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Distinguishing of Abuse Drugs in Urine and Blood Samples of Abusers in Iran

Journal of Pharmacy and Pharmacology 2015年第8期3卷 385-390页

作者： Rezaei-Basiri Majid Behshid Mojgan Ghazi-Khansari Mahmoud Tabatabaei Seyed Mahmoud Moradi Danesh Alilu Saleh Jabbarzadeh Aahad mokhtari marziyeh Bahari Afrouz Department of Pharmacology and Toxicology School of Pharmacy Tabriz University of Medical Sciences Tabriz 51999 Iran Medical Education Research Center Tabriz University of Medical Sciences Tabriz 51999 Iran Department of Medical Surgical School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz 51999 Iran Department of Pharmacology and Toxicology School of Medicine Tehran University of Medical Sciences Tehran 13111 Iran Department of Physiology Tabriz Branch lslamic Azad University Tabriz 51999 Iran Welfare Organization of East Azarbayjan Tabriz 51999 Iran

In this study, one hundred urine samples and one hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples referred who addicts in clinics of Welfare Organization, during of detoxification treatment or maintenance treatment were screened for abuse drugs presence. Age ranges of female patients were 35 ± 15 and age range of males patients were 42 ± 18. All patients filled questionnaire and satisfy forms too. All data were analyzed by t-test and were Anowa one way, and P 〈 0.05 was considered significant. The P value of this study was P = 0.000. In this study we conclude that among all drug analytical methods the cheapest and easiest test to screening opioids and other abuse drugs in urine and blood samples is strip test for rapid diagnosis and TLC （thin-layer chromatography） is appropriate confirmation method to drug abuse distinguishing. Also tests on blood samples have high importance as a view point of accuracy to distinguishing of drugs abuse.

关键词： Abusers urine and blood samples Strip test Thin-layer chromatography abuse drugs.

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Clinical applications of the CRISPR/Cas9 genome-editing system: Delivery options and challenges in precision medicine

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Genes & Diseases 2024年第1期11卷 268-282页

作者： Mohadeseh Khoshandam Hossein Soltaninejad marziyeh Mousazadeh Amir Ali Hamidieh Saman Hosseinkhani Department of Reproductive Biology Academic Center for EducationCultureand Research(ACECR)Qom BranchQom ***Iran National Institute of Genetic Engineering and Biotechnology(NIGEB) Tehran 14155-6463Iran Faculty of Interdisciplinary Science and Technology Tarbiat Modares UniversityTehran 14117-13116Iran Pediatric Cell and Gene Therapy Research Center GeneCell&Tissue Research InstituteTehran UniversityofMedical SciencesTehran14155-6559Iran Department of Nanobiotechnology Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran Department of Biochemistry Faculty of Biological SciencesTarbiat Modares UniversityTehran 14117-13116Iran

CRISPR/Cas9 is an effective gene editing tool with broad applications for the pre-vention or treatment of numerous *** depends on CRiSPR(clustered regularly inter-spaced short palindromic repeats)as a bacterial immune system and plays as a gene editing *** to the higher specificity and efficiency of CRISPR/Cas9 compared to other editing ap-proaches,it has been broadly investigated to treat numerous hereditary and acquired ill-nesses,including cancers,hemolytic diseases,immunodeficiency disorders,cardiovascular diseases,visual maladies,neurodegenerative conditions,and a few X-linked ***/Cas9 system has been used to treat cancers through a variety of approaches,with sta-ble gene editing ***,the applications and clinical trials of CRisPR/Cas9 in various illnesses are *** to its high precision and efficiency,CRISPR/Cas9 strategies may treat gene-related illnesses by deleting,inserting,modifying,or blocking the expression of specific *** most challenging barrier to the in vivo use of CRISPR/Cas9 like off-target effects will be *** use of transfection vehicles for CRISPR/Cas9,including viral vectors(such as an Adeno-associated virus(AAV),and the development of non-viral vectors is also considered.

