Prescribing Pattern of NSAIDs and Gastro Protective Drugs in Orthopedic patients in a Tertiary Care Indian Hospital
作者单位：Professor and HeadInstitute of Clinical Research （India）BangaloreIndia Christian Medical College and HospitalLudhianaIndia Christian Medical College and HospitalLudhianaIndia
会议名称：《第十五届国际药理学大会》
会议日期：2006年
学科分类：12[管理学] 1204[管理学-公共管理] 120402[管理学-社会医学与卫生事业管理(可授管理学、医学学位)] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 10[医学]
关 键 词：NSAID Pain Prescribing pattern
摘 要：正 Gastrointestinal （GI） toxicity is often associated with the use of NSAIDs. depending upon the agent,dose and concomitant risk factors such as age. corticos-teroids. anticoagulants, alcohol etc. The aim of the present study was to investigate prescribing pattern of NSAIDs and gastroprotective drugs in orthopedic patients （340） suffering from low backache,polytrauma. arthritis etc. Non-selective COX inhibitors were more frequently prescribed （56% ） than COX-2 inhibitors （44% ） but gastro protective drugs were co-prescribed to 28% patients only. Forty-eight patients （14%） received two NSAIDs with GI protection with Proton pump inhibitors （PPI）. Twenty per cent patients on selective COX-2 inhibitors received H2-blocker or PPI. whereas 74% patients on high dose of non-selective COX inhibitors were not prescribed any gastro protective agent leading to increased incidence of GI symptoms,gastric ulceration and bleeding in 65% ***:Co-prescription of NSAIDs and gastro protective drugs is recommended.