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Functional analysis and drug response to zinc and D-penicillamine in stable ATP7B mutant hepatic cell lines

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World Journal of Gastroenterology 2016年第16期22卷 4109-4119页

作者： Gursimran Chandhok Judit Horvath Annu Aggarwal mohit Bhatt Andree Zibert Hartmut HJ Schmidt Klinik fur Transplantationsmedizin Universitatsklinikum Munster D-48149 Munster Germany Institut fur Humangenetik Westfalische Wilhelms-Universitat D-48149 Munster Germany Kokilaben Dhirubhai Ambani Hospital and Medical Research Institute Mumbai 400103 India

AIM: To study the effect of anti-copper treatment for survival of hepatic cells expressing different ATP7 B mutations in cell culture. METHODS: The most common Wilson disease(WD) mutations p.H1069 Q, p.R778 L and p.C271*, found in the ATP7 B gene encoding a liver copper transporter, were studied. The mutations represent major genotypes of the United States and Europe, China, and India, respectively. A human hepatoma cell line previously established to carry a knockout of ATP7 B was used to stably express WD mutants. m RNA and protein expression of mutant ATP7 B, survival of cells, apoptosis, and protein trafficking were ***: Low temperature increased ATP7 B protein expression in several mutants. Intracellular ATP7 B localization was significantly impaired in the mutants. Mutants were classified as high, moderate, and no survival based on their viability on exposure to toxic copper. Survival of mutant p.H1069 Q and to a lesser extent p.C271* improved by D-penicillamine(DPA) treatment, while mutant p.R778 L showed a pronounced response to zinc(Zn) treatment. Overall, DPA treatment resulted in higher cell survival as compared to Zn treatment; however, only combined Zn + DPA treatment fully restored cell viability. CONCLUSION: The data indicate that the basic impact of a genotype might be characterized by analysis of mutant hepatic cell lines.

关键词： ATP7B D-penicillamine Zinc Mutations Wilson disease Therapy

Performance Analysis and QoS Assessment of Queues over Multi-Hop Networks

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Performance Analysis and QoS Assessment of Queues over Multi...

A Case Series of 12 Patients Receiving Bilateral Transverse Abdominis Plane Blocks after Cesarean Section

International Symposium on Computing, Communication, and Control（ISCCC 2009）

作者： mohit Agrawal Navneet Tiwari Lalla Atul Singh Chaurasia Jatan Saraf Medicaps Institute of Technology and Management

In the field of computer networks the implementation,management and performance analysis of queues is one of the foremost *** selection of the various queues is totally depends upon the need of transmission of *** and Reliable propagation of data is a basic requirement of any computer *** presents scenario,there is a strong requirement of standardization,testing,and widespread deployment of active queue management [AQM] in routers,which is further responsible for the improvement of performance of today's *** performance assessment requires a concrete research effort in the measurement and deployment of router mechanisms,which advances to protect the Internet from flows that are not sufficiently responsive to congestion *** this paper,we evaluate the performance of Drop tail,DRR,RED,SFQ,and FQ by varying the number of *** are representing the detailed performance analysis & comparison of the various queues in terms of parameters like throughput,average delay and packet *** queues have been analyzed on various traffics like FTP and CBR,by varying the number of hops and the various conclusions have been drawn accordingly.

关键词： CBR,Drop tail,DRR,RED,FTP,Linux,NS2,Queue,SFQ

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Open Journal of Anesthesiology 2017年第12期7卷 407-414页

作者： Dennis Feierman Aden Bronstein Miriam Flaum Marc Dany mohit Garg Piyush Gupta Kalpana Tyagaraj Department of Anesthesiology Maimonides Medical Center Brooklyn NY USA

Transverse abdominis Plane blocks (TAP) provide effective postoperative analgesia following surgical incisions of the lower and middle abdominal wall, including those associated with cesarean section. This study investigated the efficacy of liposomal bupivacaine diluted with 0.25% bupivacaine administered in bilateral TAP blocks for post-operative analgesia after Ce-sarean section preformed under neuraxial anesthesia. The patients who received the TAP blocks with liposomal bupivacaine had noticeably low pain scores of 1.0 ± 1.4, 1.4 ± 2.1, 1.7 ± 1.9, 1.9 ± 3.3 and 1.9 ± 2.3 at 6, 12, 24, 48 and 72 hours respectively. Only 3 patients used oxycodone (5 mg)/acetaminophen (325 mg) postoperative. One patient took two tables of oxycodone (5 mg)/acetamino-phen (325 mg) after 24 hours, a second patient used oxycodone (5 mg)/aceta-minophen (325 mg) after 72 hours and the third patient was transferred to the intensive care unit (ICU) since she developed postpartum cardiac complications, and was give oxycodone (5 mg)/acetaminophen (325 mg) despite having a 0 pain score. These results suggest that patients treated bilateral TAP blocks with a mixture of liposomal and regular bupivacaine will have low pain scores, high patient satisfaction and reduce the use of postoperative narcotics.