关键词： Clinical trials CRISPR/Cas9 Gene therapy Non-viral vectors Viral vectors

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Evaluation of Abuse Drugs and Clinical Laboratory Tests Variations in Whole Blood ＆ Urine Samples of Abusers

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 69-76页

作者： Majid Rezaei Basiri Mojgan Behshid Alireza Najafi Saleh Alilou Haniyeh Mohebbi-Kamali: Fatemeh Hosseindoust marziyeh mokhtari Valiyollah Watani Ladan Aminzadeh Fatemeh Seyed Nejad Ashraf Razavi Ligha Saadat Department of Pharmacology and Toxicology School of Pharmacy Tabriz University of Medical Sciences Tabriz 51999 Iran Medical Education Research Center Tabriz University of Medical Sciences Tabriz 51999 Iran Department of Medical Surgical School of Nursing and Midwifery Tabriz University of Medical Sciences Tabriz 51999 Iran Forensic and Legal Medicine of Organization Tabriz 515 7733541 Iran Welfare Organization of East Azarbayjan Tabriz 5156935 761 Iran

In this study, five hundred urine samples and five hundred blood samples of abusers were examined for the presence of alkaloid substances and abuse drugs in urines and bloods. These numbers of blood and urine samples of addicts in clinics of welfare organization, during detoxification treatment or maintenance treatment were screened for abuse drugs presence. The all of samples were tested through as a view of clinical laboratory methods. Age ranges of female patients were 35 ~ 15 and age range of males patients were 45 ~ 15. All patients filled questionnaire and satisfy forms too. First, all fresh urine and blood samples were examined to confirm presence drugs abuses, depend on their addiction and treatment, so all samples were confirmed by two tests. Then they were examined to other clinical laboratory tests. All data were analyzed by t-test and were Anova one way and two ways of Anova Turkey, and p 〈 0.05 was considered significant. The p-value of this study was p = 0.0001. The results of this study were showed that 4% of abusers had mild increase in hematocrite level and 2% of narcotic drugs abusers had mild lower level of blood sugars than normal range and 4% of participants had increase liver enzymes such ALT （alanine transferase）, AST （aspartat transferase）, ALP （alkaline phosphatease） and 1% of them had renal failure. Although blood level BUN （blood urea nitrogen） and creatinin were examined to evaluation of their renal failure .The results in Tabriz/Iran undrevision of welfare organization clinics were approximately showed that positive results of addiction are in each of urine and blood samples. Because some of abusers directly consumed full long time agonist or partial agonists＇ drugs such as methadone and buprenorphine for their maintenance therapy in clinics. Also doing test on blood samples has high importance in distinguishing and confirmation of drugs abuse in samples. Also in this study we conclude that among all drug analytical methods the cheapest

关键词： Abusers urine and whole blood samples strip test thin-layer chromatography abuse drugs clinical laboratory tests.

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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN marziyeh SOLTANI LEILA HASHEMI AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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Acupotomy ameliorates knee osteoarthritis-related collagen deposition and fibrosis in rabbit skeletal muscle through the TGF-β/Smad pathway

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 376-385页

作者： Tingyao Hu Einar Khavaza Chuxi Liang Longfei Xing Xilin Chen Yue Xu Weiwei Ma Farid mokhtari Juan Lu Changqing Guo School of Acupuncture Moxibustion and TuinaBeijing University of Chinese MedicineBeijing 102488China Department of Traditional Chinese Medicine Peking University People's HospitalBeijing 100044China The Fifth College of Clinical Medicine Guangzhou University of Traditional Chinese MedicineGuangzhou 511436China Department of Acupuncture and Rehabilitation Guangdong Second Hospital of Traditional Chinese MedicineGuangzhou 510260China Traditional Clinic Shahid Beheshti Medical UniversityTehran ***Iran Department of Traditional Chinese Medicine Shenzhen Hospital of Southern Medical UniversityShenzhen 510515China

