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Successful liver transplantation for acute sickle cell intrahepatic cholestasis: A case report and review of the literature

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World Journal of Hepatology 2020年第3期12卷 108-115页

作者： Motasem Alkhayyat mohannad abou saleh Mohammad Zmaili Vedha Sanghi Tavankit Singh Carol Rouphael C Roberto Simons-Linares Carlos Romero-Marrero William D Carey Christina C Lindenmeyer Department of Internal Medicine Cleveland ClinicClevelandOH 44195United States Digestive Disease&Surgery Institute Department of GastroenterologyHepatology&NutritionCleveland ClinicClevelandOH 44195United States

BACKGROUND Sickle cell hepatopathy(SCH)is an inclusive term referring to any liver dysfunction among patients with sickle cell *** sickle cell intrahepatic cholestasis is one of the rarest and most fatal presentations of *** present the 23rd reported case of liver transplantation(LT)for SCH;a rare case of acute sickle cell intrahepatic cholestasis managed with LT from a hepatitis C virus(HCV)nucleic acid amplification test positive *** SUMMARY A 29-year-old male with a past medical history of sickle cell disease presented with vaso-occlusive pain *** examination,he had jaundice and a soft,nontender *** he was alert and fully oriented;within 24 h he developed new-onset *** evaluation was notable for hyperbilirubinemia,leukocytosis,anemia,thrombocytopenia,acute kidney injury and elevated international normalized ratio(INR).Imaging by ultrasound and computed tomography scan suggested a cirrhotic liver morphology with no evidence of biliary ductal *** patient was diagnosed with acute sickle cell intrahepatic cholestasis after excluding competing etiologies of acute liver *** underwent LT from an HCV nucleic acid amplification test positive donor 9 d after initial *** liver explant was notable for widespread sinusoidal dilatation with innumerable clusters of sickled red blood cells and *** postoperative day 3,HCV RNA was detectable in the patient's peripheral blood and anti-HCV therapy with glecaprevir/pibrentasvir was initiated on postoperative day *** subsequently achieved sustained virologic response after completing 3 mo of therapy and has been followed clinically for 12 mo *** This case highlights the utility of LT as a viable treatment option for acute sickle cell intrahepatic cholestasis.

关键词： Case report Sickle cell hepatopathy Acute intrahepatic cholestasis Liver transplant Hepatitis C virus Post-operative surveillance

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Implications of artificial intelligence in inflammatory bowel disease: Diagnosis, prognosis and treatment follow up

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Artificial Intelligence in Gastroenterology 2021年第3期2卷 85-93页

作者： Ashraf Almomani Asif Hitawala Mohammad Abureesh Thabet Qapaja Dana Alshaikh Mohammad Zmaili mohannad abou saleh Motasem Alkhayyat Department of Internal Medicine Cleveland Clinic Fairview HospitalClevelandOH 44111United States Department of Internal Medicine Staten Island University HospitalNew York CityNY 10305United States Department of Internal Medicine Cleveland Clinic FoundationClevelandOH 44195United States School of Medicine Mutah UniversityAlkarak 61710Jordan Department of Gastroenterology and Hepatology Cleveland Clinic FoundationClevelandOH 44195United States

Driven by the tremendous availability of data,artificial intelligence(AI)using deep learning has emerged as a breakthrough computer technology in the last few decades and has recently been acknowledged by the Task Force on AI as a golden opportunity for *** its ability to understand,learn from and build on non-linear relationships,AI aims to individualize medical care in an attempt to save time,cost,effort and improve patient’s *** has been applied in multiple medical fields with substantial progress made in gastroenterology mainly to facilitate accurate detection of pathology in different disease processes,among which inflammatory bowel disease(IBD)seems to drag significant attention,specifically by interpreting imaging studies,endoscopic images and videos and-to a lesser extent-disease ***,models have been built to predict IBD occurrence,flare ups,persistence of histological inflammation,disease-related structural abnormalities as well as disease *** this article,we will review the applications of AI in IBD in the present medical literature at multiple points of IBD timeline,starting from disease prediction via genomic assessment,diagnostic phase via interpretation of radiological studies and AI-assisted endoscopy,and the role of AI in the evaluation of therapy response and prognosis of IBD patients.

