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Combinatorial therapies for spinal cord injury repair

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Neural Regeneration Research 2025年第5期20卷 1293-1308页

作者： Carla s.sousa Andreia Monteiro António j.salgado Nuno A.silva Life and Health sciences Research Institute(ICVs) School of MedicineUniversity of MinhoCampus de Gualtar-gualtarBragaPortugal ICVs/3B’s Associate Lab PT Government Associated LabCampus de Gualtar-gualtarBragaPortugal

spinal cord injuries have profound detrimental effects on individuals, regardless of whether they are caused by trauma or non-traumatic events. The compromised regeneration of the spinal cord is primarily attributed to damaged neurons, inhibitory molecules, dysfunctional immune response, and glial scarring. Unfortunately, currently, there are no effective treatments available that can fully repair the spinal cord and improve functional outcomes. Nevertheless, numerous pre-clinical approaches have been studied for spinal cord injury recovery, including using biomaterials, cells, drugs, or technological-based strategies. Combinatorial treatments, which target various aspects of spinal cord injury pathophysiology, have been extensively tested in the last decade. These approaches aim to synergistically enhance repair processes by addressing various obstacles faced during spinal cord regeneration. Thus, this review intends to provide scientists and clinicians with an overview of pre-clinical combinatorial approaches that have been developed toward the solution of spinal cord regeneration as well as update the current knowledge about spinal cord injury pathophysiology with an emphasis on the current clinical management.

关键词： electric stimulation neural tissue regeneration neuroprotection polytherapy spinal cord injury

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William j.Flerlage Mark L.Dell’Acqua Brian M.Cox Fereshteh s.Nugent Uniformed services University of the Health sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a major contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAps).

关键词： function supporting

Treating amyotrophic lateral sclerosis with allogeneic schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： pascal j.Goldschmidt-Clermont Aisha Khan George jimsheleishvili patricia Graham Adriana Brooks Risset silvera Alexander j.p.Goldschmidt Damien D.pearse W.Dalton Dietrich Allan D.Levi james D.Guest Miller school of Medicine University of MiamiMiamiFLUSA stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami project to Cure paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,schwann cell function may also be ***,important signaling and potential trophic activities of schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FDA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic schwann cell-derived exosomal vesicles to potentially restore impaired schwann cell and motor neuron *** confirmed that cultured schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s schwann cells to allogeneic schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic schwann cell-derived exosomal vesicles diluted in 40 mL of Dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction schwann cell

Transition to a low-carbon city： lessons learned from suzhou in China

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Frontiers of Environmental science & Engineering 2012年第3期6卷 373-386页

作者： Wenling LIU Can WANG Xi XIE Arthur p.j.mol jining CHEN school of Environment Tsinghua UniversityBeijing 100084China Environmental policy Group Wageningen UniversityWageningen 6706 KNthe Netherlands The Administrative Centre for China's Agenda 21 Beijing 100038China

Climate change has become one of the most serious challenges facing humanity; developing a low- carbon economy provides new opportunities for addressing this issue. Building a low-carbon city has been pursued by people with a high degree of enthusiasm in China. Different from actions at the national level and distinct from practices of developed countries, low-carbon development in Chinese cities should be placed on diverse concerns. Taking suzhou of jiangsu province of China as a case city, this paper adopts a scenario analysis approach to explore strategic focal points in the transition to a low- carbon city. Within this transition, we mainly focus on the different contributions from two factors-economic restruc- turing and technological upgrading. scenario analysis results show that 1） in the case of no breakthrough technologies, it is difficult to achieve absolute emission reductions; 2） technologies involved in optimizing energy structure and improving energy efficiency of basic service sectors should be highly emphasized in local planning; 3） in comparison with technological upgrading, economic structural adjustment could be a stronger contributor to mitigation, which is one of the main differences from developed countries. However, the key issue of economic restructuring is to promote the growth of emerging low- carbon industries, which requires not only a strategic choice of new industries but also an introduction of advanced low-carbon technologies. It is also found that establishing a local carbon emissions accounting system is a prerequisite and the first priority for realizing a low-carbon transition and government capacity buildings should be strengthened accordingly.

关键词： low-carbon city economic restructuring tech- nology upgrading

A systematic review of progenitor survival and maturation in parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of parkinson's disease.A defined systematic search of the pubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells parkinson's disease survival transplant

An implementation assessment of China's Environmental Information Disclosure Decree

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journal of Environmental sciences 2010年第10期22卷 1649-1656页

作者： Lei Zhang Arthur E j mol Guizhen He Yonglong Lu school of Environment and Natural Resources Renmin University of China Beijing 100872 China Environmental policy Group Wageningen University Hollandseweg 1 6706 KN Wageningen The Netherlands state Key Laboratory of Urban and Regional Ecology Research Center for Eco-Environmental Sciences Chinese Academy of Sciences Beijing 100085 China