Objective To investigate the effects of acupotomy on skeletal muscle fibrosis and collagen deposition in a rabbit knee osteoarthritis(KOA)*** Rabbits(n=18)were randomly divided into control,KOA,and KOA+acupotomy(Apo)groups(n=6).The rabbits in the KOA and Apo groups were modeled using the modified Videman's method for 6 *** modeling,the Apo group was subjected to acupotomy once a week for 3 weeks on the vastus medialis,vastus lateralis,rectus femoris,biceps femoris,and anserine bursa tendons around the *** behavior of all animals was recorded,rectus femoris tissue was obtained,and histomorphological changes were observed using Masson staining and transmission electron *** expression of transforming growth factor-β1(TGF-β1),Smad 3,Smad 7,fibrillar collagen types I(Col-I)and III(Col-III)was detected using Western blot and real-time polymerase chain reaction(RT-PCR).Results Histological analysis revealed that acupotomy improved the microstructure and reduced the collagen volume fraction of rectus femoris,compared with the KOA group(P=.034).Acupotomy inhibited abnormal collagen deposition by modulating the expression of fibrosis-related proteins and mRNA,thus preventing skeletal muscle *** blot and RT-PCR analysis revealed that in the Apo group,Col-I,and Col-III protein levels were significantly lower than those in the KOA group(both P<.01),same as Col-I and Col-III mRNA levels(P=.0031;P=.0046).Compared with the KOA group,the protein levels of TGF-β1 and Smad 3 were significantly reduced(both P<.01),as were the mRNA levels of TGF-β1 and Smad 3(P=.0007;P=.0011).Conversely,the levels of protein and mRNA of Smad 7 were significantly higher than that in the KOA group(P<.01;P=.0271).Conclusion Acupotomy could alleviate skeletal muscle fibrosis and delay KOA progress by inhibiting collagen deposition through the TGF-β/Smad pathway in the skeletal muscle of KOA rabbits.

关键词： Acupotomy Knee osteoarthritis Skeletal muscle Fibrosis Collagen deposition

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WHOLLY AROMATIC CHIRAL POLYAMIDES BEARING PENDANT PHTHALIMIDO AND L-ISOLEUCINE MOITIES

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Chinese Journal of Polymer Science 2010年第6期28卷 859-867页

作者： Shadpour Mallakpour marziyeh Khani Organic Polymer Chemistry Research Laboratory Department of ChemistryIsfahan University of Technology

A potential biodegradable and optically active bulky chiral aromatic amide-imidic diacid monomer,（2S,3S）-5-（3- methyl-2-phthalimidylpentanoylarnino）isophthalic acid（7）,containing a rigid phthalimide and flexible L-isoleucine pendant group was synthesized in three *** aromatic polyamides including pendant phthalimido groups and flexible side spacers have been synthesized by direct polycondensation reaction of equimolar amounts of different aromatic diamines with an optically active diacid 7,using N-methyl-2-pyrrolidone（NMP） as a solvent and triphenyl phosphite/CaCl_2/pyridine as a condensing *** polyamides were characterized by FTIR,~1H-NMR spectroscopy,specific rotation, thermogravimetric and elemental *** resulting polymers have inherent viscosities in the range of 0.21-0.45 dL/g. Amino acid existence in this backbone results in optically active *** to introduction of bulky and flexible groups in these polyamides,they show improved solubility in polar aprotic solvents such as NMP and dimethylacetamide and also good thermal stability（10%weight loss temperatures in excess of 330℃,and char yields at 600℃in nitrogen higher than 62%）.

关键词： Polyamides Biodegradable Thermally stable polymers Thermogravimetric analysis Polycondensation reaction

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Mechanism Based Pharmacokinetic Pharmacodynamic Modeling of Vildagliptin as an Add-on to Metformin for Subjects with Type 2 Diabetes

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Computer Modeling in Engineering & Sciences 2018年第2期114卷 153-171页

作者： marziyeh Eftekhari Omid Vahidi School of Chemical Petroleum and Gas EngineeringIran University of Science and TechnologyNarmakTehranIran

Various drugs are used to maintain normoglycemia in subjects with type 2 diabetes *** combination of the drugs from different classes in one single tablet may enhance the effectiveness of the anti-diabetic *** investigate the impact of combining drugs on the glucose regulation of subjects with type 2 diabetes,we propose a pharmacokinetic/pharmacodynamics(PK/PD)mathematical modeling approach for a combination of metformin and vildagliptin *** the proposed modeling approach,two separate PK models representing oral administration of metformin and vildagliptin for diabetic subjects are interconnected to a PD model comprising a detailed compartmental physiological model representing the regulatory effect of insulin,incretins and glucagon hormones on glucose concentration in a human *** impact of doses of individual drugs and their combination on the blood glucose concentration of a group of type 2 diabetic subjects is *** is indicated that while administration of individual drugs reduces the blood glucose levels,since they have separate mechanisms of action,combining them synergizes lowering the blood glucose levels.

