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Effect of an amalgamated antibiotic and its connection to cytogenotoxicity and histo-architectural malformations in stinging catfish

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Emerging Contaminants 2022年第1期8卷 381-390页

作者： Mostt Tajnova Islam golam Mohammod Mostakim Md golam Azom Umme Ohida Rahman Mst Mansura khan mohd golam quader khan M.Sadiqul Islam Department of Fisheries Biology&Genetics Bangladesh Agricultural UniversityMymensingh2202Bangladesh Graduate Training Institute(GTI) Bangladesh Agricultural UniversityMymensingh2202Bangladesh Department of Marine Fisheries Science Bangladesh Agricultural UniversityMymensingh2202Bangladesh

Intensive fish farming has an excessive prevalence of infection and is typically controlled by the administration of *** amalgamated antibiotics are a relatively novel therapeutic idea and more effective than traditional antibiotic monotherapy,they can also have a toxic effect on the fish body when it is administered *** study investigated the cyto-genotoxic effects on erythrocytes and histo-architectural malformations in the liver and kidneys of stinging catfish(Heteropneustes fossilis)in relation to Enrocip plus use as an amalgamated antibiotic *** experimental fish with an initial average weight of 17.38±1.94 g were divided into four treatment groups with antibiotic doses:according to the recommendation of the manufacturer 0.167 mg/ml Enrocip plus was used as a standard dose(x)and it was treated as T3,while 0%of the standard dose(0×mg/ml),1/2×(0.083 mg/ml),and 2×(0.333 mg/ml)were treated as T1,T2 and T4,respectively for a period of 30 *** observed erythrocyte cellular deformities(ECD)were twin,tear-drop,serrated,tail budded and de-membranated cells,whereas the erythrocyte nuclear deformities(END)were a nuclear bridge,bi-nucleus,nuclear termination,karyopyknosis,and micronucleus at different concentrations of Enrocip *** ECD and END percentages experienced the interaction of antibiotic dose and exposure time,and were significantly different(P<0.01).Significant changes in hepatocytes,mild to severe necrosis,vacuole formation,and hepatopancreas damage were also observed in the liver of the treated fish whereas highly degraded renal tubules and hematopoietic tissue,glomerular occlusion,and vacuolation were evident in the *** current investigation fully emphasizes the adverse effects of amalgamated antibiotics on the cytogenotoxicity and the histomorphology of the kidneys and liver of ***,the use of an amalgamated antibiotic in aquaculture must be carefully evaluated.

关键词： Antibiotic Cytotoxicity Genotoxicity Histomorphological defects Stinging catfish

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Assessment of genetic diversity, detection of strain-specific single nucleotide polymorphisms and identification of the Bangladesh and Vietnam strain of Channa striata by PCR-RFLP analysis of the mitochondrial COI gene fragment

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Aquaculture and Fisheries 2022年第3期7卷 287-295页

作者： Md Samsul Alam Foyjunnesa Projna Mst.Sadia Zafrin Rituparna Das mohd golam quader khan Department of Fisheries Biology and Genetics Bangladesh Agricultural UniversityMymensingh2202Bangladesh

Striped snakehead(Channa striata)has enormous fisheries and aquaculture importance due to its high market demand and food ***,Vietnam strain of the species has been introduced to Bangladesh for ***,it is essential to develop a reliable molecular technique that can distinguish the Bangladesh strain from the Vietnam ones as biological invasion by feral exotic fish to the wild may cause enduring damage to ecosystem and species *** clips from snakehead samples were collected from six locations and total DNA was *** cytochrome oxidase c 1(COI)gene fragment was amplified by PCR using the Fish F1/R1 primer set and sequenced for analysis of intra-and inter-strain genetic diversity and detection of single nucleotide polymorphism to distinguish the Vietnam strain from Bangladesh ones.A total of 15 haplotypes were identified with an overall haplotype diversity of *** median-joining network created based on COI gene sequences clearly differentiated the Bangladesh strain from the strain of Vietnamese origin by a total of 18 single nucleotide *** In silico restriction analysis revealed AluI was the most suitable restriction enzyme that produced diagnostic restriction profiles of the two strains of ***-RFLP analysis by the restriction enzyme AluI created distinguishing restriction profile similar to that in the In silico *** work illustrates a simple,reliable and inexpensive molecular tool for the identification of the Bangladesh and Vietnam strains of *** by one-step PCR and restriction of the COI gene fragment.

