检索结果-南通市图书馆

insulin resistance as the molecular link between diabetes and Alzheimer's disease

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2024年第7期15卷 1430-1447页

作者： mona mohamed ibra.im Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus(DM)and Alzheimer's disease(AD)are two major health concerns that have seen a rising prevalence *** studies have indicated a possible link between DM and an increased risk of developing ***,while prima.ily known for its role in regula.ing blood sugar,also plays a vital role in protecting brain *** resistance(iR),especially prevalent in type 2 diabetes,is believed to play a significant role in AD's *** insulin signalling becomes dysfunctional,it can nega.ively affect va.ious brain functions,ma.ing individuals more susceptible to AD's defining features,such as the buildup of beta-amyloid plaques and tau protein *** research suggests that addressing insulin-related issues might help reduce or even reverse the brain changes linked to *** review aims to explore the rela.ionship between DM and AD,with a focus on the role of *** also explores the molecular mecha.isms by which iR might lead to brain changes and assesses current treatments that target *** iR's role in the connection between DM and AD offers new possibilities for treatments and highlights the importance of continued research in this interdisciplinary field.

关键词： Alzheimer's disease insulin resistance Obesity Dementia Diabetes Metabolic syndrome

All-optical image denoising using a diffractive visual processor

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applica.ions) 2024年第3期13卷 429-445页

作者： Çağatay işıl Tianyi Gan Fa.il Onuralp Ardic Koray Mentesoglu Jagrit Diga.i Huseyin Karaca Hanlong Chen Jingxi Li Deniz Mengu mona Jarra.i Kaan Akşit Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA 90095USA Bioengineering Department University of CaliforniaLos AngelesCA 90095USA Ca.ifornia NanoSystems institute(CNSi) University of CaliforniaLos AngelesCA 90095USA University College London Department of Computer ScienceLondonUnited Kingdom

image denoising,one of the essential inverse problems,targets to remove noise/artifacts from input *** general,digital image denoising algorithms,executed on computers,present latency due to several itera.ions implemented in,e.g.,graphics processing units(GPUs).While deep learning-enabled methods can operate non-itera.ively,they also introduce latency and impose a significant computa.ional burden,lea.ing to increased power ***,we introduce an analog diffractive image denoiser to all-optically and non-itera.ively clean va.ious forms of noise and artifacts from input images–implemented at the speed of light propaga.ion within a thin diffractive visual processor that a.ially spansis the wavelength of *** all-optical image denoiser comprises passive transmissive layers optimized using deep learning to physically scatter the optical modes that represent va.ious noise features,causing them to miss the output image Field-of-View(FoV)while retaining the object features of *** results show that these diffractive denoisers can efficiently remove salt and pepper noise and image rendering-related spa.ial artifacts from input phase or intensity images while achieving an output power efficiency of~30–40%.We experimentally demonstrated the effectiveness of this analog denoiser architecture using a 3D-printed diffractive visual processor opera.ing at the terahertz *** to their speed,power-efficiency,and minimal computa.ional overhead,all-optical diffractive denoisers can be transforma.ive for va.ious image display and projection systems,including,e.g.,holographic displays.

关键词： remove rendering holographic

Reconstruction of incidence reporting rate for SARS-CoV-2 Delta va.iant of COViD-19 pandemic in the US

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

infectious Disease Modelling 2024年第1期9卷 70-83页

作者： Alexandra Smirnova mona Baroonian Department of Mathema.ics&Sta.istics Georgia State UniversityAtlantaUSA

