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Liver cirrhosis and arterial hypertension

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World journal of Gastroenterology 2006年第5期12卷 678-685页

作者： jens h henriksen Soren moller Department of Clinical Physiology 239University of CopenhagenH:S Hvidovre HospitalCopenhagenDenmark

Characteristic findings in patients with cirrhosis are vasodilatation with low overall systemic vascular resistance, high arterial compliance, increased cardiac output, secondary activation of counter-regulatory systems （renin-angiotensin-aldosterone system, sympathetic nervous system, release of vasopressin）, and resistance to vasopressors. The vasodilatory state is mediated through adrenomedullin, calcitonin generelated peptide, nitric oxide, and other vasodilators, and is most pronounced in the splanchnic area. This constitutes an effective （although relative） counterbalance to increased arterial blood pressure. This review considers the alterations in systemic hemodynamics in patients with cirrhosis in relation to essential hypertension and arterial hypertension of the renal origin. Subjects with arterial hypertension （essential, secondary） may become normotensive during the development of cirrhosis, and arterial hypertension is rarely manifested in patients with cirrhosis, even in cases with renovascular disease and high circulating renin activity. There is much dispute as to the understanding of homoeostatic regulation in cirrhotic patients with manifest arterial hypertension. This most likely includes the combination of vasodilatation and vasoconstriction in parallel.

关键词： Arterial compliance Central vascular filling Chyperdynamic circulation Kidney function, Nitric oxide Blood pressure regulation Renin-angiotensin-aldosterone system Sympathetic nervous system Vasodilatation Vasoconstriction

儿童和青少年高血压(大连“2008年全国高血压与糖尿病学术研讨会”讲座)

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中华高血压杂志 2008年第8期16卷 753-754页

作者： james h moller 陈小明 Department of Pediatrics University of MinnesotaMinneapolisMN 55455USA MD

在过去的50年里，高血压的患病年龄有年轻化倾向。随着社会的发展，人们发现越来越多的儿童和青少年患有高血压。50年前，大家认为大部分的高血压是“继发”于其他情况的，比如慢性肾脏疾病。儿童“原发性”高血压非常罕见。当前，人们... 详细信息

在过去的50年里，高血压的患病年龄有年轻化倾向。随着社会的发展，人们发现越来越多的儿童和青少年患有高血压。50年前，大家认为大部分的高血压是“继发”于其他情况的，比如慢性肾脏疾病。儿童“原发性”高血压非常罕见。当前，人们则认为大多数高血压是“原发性”的，与肥胖和缺乏体育活动有关。

关键词：高血压青少年学术研讨会儿童糖尿病讲座大连慢性肾脏疾病

A high temperature equation of state for the h2O-CaCl2 and h2O-MgCl2 systems

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A high temperature equation of state for the H2O-CaCl2 and H...

Plant cytochrome P450 plasticity and evolution

中国科学院地质与地球物理研究所2006学术年会

作者： Nancy moller j.h. h.Weare Department of Chemistry and Biochemistry 0340University of CaliforniaSan DiegoLa JollaCA 92093USA

An equation of state(EOS) is developed for salt-water systems in the high temperature *** an example of the applications,this EOS is parameterized for the calculation of density, immiscibility,and the compositions of coexisting phases in the CaCl-hO and MgCl-hO systems from 523 to 973 K and from saturation pressure to 1500 *** available volumetric and phase equilibrium measurements of these binaries are well represented by this *** EOS is based on a helmholtz free energy representation constructed from a reference system containing hard-sphere and polar contributions plus an empirical *** the temperature and pressure range in this study,the electrolyte solutes are assumed to be *** water molecules are modeled as hard spheres with point dipoles and the solute molecules,MgCl and CaCl,as hard spheres with point *** free energy of the reference system is calculated from an analytical representation of the helmholtz free energy of the hard-sphere contributions and perturbative estimates of the electrostatic *** empirical correction used to account for deviations of the reference system predictions from measured data is based on a virial *** formalism allows generalization to aqueous systems containing insoluble gases (CO,Ch),alkali chlorides(NaCl,KCl),and alkaline earth chlorides(CaCl,MgCl).The program of this model is available as an electronic annex(see EA1 and EA2) and can also be downloaded at:http://***/***.

