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Quite amusing stem cells:muse cells

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Neural Regeneration Research 2023年第11期18卷 2377-2378页

作者： molly monsour Cesar V.Borlongan University of South Florida morsani College of medicine TampaFLUSA Department of Neurosurgery and Brain Repair University of South FloridaMorsani College of MedicineTampaFLUSA

Stem cells may be the future of therapeutics for stroke due to their regenerative and immunomodulatory *** barriers faced when employing stem cells,however,include faulty migration,low cell survival,and diminished proliferation.m ultilineage-differentiating stress ensuring (muse) cells,a subset of mesenchymal stem cells,overcome these *** cells aid in neuroregeneration,have immense regenerative potential,and are pluripotent,non-tumorigenic,and *** stroke specifically,these cells may restore an a nti-inflammatory environment,regenerate damaged neurons,and integrate into the neuronal *** fact,muse cells may be aptly designed to ameliorate neurovascular unit damage following stroke and observed in other neuroinflammatory disorders.

关键词： modulator overcome integrate

Every breath you take:assessing metabolic costs of toxin resistance in garter snakes(Thamnophis)

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Integrative Zoology 2022年第4期17卷 567-580页

作者： Haley A.mONIZ molly A.RICHARD C.m.GIENGER Chris R.FELDmAN Department of Biology University of NevadaRenoNevadaUSA Program in Ecology Evolution and Conservation BiologyUniversity of NevadaRenoNevadaUSA Department of Biology and Center of Excellence for Field Biology Austin Peay State UniversityClarksvilleTennesseeUSA

Trait specialization often comes at the expense of original trait function,potentially causing evolutionary tradeoffs that may render specialist populations vulnerable to ***,many specialized adaptations evolve repeatedly,suggesting selection favors specialization in specific *** garter snake(Thamnophis)populations possess specialized mutations in voltage-gated sodium channels that allow them to consume Pacific newts(Taricha)defended by a highly potent neurotoxin(tetrodotoxin).These mutations,however,also decrease protein and muscle function,suggesting garter snakes may suffer evolutionary *** measured a key physiological process,standard metabolic rate(SmR),to investigate whether specialized adaptations in toxin-resistant garter snakes affect baseline energy *** snakes,skeletal muscles influence metabolism and power ventilation,so inefficiencies of sodium channels in these muscles might impact whole-animal energy ***,because sodium channels are membrane-bound proteins,inefficiencies of channel kinetics and performance might be exacerbated at suboptimal *** measured SmR in 2 species,Thamnophis atratus and Thamnophis sirtalis,that independently evolved tetrodotoxin resistance through unique mutations,providing replicate experiments with distinct underlying genetics and potential physiological *** our expectations,neither resistance phenotype nor sodium channel genotype affected metabolism and resistant snakes did not perform worse under suboptimal body ***,*** and *** show nearly identical rates of mass-adjusted energy expenditure at both temperatures,despite differing eco-morphologies,life histories,and distant phylogenetic *** findings suggest SmR may be a conserved feature of Thamnophis,and that any organismal tradeoffs may be compensated to retain whole-animal function.

关键词： adaptation standard metabolic rate tetrodotoxin toxin-resistance tradeoff

Nurses’ and midwives’ participation and utilization of health-related research in Kenya: Implications for evidence-based practice

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International Journal of Nursing Sciences 2023年第2期10卷 199-205页

作者： Daniel m.Nzengya Albanus K.mutisya miriam C.A.Wagoro molly Secor-Turner Joan Edwards Research and Innovation St.Paul’s UniversityLimuruKenya School of Nursing Jomo Kenyatta University of Agriculture&TechnologyNairobiKenya Department of Nursing Sciences University of NairobiNairobiKenya mark and Robyn Jones College of Nursing Montana State UniversityBozemanMTUSA Nelda C.Stark College of Nursing Texas Woman's UniversityHoustonTXUSA

Objective To assess the level of participation of nurses and midwives in health-related research,determine the status of utilization of research to inform nursing and midwifery practice in Kenya,and explore perspectives of nurses and midwives about strategies to empower nurses/midwives to engage in health research in *** Data were extracted from online survey responses of 156 nurse and midwife educators,practitioners,and managers/*** version 26 was used to analyze quantitative data;qualitative data were analyzed using Excel to organize data into *** Over one-third of participants reported ever publishing research(37.2%,58/156).Participants reported using knowledge gained in nursing school to guide practice most frequently(n=148).Utilization of research findings to guide practice was reported by 80.3%(110/137)of *** to enhance participation in the research included research training,research forums,policy reforms,and emphasis on research in *** There is need to intensify and prioritize proposed strategies to empower nurses/midwives to engage in health research.