关键词： COI Channa striata snakehead Genetic diversity SNP PCR-RFLP

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Microplastic Impacts on Greenhouse Gases Emissions in Terrestrial Ecosystems

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Open Journal of Soil Science 2024年第1期14卷 64-80页

作者： Tazeen Fatima khan M. M. golam Rabbani Department of Soil Water and Environment University of Dhaka Dhaka Bangladesh Lancaster Environment Centre University of Lancaster Lancaster UK

Microplastics can influence global climate change by regulating the emissions of greenhouse gases from different ecosystems. The effects of microplastics in terrestrial ecosystems are still not well studied particularly greenhouse gases emissions. Thus, we conducted a laboratory experiment over a period of 90 days with two types of microplastics (differing in their chemical structure), high density polyethylene (HDPE) and low density polyethylene (LDPE), which were applied to the soil at a rate of 0% to 0.1% (w/w). The overarching aim was to investigate the effects of microplastic type, microplastic concentration and days of exposure on greenhouse gases emissions. We also used original and artificially weathered microplastics (the same HDPE and LDPE) to make a comparison of greenhouse gases emissions between the original microplastics treated soils and the soils treated with weathered microplastics. Our findings showed that HDPE and LDPE microplastics significantly increased the emissions of greenhouse gases from the soil than that of the control soils. Emissions were increased with the increases in the level of microplastic in the soil. The weathered microplastic emitted greater quantity of greenhouse gases compared to that of the original microplastics. In contrast to a low initial emission quantity, the emissions were gradually increased at the termination of the experiment. Our experiment on the emissions of greenhouse gases from the soil vis-à-vis microplastic additions indicated that the microplastic increased the emissions of greenhouse gases in terrestrial ecosystems, and pervasive microplastic impacts may have consequences for the global climate change. Greenhouse gases emissions from the soil not only depend on the type and concentration of the microplastic, but also on the days of exposure to the microplastic.

关键词： Microplastic Climate Change Greenhouse Gas Type Concentration

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Effect of Trimetazidine on Functional Capacity in Patient with Ischaemic Cardiomyopathy (TOFCAPI)

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International Journal of Clinical Medicine 2024年第2期15卷 55-67页

作者： Mohsin Ahmed golam Morshed Mahmood Hasan khan Md. Arifur Rahman Muhammed Aminur Razzaque Shariful Islam Sayeedur Rahman khan Chowdhury Md. Kudrat-E-Khuda Salahuddin Anis Shiblee Md. Habibur Rahman Department of Cardiology National Institute of Cardiovascular Diseases Dhaka Bangladesh Department of Cardiology Government Employee’s Hospital Dhaka Bangladesh Department of Cardiology Delta Hospital Ltd. Dhaka Bangladesh IPDI Foundation Dhaka Bangladesh

Objective: This study aimed to evaluate the efficacy of trimetazidine on exercise capacity via a six-minute walk test in patients with ischaemic cardiomyopathy and also evaluate the effect of trimetazidine on left ventricular function via echocardiography in the same population. Methods: This prospective observational study, conducted at the National Institute of Cardiovascular Diseases in Dhaka, Bangladesh, enrolled 200 patients with ischaemic cardiomyopathy and a depressed left ventricular ejection fraction (LVEF Results: In this study (n = 200) of ischaemic cardiomyopathy patients, the mean age was 58 years, with 76% of the patients being male. All study subjects received GDMT (Guideline-Directed Medical Therapy) for angina and heart failure. Those who received the modified released form of trimetazidine developed lesions during the 1st and 2nd follow-ups, during which the LVEF, LVIDd, and six-minute walk distance significantly improved (p Conclusion: The findings of the present study demonstrated that the addition of modified-release trimetazidine to GDMT can improve exercise capacity and left ventricular function in patients with ischaemic cardiomyopathy.

