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Suspended particulate matter promotes epithelial-to-mesenchymal transition in alveolar epithelial cells via TGF-β1-mediated ROS/IL-8/SMAD3 axis

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Journal of Environmental Sciences 2024年第7期141卷 139-150页

作者： Shahrzad Molavinia Dian Dayer mohammad Javad Khodayar Gholamreza Goudarzi Maryam Salehcheh Cellular and Molecular Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Department of Toxicology School of PharmacyAhvaz Jundishapur University of Medical SciencesAhvazIran Student Research Committee Ahvaz Jundishapur University of Medical SciencesAhvazIran Toxicology Research Center Medical Basic Sciences Research InstituteAhvaz Jundishapur University of Medical SciencesAhvazIran Air Pollution and Respiratory Diseases Research Center Ahvaz Jundishapur University of Medical SciencesAhvazIran Iranian Scientific Association of Clean Air TehranIran

Epidemiological evidence presents that dust storms are related to respiratory diseases,such as pulmonary fibrosis(PF).However,the precise underlying mechanisms of SPM-elicited adverse effects still need to be ***-mesenchymal transition(EMT)process is a characteristic of *** discussed whether suspended particulate matter(SPM)is involved in EMT induction via transforming growth factor-β1(TGF-β1).In this study,a detailed elemental analysis(55 elements),particle size,and morphology were *** investigate the toxicity of SPM,an MTT test was performed to detect cell ***,A549cells were exposed to selected concentrations of SPM(20 and 40μg/mL)for single and repeated *** DCFH-DA assay showed that exposure to SPM could produce reactive oxygen species(ROS).The ELISA assay demonstrated increased levels of interleukin-8(IL-8)and TGF-β1 in the *** blot was used to detect the expression of proteins associated with EMT and the SMAD3-dependent *** of western blot demonstrated that E-cadherin was reduced,whereas p-SMAD3,vimentin,andα-smooth muscle actin were *** findings indicated that SPM triggered EMT by induction of oxidative stress,inflammation,and the TGF-β1/SMAD3 pathway activation.

关键词： Particulate matter TGF-β1 Oxidative stress Epithelial-mesenchymal transition Pulmonary fibrosis Cells

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Correlation between platinum–aluminide coating features and tensile behavior of nickel-based superalloy Rene?80

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Rare Metals 2024年第10期43卷 5391-5402页

作者： mohammad Mehdi Barjesteh Seyed Mehdi Abbasi Karim Zangeneh Madar Kourosh Shirvani Metallic Materials Research Center Malek Ashtar University of Technology (MUT) Department of Advanced Materials and New Energies Iranian Research Organization for Science and Technology (IROST)

The effect of platinum （a rare metal）–aluminide coating parameters on the tensile properties of nickel-based superalloy Rene?80 was evaluated at 871。*** this purpose,initial layers of platinum with different thicknesses （2,4,6 and 8μm） were coated on tensile samples Then,low-temperature high-activity （LTHA） and hightemperature low-activity （HTLA） processes were used for *** of microstructural evaluations using scanning electron microscope （SEM） and phase analysis by X-ray diffraction （XRD） showed a three-layer structure coating for different platinum layer thicknesses and both aluminizing *** the thickness of the platinum layer from 2 to 8μm led to the improvement in the final coating thickness from 91.6 to 102.1μm in *** increase was from 128.1 to 148.6 μm in *** results of hot tensile tests at 871℃ showed a decrease in strength properties of the coated samples compared to the uncoated ***,HTLA and high thicknesses of the initial platinum layer showed an intense *** results of fractographic evaluations abou uncoated samples showed a ductile *** the other hand,coated samples showed a simultaneous ductile and brittle fracture failure *** the main fracture morphology was brittle cleavage fracture which was for the HTLA.