关键词： Artificial intelligence Machine learning Inflammatory bowel disease

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case of familial hyperlipoproteinemia type Ⅲ hypertriglyceridemia induced acute pancreatitis: role for outpatient apheresis maintenance therapy

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World Journal of Gastroenterology 2017年第40期23卷 7332-7336页

作者： mohannad abou saleh Emad Mansoor Gregory S Cooper Department of Internal Medicine University Hospitals Cleveland Medical Center Case Western Reserve University Division of Gastroenterology and Liver Disease Department of Internal Medicine University Hospitals Cleveland Medical Center Case Western Reserve University

Hypertriglyceridemic pancreatitis(HTGP) accounts for up to 10% of acute pancreatitis presentations in nonpregnant individuals and is the third most common cause of acute pancreatitis after alcohol and gallstones. There are a number of retrospective studies and case reports that have suggested a role for apheresis and insulin infusion in the acute inpatient setting. We report a case of HTGP in a male with hyperlipoproteinemia type Ⅲ who was treated successfully with insulin and apheresis on the initial inpatient presentation followed by bi-monthly outpatient maintenance apheresis sessions for the prevention of recurrent HTGP. We also reviewed the literature for the different inpatient and outpatient management modalities of HTGP. Given that there are no guidelines or randomized clinical trials that evaluate the outpatient management of HTGP, this case report may provide insight into a possible role for outpatient apheresis maintenance therapy.

关键词： Apheresis Pancreatitis Plasmapheresis Outpatient Hypertriglyceridemia

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CO_(2)utilization in syngas conversion to dimethyl ether and aromatics:Roles and challenges of zeolites-based catalysts

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Journal of Energy Chemistry 2023年第4期79卷 418-449页

作者： Ali A.Al-Qadri Galal A.Nasser Haruna Adamu Oki Muraza Tawfik A.saleh Department of Chemical Engineering King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia Interdisciplinary Research Center for Hydrogen and Energy Storage(IRC-HES) King Fahd University of Petroleum&MineralsDhahran 31261Saudi Arabia Department of Environmental Management Technology and Department of ChemistryAbubakar Tafawa Balewa UniversityBauchiNigeria Department of Chemistry King Fahd University of Petroleum and MineralsDhahran 31261Saudi Arabia

Several studies have proven a strong correlation between global warming and CO_(2)***,38 billion tons of CO_(2)are approximately emitted into the *** CO_(2)via chemical conversion to clean fuels and value-added aromatics can substantially contribute to controlling the *** the thermodynamic and environmental limitations of hydrogenation of CO_(2)alone to value-added aromatics and fuels,CO_(2)utilization has currently emerged as a promising and practical approach for the production of fuels and aromatics with simultaneous utilization of both CO and CO_(2)*** such,the approach is economically ***_(2)could be converted directly to fuels by the hydrogenation process or as a part of a syngas *** ether(DME)is a clean fuel with a higher energy density,which could be used as a substituent for several fuels such as *** the same vein,value-added aromatics such as benzene,toluene,and xylene(BTX)can be produced from a similar ***,we report a review that collects the most recent studies for the conversion of CO_(2)to DME and aromatics via zeolite-based bifunctional *** highlighted the main routes for producing DME and aromatics,as well as thoroughly discussed the conducted studies on CO_(2)hydrogenation and CO_(2)-rich syngas utilized as feedstock for conversion to DME and *** CO_(2)hydrogenation mostly occurs through the methanol-mediated reaction route but is most often limited by low selectivity and catalyst deactivation,particularly in the utilization of CO_(2)alone for the reduction *** review takes an overview of the progress made so far and concluded by identifying the roles and challenges of zeolite-based catalysts for CO_(2)utilization and conversion to DME and ***,despite the incredible growth the field received in the last couple of years,however,many research challenges and opportunities associated with this process are still abou

关键词： Clean fuel DME Aromatics Bifunctional catalyst CO_(2)mitigation

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Two-stage procedure in the management of selected cases of keratoconus: clear lens extraction with aspherical IOL implantation followed by WFG-PRK

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International Journal of Ophthalmology(English edition) 2018年第11期11卷 1761-1767页

作者： Waleed abou Samra Tharwat Mokbel Mohammed Elwan Sameh saleh Ahmed Elwehidy Mohammed Iqbal Adel Ellayeh Department of Ophthalmology Faculty of Medicine Mansoura University Department of Ophthalmology Faculty of Medicine Sohag University