关键词： Bangladesh Heart Failure Exercise Capacity Trimetazidine Ischaemic Cardiomyopathy

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Rural Resilience: A Comprehensive Study on Water Supply, Sanitation, Disease Patterns, and Hygiene Practices in Munshiganj, Bangladesh

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Journal of Environmental Protection 2024年第1期15卷 63-75页

作者： Jubayer Hoque Rifat Islam Md. Mustafizur Rahman Md. golam Rabbani Md. Selim Reja Saifur Rahman Soykat Saim Raiyan Md. Shafiqul Ahsan Emon Sakil khan Department of Environmental Science and Disaster Management Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh Department of Political Science Bangabandhu Sheikh Mujibur Rahman Science and Technology University GopalgnjBangladesh Department of Statistics Bangabandhu Sheikh Mujibur Rahman Science and Technology University Gopalgnj Bangladesh

This research project investigates the current status of water supply, sanitation, and hygiene practices in Munshiganj District, Bangladesh. Data collection involved a structured questionnaire and a reconnaissance survey. Findings reveal that 30% of individuals rely on surface water (hand-tube wells, rivers, and ponds), prioritized as canal > river > pond, while 70% depend on groundwater (subterranean electric motor, deep tube-well). Drinking water is generally sufficient, with 95% reporting adequacy throughout the year. About 45% use hand tube-well water, 28% use deep tube-well water, and 11% use supply tap water for various purposes. Bathing trends include underground water through electric motor > pond > hand tube-well water > river, while for cooking, the order is underground water through electric motor > pond > hand tube-well water > river. Toilet water supply ranks as supply tap water > hand tube-well water > deep tube-well water. Although sanitation awareness is high, some lack knowledge of good hygiene practices. After defecating, handwashing methods include soap, ash, soil, or water. Children’s waste disposal varies, with some discarding it in open areas. Approximately 40% suffer from diseases like Diarrhoea due to unsafe water, primarily affecting children and elders. Training exists, but a significant portion lacks sanitation education. Dry skin or exposure to cold water may cause temporary irritation. Local government involvement in sanitation efforts is less active compared to non-governmental organizations. Results emphasize the need to enhance community awareness of safe water supplies and sanitation practices. .

关键词： Water Supply Sanitation Practices Hygiene Awareness Groundwater Dependency Community Health Intervention

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Mainstreaming Decentralization and Collaboration in Disaster Risk Management:Insights from Coastal Bangladesh

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International Journal of Disaster Risk Science 2023年第3期14卷 382-397页

作者： Mohammad Abdul quader Amanat Ullah khan Md.Abdul Malak Matthieu Kervyn Department of Geography Earth System ScienceVrije Universiteit Brussel1050 BrusselsBelgium Department of Geography and Environment Jagannath UniversityDhaka 1100Bangladesh Department of Geography and Environment Dhaka UniversityDhaka 1000Bangladesh Department of Environmental Science Bangladesh University of ProfessionalsDhaka 1216Bangladesh

Bangladesh is renowned in disaster risk reduction(DRR)for active involvement of community people and local disaster management institutions in DRR *** study aimed to describe the disaster risk management(DRM)institutions and assess their functioning in six coastal unions across the three coastal zones of *** qualitative and quantitative research approaches were *** study focused on two key local institutions—the Union Disaster Management Committees(UDMCs)and the Cyclone Preparedness Program(CPP)—functioning at the union level in *** institutions have both horizontal and vertical collaborations with other ***,we argue that the UDMCs'external dependencies in their functioning indicate their limited financial and administrative autonomy,which is a barrier to successfully institutionalizing disaster *** results show that the CPP is the most successful program,markedly increasing the trust of the people in warning dissemination and evacuation efforts in the event of a *** the adoption of decentralized risk management systems has resulted in significant progress in increased rate of evacuation and reduced death rate and damage,lack of funding and equipment,limited coordination between institutions,lack of skilled and knowledgeable workforce,and inappropriate power structures may reduce the effectiveness of DRR activities prior to,during,and following disasters.

