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An Observational Study on the Management of COVID-19 Patients in Limited-Resource Hospitals

Journal of Clinical and Nursing Research 2022年第3期6卷 43-53页

作者： Marwa O Elgendy Ahmed M Khalaf Ahmed O El-Gendy mona A Abdelrahman Sara O El Gendy Ahmed M Abdel Hamied Omar Essam Karim Al Amir Esraa M Yousry Mohamed EA Abdelrahim Department of Clinical Pharmacy Teaching Hospital of Faculty of MedicineFaculty of MedicineBeni-Suef UniversityBeni-Suet Egypt Department of Clinical Pharmacy Faculty of PharmacyNahda University(NUB)Egypt Internal Medicine Department Faculty of MedicineBeni-Suef UniversityBeni-Suef Egypt Department of Microbiology and Immunology Faculty of PharmacyBeni-Suef UniversityBeni-Suef Egypt Department of Clinical and Chemical Pathology Faculty of MedicineBeni-Suef UniversityBeni-SuefEgypt Department of Pediatric Medicine Ministry of HealthBeni-Sueft Egypt Ministry of Health Beni-SuefEgypt Department of General Surgery Ministry of HealthBeni-Suefi Egypt Faculty of Agriculture Fayoum University Egypt Clinical Pharmacy Department Faculty of Pharmacy Beni-Suef UniversityBeni-Suef Egypt

Background:The purpose of this study was to evaluate the effectiveness of limited-resource hospitals in managing mild and moderate hospitalized cases of COVID-19 with comorbidities and in preventing their progression to severe ***:Data were obtained from 88 moderate COVID-19 patients with comorbidities who were admitted to limitedresource *** data were classified into several parts:comorbidities,chronic medication before hospital admission,symptoms of COVID-19 before and during hospitalization,clinical features,laboratory findings on hospital admission,complications during hospitalization,as well as worst laboratory values during hospitalization,hospital stay,and *** clinical features,laboratory results,type of oxygen therapy used,and the final treatment outcome were all evaluated to assess for any potential ***:All patients were alive upon *** admission,the majority of patients(60.2%)received COVID-19 treatment,and the average hospital stay was 12 *** most common symptoms were fever(88.7%),cough(95.5%),shortness of breath(90.9%),myalgia(84.1%),confusion(63.6%),headache(62.5%),sore throat(88.7%),rhinorrhea(17%),chest pain(58%),diarrhea(19.3%),nausea and vomiting(38.6%),anosmia(62.5%),as well as dysgeusia(64.8%).Based on chest radiograph or computed tomography(CT)scan,9.1%of the patients had unilateral pneumonia,90.9% had bilateral pneumonia,and 96.6% had multiple mottling and ground-glass *** was found associated with a significant increase in headache(p=0.005),rhinorrhea(p=0.013),chest pain(p=0.007),and the need for positive airway pressure(p=0.008).Between pre-and post-hospital admissions,there was a significant increase in lactate dehydrogenase and ferritin but a decrease in platelet,D-dimer,hemoglobin,lymphocytes,neutrophils,and total leucocyte count(p<0.001).There was a significant association between hospital stay and D-dimer level(p=0.05).Conclusion:Limited-resource hospitals in Egypt w

关键词： COVID-19 Limited-resource hospitals COVID-19 laboratory tests Comorbidities

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少突胶质细胞连接蛋白研究:Cx32与突变型或野生型Cx47组成的异型通道不影响缝隙连接功能

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神经损伤与功能重建 2021年第4期16卷 F0003-F0003页

作者： Charles K Abrams Rafael E Flores-Obando Gabriel D Dungan Elina Cherepanova mona M Freidin 唐颖馨(编译) Department of Neurology and Rehabilitation University of Illinois at Chicago College of MedicineChicagoIllinoisUSA Department of Neurology SUNY Downstate Medical CenterBrooklynNew YorkUSA 不详

少突胶质细胞上表达有两种缝隙连接蛋白,连接蛋白32(Cx32)和Cx47。因此,可能会形成由Cx47和Cx32两种单体组成的异型通道。Cx47突变会导致Pelizaeus-Merzbacer样疾病1型(PMLD1)和遗传性痉挛性轻瘫44型(SPG44)。Cx47突变体之间或与Cx32之... 详细信息

