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Specific and cross-reactive immune response against Mycobacterium tuberculosis antigens in mice immunized with proteoliposomes from Mycobacterium bovis BCG

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Asian Pacific Journal of Tropical Biomedicine 2017年第3期7卷 188-192页

作者： Nadine Alvarez DaymíSerpa Ramlah Kadir Yanely Tirado Reinier Borrero Sonsire Fernández Rubén Cabrera Yolanda Valdes Caridad Zayas Reinaldo Acevedo Luis Izquierdo María Elena Sarmiento mohd-nor norazmi JoséLuis Pérez Armando Acosta Finlay Institute School of Health Sciences University Sains Malaysia Institute for Research in Molecular Medicine University Sains Malaysia

Objective: To characterize the immunogenicity and the induction of cross-reactive responses against Mycobacterium tuberculosis(M. tuberculosis) of a proteoliposome(PL)from Mycobacterium bovis Bacillus Calmette–Guerin(BCG) with and without alum hydroxide(AL) as adjuvant(PLBCG-AL and PLBCG, respectively) in BALB/c ***: BALB/c mice were inoculated with phosphate buffer solution, BCG, PLBCG and PLBCG-AL. The humoral immunogenicity was determined by ELISA [immunoglobulin G(Ig G), Ig G1 and Ig G2a] and the cellular immunogenicity was evaluated in vivo by delayed type hypersensitivity. The humoral cross-reactive response against M. tuberculosis was determined by Western ***: Sera from animals immunized with PLBCG-AL and PLBCG showed significant increase in specific total Ig G and Ig G1 antibodies and the presence of cross-reactive antibodies against M. tuberculosis antigens, which were more intense with the use of alum as adjuvant. Mice immunized with PLBCG and PLBCG-AL also showed a specific cellular response in ***: The cellular and humoral immunogenicity of PLBCG and the capacity to induce cross-reactive responses against M. tuberculosis is in agreement with the protective capacity previously demonstrated by this vaccine candidate and supports the continuation of its evaluation in further stages.

关键词： BCG Immunogenicity Mycobacterium tuberculosis Proteoliposomes

Role of toll like-receptor 2 in inflammatory activity of macrophage infected with a recombinant BCG expressing the C-terminus of merozoite surface protein-1 of Plasmodium falciparum

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Asian Pacific Journal of Tropical Biomedicine 2018年第7期8卷 333-339页

作者： nor Munirah Zakaria Rapeah Suppian norazmi mohd nor nor Fazila Che Mat School of Health Sciences Health Campus Universiti Sains Malaysia

Objective: To investigate the role of toll-like receptor 2(TLR2) in inflammatory activity of macrophage infected with the recombinant Mycobacterium bovis bacillus Calmette-Guerin(rBCG). Methods: Mouse macrophage cell line J774 A.1 was infected with Mycobacterium bovis bacillus Calmette-Guerin(BCG) and rBCG cultures for 48 h in the presence or absence of 10 μg/mL of TLR2 inhibitor. Untreated macrophages were used as a negative control while lipopolysaccharide-stimulated macrophages were used as a positive control. The ability of the macrophage to engulf the BCG and rBCG in the absence or presence of TLR2 inhibitor was assessed using a phagocytic assay, while the production of inflammatory cytokines and nitric oxide by the infected macrophages was evaluated using ELISA and Griess reagent method, while the expression of the inducible nitric oxide synthase was determined using Western blot analysis. Results: The results showed that blocking TLR2 function reduced the phagocytic activity, nitric oxide production and proinflammatory cytokine secretion such as TNF-α, IL-1β and IL-12 p40 as well as inducible nitric oxide synthase expression in the infected macrophages. These data showed the importance of TLR2 in the activation of macrophages following BCG and r BCG infections. Conclusions: Through exploring the immunological mechanism which underlies the protection conferred by the candidate vaccine, this study will improve our understanding of the vaccine candidate's mechanism to protect the host from malaria infection.

