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Pediatric Non-Hodgkin Lymphoma: A Retrospective 7-Year Experience in Children &Adolescents with Non-Hodgkin Lymphoma Treated in King Fahad Medical City (KFMC)

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Journal of Cancer Therapy 2015年第4期6卷 299-314页

作者： Nahla Ali Mobark Suha A. Tashkandi Wafa Al Shakweer Khalid Al Saidi Suha A. Fataftah mohammed M. Al Nemer Awatif Alanazi mohammed Rayis Walid Ballourah Othman Mosleh Zaheer Ullah Fahad El Manjomi musa Al Harbi Department of Pediatric Hematology and Oncology Comprehensive Cancer Centre KFMC Riyadh Saudi Arabia Department of Cytogenetic and Molecular Cytogenetic Laboratory KFMC Riyadh Saudi Arabia Department of Anatomical Pathology KFMC Riyadh Saudi Arabia

Background: Non-Hodgkin’s lymphoma is an aggressive malignant disease in children and adolescents. Although it is the fourth most common malignancy in Saudi children as reported in Saudi cancer registry, less information is available about pediatric Non-Hodgkin lymphoma and its outcome in Saudi Arabia. Study Objectives: To provide demographic data, disease characteristics, treatment protocol, toxicity and outcome of treatment in children & adolescents with Non-Hodgkin’s lymphoma treated at KFMC. This study will form base line for future studies about pediatric Non-Hodgkin’s lymphoma in KFMC, which may help to improve outcome for children with cancer in Saudi Arabia. Study Patients and Method: We retrospectively analyzed 28 children and adolescents diagnosed to have Non-Hodgkin’s lymphoma at KFMC between December 2006 and December 2013, followed-up through June 2014. Results: Of the 28 patients, 10 (35.7%) girls and 18 (64.3%) boys, the male-to-female ratio was 1.8;1. The median age at time of diagnosis was 6.4 years old (range 2.0 to 13.0 years old). The majority of patients (64.3%) were aged between 5 and 12 years old. Burkitt’s lymphoma BL/BLL was the most common pathological subtype (60.7%), and DLBCL was the second most common subtype (21.4%). Abdominal and Retroperitoneal involvement was the most common primary site (78.6%) including the ileocaecal region. Most of the children presented with advanced Stage III and IV (75%), Cytogenetic study which screens specifically for the t (8;14) (q24;q32) a characteristic genetic feature of Burkitt’s Lymphoma was obtained from 21 patients, variant rearrangement was observed in 3/21 samples and complex chromosomes karyotype in addition to IGH/MYC rearrangement was observed in 2/21 samples. Those patients presented with very aggressive lymphoma and combined BM and CNS involvement. We use the French-American-British Mature B-Cell Lymphoma 96 Protocol (FAB LMB 96) for treatment fornewly diagnosed Mature B-Cell type NHL and hi

关键词： Non-Hodgkin Lymphoma Disease Patients Children and Adolescents

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SARS-CoV-2 spike protein and RNA dependent RNA polymerase as targets for drug and vaccine development: A review

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Biosafety and Health 2021年第5期3卷 249-263页

作者： Yusuf Muhammed Abduljalal Yusuf Nadabo Mkpouto Pius Bashiru Sani Jafar Usman Nasir Anka Garba Jaafaru mohammed Sani Basit Opeyemi Olayanju Sunday Zeal Bala musa Garba Abdullahi Misbahu Sambo Department of Biochemistry Federal UniversityGusauNigeria Faculty of Pharmaceutical Sciences Ahmadu Bello University ZariaNigeria Department of Medical Genetics University of CambridgeCB21TNUnited Kingdom Department of Microbiology Federal University of LafiaNigeria Department of Biochemistry Kaduna State UniversityNigeria Department of Chemistry and Biochemistry Florida International UniversityFL 33199USA Department of Biochemistry Bayero University KanoNigeria Faculty of Pharmaceutical Sciences Kaduna State UniversityNigeria Department of Biochemistry Abubakar Tafawa Balewa University BauchiNigeria

The present pandemic has posed a crisis to the economy of the world and the health ***,the race to expand research to understand some good molecular targets for vaccine and therapeutic development for SARS-CoV-2 is *** newly discovered coronavirus 2019(COVID-19)is a positive sense,single-stranded RNA,and enveloped virus,assigned to the beta CoV *** virus(SARS-CoV-2)is more infectious than the previously detected coronaviruses(MERS and SARS).Findings from many studies have revealed that S protein and RdRp are good targets for drug repositioning,novel therapeutic development(antibodies and small molecule drugs),and vaccine *** such as chloroquine,convalescent plasma,monoclonal antibodies,spike binding peptides,and small molecules could alter the ability of S protein to bind to the ACE-2 receptor,and drugs such as remdesivir(targeting SARS-CoV-2 RdRp),favipir,and emetine could prevent SASR-CoV-2 RNA *** novel vaccines such as mRNA1273(Moderna),3LNP-mRNAs(Pfizer/BioNTech),and ChAdOx1-S(University of Oxford/Astra Zeneca)targeting S protein have proven to be effective in combating the present *** exploration of the potential of S protein and RdRp is crucial in fighting the present pandemic.