关键词： Methane hydrate carbon dioxide hydrate thermodynamic stability electrolyte solution phase equilibrium formation conditions

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Molecular Plant 2021年第10期14卷 1244-1265页

作者： Cecilie Cetti hansen David R.Nelson Birger Lindberg moller Daniele Werck-Reichhart Plant Biochemistry Laboratory Department of Plant and Environ mental ScienceUniversity of CopenhagenCopenhage nDenmark VILLUM Research Center for Plant Plasticity University of CopenhagenCopenhagenDenmark Department of Microbiology Immunology and BiochemistryUniversity of Tennessee Health Science CenterMemphisTNUSA Institute of Plant Molecular Biology Centre National de la Recherche Scientifique(CNRS)University of StrasbourgStrasbourgFrance

The superfamily of cytochrome P450(CYP)enzymes plays key roles in plant evolution and metabolic *** review provides a status on the CYP Iandscape within green algae and land *** 11 conserved CYP clans known from vascular plants are all present in green algae and several green algaespecific clans are *** 71,72,and 85 remain the largest CYP clans and include many taxaspecific CYP(sub)families reflecting emergence of linage-specific *** features and dynamics of CYP plasticity and evolution are discussed and exemplified by selected biosynthetic *** substrate promiscuity is commonly observed for CYPs from large families,favoring retention of gene duplicates and neofunctionalization,thus seeding acquisition of new *** of biosynthetic pathways producing metabolites with sporadic distribution across plant phylogeny reveals multiple exampies of convergent evolution where CYPs have been independently recruited from the same or different CYP families,to adapt to similar environmental challenges or ecological *** only a single or a few mutations are required for functional interconversion.A compilation of functionally characterized plant CYPs is provided online through the Plant P450 Database(***/public/vgrid/PlantP450/).

关键词： land plants green algae diversificati on promiscuity neofunctionalization convergent evolution functionalities plant metabolism

Better Glycaemic Outcome, Low Levels of Acute Severe Complications, and high Patient Satisfaction in Routine Practice in Type 1 Diabetes Treated with an Insulin Pump

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journal of Diabetes Mellitus 2014年第4期4卷 304-310页

作者： h. j. Gjessing U. L. jorgensen C. C. moller j. Pedersen E. Grodum K. Schousboe Diabetes Outpatient Clinic Medical Department Fredericia Hospital Sygehus Lilleb&aelig lt Dronningensgade 97 7000 Fredericia Denmark

Treatment of patients with Type 1 diabetes with continuous subcutaneous insulin infusion (CSII) was re-introduced in Denmark in this millennium and initiated in the diabetes clinic, Fredericia hospital, in 2005. The aim of the present study was to present yearly data of quality from 2005 to 2013 from a clinical database of patients treated with CSII in routine practice. Methods: A database was established in 2009-2010. Data from 2005 to 2009 are retrospective, data from 2009 to 2013 prospective. From 2009, patient satisfaction was measured by validated questionnaires. Results: By 31 December 2013, the database contained data from 143 active patients. hbA1C (median and range) decreased from 64 (40 - 126) mmol/mol (8.0 (5.8 - 13.7)%) (n = 104) to 60 (36 - 98) mmol/mol (7.6 (5.4 - 11.1)%) (n = 134) (p he improved glycaemic control was maintained each year until ≥5 years after initiation of CSII (p here was no change in weight. The number of attacks of severe hypoglycaemia was reduced from 60 attacks in 21 patients (n = 104) the year before CSII to only 5 attacks in 5 patients in 2013 (n = 134) (p h year after initiation of CSII until ≥5 years, the number of episodes of severe hypoglycaemia was reduced (p have been registered in eight patients corresponding to an incidence of 1.4 episodes per 100 patient years. Patient satisfaction was high one year after initiation of CSII (p hange of treatment to CSII is accompanied by an improvement in glycaemic control, very pronounced reduction in severe hypoglycaemia, low levels of diabetic ketoacidosis, and pronounced patient satisfaction.