关键词： Macrophages Mycobacterium bovis bacillus Calmette-Guerin Plasmodium falciparum Proinflammatory cytokine Toll-like receptor 2

Influence of contact pressure and sliding speed dependence on the tribological characteristics of an activated carbonepoxy composite derived from palm kernel under dry sliding conditions

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Friction 2019年第3期7卷 227-236页

作者： Dayang nor Fatin MAHMUD mohd Fadzli Bin ABDOLLAH nor Azmmi Bin MASRIPAN noreffendyTAMALDIN Hilmi AMIRUDDIN Faculty of Mechanical Engineering Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian TunggalMelaka76100Malaysia Centre for Advanced Research on Energy Universiti Teknikal Malaysia MelakaHang Tuah JayaDurian TunggalMelaka76100Malaysia

The objective of this work is to investigate the influence of contact pressure and sliding speed on the coefficient of friction and wear of an activated carbon-epoxy composite derived from palm kernel under dry sliding conditions.A wear mode map approach was employed to identify the transitions from mild to severe wear of the *** dry sliding test was executed by utilizing a ball-on-disc tribometer at different contact pressures and sliding speeds with a constant sliding distance and operating *** results showed that,regardless of the sliding speed,the friction coefficient and wear rate of the composite increased drastically when a critical limit of contact pressure is *** for the sliding speed,both the friction coefficient and wear rate increased first and thereafter decreased at a higher speed of 500 rpm.A wear mode map is proposed to classify the boundary from mild to severe wear *** predominant wear failures identified include micro-crack,fine grooves,debonding,delamination,debris,broken carbon,and fracture.

关键词： activated carbon agriculture waste palm kernel friction and wear pressure and speed

A mouse model of weight-drop closed head injury:emphasis on cognitive and neurological deficiency

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Neural Regeneration Research 2016年第4期11卷 630-635页

作者： Igor Khalin nor Laili Azua Jamari Nadiawati Bt Abdul Razak Zubaidah Bt Hasain mohd Asri bin mohd nor mohd Hakimi bin Ahmad Zainudin Ainsah Bt Omar Renad Alyautdin Faculty of Medicine and Defence Health National Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Chemistry Department Centre for Defence Foundation StudiesNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Department of Civil Engineering Faculty of EngineeringNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Centre for Research and Innovation Management National Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Scientific Centre for Expertise of Medical Application Products Petrovsky BlvdMoscowRussia

Traumatic brain injury（TBI） is a leading cause of death and disability in individuals *** a clinically relevant TBI model in small-sized animals remains fairly *** good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and *** this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal *** found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male *** disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after *** from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI.

关键词： nerve regeneration traumatic brain injury neurological severity score passive avoidance weightdrop injury model C57BL/6 mice neural regeneration

Recovery of bird communities following the construction of a large-scale hydroelectric dam

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Ecological Processes 2021年第1期10卷 408-417页

作者： Affan Nasruddin-Roshidi Mohammad Saiful Mansor nor Adibah Ismail Ehwan Ngadi mohd Izzat-Husna Shahril Mod Husin Farah Shafawati mohd-Taib Rahmah Illias Shukor Md nor Department of Biological Sciences and Biotechnology Faculty of Science and TechnologyUniversiti Kebangsaan Malaysia43600 BangiSelangorMalaysia Kolej GENIUS Insan Universiti Sains Islam MalaysiaBandar Baru Nilai71800 NilaiNegeri SembilanMalaysia TNB Research Sdn Bhd No.1Kawasan Institusi PenyelidikanJalan Ayer Itam43000 KajangSelangorMalaysia Department of Wildlife and National Parks(PERHILITAN) Km.10Jln Cheras56100 Kuala LumpurWilayah PersekutuanMalaysia.