少突胶质细胞上表达有两种缝隙连接蛋白,连接蛋白32(Cx32)和Cx47。因此,可能会形成由Cx47和Cx32两种单体组成的异型通道。Cx47突变会导致Pelizaeus-Merzbacer样疾病1型(PMLD1)和遗传性痉挛性轻瘫44型(SPG44)。Cx47突变体之间或与Cx32之间形成的异型通道可能是这些疾病的发病机理之一。本研究将利用电生理学和抗体相关研究方法来检验这些可能的机制。当同时表达Cx32和Cx47的细胞与表达Cx32或Cx47的细胞配对组成异型通道时,其特性与由Cx32或Cx47组成的同型通道无差别。同样的,将同时表达Cx32和Cx47的细胞与表达Cx30或Cx43的细胞配对产生的通道的特性与异型通道Cx32/Cx30或Cx47/Cx43没有区别。本研究对表达Cx32和4种突变形式的Cx47(与SPG44或p.P87S相关的p.I33M,与PMLD1相关的p.Y269D或p.M283T)的细胞进行了评估,结果显示这些突变体均未对Cx32的功能产生影响。共表达Cx32WT(野生型)和Cx47WT的免疫染色细胞显示Pearson相关系数接近零,表明任何重叠都是由于偶然。统计分析显示,p.Y269D与Cx32显著负相关,表明Cx32与该突变体的重叠低于随机的可能性。Cx32和Cx47WT及其突变体的免疫共沉淀仅显示极低水平的免疫共沉淀蛋白。综上所述,本研究结果显示,PMLD1或SPG44突变体与Cx32缝隙连接之间的相互作用不会导致这些疾病的发生。

关键词：连接蛋白32 连接蛋白47 Pelizaeus-Merzbacer样病1型缝隙连接脑白质营养不良

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肾虚型系统性红斑狼疮卵巢储备功能下降的研究

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广州中医药大学学报 2018年第4期35卷 575-580页

作者：刘茜谢江琳王犀子莫娜李琛琛张明英刘丽娟陈光星广州中医药大学第一附属医院风湿科广东广州510405

【目的】探讨系统性红斑狼疮(SLE)女性患者血清抗缪勒氏管激素(AMH)水平与肾虚的相关性。【方法】102例18~45岁的SLE女性患者中,49例为肾虚型,53例为非肾虚型。分析肾虚组与非肾虚组SLE患者的临床症状、疾病活动度(SLEDAI-2K)、自身抗... 详细信息

【目的】探讨系统性红斑狼疮(SLE)女性患者血清抗缪勒氏管激素(AMH)水平与肾虚的相关性。【方法】102例18~45岁的SLE女性患者中,49例为肾虚型,53例为非肾虚型。分析肾虚组与非肾虚组SLE患者的临床症状、疾病活动度(SLEDAI-2K)、自身抗体水平(补体C3和C4、免疫球蛋白IgG和IgM、ds-DNA等)和血清AMH水平的差异,并与50例正常对照组比较。【结果】(1)相较于非肾虚组SLE患者,肾虚组SLE患者病程更长(P0.05)。(2)肾虚组月经减少的情况较非肾虚组更加常见(P<0.01),并且显示与肾虚具有较高的关联强度(OR=13.23,95%CI为5.14~34.19)。(3)经过和未经过环磷酰胺(CYC)治疗的肾虚组SLE女性患者的AMH水平均较正常对照组降低(P<0.01或P<0.05)。另一方面,未经过CYC治疗的肾虚组SLE女性患者比未经过CYC治疗的非肾虚组SLE女性患者AMH水平低(P=0.000)。(4)在未经过CYC治疗的肾虚组SLE女性患者中AMH水平降低的频率大大增加,32例患者中有13例AMH出现减少(占40.6%),而正常对照组50例中仅1例AMH出现减少(占2.0%),差异有统计学意义(χ~2=20.56,P=0.000),并且显示与肾虚具有较高的关联强度(OR=33.5,95%CI为4.10~274.27)。【结论】肾虚与SLE患者肾炎、血细胞减少、月经减少和AMH水平降低有关,提示肾虚可能严重损害育龄期SLE女性患者的卵巢储备功能。