关键词： SARS-CoV-2 Spike protein(S protein) RNA dependent RNA polymerase(RdRp) Drug repositioning SARS-CoV-2-vaccines

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Studies on Land Resource Inventory for Agricultural Land Use Planning in Northern Transition Zone of India through Remote Sensing and GIS Techniques

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Journal of Geographic Information System 2021年第6期13卷 710-728页

作者： Denis Magnus Ken Amara Sayyadsaheb A. Nadaf Daniel Hindogbe Saidu Osman S. Vonu Raymond Morie musa Philip Jimia Kamanda Patrick A. Sawyerr John Christian Mboma Saidu Deggy Mansaray mohammed Azim Sannoh Department of Soil Science & Agricultural Chemistry University of Agricultural Sciences Dharwad Dharwad India Department of Soil Science School of Agriculture & Food Sciences Njala University Njala Campus Freetown Sierra Leone Department of Agriculture Food Security & Livelihood Sustainable Cassava Commercialization through Entrepreneurs Strengthening & Support (SUCCESS) Project BRAC Bo Sierra Leone Department of Soil Science Eastern Technical University of Sierra Leone Private Mail Bag Kenema Sierra Leone Department of Agricultural Education Eastern Technical University of Sierra Leone Private Mail Bag Kenema Sierra Leone Department of Extension & Rural Sociology School of Agriculture & Food Sciences Njala University Freetown Sierra Leone Department of Social Studies Eastern Technical University of Sierra Leone Private Mail Bag Kenema Sierra Leone

Land suitability analysis is a prerequisite to achieving optimum utilization of available land resources. Hence, a study on land resource inventory for agricultural land use planning was conducted in the Northern Transition Zone of India to determine land capability and develop a suitability map for wheat and sorghum-based on physical and climatic factors of production using remote sensing and GIS techniques. Detailed soil survey information was used for this exercise. Four series (Singhanhalli, Mugli, Bogur and Venkatapur series) were identified and mapped into seventeen mapping units. Land capability classification showed that a greater portion of the study area belonged to class III followed by class IV with limitations of erosion, wetness and varying soil properties. Four land capability classes viz., II, III, IV, and VI, and seven subclasses viz., IIsf, IIItsf, IVs, IVt, IVts, IVtsf and VIt were identified. Major limitations of these subclasses were slope, erosion, depth, texture, coarse fragments, pH, organic carbon and base saturation. Soil suitability assessment revealed that the soils are moderately suitable to permanently not suitable. About 234 ha (31.6%) is moderately suitable, 494 ha (65.0%) marginally suitable and 10.2 ha (1.3%) permanently not suitable for wheat;while 78.5 ha (10.3%) is moderately suitable, 633.4 ha (82.3%) marginally suitable and 32.6 ha (4.3%) permanently not suitable for sorghum respectively. The moderate, marginal and permanent non-suitability was due to moderate, severe and very severe limitations respectively. However, it is possible to achieve potential yield of the crops in the study area if these limitations are addressed.

关键词： Land Resource Inventory Soil Suitability Land Use Planning Land Evaluation Soil Survey Remote Sensing Soil Mapping

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Serum leptin level in Sudanese women with unexplained infertility and its relationship with some reproductive hormones

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World Journal of Biological Chemistry 2022年第5期13卷 83-94页

作者： Abdullah Abdulslam Abdullah musa Ahmed Adesina Oladokun Nasir Adam Ibrahim Shahd Nourain Adam Department of Reproductive Health Sciences Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119OyoNigeria Department of Obstetrics and Gynecology College of MedicineUniversity of IbadanIbadan 119OyoNigeria Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Veterinary Surgery Faculty of Veterinary MedicineAL-Salam UniversityAl-fula 120West KordofanSudan Department of Biology Faculty of ScienceImam Mohammed Ibn Saud Islamic UniversityRiyadh 13318Saudi Arabia Department of Biochemistry and Physiology Faculty of Veterinary MedicineUniversity of Al-butanaRuffaa 210Sudan College of Nursing University of BahriKhartoum 12217Sudan