AIM： To assess the objective and subjective results of a two-stage procedure for management of keratoconus： clear lensectomy with aspherical intraocular lens（IOL） implantation followed by wave front-guided photorefractive keratotomy（WFG-PRK）.METHODS： This prospective interventional non-randomized study included patients aged 35 years old or more with grade I and II stable keratoconus, a clear visual axis, minimal corneal thickness（MCT） 420 μm or more and average keratometric reading（K） less than 54 diopter（D）. Refraction of all selected eyes should be-8.00 D sphere or more with less than-6.00 D cylinder and could be corrected two lines or more with spectacles or contact lenses. All studied eyes underwent a two-stage approach treatment： first refractive lens exchange and aspherical IOL implantation followed, after at least 3 mo, by WFGPRK. Pre and postoperative complete ophthalmological examination were performed. Topographical, visual and aberrometric results were recorded and evaluated during 6 mo follow up period. Moreover, patient satisfaction and other subjective outcomes were also ***： The 13 eyes of 11 patients diagnosed with stable keratoconus and aged from 39 to 49 y（42.4±6.2 y） were enrolled in the study. At baseline, 8 eyes had grade I and 5 eyes had grade II keratoconus. The manifest sphere was-10.3±4.2 D（ranged from-8.0 to-14.0 D） and the manifest cylinder was-4.2±1.2 D（ranged from-1.75 to-5.50 D）. After the two-stage procedure, sphere and cylinder reduced significantly to-0.43±0.22 D and-1.3±0.72 D respectively（P〈0.001）. There was also a highly significant improvement in the mean uncorrected distance visual acuity（UDVA） from logMAR 1.41±0.49 preoperatively to 0.51±0.16 postoperatively（P〈0.001） and the mean corrected distance visual acuity（CDVA） from 0.76±0.24 preoperatively to 0.49±0.13 after the operation（P〈0.001）. All aberrometric and mesopic vision parameters and most of the topographical indices demonstrated highly significant improveme

关键词： keratoconus clear lensectomy wave front guided photorefractive keratotomy

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Functional and anatomical evaluation of the effect of nepafenac in prevention of macular edema after phacoemulsification in diabetic patients

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International Journal of Ophthalmology(English edition) 2019年第3期12卷 387-392页

作者： Tharwat Mokbel Sameh saleh Mona Abdelkader Sherief E.El-khouly Waleed abou Samra Mohamed Mamdouh Mansoura Ophthlmic Center Faculty of Medicine Mansoura University

AIM: To evaluate the effect of prophylactic administration of nepafenac in prevention of macular edema occurring in diabetic patients after phacoemulsification and to investigate the correlation between optical coherence tomography(OCT) foveal thickness and multifocal electroretinogram(MF-ERG) ***: The study included two groups. Group 1 included 50 diabetic patients with senile cataract(50 eyes, 30 females, 20 males, aged 55±7 y) received nepafenac 0.1% eye drop. Group 2 included another 50 diabetic patients with senile cataract(50 eyes, 22 female, 28 males, aged 53.8±8 y) did not receive nepafenac. All patients were followed up for 3 mo postoperatively. OCT and MF-ERG were done preoperative and at 1 wk, 1, 2 and 3 ***: The mean foveal thickness was statistically significantly lower in Group 1. Five eyes in Group 2 developed clinical cystoid macular oedema(CMO)(10%), and no patients in Group 1 developed central macular thickening more than 50 μm. There were insignificant differences in MF-ERG amplitudes and latencies between the two groups except in the five eyes that developed CMO, there statistically significant reduction of MF-ERG amplitude with increase in foveal thickness. CONCLUSION: Perioperative nepafenac reduces the incidence of CMO following uncomplicated phacoemulsification significantly. Nepafenac has no side effects.

关键词： nepafenac macular edema cataract surgery diabetes optical coherence tomography multifocal electroretinogram

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Isolation and characterization of marine-derived actinomycetes with cytotoxic activity from the Red Sea coast

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Asian Pacific Journal of Tropical Biomedicine 2016年第8期6卷 651-657页

作者： Mohamed saleh Abdelfattah Mohammed Ismail Youssef Elmallah Usama Wahid Hawas Lamia Taha abou El-Kassema Mennat Allah Gamal Eid Marine Natural Products Research Unit Faculty of Science Helwan University Marine Chemistry Department Faculty of Marine Sciences King Abdulaziz University Pharmacognosy Department National Research Centre

Objective: To isolate and evaluate the cytotoxic activity of different actinomycetes species isolated from the Red Sea coast in Sharm el-Sheikh, ***: Forty actinomycetes strains were isolated from different sediments and seawater samples collected from the Red Sea coast in Egypt. Actinomycetes were recognized by morphological and microscopic examinations. Cell viability and cytotoxicity induced by the crude extracts on breast cancer cell lines MDA-MB-231 were assessed using methylene blue assay. The strains with promising cytotoxic activity were identified by sequencing and amplifying the 16 S r RNA genes. The antibacterial activities of the crude extracts were performed using Kirby–Bauer disc diffusion ***: The results indicated that five ethyl acetate extracts exhibited cytotoxicity towards breast cancer cell lines MDA-MB-231. The highest cytotoxic activity was found for the ethyl acetate extracts of EGY2 and EGY39. The isolate EGY3 was identified as a new Streptomyces species, while the actinomycete EGY22 was found to be a member of the genus Nocardiopsis sp. The crude extract of the isolate EGY8 showed slightly high antimicrobial activity against different test ***: The results of the present study reveal that marine sediments of the Red Sea are a potent source of novel species of actinomycetes. The isolates may be useful in discovery of novel bioactive compounds and an important step in the development of microbial natural product research.