关键词： Liposomal Bupivacaine Exparel TAP Block Cesarean-Section

Prescribing Pattern of NSAIDs and Gastro Protective Drugs in Orthopedic patients in a Tertiary Care Indian Hospital

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Prescribing Pattern of NSAIDs and Gastro Protective Drugs in...

股骨近端骨折——单极与双极人工股骨头置换的比较

第十五届国际药理学大会

作者： Anoop K.Agarwal Rtika R.Abraham mohit Girotra Professor and Head Institute of Clinical Research （India）BangaloreIndia Christian Medical College and Hospital LudhianaIndia Christian Medical College and Hospital LudhianaIndia

＜正＞ Gastrointestinal （GI） toxicity is often associated with the use of NSAIDs. depending upon the agent,dose and concomitant risk factors such as age. corticos-teroids. anticoagulants, alcohol etc. The aim of the present study was to investigate prescribing pattern of NSAIDs and gastroprotective drugs in orthopedic patients （340） suffering from low backache,polytrauma. arthritis etc. Non-selective COX inhibitors were more frequently prescribed （56% ） than COX-2 inhibitors （44% ） but gastro protective drugs were co-prescribed to 28% patients only. Forty-eight patients （14%） received two NSAIDs with GI protection with Proton pump inhibitors （PPI）. Twenty per cent patients on selective COX-2 inhibitors received H2-blocker or PPI. whereas 74% patients on high dose of non-selective COX inhibitors were not prescribed any gastro protective agent leading to increased incidence of GI symptoms,gastric ulceration and bleeding in 65% ***:Co-prescription of NSAIDs and gastro protective drugs is recommended.

关键词： NSAID Pain Prescribing pattern

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中华创伤骨科杂志 2011年第3期13卷 270-276页

作者： mohit Bhandari 王簕(译) 杨云峰(译) AO Publishing Switzerland Clavadelerstrasse CH-7270 Davos Platz 广州医学院第三附属医院骨科上海同济大学同济医院骨科

5项随机对照研究的证据显示：单极与双极人工股骨头置换术治疗股骨近端骨折的疗效相当，其中涉及功能恢复、短期或长期死亡率、再脱位风险及感染率等几个方面。其中仅1项研究随访比例大于85％，由于部分随访比例低，所以结论存在偏倚。... 详细信息

5项随机对照研究的证据显示：单极与双极人工股骨头置换术治疗股骨近端骨折的疗效相当，其中涉及功能恢复、短期或长期死亡率、再脱位风险及感染率等几个方面。其中仅1项研究随访比例大于85％，由于部分随访比例低，所以结论存在偏倚。有必要采用严格方法学，提高随访比例，进一步开展随机对照研究以明确两种方法何者更优、更安全。

关键词：双极人工股骨头置换术股骨近端骨折单极随机对照研究功能恢复死亡率感染率再脱位

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了解嵌入系统的引导技术

电子设计技术 EDN CHINA 2011年第6期18卷 51-55页

作者： mohit Arora Varun Jain 飞思卡尔半导体公司

引导是指在接通电源和装入应用之间,系统完成的一系列步骤,它在理论上简单,但实际上经常很复杂。引导加载器的主要任务是装入操作系统,但软硬件工程师对这个过程的看法并不相同。

关键词：嵌入式系统引导加载器

Utility of endoscopic ultrasound and endoscopy in diagnosis and management of hepatocellular carcinoma and its complications: What does endoscopic ultrasonography offer above and beyond conventional cross-sectional imaging?