BACKGROUND The excessive concentration of leptin has negative effects on all aspects of female *** this established relationship,the exact role of leptin in women’s fertility is not clear enough and needs more *** To evaluate the serum leptin levels in Sudanese women and to ascertain the relationship between serum leptin levels and unexplained infertility(UI).METHODS A matched(age and body mass index)case-control study was conducted from March 2021 to February *** study samples were 210 women with UI and 190 fertile women of reproductive age who were attending the maternity hospitals and fertility clinics in Khartoum state *** serum concentration of leptin and other serum biomarkers were determined using enzyme-linked immunosorbent *** The results showed that there was a highly statistically significant difference between the two groups(P0.80),for leptin level,LH/FSH ratio,PRL level,and E2/T ratio,and large(effect size 0.50-≤0.80)for FSH and *** This study reveals that leptin could be a potential biomarker for UI in Sudanese women and it may be useful for identifying women with a high risk of infertility.

关键词： Leptin Serum level Unexplained infertility Sudanese women Reproductive hormones

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Effect of Preoperative Dutasteride on Bleeding Related to Transurethral Resection of Prostate in Patients with Benign Prostatic Hyperplasia

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Journal of Biosciences and Medicines 2019年第5期7卷 157-169页

作者： Md. Mostafiger Rahman Fatema-Tuj Johura Md. Amanur Rasul Abul Kalam mohammed musa Bhuiyan Mohammad Ibrahim Ali Md. Sazzad Hossain Md. Kamrul Islam A. K. M. Shahidur Rahman Fahad Al Shatil Ashrafee Department of Urology Prime Medical College Rangpur Bangladesh Department of Pharmacology Prime Medical College Rangpur Bangladesh Department of Urology Dhaka Medical College Dhaka Bangladesh Department of Urology Dhaka Medical College Hospital (DMCH) Dhaka Bangladesh Apollo Hospital Ltd. Ghulsan Dhaka Bangladesh Zilla-Sadar Hospital Hobigong Bangladesh Department of Nephrology Bangabandhu Sheikh Mujib Medical University (BSMMU) Dhaka Bangladesh

Background: Transurethral resection of prostate (TURP) is the gold standard in the surgical treatment of symptomatic benign prostatic hyperplasia (BPH). Blood loss is one of the most common complications of TURP. Objective: To evaluate the effect of preoperative dutasteride on bleeding related to TURP in patients with BPH. Materials and Methods: This prospective interventional study was done in the department of urology, Dhaka Medical College Hospital, Dhaka, Bangladesh during the period of July 2016 to June 2017. A total of 70 cases of BPH planned for TURP were included in this study according to the statistical calculation. Patients were randomly allocated to control group A (TURP without dutasteride) and dutasteride group B (TURP with dutasteride). Each group consisted of 35 patients. Group B patients were treated with dutasteride 0.5 mg/day for 4 weeks before TURP. The main outcome of blood loss was evaluated in terms of reduction in serum hemoglobin (Hb) and hematocrit (Hct) levels, which were measured before and 24 hours after surgery. Data were analyzed and compared by statistical tests. Results: Comparison of outcome between groups shows that there was a significant difference in term of pre-post operative change of hemoglobin and hematocrit levels in the control group A compared to the dutasteride group B (Hb = 2.96 ± 0.80 gm/dl vs. 1.81 ± 0.71 gm/dl, respectively, p = 0.001;Hct = 11.20% ± 2.12% vs. 6.07% ± 2.02%, respectively, p = 0.02). A significant lower mean blood loss was observed in the dutasteride group compared to the control group. Conclusion: Preoperative dutasteride therapy reduces blood loss related to TURP in patients with BPH. This therapy can be practiced to reduce surgical bleeding associated with TURP.

关键词： Benign Prostatic Hyperplasia (BPH) Dutasteride Transurethral Resection of Prostate (TURP)

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The Occurence of Gastrointestinal Helminths in Slaughtered Cattle in Azare, North-East Nigeria

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Journal of Zoological Research 2021年第1期3卷 1-8页

作者： musa Umar Bashir mohammed Abubakar Haladu Ali Gagman Abubakar Sadiq Yusuf Department of Biological Sciences Bauchi State University GadauPMB 065BauchiNigeria