关键词： Coastal Bangladesh Cyclone preparedness program(CPP) Decentralization Disaster risk governance Institutional linkage Union disaster management committee(UDMC)

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A New Handover Management Model for Two-Tier 5G Mobile Networks

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Computers, Materials & Continua 2022年第6期71卷 5491-5509页

作者： Mohammad Arifin Rahman khan Mohammed golam Kaosar Mohammad Shorfuzzaman Kire Jakimoski Department of Computer Science and Engineering Bangladesh UniversityDhaka1207Bangladesh Discipline of IT Media and CommunicationsMurdoch UniversityPerthWA6150Australia Department of Computer Science College of Computers and Information TechnologyTaif UniversityTaif21944Saudi Arabia Faculty of Informatics AUE-FON UniversitySkopjeRepublic of North Macedonia

There has been an exponential rise in mobile data traffic in recent times due to the increasing popularity of portable devices like tablets,smartphones,and *** rapid rise in the use of these portable devices has put extreme stress on the network service providers while forcing telecommunication engineers to look for innovative solutions to meet the increased *** solution to the problem is the emergence of fifth-generation(5G)wireless communication,which can address the challenges by offering very broad wireless area capacity and potential cut-power *** application of small cells is the fundamental mechanism for the *** use of small cells can enhance the facility for higher capacity and ***,it must be noted that small cells deployment will lead to frequent handovers of mobile *** the importance of small cells in 5G,this paper aims to examine a new resource management scheme that can work to minimize the rate of handovers formobile phones through careful resources allocation in a two-tier ***,the resource management problem has been formulated as an optimization issue thatwe aim to overcome through an optimal *** find a solution to the existing problem of frequent handovers,a heuristic approach has been *** solution is then evaluated and validated through simulation and testing,during which the performance was noted to improve by 12%in the context of handover ***,this model has been observed to be more efficient as compared to the existing model.

关键词： Two-tier mobile networks small cell densification management of mobility handover cost average throughput power consumption

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e-antigen-negative chronic hepatitis B in Bangladesh

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Hepatobiliary & Pancreatic Diseases International 2008年第4期7卷 379-382页

作者： Nooruddin Ahmad Shahinul Alam golam Mustafa Abul Barkat Muhammad Adnan Rahat Hasan Baig Mobin khan Department of Hepatology Bangabandhu Sheikh Mujib Medical UniversityShahbagDhakaBangladesh

BACKGROUND:Bangladesh is a densely populated country where about 10 million people are chronically infected with hepatitis B virus(HBV).The aim of the present study was to evaluate the biochemical,virological and histological characteristics of HBeAg-negative chronic hepatitis B(CHB). METHODS:Patients were included in this study if they were chronically infected with HBV with detectable *** patients who were co-infected with human immunodeficiency virus,hepatitis delta virus or hepatitis C virus,and previously subjected to antiviral treatment,and those with hepatocellular carcinoma were *** study was conducted during the period of January 2001 to December *** this period 2617 patients with CHB were ***-positive cases were included to compare the *** them,237 cases underwent liver biopsy. RESULTS:2296 patients(87.7%)were male,with a mean age of 28.9±13.7 years.2375 patients(90.8%)had CHB,and 242(9.2%)were *** DNA levels were 7.6±1.5 copies/ml,ALT was 111.3±212.5 U/L,and AST was 91.5± 148.9 U/*** number of HBeAg-negative CHB cases was 1039(39.7%).HBeAg-negative patients with a lower DNA load were older,and they had more fibrotic changes in the liver than HBeAg-positive *** two groups did not differ in necroinflammatory activity,but the former had lower ALT and AST *** was more common in e-antigen-negative ***:e-antigen-negative CHB patients are older and have more hepatic fibrosis patients than HBeAg-positive patients,although they have similar necroinflammatory activity.