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World Journal of Gastrointestinal Endoscopy 2018年第2期10卷 56-68页

作者： mohit Girotra Kaartik Soota Amaninder S Dhaliwal Rtika R Abraham Mauricio Garcia-Saenz-de-Sicilia Benjamin Tharian Division of Gastroenterology University of Miami Miller School of Medicine Division of Gastroenterology and Hepatology University of Iowa School of Medicine Division of Gastroenterology and Hepatology University of Nebraska School of Medicine Department of Medicine University of Miami Miller School of Medicine Division of Gastroenterology and Hepatology University of Arkansas for Medical Sciences Division of Gastroenterology University of Arkansas for Medical Sciences

Hepatocellular carcinoma constitutes over 90% of the primary liver tumors, the rest being cholangiocarcinoma. It has an insidious presentation, which is responsible for the delayed presentation. Hence, the management strategy relies on screening to diagnose it an early stage for curative resection and/or treatment with local ablative techniques or chemotherapy. However, even with different screening programs, more than 60% of tumors are still detected at an advanced stage, leading to an unchanged mortality rate, thereby implying a room for improvement in the screening and diagnostic process. In the last few years, there has been evolution of utility of endoscopy, specifically endoscopic ultrasonography along with Fine needle aspiration, for this purpose, which we comprehensively review in this article.

关键词： Hepatocellular carcinoma Liver Cancer Fine needle aspiration Endoscopy Endoscopic ultrasound Endoscopic ultrasonography Staging Management Treatment

Individuals with and without normal tension glaucoma exhibit comparable performance on tests of cognitive function

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1721-1728页

作者： Qi N.Cui David Green mohit Jethi Todd Driver Travis C.Porco Jane Kuo Shan C.Lin Robert L.Stamper Ying Han Cynthia S.Chiu Saras Ramanathan Michael E.Ward Katherine Possin Yvonne Ou Department of Ophthalmology University of California San Francisco University of Pennsylvania Francis I.Proctor Foundation University of California San Francisco Glaucoma Center of San Francisco Department of Neurology University of California San Francisco Neurogenetics Branch National Institute of Neurological Disorders and StrokeNational Institutes of Health

AIM:To evaluate aspects of cognition impacted by individuals with and without normal tension ***:Fifty normal tension glaucoma(NTG)and 50 control patients≥50 y of age were recruited from the UCSF Department of *** data and glaucoma parameters were extracted from electronic medical records for both *** of executive function[Executive Abilities:Measures and Instruments for Neurobehavioral Evaluation and Research(EXAMINER)]and learning and memory[California Verbal Learning Test–Second Edition(CVLT-II)]were administered to both NTG and ***,handedness,best-corrected visual acuity,maximum intraocular pressure,optic nerve cup-todisc ratio,visual field and optic nerve optical coherence tomography parameters,and a measure of general health(Charlson Comorbidity Index)were compared between NTG and controls as well as within NTG *** linear regression was used to compare group performances on the EXAMINER battery and CVLT-II while controlling for age,sex,and years of ***:NTG and controls were comparable with respect to age,sex,race,education,handedness,and the Charlson Comorbidity Index(P>0.05 for all).Performance on the EXAMINER composite score and the CVLT-II did not differ between NTG and controls(P>0.05 for both).CONCLUSION:This is the first prospective study in which the cognitive function of subject with NTG were evaluated using a comprehensive,computerized neurocognitive *** with NTG do not perform worse than unaffected controls on tests of executive function,learning,and memor *** do not suppor t the hypothesis that individuals with NTG are at higher risk for cognitive dysfunction and/or dementia.

关键词： low tension glaucoma dementia mild cognitive impairment neurodegeneration memory and executive function

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桡骨远端骨折外固定与石膏制动保守治疗比较

中华创伤骨科杂志 2008年第3期10卷 277-284页

作者： mohit Bhandari Beate P Hanson 李旭(译校) AO Publishing Switzerland Clavadelerstrasse CH-7270 Davos Platz 广州市儿童医院骨科

三项随机或半随机对照研究中的证据表明，在以女性为主的老年桡骨远端骨折患者中，无论是用外固定（EF）或石膏制动治疗，医疗评价或患者自我评价的结果并无差异。另一项研究结果显示，在以男性为主的年轻患者中，使用EF者的医疗评价要... 详细信息

三项随机或半随机对照研究中的证据表明，在以女性为主的老年桡骨远端骨折患者中，无论是用外固定（EF）或石膏制动治疗，医疗评价或患者自我评价的结果并无差异。另一项研究结果显示，在以男性为主的年轻患者中，使用EF者的医疗评价要优于使用石膏者。

关键词：骨折外固定石膏制动桡骨远端保守治疗半随机对照研究医疗评价骨折患者制动治疗