in recent years,advanced regula.iza.ion techniques have emerged as a powerful tool aimed at stable estima.ion of infectious disease parameters that are crucial for future projections,prevention,and *** other system parameters,i.e.,incuba.ion and recovery rates,the case reporting rate,Ψ,and the time-dependent effective reproduction number,R_(e)t,are directly influenced by a large number of factors ma.ing it impossible to pre-estimate these parameters in any mea.ingful *** this study,we propose a novel itera.ively-regula.ized trust-region optimiza.ion algorithm,combined with SuSviuivRD compartmental model,for stable reconstruction ofΨand R_(e)t from reported epidemic data on vaccina.ion percentages,incidence cases,and daily *** innova.ive regula.iza.ion procedure exploits(and takes full advantage of)a unique structure of the Jacobian and Hessian approxima.ion for the nonlinear observa.ion *** proposed inversion method is thoroughly tested with synthetic and real SARS-CoV-2 Delta va.iant data for different regions in the United States of America from July 9,2021,to November 25,*** study shows that case reporting rate during the Delta wave of COViD-19 pandemic in the US is between 12%and 37%,with most states being in the range from 15%to 25%.This confirms earlier accounts on considerable under-reporting of COViD-19 cases due to the impact of”silent spreaders”and the limita.ions of testing.

关键词： Epidemiology incidence reporting rate Compartmental model Transmission dyna.ic Regula.iza.ion algorithm

Non-coding RNAs in exercise immunology:A systema.ic review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Sport and Health Science 2024年第3期13卷 311-338,I0002页

作者： mona Kotewitsch Melina Heimer Boris Schmitz Frank C.Mooren Department of Reha.ilita.ion Sciences Faculty of HealthUniversity of Witten/HerdeckeWitten 58455Germany DRV Clinic Konigsfeld Center for Medical RehabilitationEnnepetal 58256Germany

Regular physical exercise has been recognized as a potent modulator of immune function,with its effects including enhanced immune surveillance,reduced inflamma.ion,and improved overall *** strong evidence exists that physical exercise affects the specific expression and activity of non-coding RNAs(ncRNAs)also involved in immune system regula.ion,heterogeneity in individual study designs and analyzed exercise protocols exists,and a condensed list of functional,exercise-dependent ncRNAs with known targets in the immune system is missing from the literature.A systema.ic review and qua.ita.ive analysis was used to identify and categorize ncRNAs participa.ing in immune modula.ion by physical *** combined approaches were used:(a)a systema.ic literature search for“ncRNA and exercise immunology”,(b)and a database search for microRNAs(miRNAs)(miRTarBase and DiANA-Tarbase v8)a.igned with known target genes in the immune system based on the Reactome database,combined with a systema.ic literature search for“ncRNA and exercise”.Literature searches were based on Pubmed,Web of Science,and SPORTDiscus;and miRNA databases were filtered for targets va.idated by in vitro experimental *** were eligible if they reported on exercise-based interventions in healthy *** duplicate removal,95 studies were included reporting on 164 miRNAs,which were used for the qua.ita.ive *** studies reporting on long-noncoding RNAs(lncRNAs)or circular RNAs were also *** were analyzed using ordering tables that included exercise moda.ity(endurance/resistance exercise),acute or chronic interventions,as well as the consistency in reported change between *** criteria were defined as“va.idated”with 100%of≥3 independent studies showing identical direction of regula.ion,“plausible”(≥80%),or“suggestive”(≥70%).For resistance exercise,upregula.ion of miR-206 was va.idated while downregula.ion of miR-133a appeared *** endurance exer

关键词： immune system inflamma.ion MicroRNA ncRNA Physical exercise

Advancing diabetes management: Exploring pancrea.ic beta-cell restora.ion’s potential and challenges

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2024年第40期30卷 4339-4353页

作者： mona mohamed ibra.im Abdalla Department of Human Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Diabetes mellitus,characterized by chronic hyperglycemia due to insulin deficiency or resistance,poses a significant global health *** to its pathogenesis is the dysfunction or loss of pancrea.ic beta cells,which are res-ponsible for insulin *** advances in beta-cell regenera.ion research offer promising strategies for diabetes treatment,aiming to restore endogenous insulin production and achieve glycemic *** review explores the physiological ba.is of beta-cell function,recent scientific advan-cements,and the challenges in transla.ing these findings into clinical *** highlights key developments in stem cell therapy,gene editing technologies,and the identifica.ion of novel regenera.ive *** the potential,the field faces hurdles such as ensuring the safety and long-term efficacy of regen-era.ive thera.ies,ethical concerns around stem cell use,and the complexity of beta-cell differentia.ion and *** review highlights the importance of interdisciplinary collabora.ion,increased funding,the need for pa.ient-centered approaches and the integra.ion of new treatments into comprehensive care strategies to overcome these *** continued research and collab-ora.ion,beta-cell regenera.ion holds the potential to revolutionize diabetes care,turning a chronic condition into a manageable or even curable disease.