关键词： Type 1 Diabetes CSII Glycaemic Control hypoglycaemia Ketoacidosis Patient Satisfaction

Annual spatio-temporal migration patterns of hooded Cranes wintering in Izumi based on satellite tracking and their implications for conservation

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Avian Research 2018年第3期9卷 264-272页

作者： Chunrong Mi Anders Pape moller Yumin Guo College of Nature Conservation Beijing Forestry UniversityBeijing 100083China Ecologie Systématique Evolution UniversitéParis-SudCNRSAgroParisTechUniversitéParis-Saclay91405 Orsay CedexFrance

Background: The hooded Crane(Grus monacha) is listed as a vulnerable species by IUCN. Knowledge about the migration of the hooded Crane is still limited. here we reported the spatio-temporal migration patterns of hooded Cranes wintering in Izumi, japan, as well as important stopover areas for their ***: Four adult and five subadult cranes, all wintering in Izumi, japan, were fitted with satellite transmitters(GPS–GSM system) at their stopover sites in northeastern China in 2014 and 2015. We analyzed the time and duration of adults and subadults in spring and autumn migration, as well as the time and duration they stayed in breeding and wintering ground. In addition, we analyzed the land use of the cranes in stopover ***: Adult cranes took much longer time to migrate both north in spring(mean days) compared with subadult cranes(15.3 and 5.2 days, respectively). h= 44.3 days) and south in fall(mean = 54.0 owever, the subadults had longer wintering(mean = 149.8 days) and nomadic(breeding season for adults) seasons(mean d with adults(133.8 and 122.3 days, respectively). Three important stopover areas have been= 196.8 days) compare identified: the region around Muraviovka Park in Russia, the Songnen Plain in China, and the west coast of South Korea, where cranes spent most of their migration time(62.2 and 85.7% in spring and autumn, respectively). During migration, nomadic period and winter, hooded Cranes usually stay in croplands for resting and feeding. In non-wintering season, less than 6% of stopover sites were located within protected ***: Overall, our results contribute to understanding the annual spatio-temporal migration patterns of hooded Cranes in the eastern flyway, and planning conservation measures for this species.

关键词： Conservation Eastern migration route hooded Cranes(Grus monacha) Izumi Satellite tracking Spatiotemporal migration patterns

Uptake of citrate-coated iron oxide nanoparticles into atherosclerotic lesions in mice occurs via accelerated transcytosis through plaque endothelial cells

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Nano Research 2016年第11期9卷 3437-3452页

作者： Wolfram C. Poller Evelyn Ramberger Philipp Boehm-Sturm Susanne Mueller Konstantin moller Norbert Lowa Frank Wiekhorst Susanne Wagner Matthias Taupitz Eyk Schellenberger Gert Baumann Karl Stangl Verena Stangl Antje Ludwig Medizinische Klinik mit Schwerpunkt Kardiologie und Angiologie Charite-Universitatsmedizin Berlin Campus Mitte Chariteplatz 1 10117 Berlin Germany Abteilung fur Experimentelle Neurologie Center for Stroke Research Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Charite Core Facility '7 T experimental MRIs' Charite-Universitatsmedizin Berlin Chariteplatz 1 10117 Berlin Germany Physikalisch-Technische Bundesanstalt Abbestr. 2-12 10587Berlin Germany Institut fur Radiologie Charite-Universitatsmedizin Berlin Campus Mitte Charit@platz 1 10117 Berlin Germany DZhK (German Centre for Cardiovascular Research) partner site Berlin 10115 Berlin Germany Berlin Institute of health (BIh) 10117 Berlin Germany

Very small superparamagnetic iron oxide nanoparticles （VSOPs） rapidly accumulate in atherosclerotic lesions, thereby enabling plaque visualization by magnetic resonance imaging （MRI）. This study was performed to identify the uptake mechanisms of VSOPs into atherosclerotic plaques. Low-density lipoprotein receptor-deficient （LDLR^-/-） mice with advanced atherosclerosis were analyzed using MRI and transmission electron microscopy （TEM） at various time points after intravenous administration of VSOPs. Post-mortem MRI detected VSOP labeling of atherosclerotic plaques 10 min after injection, and the signal increased over the first 3 h. TEM revealed that the intensive plaque labeling was mediated by accelerated transcytosis of VSOPs through endothelial cells overlaying atherosclerotic lesions. Experiments with endocytosis inhibitors and small interfering RNA （siRNA） revealed a dynamin-dependent mechanism involving both clathrin- and caveolin-mediated processes. In cell culture experiments, endothelial VSOP uptake was enhanced under proatherogenic flow and TNFα stimulation, conditions that are both present in plaque areas. Our study demonstrates that VSOPs enable non-invasive MRI assessment of accelerated endothelial transcytosis, an important pathomechanism in atherosclerotic plaque formation.

关键词： atherosclerosis,unstable plaques,magnetic resonanceimaging decreased endothelial barrier function,superparamagnetic ironoxide nanoparticles