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Trigonella foenum-graecum seed extract modulates expression of lipid metabolism-related genes in HepG2 cells

Asian Pacific Journal of Tropical Biomedicine 2019年第6期9卷 240-248页

作者： Maryam mohammad-Sadeghipour Mehdi Mahmoodi Soudeh Khanamani Falahati-pour Alireza Khoshdel mohammad Ali Fahmidehkar mohammad reza mirzaei Mojgan Noroozi Karimabad mohammad rezaHajizadeh Department of Clinical Biochemistry Faculty of MedicineRafsanjan University of Medical SciencesRafsanjanIran Molecular Medicine Research Center Inistitute of Basic Medical Sciences ResearchRafsanjan University of Medical SciencesRafsanjanIran Department of Clinical Biochemistry Afzalipoor Faculty of MedicineKerman University of Medical SciencesKermanIran Pistachio Safety Research Center Rafsanjan University of Medical SciencesRafsanjanIran Department of Clinical Biochemistry Faculty of Medicineand Pistachio Safety Research CenterRafsanjan University of Medical SciencesRafsanjanIran Department of Laboratory Sciences School of Paramedical SciencesTorbat Heydariyeh University of Medical SciencesTorbat HeydariyehIran

Objective:To investigate anti-dyslipidemic effects of hydroalcoholic fenugreek seed extracts,diosgenin,and 4-OH-Ile on HepG2 cell ***:HepG2 cells were treated with hydroalcoholic fenugreek seed extracts,diosgenin,4-OH-Ile,and ***20 was calculated using the MTT *** cells were then pretreated with IC20 concentrations for 24 and 48 *** time PCR was employed to measure expression of liver X receptor alpha(LXR a),sterol regulatory element-binding protein-1 C(SREBP-1 C),acetyl-CoA carboxylase(ACC),fatty acid synthase(FAS),fibroblast growth factor 21(FGF21),peroxisome proliferator-activated receptor gamma(PPAR γ),and lowdensity lipoprotein receptor(LDLR).Results:The results showed that LXR α(P=0.003,P<0.001).,SREBP-1 C(P<0.001,P<0.001),ACC(P=0.002,P=0.006),and FAS(P<0.001,P<0.001)were downregulated significantly,while FGF21(P<0.001,P<0.001),PPAR γ(P=0.004,P<0.001),and LDLR(P<0.001,P<0.001)were upregulated significantly in HepG2 cells treated with the IC20 of hydroalcoholic fenugreek seed extracts,diosgenin,4-OH-Ile,and orlistat in 24 and 48 h,***:Hydroalcoholic fenugreek seed extracts,diosgenin,and 4-OH-Ile significantly modulate the expression of some important lipid metabolism related genes,which is similar to *** foenum.-graecum seed extract or its derivatives should be further investigated for their dyslipidemia effects and its complications.

关键词： Fenugreek seed extract Diosgenin 4-Hydroxy-L-isoleucine Dyslipidemia Obesity

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A new robust fuzzy method for unmanned flying vehicle control

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Journal of Central South University 2015年第6期22卷 2166-2182页

作者： Mojtaba mirzaei mohammad Eghtesad mohammad Mahdi Alishahi Department of Mechanical Engineering Shiraz University

A new general robust fuzzy approach was presented to control the position and the attitude of unmanned flying vehicles(UFVs). Control of these vehicles was challenging due to their nonlinear underactuated behaviors. The proposed control system combined great advantages of generalized indirect adaptive sliding mode control(IASMC) and fuzzy control for the UFVs. An on-line adaptive tuning algorithm based on Lyapunov function and Barbalat lemma was designed, thus the stability of the system can be guaranteed. The chattering phenomenon in the sliding mode control was reduced and the steady error was also alleviated. The numerical results, for an underactuated quadcopter and a high speed underwater vehicle as case studies, indicate that the presented adaptive design of fuzzy sliding mode controller performs robustly in the presence of sensor noise and external disturbances. In addition, online unknown parameter estimation of the UFVs, such as ground effect and planing force especially in the cases with the Gaussian sensor noise with zero mean and standard deviation of 0.5 m and 0.1 rad and external disturbances with amplitude of 0.1 m/s2 and frequency of 0.2 Hz, is one of the advantages of this method. These estimated parameters are then used in the controller to improve the trajectory tracking performance.

关键词： adaptive fuzzy sliding-mode control unmanned flying vehicle control underactuated system Lyapunov stability high speed underwater vehicle

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Stabilizing silica nanoparticles in high saline water by using polyvinylpyrrolidone for reduction of asphaltene precipitation damage under dynamic condition

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Chinese Journal of Chemical Engineering 2019年第5期27卷 1021-1029页

作者： mohammad reza Aghajanzadeh mohammad Sharifi Department of Petroleum Engineering Amirkabir University of Technology

In this study, the performance of stable nanofluid containing SiO2 nanoparticles dispersed and stabilized in high salinity brine for asphaltene inhibition in dynamic condition is evaluated. In the first stage of this work, the stability of silica nanoparticles in different range of water salinity(0–100000 mg·L-1) is investigated. Next, stable nanofluid containing highest salinity is selected as asphaltene inhibitor agent to inject into the damaged core sample. The estimated values of oil recovery for base case, after damage process and after inhibition of asphaltene precipitation using nanofluid are 51.6%, 36.1% and 46.7%, respectively. The results showed the reduction in core damage after using nanofluid. In addition, the relative permeability curves are plotted for the base case, after damage process and also after inhibition of asphaltene precipitation using nanofluid. Comparison of relative permeability curves shows, relative permeability of oil phase decreased after damage process as compared with the base case. But after using nanofluid the oil relative permeability curve has shifted to the right and effective permeability of oil phase has been improved.

