Quite amusing stem cells:Muse cells

作     者：Molly Monsour Cesar V.Borlongan Molly Monsour;Cesar V.Borlongan

作者机构：University of South Florida Morsani College of MedicineTampaFLUSA Department of Neurosurgery and Brain RepairUniversity of South FloridaMorsani College of MedicineTampaFLUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2023年第18卷第11期

页      面：2377-2378页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100101[医学-人体解剖与组织胚胎学] 10[医学] 

基　　金：CVB was funded by the National Institutes of Health NIH R01NS090962,NIH R01NS102395,NIH R21 NS1095 75 CVB was funded and received royalties and stock options from Astellas,Asterias,Sanbio,Athersys,KMPHC International Stem Cell Corporation and has also received consultant compensation from Chiesi Farmaceutici。 

主　　题：modulator overcome integrate 

摘      要：Stem cells may be the future of therapeutics for stroke due to their regenerative and immunomodulatory capabilities.Major barriers faced when employing stem cells,however,include faulty migration,low cell survival,and diminished proliferation.M ultilineage-differentiating stress ensuring (Muse) cells,a subset of mesenchymal stem cells,overcome these barriers.Muse cells aid in neuroregeneration,have immense regenerative potential,and are pluripotent,non-tumorigenic,and immunomodulatory.In stroke specifically,these cells may restore an a nti-inflammatory environment,regenerate damaged neurons,and integrate into the neuronal architecture.In fact,Muse cells may be aptly designed to ameliorate neurovascular unit damage following stroke and observed in other neuroinflammatory disorders.