关键词： Pharmacokinetics pharmacodynamics mathematical modeling anti-diabetic drugs metformin vildagliptin

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Hydrophilic polymeric membrane supported on silver nanoparticle surface decorated polyester textile:Toward enhancement of water flux and dye removal

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Chinese Journal of Chemical Engineering 2020年第3期28卷 901-912页

作者： marziyeh Mofradi Hajir Karimi Mehrorang Ghaedi Chemical Engineering Department Yasouj UniversityYasoujIran Chemistry Department Yasouj UniversityYasoujIran

A novel mixed matrix nanofiltration membrane was constructed by coating a casting solution containing polyvinylidene fluoride(PVDF),polyethylene glycol(PEG)as hydrophilic agent,zeolitic like framework-67(ZIF-67),ethylenediamine as cross-linking agent on Ag-nanoparticle-decorated polyester textile(PT)support(PT/AgNPs/PVDF-PEG/ZIF-67).PT/Ag-NPs/PVDF-PEG/ZIF-67 morphology,crystalline structure,surface chemical composition and hydrophilicity of PT/Ag-NPs/PVDF-PEG/ZIF-67 were fully characterized by field emission scanning electron microscopy(FE-SEM),X-ray diffraction(XRD),Fourier transform infrared spectroscopy(FT-IR)and water contact angle technique,***/Ag-NPs/PVDF-PEG/ZIF-67 was applied in cross module set-up for removal of contaminated water containing rose bengal(RB)*** effect of operational parameters such as dye concentration,solution pH and flow rate on performance of PT/Ag-NPs/PVDF-PEG/ZIF-67 were investigated and optimized by central composite design(CCD).Casting solution containing 0.5 wt.%ZIF-67 as optimum value showed the good wettability,high pure water flux(PWF;35.8 L·m-2·h-1),flux recovery ratio(FRR;90%),dye removal efficiency(96.41%).The selectivity factor of 12.72 and 14.42 was found to be for RB in the presence of amido black and methylene blue as interferent dyes,respectively,which showed a good selective recognition ability for RB dye.

关键词： Ag nanoparticles Hydrophilic membrane Polyester textile Polyethylene glycol Zeolitic like framework-67

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Theoretical Study of Stability and Electronic Characteristics in Various Complexes of Psoralen as an Anticancer Drug in Gas Phase,Water and CCl_(4) Solutions

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Chemical Research in Chinese Universities 2022年第6期38卷 1414-1424页

作者： MOHAMMADI marziyeh MAHINIAN Maryam KHANMOHAMMADI Azadeh Department of Chemistry Faculty of ScienceVali-e-Asr University of RafsanjanP.O.Box:77176RafsanjanIran Department of Chemistry Payame Noor UniversityP.O.Box:19395-3697TehranIran

The present research employs density functional theory(DFT)computations to analyze the structure and energy of complexes formed by psoralen drug with alkali(Li^(+),Na^(+),K^(+))and alkaline earth(Be^(2+),Mg^(2+),Ca^(2+))metal *** computations are conducted on M06-2X/aug-cc-pVTZ level of theory in the gas phase and *** Atoms in Molecules(AIM)and natural bond orbital(NBO)analyses are applied to evaluating the characterization of bonds and the atomic charge distribution,*** results show that the absolute values of binding energies decrease with going from the gas phase to the ***,the considered complexes in the water(as a polar solvent)are more stable than the CCl_(4)(as a non-polar solvent).The DFT based chemical reactivity indices,such as molecular orbital energies,chemical potential,hardness and softness are also *** outcomes show that the considered complexes have high chemical stability and low reactivity from the gas phase to the ***,charge density distributions and chemical reactive sites of a typical complex explored in this study are obtained by molecular electrostatic potential surface.

关键词： Psoralen Cation-π Density function theory(DFT) Atoms in Molecules(AIM) Natural bond orbital(NBO)

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Exact Solutions of the Harry-Dym Equation

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Communications in Theoretical Physics 2011年第2期55卷 204-208页

作者： Reza mokhtari Department of Mathematical Sciences Isfahan University of Technology

The aim of this paper is to generate exact travelling wave solutions of the Harry-Dym equation through the methods of Adomian decomposition, He＇s variational iteration, direct integration, and power series. We show t... 详细信息

关键词： Harry-Dym equation exact travelling wave solution Adomian decomposition method variational iteration method direct integration method power series method

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