A mouse model of weight-drop closed head injury:emphasis on cognitive and neurological deficiency

作     者：Igor Khalin Nor Laili Azua Jamari Nadiawati Bt Abdul Razak Zubaidah Bt Hasain Mohd Asri bin Mohd Nor Mohd Hakimi bin Ahmad Zainudin Ainsah Bt Omar Renad Alyautdin 

作者机构：Faculty of Medicine and Defence HealthNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Chemistry DepartmentCentre for Defence Foundation StudiesNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Department of Civil EngineeringFaculty of EngineeringNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Centre for Research and Innovation ManagementNational Defence University of MalaysiaKem Sungai BesiKuala LumpurMalaysia Scientific Centre for Expertise of Medical Application ProductsPetrovsky BlvdMoscowRussia 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2016年第11卷第4期

页      面：630-635页

核心收录：

学科分类：1002[医学-临床医学] 100205[医学-精神病与精神卫生学] 10[医学] 

基　　金：supported by a grant from the Ministry of Higher Education of Malaysia No.RAGS/2013/UPNM/SKK/01/2 

主　　题：nerve regeneration traumatic brain injury neurological severity score passive avoidance weightdrop injury model C57BL/6 mice neural regeneration 

摘      要：Traumatic brain injury（TBI） is a leading cause of death and disability in individuals *** a clinically relevant TBI model in small-sized animals remains fairly *** good screening of potential therapeutics,which are effective in the treatment of TBI,animal models of TBI should be established and *** this study,we established mouse models of closed head injury using the Shohami weight-drop method with some modifications concerning cognitive deficiency assessment and provided a detailed description of the severe TBI animal *** found that 250 g falling weight from 2 cm height produced severe closed head injury in C57BL/6 male *** disorders in mice with severe closed head injury could be detected using passive avoidance test on day 7 after *** from this study indicate that weight-drop injury animal models are suitable for further screening of brain neuroprotectants and potentially are similar to those seen in human TBI.