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在按摩师和浴疗服务员中的过敏性及刺激性皮肤和气道疾病

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世界核心医学期刊文摘（皮肤病学分册） 2005年第10期1卷 53-53页

作者： We.becher R Baur X moll i Latza U U. Latza 惠海英 Betriebliche Epidemiologie Ordinariat und Zentralinstitut fur Arbeitsmedizin Seewartenstr. 10 20459 Hamburg Germany.Dr

The profession of masseur or bath attendant involves intense contact with multiple potential allergens and irritants. There is a complete lack of epidemiological studies for this professional group in spite of the general agreement that sensitization to ingredients of beauty and healthcare products such as fragrances is common. in this review, we critically review the relevant literature, and present own results from recently performed analyses of the German information Network of Departments of Dermatology (iVDK). Fragrances, preservatives, emulsifiers, and antioxidants are relevant from the allergological perspective. in order to evaluate the particular importance of these and other potentially important allergens for occupational dermatology, further systematic research in allergology as well as epidemiological studies are needed.

关键词：气道疾病浴疗变态反应学致敏作用刺激剂医疗保健抗氧化剂职业人群乳化剂

C_c(X)Spaces with X Locally Compact

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Acta Mathematica Sinica,English Series 2007年第9期23卷 1593-1600页

作者： J.C.FERRANDO S.moll Centro de investigación Operativa Universidad Miquel Hernández Departamento de Matemática Aplicada Universidad Politécnica

in this paper, we show, among other results, that if X is a [separable] locally compact space X [satisfying the first countability axiom] then the space Cc （X） has countable tightness [if and only if it has bounding tightness] if and only if it is Frechet-Urysohn, if and only if Cc （X） contains a dense （LM） subspace and if and only if X is a-compact.

关键词： Frechet-Urysohn space countable [bounding] tightness (LM)-space

Radiation-induced intestinal inflammation

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World Journal of Gastroenterology 2007年第22期13卷 3043-3046页

作者： Meritxell mollà Julián Panés Radioncology Department Instituto Oncologico Teknon Barcelona Spain Gastroenterology Department Hospital Clínic de Barcelona CIBER-EHD Spain

Radiation induces an important inflammatory response in the irradiated organs, characterized by leukocyte infiltration and vascular changes that are the main limiting factor in the application of this therapeutic modality for the treatment of cancer. Recently, a considerable investigative effort has been directed at determining the molecular mechanisms by which radiation induces leukocyte recruitment, in order to create strategies to prevent intestinal inflammatory damage. in these review, we consider current available evidence on the factors governing the process of leukocyte recruitment in irradiated organs, mainly derived from experimental studies, with special attention to adhesion molecules, and their value as therapeutic targets.

关键词： inflammation Radiation Leukocyte Endothelium Adhesion molecules

Mdm2 as a chromatin modifier

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Journal of Molecular Cell Biology 2017年第1期9卷 74-80页

作者： Magdalena Wienken Ute M. moll Matthias Dobbelstein institute of Molecular Oncology Gottingen Center for Molecular Biosciences (GZMB) University Medical Center Gottingen Gottingen 37077 Germany Department of Pathology School of Medicine Stony Brook University Stony Brook NY 11794 USA

Mdm2 is the key negative regulator of the tumour suppressor p53, making it an attractive target for anti-cancer drug design. We recently identified a new role of Mdm2 in gene repression through its direct interaction with several proteins of the polycomb group （PcG） family. PcG proteins form polycomb repressive complexes PRC1 and PRC2. PRC2 （via EZH2） mediates histone 3 lysine 27 （H3K27） trimethyiation, and PRC1 （via RiNG1B） mediates histone 2A tysine 119 （H2AK119） monoubiquitination. Both PRCs mostly support a compact and transcriptionally silent chromatin structure. We found that Mdm2 regulates a gene expression pro- file similar to that of PRC2 independent of p53. Moreover, Mdm2 promotes the sternness of murine induced pluripotent stem cells and human mesenchymal stem cells, and supports the survival of tumour cells. Mdm2 is recruited to target gene promoters by the PRC2 member and histone methyltransferase EZH2, and enhances PRC-dependent repressive chromatin modifications, specif- icaUy H3K27me3 and H2AK119ubl. Mdm2 also cooperates in gene repression with the PRC1 protein RiNGiB, a H2AK119 ubiqui- tin ligase. Here we discuss the possible implications of these p53-independent functions of Mdm2 in chromatin dynamics and in the stem cell phenotype. We propose that the p53-independent functions of Mdm2 should be taken into account for cancer drug design. So far, the majority of clinically tested Mdm2 inhibitors target its binding to p53 but do not affect the new functions of Mdm2 described here. However, when targeting the E3 ligase activity of Mdm2, a broader spectrum of its oncogenic activities might become druggable.