A Cross-sectional Study was carried out to determine the prevalence of gastrointestinal(G.I.)helminths parasites in slaughtered cattle at Azare abattoir,Katagum Local Government Area,Bauchi State,North-Eastern *** hundred and twenty faecal samples were examined using the floatation and sedimentation *** of the total samples tested,*** infections were detected in 62 samples tested,giving an overall prevalence of 51.6%.Class nematodes are the most diverse class(56.5%),followed by trematodes(35.5%),while cestodes are the least prevalent(8.1%).There was a statistically significant difference in ***’prevalence among different classes(p0.05).The Red Bororo breeds had the highest prevalence of 75%,while the least was recorded in White Fulani and Sokoto Gudali,40%*** was a statistically significant difference in G.I helminth infection’s prevalence rate to breed(p<0.05).This study revealed that Fasciola spp.(15%)is the most prevalent *** parasites detected,followed by Oesophagostomum spp(11.7%);Haemonchus spp.(9.2%);Strongyloides spp.(8.3%),Schistosoma spp.(3.3%);and Moniezia spp.(1.67%).Our findings from the present study revealed a high prevalence of *** species affecting cattle in Azare,North-East ***,there is a great need for proper advocacy on appropriate management,regular deworming practices,and improved cattle hygiene to boost animal *** will help in curbing significant loss to Nigeria’s economy and the world in general.

关键词： Gastrointestinal helminths Parasites Cattle Bauchi Nigeria

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Five-year retrospective hospital-based study on epidemiological data regarding human leishmaniasis in West Kordofan state,Sudan

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World Journal of Clinical Infectious Diseases 2022年第2期12卷 61-68页

作者： Abdullah Abdulslam Abdullah musa Ahmed Ahmed Gadeed Adam Eltayeb Safa Ahmed Suad Hamad mohammed Hussein Department of Biomedical Sciences Faculty of Veterinary SciencesUniversity of GadarifGadarif 208Sudan Department of Reproductive Health Sciences Pan African University Life and Earth Sciences InstituteUniversity of IbadanIbadan 119Oyo StateNigeria Department of Veterinary Surgery and Anaesthesia Faculty of Veterinary MedicineALsalam UniversityAl-fula 120West Kordofan StateSudan Environmental Studies and Research Center Al-Salam UniversityAl-fula 120West Kordofan StateSudan Al-Sadaga Hospital Al-fula 124West Kordofan StateSudan Department of Zoonotic Disease and Disease Control Ministry of Animal ResourcesAl-Hamadi 215South Kordofan StateSudan Department of Statistics and Health Information Ministry of HealthAlfula 127West Kordofan StateSudan

BACKGROUND Leishmaniasis is a neglected zoonotic disease,endemic in *** this disease is very important to inform the health care policymakers and the governments to apply proper health and economic *** To find out the frequency and distribution of human leishmaniasis based on sex and age for 5 years in the West Kordofan state,*** A 5-year retrospective study from 2016 through 2020 was carried out using local hospital records of leishmaniasis *** positive results were recorded after performing at least one of the following leishmaniasis standard tests:direct agglutination test,enzyme-linked immunosorbent assay and leishmania skin *** sex and age of each patient were *** collected data were analyzed using STATA package version *** A total of 162443 patient records from 2016 to 2020 were *** these,4.39%were found to be positive for *** disease has been more common in males(65.3%)than in females(34.7%).The highest reported prevalence(6.58%)was in patients 15-44 years,and the lowest prevalence(1.95%)was among patients≥65 *** The results of the current study indicate that leishmaniasis is endemic in the study area even though the numbers of patients in the 5 consecutive years were *** addition,the disease was common in males and *** interpretation of these findings should take into consideration the absence of information about some important confounding factors.

关键词： Epidemiology Human Leishmaniasis West Kordofan Sudan Endemicity

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Development of a zoning management plan for petra archaeological park (PAP), Jordan

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Natural Science 2011年第12期3卷 1040-1049页

作者： Said Damhoureyeh Ahmad Disi Ibrahim Al-Khader mohammed H. Abu-Dieyeh 不详

As Petra is increasingly becoming a major tourism destination in Jordan, this underlies not only challenges to conserve the habitats and species in Petra but also offers great opportunities to promote academic research and investigation, demonstrate sustainable development and initiation of environmentally sound development and nature based tourism. This investigation is based on both desktop studies and field missions. The desktop part is relied on reviewing various studies and reports that highlighting natural resources in the area. Two field missions were conducted aiming to document various information from related authorities and institutions operating in Petra and also to undertake ground truthing of habitats and species information. The missions also included interviews with Park staff, representatives from ongoing projects and initiatives in Petra (Seyaha-USAID) and many locals belonging to various tribes in Wadi musa and The Bdul. The study presents a synthesis to findings from these studies and visits. Broadly, the park can be zoned into three mega zones: 1) Wadi Arabah and the steep gorges to the west including the Artemisia and annual grasses steppe to the west, 2) Mountainous ridges and rocky slopes of the Mediterranean region located almost centrally in the park and at the southern limit and part of the eastern borders and 3) Central basin and steep limestone scarps and weathered sandstone. Based on lists of key and indicator species, some key/sensitive sites of conservation value have been suggested. Aspects of grazing, agricultural activities, tourism and water resources and their implications on management schemes have been discussed.