关键词： chronic hepatitis B Bangladesh e-antigen-negative

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Position statement of Hepatology Society, Dhaka, Bangladesh, on the management of acute variceal bleeding in a resource-limited setting

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iLIVER 2022年第4期1卷 205-208页

作者： Tanvir Ahmad Shahinul Alam Saiful Islam golam Azam Mahabubul Alam SKM Nazmul Hasan golam Mustafa Motahar Hossain MdAkmat Ali Mobin khan Kurmitola General Hospital DhakaBangladesh Department of Hepatology BSMMU General SecretaryHepatology SocietyDhakaBangladesh Department of Hepatology BSMMUBangladesh Department of Gastrointestinal-Hepatobiliary and Pancreatic Disorders(GHPD) BIRDEM HospitalBangladesh Department of Hepatology Shahid Syed Nazrul Islam Medical CollegeKishoregonjBangladesh Square Hospital Bangladesh Addin Medical College DhakaBangladesh

Variceal bleeding is one of the important signs of decompensation in patients with cirrhosis of the *** is always a medical emergency and sometimes results in *** year many patients die due to acute bleeding *** outcome depends on bleeding and its complications as well as the severity of the underlying liver *** volume resuscitation,administration of antibiotics and vasoactive drugs,and early endoscopic therapy prevent rebleeding and *** living in rural areas are first referred to a district hospital from the Upazila health complex for any medical ***,commencing the resuscitation process as well as administration of the vasoactive drug(terlipressin)at the first attending hospital before being referred to a higher center will decrease the mortality in patients presenting with acute variceal bleeding.

关键词： Variceal bleeding Resource-limited setting Terlipressin Cirrhosis Primary care physician

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Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi(Ebenaceae)

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Asian Pacific Journal of Tropical Biomedicine 2016年第5期6卷 410-417页

作者： Muhammad Ali khan Mahbubur Rahman Nazmul Sardar Saiful Islam Arman Badrul Islam Jahangir Alam khandakar Mamunur Rashid golam Sadik AHM Khurshid Alam Department of Pharmacy Bangabandhu Sheikh Mujibur Rahman Science and Technology University Department of Pharmacy University of Rajshahi Drugs and Toxins Research Division Bangladesh Council of Scientific and Industrial Research Product Development and Validation Department Square Pharmaceutical Limited Laboratory of Genetics Graduate School of BiostudiesKyoto University

Objective: To investigate the comparative effects of Diospyros blancoi(Ebenaceae)leaves(DBL), root bark(DBRB) and stem bark(DBSB) on free radicals and ***: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, ***: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed(95.760 ± 0.343)% and(67.460 ± 2.641)%scavenging with IC50of(3.10 ± 0.17) and(50.00 ± 3.11) mg/m L, respectively. The IC50 values of standard butylated hydroxytoluene and catechin(CA) for 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radicals were(8.50 ± 0.25) and(75.00 ± 0.14) mg/m L,respectively suggesting that DBSB had a significant(P DBRB > CA > ***, the phenolic [(139.91 ± 3.924) mg gallic acid equivalent/g] and flavonoid contents[(412.00 ± 16.70) mg catechin equivalent/g)] of DBSB were higher than that of other extracts. In addition, the DBSB showed the moderate cytotoxic and anticancer ***: Our results indicate that Diospyros blancoi stem bark had the significant highest antioxidant and free radical scavenging properties as well as moderate anticancer ***, we assume that the anticancer activity of this plant can be, at least in part, attributed to its content in phenolic compounds as well as its significant free radical scavenging properties.

关键词： Diospyros blancoi Free radicals Polyphenols Antioxidant Cytotoxicity Anticancer

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