关键词： Aluminizing Fractography Platinum–aluminide Rene®80 Tensile properties

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Blockchain-based governance models supporting corruption-transparency:A systematic literature review

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Blockchain(Research and Applications) 2024年第2期5卷 163-183页

作者： mohammad Mustafa Ibrahimy Alex Norta Peeter Normak School of Digital Technologies Tallinn UniversityNarva mnt 25Tallinn 10120Estonia Baltic Film Media and Arts SchoolTallinn UniversityTallinnEstonia Dymaxion OÜ TallinnEstonia

Corruption and lack of transparency remain critical challenges in governance systems around the *** issues are often perpetuated by centralized systems and their manipulation by system ***,the lack of data ownership and the monetization of user data by tech companies further increase concerns about *** light of these concerns,this study aims to review existing blockchain-based governance models and identify best-practice governance models focusing on corruption transparency,their characteristics,and *** research will also examine the role of a token economy in addressing trusted third-party issues related to asset ownership ***,we discuss the effect of smart contracts,blockchain,decentralized autonomous organizations(DAOs),Web 3.0,and multifactor challenge set self-sovereign identity authentication(MFSSIA)as modern technologies to combat corruption and achieve transparency in the public *** achieve this,we conducted a systematic literature review(SLR)comprising peer-reviewed journals,proceedings,and book chapters published between 2012 and *** the SLR methodology,45 primary and supporting studies have been selected for result extraction and ***,we discovered seven blockchain-based governance models with their characteristics and primary components.

关键词： Blockchain governance Token economy Transparency Smart contract Web 3.0 DAOs

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A thermo-mechanical simulation for the stability analysis of a horizontal wellbore in underground coal gasification

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Petroleum 2024年第2期10卷 243-253页

作者： mohammadreza Shahbazi Mehdi Najafi mohammad Fatehi Marji Ramin Rafiee Department of Mining and Metallurgical Eng. Yazd UniversityYazdIran Department of Mining Petroleum&Geophysics Eng.Shahrood University of TechnologyShahroodIran

The stability analysis of horizontal wells is essential for a successful underground coal gasification(UCG)*** this paper,a new 3D coupled thermo-mechanical numerical modeling is proposed for analyzing the stability of UCG horizontal *** this model,the effect of front abutment stresses,syngas pressure,syngas temperature and thermal stresses is considered to predict the mud weight window and drilling mud pressure during UCG *** results show that the roof caving in UCG panel has a greatest impact on the stability of horizontal ***,when the time of coal gasification is increased,the well convergence increases and for more stability it is necessary to increase the drilling mud *** research was carried out on the M2 coal seam in Mazino coal deposit(Iran).The results showed that the mud weight window for horizontal well drilling is between 0 and 33 *** appropriate stress for the maximum stability of the horizontal well,taking all the thermal and mechanical parameters into account,is 28 *** suggested numerical method is a comprehensive and consistent way for analyzing the stability of horizontal wells in UCG sites.

关键词： Underground coal gasification Thermo-mechanical simulation Numerical modeling Stress distribution Horizontal well

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Performance comparison of machine learning algorithms for maximum displacement prediction in soldier pile wall excavation

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Underground Space 2024年第3期16卷 301-313页

作者： Danial Sheini Dashtgoli mohammad Hossein Dehnad Seyed Ahmad Mobinipour Michela Giustiniani Department of Mathematics Informaticsand GeosciencesUniversity of TriesteTrieste 34127Italy National Institute of Oceanography and Applied Geophysics-OGS Borgo Grotta Gigante 42/CTriesteSgonico 34010Italy Department of Civil Engineering University of QomQom ***Iran

One of the common excavation methods in the construction of urban infrastructures as well as water and wastewater facilities is the excavation through soldier pile *** maximum lateral displacement of pile wall is one of the important variables in controlling the stability of the excavation and its adjacent ***,the application of machine learning methods is widely used in engineering sciences due to its low cost and high speed of *** paper utilized three intelligent machine learning algorithms based on the excavation method through soldier pile walls,namely eXtreme gradient boosting(XGBoost),least square support vector regressor(LS-SVR),and random forest(RF),to predict maximum lateral displacement of pile *** results showed that the implemented XGBoost model performed excellently and could make predictions for maximum lateral displacement of pile walls with the mean absolute error of 0.1669,the highest coefficient of determination 0.9991,and the lowest root mean square error *** the LS-SVR,and RF models were less accurate than the XGBoost model,they provided good prediction results of maximum lateral displacement of pile walls for numerical ***,a sensitivity analysis was performed to determine the most effective parameters in the XGBoost *** analysis showed that soil elastic modulus and excavation height had a strong influence on of maximum lateral displacement of pile wall prediction.