关键词： Archaeological Park Ecotourism Biodiversity Environmental Management Petra Jordan

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Food Security in the Face of Climate Change: Potential Roles of Underutilised Plant Species around Some Rural Homesteads in the Niger Delta

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Natural Resources 2018年第3期9卷 55-72页

作者： Elsie I. Hamadina mohammed K. Hamadina Tamunobelema B. Solomon Department of Crop and Soil Science Faculty of Agriculture University of Port Harcourt Port Harcourt Nigeria Department of Soil Science Faculty of Agriculture University of Abuja Abuja Nigeria

The food and nutrition status of the rural poor living in extreme deprivation are precarious in the event of catastrophic events occasioned by climate change. This study aimed at elaborating the potential roles of underutilised plant resources as sources of food in the face of climate change. A total of 37 plant species of different growth habits were sighted within the homesteads in the study communities. The commonest plant species around home provide food, medicine, cash, and cultural or spiritual purposes. These included Manihot esculenta (Cassava), musa sapentium var. paradisiaca (Plantains) musa sapentium (banana), Citrus sinensis (orange) and Elaeis guineensis (oil palm). Outside the home compounds to a considerable walking distance around each of the communities, a total of twenty seven (27) plant species and four habitat types (three terrestrial and one aquatic) were encountered, with Elaeis guineensis Jacq. being present in all the terrestrial ecotypes (forest, farmland and fallow regrowth). Many of the plant species encountered within the home compounds are edible;some are medicinal or have spiritual values, while most have multiple uses. Magnifera indica, Dacryodes edulis, Persea americana, Carica papaya, Chrysophyllum albidum and Ananas comosus, are cherished for their tasty fruits. Vernonia amygdalina, Telferia occidentalis, Ocimum brasilicum, Amaranthus hybridus and Gnetum africana are eaten vegetables in soups. Irvingia gabonensis (Ogbono) is valued for its seeds, which are used widely in preparing the Ogbono soup, which is widely popular across Nigeria. The kola nut (Cola nitida), bitter kola (Garcina kola) trees and yams (Dioscorea spp) serve significant spiritual/cultural roles amongst the local populace in the study area—they are always presented at ceremonies such as marriages, funerals and festivals. Plant species with mostly untapped potentials to supply food and nutrients to the rural dwellers in the study area include breadfruit (Artocarpus

关键词： Climate Change Food Security Niger Delta Home Gardens Tropical Plants

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Production and Quality of Biscuits from Composite Flours

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Journal of Food Science and Engineering 2018年第6期8卷 241-247页

作者： A.D.Ismail L.G.Abubakar N.G.Nwachukwu A.mohammed A.S.Ibrahim Department of Agricultural and Bioresource Engineering Abubakar Tafawa Balewa UniversityPMB 0248Yelwa Campus BauchiBauchi StateNigeria Department of Agricultural Biotechnology National Biotechnology Development AgencyUmar Musa Yar’Adua Express WayLugbeAbuja FCTPMB 5118WuseAbujaNigeria

Biscuits were produced from bambara nut,cowpea and wheat flour *** study was carried out to evaluate the effects of varying the proportions of these flours on the nutritional quality and general acceptability of the *** blends of composite flours were prepared by mixing wheat,bambara nut and cowpea(WBC)flours in the proportions:T1(90:5:5),T2(80:10:10),T3(70:15:15),T4(60:20:20),T5(50:25:25)and 100%whole wheat flour was used as the control(T0).Composite flours produced were subjected to functional and proximate analysis while the biscuits made from the flour blends were also subjected to sensory evaluation and proximate *** use of composite flour for the production of biscuits from cowpea and bambara nut flours as supplement for the wheat flour has improved the nutritional contents of the biscuits with protein value being highest at mixing ratio *** functional properties of the biscuits showed some significant differences(p<0.05)when compared with whole wheat *** results showed that biscuits produced from T5 formulation with proximate composition of 11.87%moisture,2.90%ash,18.61%protein and 75.62%carbohydrate was selected as the best product.

关键词： Biscuits formulation composite flour wheat cowpea bambara nut

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