China＇s 2007 Open Government Information Regulations is widely considered as a milestone in the country＇s information policy history and is praised as a ＂sunshine program＂. The Environmental Information Disclosure Decree was the first to operationalize these general regulations into a sectorai information disclosure system on environment. This study assessed the implementation of the environmental information disclosure system about six months after the Decree took effect on May 1, 2008. Through reviewing the websites of all 31 provincial Environmental protection Bureaus and the Ministry of Environmental protection, conducting an experiment with actual information disclosure request, and through interviews with all provincial Environmental protection Bureaus, this article concluded that the implementation of the environmental information disclosure system still fails short. Future improvements should focus on further publicity of the regulations and decree to enhance public participation, the establishment of an independent evaluation and supervision system for information disclosure, the exchange of experiences and best practices among provincial Environmental protection Bureaus, and on strengthening the legal status of environmental information disclosure.

关键词： environmental information disclosure environmental governance

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

ENVIRONMENTAL INFORMATION DIsCLOsURE IN CHINA： IN THE ERA OF INFORMATIZATION AND BIG DATA

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Frontiers of Law in China-selected publications from Chinese Universities 2017年第1期12卷 57-75页

作者： ZHANG Lei Arthur p. j. mol YANG shuai Renmin University of China Beijing 100872 China Rector Magnificus and Vice-president Wageningen University & Research Wageningen The Netherlands

The past decade has seen remarkable progress made in the field of environmental information disclosure in China. While the overall institutional changes and the motivation/willingness of the government to open up information are important conditions, China＇s encounter with revolutionary Information and Communication Technological （ICT） advancement and rapidly emerging big data quickly changed China from an ＂information poor environment＂ to an ＂information complex environment.＂ While most previous studies centered on those drives/constraints that were recognized in established informational governance framework, recent advancement in ICTs and emerging big data posed new challenges, opportunities and research questions. When increasing information disclosure became a new game changer in environmental governance, China has had to cope with risks and pitfalls in a new technology-empowered information environment as well. This article updated previous studies on legislation/ regulations/policies regarding environmental information disclosure in China and their implementation effectiveness, and paid special attention to China＇s recent informatization progress and emerging big data. Information disclosure was treated as a process that includes data/information generation/collection, disclosure, functional pathways of communication, and direct/indirect impacts. Changes in environmental information disclosure should be understood in a broader context of overall changing environmental governance and informatization in China. It is important to understand ICTs and information disclosure as a double-edged sword. Normative, substantive, and instrumental benefits of disclosure as well as collection and reporting costs, the issue of targeted transparency, and the risk of unintended use should be strategically considered. principles and guidelines need to be developed to avoid pitfalls while maximizing benefits.

关键词： environmental information disclosure informatization big data China

Extrusion-based additive manufacturing of Mg-Zn alloy scaffolds

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journal of Magnesium and Alloys 2022年第9期10卷 2491-2509页

作者： j.Dong N.Tümer M.A.Leeflang p.Taheri L.E.Fratila-Apachitei j.M.C.mol A.A.Zadpoor j.Zhou Department of Biomechanical Engineering Delft University of TechnologyDelft 2628 CDthe Netherlands Department of Materials science and Engineering Delft University of TechnologyDelft 2628 CDthe Netherlands

porous biodegradable Mg and its alloys are considered to have a great potential to serve as ideal bone *** recent progress in additive manufacturing(AM) has prompted its application to fabricate Mg scaffolds with geometrically ordered porous *** AM,followed by debinding and sintering,has been recently demonstrated as a powerful approach to fabricating such Mg scaffolds,which can avoid some crucial problems encountered when applying powder bed fusion AM ***,such pure Mg scaffolds exhibit a too high rate of in vitro *** the present research,alloying through a pre-alloyed Mg-Zn powder was ultilized to enhance the corrosion resistance and mechanical properties of AM geometrically ordered Mg-Zn scaffolds *** in vitro biodegradation behavior,mechanical properties,and electrochemical response of the fabricated Mg-Zn scaffolds were ***,the response of preosteoblasts to these scaffolds was systematically evaluated and compared with their response to pure Mg *** Mg-Zn scaffolds with a porosity of 50.3% and strut density of 93.1% were composed of the Mg matrix and MgZn2second phase *** in vitro biodegradation rate of the Mg-Zn scaffolds decreased by 81% at day 1,as compared to pure Mg *** 28 days of static immersion in modified simulated body fluid,the corrosion rate of the Mg-Zn scaffolds decreased from 2.3± 0.9 mm/y to 0.7±0.1 mm/*** yield strength and Young’s modulus of the Mg-Zn scaffolds were about 3 times as high as those of pure Mg scaffolds and remained within the range of those of trabecular bone throughout the biodegradation *** culture of MC3T3-E1 preosteoblasts in Mg-Zn extracts indicated favorable *** direct cell culture,some cells could spread and form filopodia on the surface of the Mg-Zn ***,this study demonstrates the great potential of the extrusion-based AM Mg-Zn scaffolds to be further develo

关键词： Additive manufacturing Material extrusion Magnesium-zinc alloy porous scaffold Biodegradation