关键词： Soldier pile wall Lateral displacements XGBoost Machine learning Artificial intelligence

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In-depth analysis of VARTM-based solid-state supercapacitors utilizing CNT-dispersed cobalt-bismuth-samarium ternary hydroxide on woven carbon fiber for enhanced energy storage

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Journal of Energy Chemistry 2024年第10期97卷 498-512,I0010页

作者： Fouzia Mashkoor Mohd Shoeb Hongjun Jeong mohammad Naved Khan Changyoon Jeong School of Mechanical Engineering Yeungnam UniversityGyeongsanGyeongbuk 38541Republic of Korea

Multi-metal hydroxides possess unique physical and chemical properties,making them promising candidates for supercapacitor working *** their electrochemical performance can be achieved through a combination with carbon *** this study,we synthesized a composite material by hydrothermally dispersed 4,6,and 10 wt%carbon nanotubes(CNT)into ternary cobaltbismuth-samarium hydroxide(CoBiSm-TOH).These nanocomposites were employed as the material for the working electrode in a *** findings reveal that at 1.5 A/g,the specific capacitance of CNT3@CoBiSm-TOH,using a three-electrode system,was found to be 852.91 F/g,higher than that of CoBi-BOH,CoBiSm-TOH,CNT1@CoBiSm-TOH and CNT5@CoBiSm-TOH-measuring 699.69,750.34,789.54 and 817.79 F/g,***,CNT3@CoBiSm-TOH electrodes exhibited a capacitance retention of around 88%over 10,000 *** demonstrate practical applicability,CNT3@CoBiSm-TOH was grown on woven carbon fiber(WCF),and a solid-state supercapacitor device was developed using the VARTM(vacuum-assisted resin transfer molding).This device displayed a specific capacitance of 272.67 F/g at 2.25 A/***,it achieved a maximum energy density of 53.01 Wh/kg at a power density of 750 W/kg and sustained excellent cycle stability over 50,000 cycles,maintaining 70%of its initial *** results underscore the importance of interfacial nanoengineering and provide crucial insights for the development of future energy storage devices.

关键词： Ternary hydroxide Carbon nanotube Synergistic effect VARTM Supercapacitor

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Opportunities and Challenges in Advancing Plant Research with Single-cell Omics

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Genomics, Proteomics & Bioinformatics 2024年第2期22卷 13-26页

作者： mohammad Saidur Rhaman Muhammad Ali Wenxiu Ye Bosheng Li Peking University Institute of Advanced Agricultural Sciences Shandong Laboratory of Advanced Agricultural Sciences in WeifangWeifang 261325China

Plants possess diverse cell types and intricate regulatory mechanisms to adapt to the ever-changing environment of *** strategies have been employed to study cell types and their developmental progressions,including single-cell sequencing methods which provide high-dimensional catalogs to address biological *** recent years,single-cell sequencing technologies in transcriptomics,epigenomics,proteomics,metabolomics,and spatial transcriptomics have been increasingly used in plant science to reveal intricate biological relationships at the single-cell ***,the application of single-cell technologies to plants is more limited due to the challenges posed by cell *** review outlines the advancements in single-cell omics technologies,their implications in plant systems,future research applications,and the challenges of single-cell omics in plant systems.

关键词： Multi-omics Single-cell transcriptomics Spatial transcriptomics Single-cell epigenomics Single-cell proteomics

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Stratigraphy of the Alveolina elliptica group from the Middle Eocene of Iran:Calibration with calcareous nannofossils biozones and description of Alveolina ozcani n. sp.

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Journal of Palaeogeography 2024年第1期13卷 54-79页

作者： Mehdi Hadi Lorenzo Consorti Ali Bahrami mohammad Parandavar Saeed Khorramdel Department of Geology Faculty of SciencesUniversity of IsfahanIsfahanIran Institute of Marine Sciences(ISMAR-CNR) Area Science ParkBasovizza34149 TriesteItaly National Iranian Oil Company Exploration DirectorateSheikh Bahaei SquareTehranIran Department of Geology Faculty of ScienceFerdowsi University of MashhadMashhadIran

Precise taxonomy and the chronostratigraphic calibration of the Middle Eocene Alveolina from Central Iran is here undertaken from the Chah-Talkh section of the southern Sabzevar region(Central Iran). We have identified Alveolina kieli, Alveolina stercusmuris and Alveolina nuttalli along with the new species Alveolina ozcani n. sp. that we include into the Alveolina elliptica group. We have also found Nummulites uroniensis, Nummulites obesus and Nummulites cf. verneuili and associated calcareous nannofossils that look reliable to make thoughtful correlations with the Shallow Benthic Zones(SBZ). The foraminiferal biostratigraphy suggests an assignment to the upper part of the lower Lutetian-lower part of the middle Lutetian,SBZ13(Middle Eocene), further strengthened through the identification of the calcareous nannofossil NP14b-NP15b or CNE8-CNE10 biozones, providing a solid correlation with the global stratigraphic standards.