Background:Habitat degradation is known to have a major impact on the composition of bird communities,yet how these communities recover following such disturbance is less *** study examined bird community changes from pre-logging to recovery over the course of habitat disturbance caused by the development of the Hulu Terengganu Hydroelectric Dam Project in Peninsular Malaysia,between 2007 and *** surveys were conducted using point count observations and mist netting in the dam area from the prelogging phase until the operation ***:It was observed that while bird species significantly declined after large-scale habitat clearance between the pre-logging and construction phases,they showed positive signs of recovery from the inundation to operation *** findings indicate that the bird community is still recovering,and the permanent loss of habitat required by most of the original species has not occurred,as evidenced by *** species composition differed across phases due to varying habitat *** turnover rate and immigration rate(recolonisation and newly recorded species)were higher between the construction and operation *** was also observed that insectivorous birds were more heavily affected than others by changes to the landscape,which highlights the versatility,survivability and tolerance of certain species to extreme disturbance and habitat ***:Although the operation phase showed an incremental change in bird species richness due to recolonisation and newly recorded species,this value remains far from that of the pre-logging *** predict that bird species recovery will continue to increase for some time before reaching a plateau among the newly created islands,reservoir and catchment area of the dam.

关键词： Dam construction Extinction Habitat recovery Recolonisation Turnover

Preparation and Properties of Poly(vinyl alcohol)/Chitosan Blend Bio-nanocomposites Reinforced by Cellulose Nanocrystals

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Chinese Journal of Polymer Science 2014年第12期32卷 1620-1627页

作者： Susan Azizi Mansor Bin Ahmad nor Azowa Ibrahim mohd Zobir Hussein Farideh Namvar Department of Chemistry Faculty of Science University Putra Malaysia Materials Synthesis and Characterization Laboratory Institute of Advanced Technology University Putra Malaysia Institute of Tropical Forestry and Forest Products Universiti Putra Malaysia Mashhad Branch Islamic Azad University

The aim of this paper is to report the effect of the addition of cellulose nanocrystals（CNCs） on the mechanical, thermal and barrier properties of poly（vinyl alcohol）/chitosan（PVA/Cs） bio-nanocomposites films prepared through the solvent casting process. The characterizations of PVA/Cs/CNCs films were carried out in terms of X-ray diffraction（XRD）, transmission electron microscopy（TEM）, scanning electron microscopy（SEM）, thermogravimetric analysis（TGA and DTG）, oxygen transmission rate（OTR）, and tensile tests. TEM and SEM results showed that at low loading levels, CNCs were dispersed homogenously in the PVA/Cs matrix. The tensile strength and modulus in films increased from 55.1 MPa to 98.4 MPa and from 395 MPa to 690 MPa respectively, when CNCs content went from 0 wt% to 1.0 wt%. The thermal stability and oxygen barrier properties of PVA/Cs matrix were best enhanced at 1.0 wt% of CNCs loading. The enhanced properties attained by incorporating CNCs can be beneficial in various applications.

关键词： Bio-nanocomposite Poly(vinyl alcohol)/chitosan Cellulose nanocrystals Mechanical properties Thermal properties.

A Preliminary Genetic Investigation of Rastrelliger Kanagurta Based on Random Amplified Polymorphic DNA and Mitochondrial ND2 Gene

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湿地科学 2008年第4期6卷 518-525页

作者： Siti Azizah mohd nor Abu Talib A mohd Ghows M A Samsudin B Aquaculture Research Group School of Biological Sciences University Sains Malaysia 11800 Minden Penang Malaysia Fisheries Research Institute 11900 Batu Maung Penang Malaysia

In a preliminary investigation, Random Amplified Polymorphic DNA (RAPD) analysis and partial mitochondrial ND2 gene sequencing were conducted to study the genetic variation of the Indian mackerel, Rastrelliger kanagurta along a 450 km stretch of its distribution on the west coast of Peninsular Malaysia. A total of 53 individuals from 6 populations were analyzed using 4 RAPD primers and a sub-sample of 15 individuals was chosen for sequencing of partial ND2 gene. Comparison between the 2 markers revealed genetic structuring in the RAPD results but genetic homogeneity for ND2 gene. Based on the former there may be at least 2 genetically differentiated groups of Rastrelliger kanagurta along this stretch.