关键词： Mdm2 polycomb repressor complex histone methylation histone ubiquitination EZH2

内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑

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中华高血压杂志 2018年第3期26卷 203-203页

作者：刘青叶鹏 Jabs M Rose AJ Lehmann LH Taylor J moll i Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A

营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮... 详细信息

营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。

关键词： Notch信号细胞转运细胞代谢心脏功能成年小鼠脂肪酸内皮血管重塑

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建设生态城市

内蒙古林业科技 1991年第4期17卷 44-46页

作者： moll,G 张立

Women Who Develop Diabetes Later in Life Have Diabetes-Associated Complications during Preceding Pregnancies

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Journal of Diabetes Mellitus 2014年第4期4卷 341-349页

作者： Ulrika moll Hakan Olsson Mona Landin-Olsson Department of Clinical Science Lund UniversityLundSweden Department of Endocrinology Skane University HospitalLundSweden Department of Oncology Skane University HospitalLundSweden

Aims:?The aim of this study was to explore the outcome of previous pregnancies in women who later developed diabetes. Method: A Swedish population based cohort of 23,524 women from 1990 aged 45 - 85 yr in 2000 when they self reported health status in a questionnaire. To identify which women who delivered we matched it towards the Swedish Medical Birth Register (SMBR). We identified 14,856 women who appeared in both registers and a total of 30,559 new birth registrations. Among these women 216 had developed diabetes after their pregnancy (ies) and additional twelve women were reported to have gestational diabetes in SMBR. These 228 women and their 455 pregnancies were compared with women without diabetes. Results: Women who developed diabetes later in life were already heavier before the pregnancy (ies) (69.2 ± 13.9 vs. 63.2 ± 10.3 kg;p ight gain during pregnancy (13.3 ± 5.4 vs. 14.1 ± 4.6 kg;p = 0.03) compared to women without diabetes. Newborns to women with diabetes diagnosed any time after pregnancy had higher birth weight (3602 vs. 3507 g;p ional age (10.5% vs. 3.1%;p ivered by caesarean section (4.8% vs. 2.7%;p = 0.005) and had lower Apgar scores. Conclusion: Women who developed diabetes after pregnancy had hyperglycaemia-associated complications during their pregnancy (ies). We therefore postulated that women with Type 2 diabetes are mainly recruited from women with earlier GDM. A general screening for GDM should identify these women and enable life style intervention that may prevent or at least delay diabetes.

关键词： Gestational Diabetes Type 2 Diabetes Pregnancy Outcome Prenatal Care Retrospective Study Fetal Macrosomia Large for Gestational Age Prediabetes

PROLOG-DBMS耦合:半解释半编译的混合式方法

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计算机科学 1990年第1期17卷 44-51页

作者：李磊 G.H.moll J.Kouloumdjian 吉林大学计算机系 Universite Claude Bernard Lyon 1 France

本文介绍了一种混合式 Prolog-DBMS 耦合技术,它既能保持解释方法和编译方法的优点,又能克服其缺点。这种技术使得随时使用关系数据库算子(比如连接算子)成为可能,同时避免了无用数据(即归结过程中不用的数据)的加载.最后,“历史”管理... 详细信息

本文介绍了一种混合式 Prolog-DBMS 耦合技术,它既能保持解释方法和编译方法的优点,又能克服其缺点。这种技术使得随时使用关系数据库算子(比如连接算子)成为可能,同时避免了无用数据(即归结过程中不用的数据)的加载.最后,“历史”管理机制保证了同一数据不会被多次加载。

关键词： PROLOG-DBMS 知识库解释编译

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明胶的氧化

感光材料 1991年第2期 28-32页

作者： F、J、moll 高志鈜

明胶氧化是为了使明胶变为惰性和无菌以及使明胶去色。氧化破坏了无机杂质以及有机杂质半胱氨酸。在强烈氧化条件下,醣类和醛类也被氧化。氧化过程中不仅杂质氧化,明胶分子中有些氨基酸也被氧化。蛋氨酸易氧化成蛋氨酸亚砜。我们用各种... 详细信息

明胶氧化是为了使明胶变为惰性和无菌以及使明胶去色。氧化破坏了无机杂质以及有机杂质半胱氨酸。在强烈氧化条件下,醣类和醛类也被氧化。氧化过程中不仅杂质氧化,明胶分子中有些氨基酸也被氧化。蛋氨酸易氧化成蛋氨酸亚砜。我们用各种氧化剂对明胶处理,然后进行化学分析。研究了氧化明胶用于照相乳剂制备中对颗粒生长的影响,结果表明氧化促进颗粒生长。加入半胱氨酸减弱氧化了的明胶中颗粒生长,然而加入较高浓度蛋氮酸时促进颗粒生长。我们认为氧化过程中明胶中主要是破坏半胱氨酸。

关键词：明胶氧化