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Low ADAMTS-13/VWF ratio and altered gut–liver axis predict complications of advanced chronic liver disease:a pilot study

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Gastroenterology Report 2022年第1期10卷 671-673页

作者： Francesca Romana Ponziani monica sacco Maira Tardugno Francesco Santopaolo Adriana Marsico Stefano Manna Stefano Lancellotti Antonio Gasbarrini Raimondo De Cristofaro Maurizio Pompili Internal Medicine and Gastroenterology–Hepatology Unit Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly Translational Medicine and Surgery Department Catholic UniversityRomeItaly Hemorrhagic and Thrombotic Diseases Service Fondazione Policlinico Universitario Agostino Gemelli IRCCSRomeItaly

Introduction Liver cirrhosis is characterized by a delicate balance between thrombosis and *** extinction due to microvascular thrombosis is involved in disease progression and anticoagulant therapy with low-molecular-weight heparin has been shown to reduce the frequency of hepatic decompensation[1].Dysbiosis and bacterial translocation,which are hallmarks of liver cirrhosis,can influence the coagulation system through inflammation or by the activation of Toll-like receptors on endothelial cells and platelets[2].However,little is known about the connections between the coagulation system,the occurrence of liver cirrhosis complications,and the gut microbiome.

关键词： complications inflammation bleeding

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Intestinal metastasis from breast cancer:Presentation,treatment and survival from a systematic literature review

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World Journal of Clinical Oncology 2021年第5期12卷 382-392页

作者： Elena Bolzacchini Olga Nigro Davide Inversini monica Giordano Giovanni Maconi Department of Oncology Ospedale Sant'AnnaASST LarianaComo 22100ItalyDepartment of Medicine and SurgeryUniversity of InsubriaVarese 21100Italy Department of Oncology Ospedale di Circolo ASST-Sette LaghiVarese 21100Italy Department of General Surgery Ospedale Sant'Antonio AbateASST LarianaCantu'22100Italy Department of Oncology Ospedale Sant'AnnaASST LarianaComo 22100Italy Department of Biomedical and Clinical Sciences Gastroenterology Unit"Luigi Sacco"University HospitalMilano 20157Italy

BACKGROUND Intestinal metastases from breast cancer(BC)arerare;available data depend mainly on case reports and case *** To conduct a review of the literature regarding presentation,diagnosis,treatment and survival of patients with intestinal metastasis from *** We identified all articles that described patients with intestinal metastasis(from duodenum to anum)from BC using MEDLINE(1975 to 2020)and EMBASE(1975 to 2020)electronic *** We found 96 cases of intestinal metastasis of *** involved large bowel(cecum,colon,sigmoid,rectum)(51%),small bowel(duodenum,jejunum,ileum)(49%),and anum(<1%).Median age of patients was *** most frequent histology was infiltrating lobular carcinoma followed by infiltrating ductal *** more than half of patients,the diagnosis was made after the diagnosis of BC(median:7.2 years)and in many cases of emergency,for bowel obstruction,bleeding or *** was achieved through endoscopy,radiological examination or *** most of the cases,patients underwent surgery with or without systemic *** of patients included in this review was available in less than 50%of patients and showed an overall median of 12 mo since diagnosis of the intestinal *** Although,intestinal metastases of BC are considered a rare condition,clinicians should consider the possibility of intestinal involvement in case of abdominal symptoms even in acute setting and many years after the diagnosis of BC,especially in patients with a histology of lobular carcinoma.

关键词： Breast cancer Intestinal metastasis Diagnosis Treatment Small bowel Large bowel

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