关键词： Evidence-based practice Kenya midwifery Nurses Research

Nitrogen Gas Saturation in Karst Springs Varies Throughout the Day

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Journal of Water Resource and Protection 2023年第2期15卷 23-32页

作者： molly A. Gross Jill m. Voorhees Abigail Semple Domagall michael E. Barnes Department of Game Fish and Parks McNenny State Fish Hatchery Spearfish South Dakota USA School of Natural Sciences Environmental Physical Science Black Hills State University Spearfish South Dakota USA

This experiment examined the fluctuations in nitrogen gas supersaturation throughout the day in three karst springs (upper, side, and lower) at mcNenny State Fish Hatchery, rural Spearfish, Lawrence County, South Dakota, USA. Total gas pressures, oxygen percent saturation, and nitrogen percent saturation were recorded six times/day on eight days over a 26-day period in each of the three springs. Total gas pressure did not vary significantly throughout the day in any of the springs. However, percent oxygen and nitrogen saturation were significantly different throughout the day in all three springs. The highest mean (SE) nitrogen supersaturation value of 118.5 (1.1)% was observed in the lower spring at 07:00. The lowest mean nitrogen supersaturation values were 114.5 (1.1)% at 13:00 in the upper spring, and 114.2 (0.2)% and 113.1 (0.7)% at 15:00 in the side and lower spring, respectively. At 118% nitrogen supersaturation, gas bubble disease is likely to occur in fish, resulting in potentially high levels of mortality if untreated spring water was used for fish production. The results of this study indicate the importance of recording nitrogen gas levels at sunrise or early in the morning, when nitrogen is highest and oxygen is lowest, to obtain accurate and reproducible data.

关键词： Karst Springs Aquifer Gas Supersaturation Nitrogen Aquaculture

mapping transcriptome-wide protein-RNA interactions to elucidate RNA regulatory programs

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Frontiers of Electrical and Electronic Engineering in China 2018年第3期6卷 228-238页

作者： molly m.Hannigan Leah L.Zagore Donny D.Licatalosi Center for RNA Science and Therapeutics Case Western Reserve University Cleveland OH 44106 USA.

Background： Our understanding of post-transcriptional gene regulation has increased exponentially with the development of robust methods to define protein-RNA interactions across the transcriptome. In this review, we highlight the evolution and successful applications of crosslinking and immunoprecipitation （CLIP） methods to interrogate protein-RNA interactions in a transcriptome-wide manner. Results： Here, we survey the vast array of in vitro and in vivo approaches used to identify protein-RNA interactions, including but not limited to electrophoretic mobility shift assays, systematic evolution of ligands by exponential enrichment （SELEX）, and RIP-seq. We particularly emphasize the advancement of CLIP technologies, and detail protocol improvements and computational tools used to analyze the output data. Importantly, we discuss how profiling protein-RNA interactions can delineate biological functions including splicing regulation, alternative polyadenylation, cytoplasmic decay substrates, and miRNA targets. Conclusions： In summary, this review summarizes the benefits of characterizing RNA-protcin networks to further understand the regulation of gene expression and disease pathogenesis. Our review comments on how future CLIP technologies can be adapted to address outstanding questions related to many aspects of RNA metabolism and further advance our understanding of RNA biology.

关键词： RNA binding proteins CLIP post-transcriptional regulation RNA networks

Highlights in applications of nanotechnology in radiation research

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Chinese Journal of Cancer Research 2013年第5期25卷 613-614页

作者： Nancy Q.Zhong molly J.Wang Editorial Office Translational Cancer Research

Translational Cancer Research （Transl Cancer Res; TCR; Print ISSN： 2218-676X; Online ISSN 2219-6803; www. ***） launched in August 2013 a special issue on Applications of Nanotechnology in Radiation Research inviting Prof. Rao V.L. Papineni from University of Kansas medical Center, Pataje G.S. Prasanna from National Cancer Institute and mansoor m. Ahmed, National Cancer Institute to serve as the Guest Editors.

关键词： ISSN Highlights in applications of nanotechnology in radiation research

Encouraging kids to hop,skip,and jump：Emphasizing the need for higher-intensity physical activity in childcare

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Journal of Sport and Health Science 2018年第3期7卷 333-336页

作者： molly Driediger Leigh m.Vanderloo Stephanie Truelove Brianne A.Bruijns Patricia Tucker school of occupational therapy university of western ontario elborn collegeLondonOntario N6G 1H1Canada child health and evaluative sciences the hospital for sick childrenTorontoON M5G OA4Canada health and rehabilitation sciences university of western ontario elborn collegeLondon.Ontario N6G 1H1Canada

*** Daily physical activity（PA）participation is crucial to the health and well-being of young *** with total physical activity（TPA;all-intensity）,moderate-to-vigorous physical activity（mVPA）,or energetic play,is associated with greater health benefits,particularly for preschoolers（3-4 years）,including but not limited to improved bone and skeletal properties and cognitive and psychosocial health.1 Centered on this,both Canada and Australia have recently established 24-Hour movement Guidelines for the Early Years,recommending that.