关键词： Alveolina Calcareous nannofossil Central neo-tethys Central Iran Middle Eocene Biostratigraphy

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Analyzing the Interplay of Sintering Conditions on Microstructure and Hardness in Indirect Additive Manufacturing of 17-4PH Stainless Steel

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Acta Metallurgica Sinica(English Letters) 2024年第9期37卷 1611-1620页

作者： Erika Lannunziata mohammad Hossein Mosallanejad Manuela Galati Gabriele Piscopo Abdollah Saboori Integrated Additive Manufacturing Center Department of Management and Production EngineeringPolitecnico di TorinoCorso Duca Degli Abruzzi 2410129TurinItaly

Indirect additive manufacturing(AM)methods have recently attracted attention from researchers thanks to their great potential for cheap,straightforward,and small-scale production of metallic *** diffusion additive manufacturing(ADAM),a variant of indirect AM methods,is a layer-wise indirect AM process recently developed based on fused deposition modeling and metal injection ***,there is still limited knowledge of the process conditions and material properties fabricated through this process,where sintering plays a crucial role in the final consolidation of ***,this research,for the first time,systematically investigates the impact of various sintering conditions on the shrinkage,relative density,microstructure,and hardness of the 17-4PH ADAM *** this reason,as-washed samples were sintered under different time-temperature *** sample density was evaluated using Archimedes,computed tomography,and image analysis *** outcomes revealed that sintering variables significantly impacted the density of brown 17-4PH Stainless Steel *** results indicated more than 99% relative densities,higher than the value reported by Markforged Inc.(~96%).Based on parallel porosities observed in the computed tomography results,it can be suggested that by modifying the infill pattern during printing,it would be possible to increase the final relative *** microhardness of the sintered samples in this study was higher than that of the standard sample provided by Markforged *** at 1330℃ for 4 h increased the density of the printed sample without compromising its mechanical *** to X-ray diffraction analysis,the standard sample provided by Markforged ***“1330℃—4 h”one had similar stable phases,although copper-rich intermetallics were more abundant in the microstructure of reference *** study is expected to facilitate the adoption of indirect metal AM methods by different sector

关键词： Indirect additive manufacturing Atomic diffusion additive manufacturing 17-4PH stainless steel Computed tomography Sintering

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Assessment of electrostatic discharge sensitivity of nitrogen-rich heterocyclic energetic compounds and their salts as high energy-density dangerous compounds:A study of structural variables

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Defence Technology（防务技术） 2024年第9期39卷 15-22页

作者： mohammad Hossein Keshavarz Sedigheh Heydari Bani Reza Bakhtiari Seyyed Hesamodin Hosseini Faculty of Applied Sciences Malek Ashtar University of TechnologyIsfahan 177415875Iran

Nitrogen-rich heterocyclic energetic compounds(NRHECs)and their salts have witnessed widespread synthesis in recent *** substantial energy-density content within these compounds can lead to potentially dangerous explosive reactions when subjected to external stimuli such as electrical ***,developing a reliable model for predicting their electrostatic discharge sensitivity(ESD)becomes *** study proposes a novel and straightforward model based on the presence of specific groups(-NH_(2) or-NH-,-N=N^(+)-O^(-)and-NNO_(2),-ONO_(2) or-NO_(2))under certain conditions to assess the ESD of NRHECs and their salts,employing interpretable structural *** a comprehensive dataset comprising 54 ESD measurements of NRHECs and their salts,divided into 49/5 training/test sets,the model achieves promising *** Root Mean Square Error(RMSE),Mean Absolute Error(MAE),and Maximum Error for the training set are reported as 0.16 J,0.12 J,and 0.5 J,***,the ratios RMSE(training)/RMSE(test),MAE(training)/MAE(test),and Max Error(training)/Max Error(test)are all greater than 1.0,indicating the robust predictive capabilities of the *** presented model demonstrates its efficacy in providing a reliable assessment of ESD for the targeted NRHECs and their salts,without the need for intricate computer codes or expert involvement.

关键词： Electrostatic discharge sensitivity Heterocyclic energetic compounds containing azole compound Interpretable structural parameter Safety

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