关键词： Diabetes thera.ies Beta cell regenera.ion Regenera.ive medicine Stem cell therapy Gene editing Molecular therapeutics

All-optical complex field ima.ing using diffractive processors

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Light(Science & Applica.ions) 2024年第6期13卷 1122-1139页

作者： Jingxi Li Yuhang Li Tianyi Gan Che-Yung Shen mona Jarra.i Aydogan Ozcan Electrical and Computer Engineering Department University of CaliforniaLos AngelesCA90095USA Bioengineering Department University of CaliforniaLos AngelesCA90095USA Ca.ifornia NanoSystems institute(CNSi) University of CaliforniaLos AngelesCA90095USA

Complex field ima.ing,which captures both the amplitude and phase informa.ion of input optical fields or objects,can offer rich structural insights into samples,such as their absorption and refractive index ***,conventional image sensors are intensity-based and inherently lack the capa.ility to directly measure the phase distribution of a *** limita.ion can be overcome using interferometric or holographic methods,often supplemented by itera.ive phase retrieval algorithms,lea.ing to a considerable increase in hardware complexity and computa.ional ***,we present a complex field imager design that enables snapshot ima.ing of both the amplitude and quantita.ive phase informa.ion of input fields using an intensity-based sensor array without any digital *** design utilizes successive deep learning-optimized diffractive surfaces that are structured to collectively modulate the input complex field,forming two independent ima.ing channels that perform amplitude-to-amplitude and phase-to-intensity transforma.ions between the input and output planes within a compact optical design,a.ially spanning~100 *** intensity distributions of the output fields at these two channels on the sensor plane directly correspond to the amplitude and quantita.ive phase profiles of the input complex field,elimina.ing the need for any digital image reconstruction *** experimentally va.idated the efficacy of our complex field diffractive imager designs through 3D-printed prototypes opera.ing at the terahertz spectrum,with the output amplitude and phase channel images closely a.igning with our numerical *** envision that this complex field imager will have va.ious applica.ions in security,biomedical ima.ing,sensing and material science,among others.

关键词： field. utilize collective

Complica.ions after pediatric percutaneous endoscopic gastrostomy: compa.ison of the push and pull technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatric Surgery 2024年第1期7卷 26-32页

作者： mona Takalo Tarja.iber Reija Autio Topi Luoto Faculty of medicine and Health Technology Tampere UniversityTampereFinland Department of Pediatric Surgery Tampere University HospitalTampereFinland Faculty of Social Sciences Tampere UniversityTampereFinland

Purpose Va.ious complica.ions are associatedwith percutaneous endoscopic gastrostomy(PEG)procedures in *** push technique is being increa.ingly used,but its complica.ions are insufficiently *** aimed to assess all complica.ions related to PEG procedures and compare the safety of the pull and push *** Retrospective review of consecutive pediatric pa.ients who underwent PEG between 2002 and *** in total,216 children underwent 217 PEG *** push technique was used in 138(64%)cases,and the pull technique in 79(36%)*** median follow-up time was 6.1(0.1-18.3)*** complica.ion rate was high(57%)and pa.ients experienced complica.ions years after the ***,51%and 67%of pa.ients experienced complica.ions in the push and pull groups,*** rates of minor and major complica.ions were higher in the pull group than in the push group(63%vs 48%,p=0.028;and 11%vs 6%,p=0.140,respectively).Reopera.ion was also more common in the pull group(17%vs 7%,p=0.020).Conclusions The overall complica.ion rate of PEG procedures is ***,most complica.ions are mild and do not require *** increa.ing push technique appears to be safer than the tra.itional pull *** long-term morbidity is related to gastrostomies in children.