关键词： Encouraging kids to hop,skip,and jump:Emphasizing the need for higher-intensity physical activity in childcare

Clonidine use during dexmedetomidine weaning:A systematic review

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World Journal of Critical Care medicine 2023年第1期12卷 18-28页

作者： Sanu Rajendraprasad molly Wheeler Erin Wieruszewski Joseph Gottwald Lindsey A.Wallace Danielle Gerberi Patrick m Wieruszewski Nathan J Smischney Department of Pulmonary&Critical Care Mayo ClinicRochesterMN 55905United States Department of Pharmacy Mayo ClinicRochesterMN 55905United States Department of Anesthesiology&Perioperative medicine Mayo ClinicRochesterMN 55905United States Critical Care medicine Independent multidisciplinary Program Mayo ClinicRochesterMN 55905United States mayo medical Libraries Mayo ClinicRochesterMN 55905United States

BACKGROUND Dexmedetomidine is a centrally acting alpha-2A adrenergic agonist that is commonly used as a sedative and anxiolytic in the intensive care unit(ICU),with prolonged use increasing risk of withdrawal symptoms upon sudden *** clonidine is an enterally available alpha-2A adrenergic agonist,it may be a suitable agent to taper off dexmedetomidine and reduce withdrawal *** appropriate dosing and conversion strategies for using enteral clonidine in this context are not *** objective of this systematic review is to summarize the evidence of enteral clonidine application during dexmedetomidine weaning for prevention of withdrawal *** To systematically review the practice,dosing schema,and outcomes of enteral clonidine use during dexmedetomidine weaning in critically ill *** This was a systematic review of enteral clonidine used during dexmedetomidine weaning in critically ill adults(≥18 years).Randomized controlled trials,prospective cohorts,and retrospective cohorts evaluating the use of clonidine to wean patients from dexmedetomidine in the critically ill were *** primary outcomes of interest were dosing and titration schema of enteral clonidine and dexmedetomidine and risk factors for dexmedetomidine *** secondary outcomes included prevalence of adverse events associated with enteral clonidine use,re-initiation of dexmedetomidine,duration of mechanical ventilation,and ICU length of *** A total of 3427 studies were screened for inclusion with three meeting inclusion criteria with a total of 88 *** three studies were observational,two being prospective and one *** all included studies,the choice to start enteral clonidine to wean off dexmedetomidine was made at the discretion of the *** time ranged from 13 to 167 h on *** clonidine was started in the prospective studies in a similar protocolized method,with 0.3 mg every 6 *** starti

关键词： Clonidine Dexmedetomidine Intensive care unit Withdrawal Weaning

Scales of snow depth variability in high elevation rangeland sagebrush

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Frontiers of Earth Science 2017年第3期11卷 469-481页

作者： molly E. TEDESCHE Steven R. FASSNACHT Paul J. mEImAN Watershed Science Department of Ecosystem Science and Sustainability Colorado State University Fort Collins CO 80523-1476 USA Intemational Arctic Research Center Water & Environmental Research Center Institute of Northern Engineering University of Alaska Fairbanks Fairbanks AK 99775 USA Cooperative Institute for Research in the Atmosphere Fort Collins CO 80523-1375 USA Natural Resources Ecology Laboratory Fort Collins CO 80523-1499 USA Abt. Kartographie GIS & Femerkundung Geographisches Institut Georg-August-Universitat Gottingen 37077 Gottingen Germany Rangeland Ecosystem Science Department of Forest and Rangeland Stewardship Colorado State University Fort Collins CO 80523 USA

In high elevation semi-arid rangelands, sage- brush and other shrubs can affect transport and deposition of wind-blown snow, enabling the formation of snowdrifts. Datasets from three field experiments were used to investigate the scales of spatial variability of snow depth around big mountain sagebrush （Artemisia tridentata Nutt.） at a high elevation plateau rangeland in North Park, Colorado, during the winters of 2002, 2003, and 2008. Data were collected at multiple resolutions （0.05 to 25 m） and extents （2 to 1000 m）. Finer scale data were collected specifically for this study to examine the correlation between snow depth; sagebrush microtopogra- phy, the ground surface, and the snow surface, as well as the temporal consistency of snow depth patterns. Vario- grams were used to identify the spatial structure and the moran＇s I statistic was used to determine the spatial correlation. Results show some temporal consistency in snow depth at several scales. Plot scale snow depth variability is partly a function of the nature of individual shrubs, as there is some correlation between the spatial structure of snow depth and sagebrush, as well as between the ground and snow depth. The optimal sampling resolution appears to be 25-cm, but over a large area, this would require a multitude of samples, and thus a random stratified approach is recommended with a fine measurement resolution of 5-cm.

关键词： snow hydrology high elevation rangelands,spatial statistics variograms snow pack spatial variability,snow drifts