendzonka Poznań University of Life Sciences Adam Mickiewicz University

Pollinators are important to wild and cultivated plants, and the same plants are important to pollinators as well.A very important source of pollen and nectar to pollinators are willows（Salix spp.）.The aim of this study was to demonstrate which Apoidea species are attracted by a species-diverse willow plantation（Poznań University of Life Sciences Willow Collection, Poland）, the proportion of the number of honeybees to other species from the Apoidea superfamily visiting willow plantations, and whether the flowering date of male and female willow individuals affect the species composition and number of *** of willow phenology were carried out in the second year of willow growth, from March 9 to December 7, *** insects were observed between April 6 and May 11, *** results of this study showed 30 Apoidea *** 1591 Apoidea individuals, only 17 honeybee individuals were *** results show that the willow pollen production optimum occurred when the minimum air temperatures stopped dropping below *** parameter and this period are also related to the intensification of the occurrence of the noted *** can also be concluded that the pollen production season precedes the flowering optimum of female flowers and that the optimum flowering of female flowers is correlated with a significant increase in air temperature.

关键词： Willows Apoidea Pollinators Air Temperature

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Study of coronary sinus anatomy during levophase of coronary angiography

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World Journal of Cardiology 2022年第6期14卷 372-381页

作者： Akshyaya Pradhan Vrishank Bajaj Pravesh Vishwakarma monika Bhandari Akhil Sharma Gaurav Chaudhary Sharad Chandra Rishi Sethi Varun Shankar Narain Sudhanshu Dwivedi Department of Cardiology King George Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND Coronary sinus(CS)imaging has recently gained importance due to increasing need for mapping and ablation of electrophysiological arrhythmias and left ventricular(LV)pacing during cardiac resynchronization therapy(CRT).Retrograde venogram is the current standard for imaging CS and its *** To evaluate CS anatomy during levophase of routine coronary angiography to aid LV lead implantation during *** In this prospective observational study,164 patients undergoing routine coronary angiography for various indications(Chronic stable angina-44.5%,acute coronary syndrome-39.5%,Dilated cardiomyopathy-11%,atypical chest pain-5%)were *** phase(levophase)of left coronary injection was recorded in left anterior oblique-cranial and right anterior oblique-cranial *** of coronary veins,width and shape of CS ostium,angulations of proximal CS with body of CS were ***,size,take-off angle and tortuosity of posterolateral vein(PLV),anterior interventricular veins(AIV)and middle cardiac vein(MCV)were also *** During levophase,visibility grade(Muhlenbruch grade)for coronary veins was 3 in 74%and 2 in 26%of *** of CS did not correlate with body mass *** diameter of CS ostium was15 mm in 48%,42%and 10%of patients *** CS was tubular in 136(83%)patients and funnel-shaped in 28(17%)*** take-off angulation between ostium and body of CS was seen in 16(10%)*** or more PLV were present in 8 patients while PLV was absent in 52(32%)*** of take-off of PLV with body of CS was favourable(0°-45°)in 65(40%)*** angle was 45°-90°in 36 patients and difficult take-off angle(>90°)was seen in 8 *** of PLV reached distal third of myocardium in 84 cases and middle third in 11 *** was no tortuosity in 79 cases,a single bend in 29 cases and more than 2 bends in 4 *** nine(24%)patients had other veins supplying poste

关键词： Posterolateral vein Ostium Angiography Sharp take off Favourable angulation

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