关键词：系统性红斑狼疮肾虚抗缪勒氏管激素(AMH) 卵巢储备功能

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隔离环境下通过胚胎移植获得无菌状态的小鼠

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中国比较医学杂志 2006年第7期16卷 423-423页

作者： Inzunza.Josē Midtvedt.Tore Fartoo.mona Norin.Elisabeth sterlund.Ewa Persson.Anna-Karin hrlund-Richter.Lars

The technique of embryo transfer has been evaluated for the purpose of changing the mouse stocks to a germfree(GF)*** results showreproducible and quality-assured conversion of animalstothose which are negativeforthe presence of *** and easy access to GF mice is advantageous for studies of selected microflora andtheir cross-talks withthe host,when applying,***,proteomic and metabolic *** studyinvolved embryotransfer in anisolator environment,thereby allowingimplantationof cleansed embryosinto GFrecipients under well-controlled *** recipientfemales gave birth normally andtookcare of the offspringasif they were their own pups,thus enhancing the survival *** to full technical resources required to maintain GFisolators are,however,a *** this study,we used stainless steel isolators designed by Gustafsson(1959),on which a stereomicroscope wasmountedtofacilitate embryo transfer inside the *** use of embryo transfer and isolator techniques will facilitate the availability ofvarious mouse mutant models under different gnotobiotic conditions,GF,monoxenic or polyxenic animals,to enable comparison withconventional animals for physiological and pathophysiological studies.

关键词： MICE GERMFREE EMBRYOTRANSFER ISOLATOR

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宝马世界

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城市环境设计 2020年第4期126卷 134-149页

作者：沃尔夫·狄·普瑞克斯 Paul Kath Tom Wiscombe Waltraut Hoheneder mona Marbach Hans Aescht Beatrix Basting Guy Bebiè Chris Beccone Johannes Behrens Marcelo Bernardi Pawel Bodzak Verena Boyer Antja Bulthaup Claudia Buhmann Timo Carl Jan Chaldil Ing Tse Chen Tadeusz Chimiak Andrea Christmann Patrick Erhardt Stephan Exsternbrink Wolfgang Fiel Benedikt Frass Helmut Fr?tscher Volker Gessendorfer Andrea Graser Lukas Haller Markus Henning Armin Hess Jens Hoff Tamas Horvath Robert Huebser Astrid Jagersberger Marin Jurycz Gregor Kassl Areta Keller Markus Klausecker Tobias Klein Martin Konrad Quirin Krumbholz Caroline Kufferath Marion Lattenmayer Stefan Laub Wolfgang Leitgeb Andreas Mieling Karin Miesenberger Dennis Milam Elke Müller Henrike Münker Claudia Nehammer Martin Oberascher Alexander Ott Stefan Pfefferle Florian Pfeifer Markus Pillhofer Ekkehard Rehfeld Goswin Rothenthal Wolfgang Ruthensteiner Jasmin Sauerbier Florian Schafschetzy Kristina Schinegger Karolin Schmidbaur Patrick Schneider Katharina Schneider Hubert Schoba Angus Schoenberger Andrea Sch?ning Anja Sorger Gernot Stangl Mark Steinmetz Sigrid Steinwender Martina Tippelskirch Dionicio Valdez Pascal Vauclair Akvile Rimantaite Andreas Weissenbach Heribert Wolfmayer Irina Zahler 2007 Ari Marcopoulos Gerald Zugmann Hélène Binet Duccio Malagamba Marcus Buck Christian Richters Richard Walch

项目大事记/CHRONOLOGY竞赛（一等奖）/Competition（1st Prize）:2001规划设计起始时间/Start of Planning:11/2001施工起始时间/Start of Construction:08/2003投入使用/Opening:20/10/2007-21/10/2007项目参数/PROJECT DATA用地面积/Site Area:约25 000m2/Approx. 25 000m2建筑毛面积/Gross Floor Area:约73 000m2（除坡道）=100%/Approx.73 000m2（excluding ramps）=100%地上建筑毛面积/Gross Floor Area above ground:约28 500m2=40%/Approx.28 500m2=40%地下建筑毛面积/Gross Floor Area underground:约44 500m2=60%/Approx.44 500m2=60%

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