关键词：基因 DNA分析分析方法生物技术水生生物

Multi-valued interval neutrosophic linguistic soft set theory and its application in knowledge management

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CAAI Transactions on Intelligence Technology 2020年第3期5卷 200-208页

作者： nor Liyana Amalini mohd Kamal Lazim Abdullah Ilyani Abdullah Muhammad Saqlain Faculty of Ocean Engineering and Informatics Universiti Malaysia Terengganu21030 Kuala NerusTerengganuMalaysia Department of Mathematics Lahore Garrison UniversityDHA Phase VISector-CLahorePakistan

This study proposed the concepts of a multi-valued interval neutrosophic linguistic soft set(MVINLSS)by integrating the concepts of multi-valued interval neutrosophic soft set and linguistic *** is presented as it can deal with ambiguous and uncertain information in decision making which is characterised by linguistic *** proposed set amalgamates quantitative assessment with the qualitative assessment which can solve complex problems with ambiguity,uncertainty,and *** can be an effective tool to describe the real decision-makers’opinions and reflect their ***,the authors propose the basic operational rules of ***,they define a multi-valued interval neutrosophic linguistic soft weighted arithmetic averaging *** work proposed a multi-criteria decision-making(MCDM)method which considers different priority levels of criteria and the criteria values take the form of multi-valued interval neutrosophic linguistic soft ***,the proposed MCDM method is applied to the knowledge management case,considering 11 criteria.

关键词： valued qualitative integrating

Distribution of Chironomidae (Insecta: Diptera) in polluted rivers of the Juru River Basin, Penang, Malaysia

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Journal of Environmental Sciences 2010年第11期22卷 1718-1727页

作者： Salman A. Al-Shami Che Salmah Md Rawi Abu HassanAhmad Siti Azizah mohd nor School of Biological Sciences Universiti Sains Malaysia Centre for Marine and Coastal Studies Universiti Sains Malaysia

The influence of physical and chemical parameters on the abundance and diversity of chironomids was studied in six rivers with moderate to highly polluted water in the Juru River Basin. The rivers： Ceruk Tok Kun （CTKR） as reference site, and polluted rivers of Pasir （PR）, Juru （JR）, Permatang Rawa （PRR）, Ara （AR） and Kilang Ubi （KUR） were sampled over a period of five months （November 2007–March 2008）. Nine chirnomid species： Chironimus kiiensis, C. javanus, Polypedilum trigonus, Microchironomus sp., Dicrotendipes sp., Tanytarsus formosanus, Clinotanypus sp., Tanypus punctipennis and Fittkauimyia sp. were identified. Assessment of their relationships with several environmental parameters was performed using the canonical correspondence analysis （CCA）. Tanytarsus formosanus was the most dominant in the relatively clean CTKR and moderately polluted JR with mean densities of 19.66 and 25.32 m 2 , respectively while C. kiiensis was abundant in more polluted rivers. Tanytarsus formosanus, Dicrotendipes sp. and Microchironomus sp. were grouped under moderate to high water temperature, total organic matter （TOM）, total suspended solids （TSS）, velocity, pH, phosphates and sulphates. However, Tanypus punctipennis, Fittkauimyia sp., and Clinotanypus sp. were associated with high contents of river sediment such as TOM, Zn and Mn and water ammonium-N and nitrate-N and they were associated with higher dissolved oxygen （DO） content in the water. Chironomus kiiensis, C. javanus and P. trigonus showed positive relationships with TOM, ammonium-N and nitrate-N as well as trace metals of Zn, Cu and Mn. These three species could be considered as tolerant species since they have the ability to survive in extreme environmental conditions with low DO and high concentrations of pollutants. Based on the water parameter scores in all rivers, the highest diversity of chironomid larvae was reported in CTKR. With higher concentrations of organic and/or inorganic pollutants as reported in PPR, K

关键词： chironomid larvae Juru River physicochemical parameters canonical correspondence analysis