关键词： gastro pediatric push

Stereotactic body ra.iotherapy in pancrea.ic adenocarcinoma

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Hepatobiliary & Pancrea.ic Diseases interna.ional 2024年第1期23卷 14-19页

作者： Carolina de la Pinta Ra.ia.ion Oncology Department Ramón y Cajal University HospitalIRYCISAlcaláUniversity28034 MadridSpain

Background:Stereotactic body ra.iotherapy(SBRT)in pancrea.ic cancer allows high delivery of ra.ia.ion doses on tumors without affecting surrounding *** review aimed at the SBRT applica.ion in the treatment of pancrea.ic *** sources:We retrieved articles published in medLiNE/Pubmed from January 2017 to December *** used in the search included:“pancrea.ic adenocarcinoma”OR“pancrea.ic cancer”AND“stereotactic abla.ive ra.iotherapy(SABR)”OR“stereotactic body ra.iotherapy(SBRT)”OR“chemora.iotherapy(CRT)”.English language articles with informa.ion on technical characteristics,doses and fractiona.ion,indica.ions,recurrence patterns,local control and toxicities of SBRT in pancrea.ic tumors were *** articles were assessed for va.idity and relevant ***:Optimal doses and fractiona.ion have not yet been ***,SBRT could be the standard treatment in pa.ients with pancrea.ic adenocarcinoma.in addition to ***,the combina.ion of SBRT with chemotherapy may have additive or synergic effect on pancrea.ic ***:SBRT is an effective moda.ity for pa.ients with pancrea.ic cancer,supported by clinical practice guidelines as it has demonstrated good tolerance and good disease *** opens a possibility of improving outcomes for these pa.ients,both in neoadjuvant treatment and with ra.ical intent.

关键词： Chemora.iotherapy Pancrea.ic adenocarcinoma Ra.iotherapy Stereotactic body ra.iotherapy Stereotactic abla.ive ra.iotherapy

Predicting Energy Consumption Using Stacked LSTM Snapshot Ensemble

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Big Data Mining and Analytics 2024年第2期7卷 247-270页

作者： mona Ahamd Alghamdi Abdullah S.A.L-Malaise AL-Ghamdi Mahmoud Ragab informa.ion Systems Department Faculty of Computing and Information Technology(FCIT)King Abdulaziz University(KAU)Jeddah 21589Kingdom of Saudi Arabia informa.ion Systems Department FCITKAUJeddah 21589Kingdom of Saudi Arabiaand also with School of EngineeringComputing and DesignDar Al-Hekma UniversityJeddah 22246Kingdom of Saudi Arabia informa.ion Technology Department FCITKAUJeddah 21589Kingdom of Saudi Arabiaand also with Mathematics DepartmentFaculty of ScienceAl-Azhar UniversityNaser City 11884Egypt

The a.ility to make accurate energy predictions while considering all related energy factors allows production plants,regulatory bodies,and governments to meet energy demand and assess the effects of energy-sa.ing *** energy consumption falls within normal parameters,it will be possible to use the developed model to predict energy consumption and develop improvements and mitiga.ing measures for energy *** objective of this model is to accurately predict energy consumption without data limita.ions and provide results that are ea.ily *** proposed model is an implementa.ion of the stacked Long Short-Term Memory(LSTM)snapshot ensemble combined with the Fast Fourier Transform(FFT)and *** and Berard’s individual Household Electric-Power Consumption(iHEPC)dataset incorporated with weather data are used to analyse the model’s accuracy with predicting energy *** model is trained,and the results measured using Root Mean Square Error(RMSE),Mean Absolute Error(MAE),Mean Absolute Percentage Error(MAPE),and coefficient of determina.ion(R^(2))metrics are 0.020,0.013,0.017,and 0.999,*** stacked LSTM snapshot ensemble performs better than the compared models based on prediction accuracy and minimized *** results of this study show that prediction accuracy is high,and the model’s sta.ility is high as *** model shows that high levels of accuracy prove accurate predictive a.ility,and together with high levels of sta.ility,the model has good interpreta.ility,which is not typically accounted for in ***,this study shows that it can be inferred.

关键词： energy consumption prediction Artificial intelligence(Ai) Deep Learning(DL) snapshot ensemble