关键词： Red Sea Breast cancer Actinomycetes 16S rRNA Cytotoxicity

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Black Holes in the Light of Field Theory and Quantum Mechanics

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Journal of High Energy Physics, Gravitation and Cosmology 2019年第3期5卷 612-622页

作者： Ahmad Tarhini Khalil abou-saleh Physics Department Faculty of Sciences Lebanese University Nabatieh Lebanon

The black hole is a region in space where things may fall into it but nothing can come out. We present a study of the physics of a black hole using a quantum field theory frame based on the WZW model in a suitable mathematical frame. Based on the Schwarzschild metric, we show the different regions of our universe with the present singularities. Then we introduce the calculation of a black hole mass using the perturbation theory. We further discuss Hawking radiation and its quantum mechanical implications. At some limits, the space time can represent a black hole with a singularity hidden by the horizon.

关键词： Black Holes Field Theory Schwarzschild Solution Hawking Radiation

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Does the scleral encircling band provide a protective effect against the progression of diabetic retinopathy?

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International Journal of Ophthalmology(English edition) 2019年第9期12卷 1408-1414页

作者： Hossam Youssef abouelkheir Amani E Badawi Amr M.Abdelkader Amr El-Kanishy Sameh saleh Waleed Ali abou Samra Manal Ali Kasem Tharwat Mokbel Mansoura Ophthalmic Center Faculty of Medicine Mansoura University

AIM: To evaluate the effect of scleral encircling bands on the development and progression of diabetic retinopathy(DR) in diabetic ***: The medical records of diabetic patients who underwent unilateral retinal detachment(RD) surgery using scleral buckle and encircling band were reviewed retrospectively. Both eyes of patients were included in the study: one eye in each patient had a scleral buckle with encircling band(the operated eye) and the other one is the non-operated eye. The demographic characters, duration of diabetes and period between surgery and the last recall visit were retrieved from each patient. All the cases underwent fundus photo and fluorescein angiography(when indicated) to confirm the DR ***: Totally 25 patients fulfilled the inclusion and the exclusion criteria were become eligible for the study. A total of 50 eyes of 25 patients were enrolled in this analysis. The mean period of time passed from surgery with encircling band and the last reassessment visit was 12.5±2 y. Even though DR could develop in the operated eyes, it was at a less degree of severity compared to the non-operated eyes of same patients(P=0.027).CONCLUSION: Scleral encircling bands have protective effects against the development and progression of DR.

关键词： diabetic retinopathy scleral encircling bands retinal detachment

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Solving Diffusion Time in Heterogeneous Microscale Rock Matrix by 3D Computations: Non-Fickian Dispersion Observed in Porous Media

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Journal of Geoscience and Environment Protection 2019年第12期7卷 42-52页

作者： Khalil abou-saleh Jalal Dweik Youssef Haidar Abbas Ghaddar Department of Physics Faculty of Sciences V Lebanese University Nabatieh Lebanon

Understanding and simulating the underlying microscopic physics of the rock matrix is very useful for determining macroscopic physical properties such as permeability. Matrix diffusion is an important transport parameter controlling the late-time behaviour of breakthrough curves (BTCs). We compute the memory function, implemented in the sink/source term of Mobile-immobile mass transfer by solving the matrix diffusion using a time diffusion random-walk approach. The diffusion is controlled by different parameters like the porosity, tortuosity, mobile-immobile interface and immobile domain cluster shapes. All these properties are investigated by X-ray microtomography that captures the main characteristics of matrix diffusion at three dimensions. We compare the memory function deduced from the field-scale tracer tests well with the computed memory function. Simulation results of the memory function appeared to be coherent with that measured from the tracer test for a large tortuosity value. Probably, the diffusion paths are longer, and they are controlled by the properties mentioned above. From a representative elementary volume of natural reservoirs studied here, we conclude that, microscale diffusion process in the immobile domain play a crucial role to better understand the non-Fickian dispersion measured from the tracer test.

关键词： Matrix Diffusion Time Domain Random Walk Memory Function Mobile-Immobile Mass Transfer

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