关键词： Formation damage Enhanced oil recovery Salinity Asphaltene Core flooding Nano particles

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Experimental investigation of different brines imbibition influences on co-and counter-current oil flows in carbonate reservoirs

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Chinese Journal of Chemical Engineering 2021年第5期34卷 17-29页

作者： Pouyan Ahmadi mohammad reza Aghajanzadeh Masoud Riazi mohammad reza Malayeri mohammad Sharifi Enhanced Oil Recovery(EOR)Research Centre IOR/EOR Research InstituteShiraz UniversityShirazIran Helmholtz Centre for Environmental Research-UFZ LeipzigGermany Department of Petroleum Engineering Amirkabir University of TechnologyTehranIran Institut für Verfahrenstechnik und Umwelttechnik Technische Universität DresdenGermany

Imbibition of water,as wetting phase in oil-wet fractured carbonate reservoirs,plays a key role in fluid flow between matrix and fracture *** type of injected seawater and its chemistry would profoundly influence the imbibition *** this study,the impact of smart water(a brine that its ions have been adjusted to facilitate oil recovery)and low salinity water on co-and counter-current imbibition processes for oil-wet carbonate cores has been experimentally *** results show an increase of about 10% in oil recovery for co-and counter-currents for smart seawater imbibition compared to that of low salinity *** addition,as a result of the influence of co-and counter-current on each other,by co-current removal from one core face,the countercurrent in the other face would be intensified by as much as about 75%.A close examination of different lengths(5,7 and 9 cm)of carbonate cores with the same permeability revealed that by decreasing porous medium length,the amount of counter-current producing oil would be decreased so that in the 5 cm core,counter current oil production will not *** similar core lengths by increasing permeability,the share of counter current flow would be decreased approximately 18% since the capillary pressure could not overcome non-wetting phase viscous *** the role of matrix length along with a modified brine(which is designed according to the matrix mixture)strengthen the relevant mechanisms to have more oil production so that the higher thickness of matrix causes the higher amount of co-current oil producing and consequently more total recovery.

关键词： Smart water Co-current Counter current Wettability alteration Oil recovery

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Stochastic price based coordinated operation planning of energy storage system and conventional power plant

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Journal of Modern Power Systems and Clean Energy 2019年第5期7卷 1020-1032页

作者： mohammad reza SHEIBANI Gholam reza YOUSEFI mohammad Amin LATIFY Department of Electrical and Computer Engineering Isfahan University of TechnologyIsfahan 84156-83111Iran

A generation company(GENCO)which has a conventional power plant(CPP)intends to add an energy storage system(ESS)beside the CPP to increase its flexibility and *** this purpose,a new model is proposed for coordinated operation planning of the CPP and ESS in energy and spinning reserve markets in the presence of a bilateral *** proposed model is based on the stochastic price based unit commitment(PBUC)and price based storage commitment(PBSC).The uncertainties of the energy and spinning reserve prices and delivery requests in the spinning reserve market are modeled via scenarios based upon historical *** proposed model maximizes the profitability of the ESS beside the CPP and encourages the GENCO to invest the *** technology options to use beside the CPP are determined by economic *** results show that utilization of ESSs improves the technical operation of CPPs,as well as GENCOs’profitability.

关键词： Energy storage system Conventional power plant Operation planning Price based unit commitment

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The Hippo Tumor Suppressor Pathway(YAP/TAZ/TEAD/MST/LATS)and EGFR-RAS-RAF-MEK in cancer metastasis

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Genes & Diseases 2021年第1期8卷 48-60页

作者： mohammad reza Zinatizadeh Seyed Rouhollah Miri Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Catarina Raposo Hamid reza mirzaei mohammad Esmaeil Akbari Habibollah Mahmoodzadeh Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Department of Immunology School of MedicineTehran University of Medical SciencesTehranIran Department of Immunology Medical SchoolShahid Beheshti University of Medical SciencesTehranIran Faculty of Pharmaceutical Sciences State University of Campinas-UNICAMP Campinas SPBrazil Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Hippo Tumor Suppressor Pathway is the main pathway for cell growth that regulates tissue enlargement and organ size by limiting cell *** pathway is activated in response to cell cycle arrest signals(cell polarity,transduction,and DNA damage)and limited by growth factors or mitogens associated with EGF and *** major pathway consists of the central kinase of Ste20 MAPK(Saccharomyces cerevisiae),Hpo(Drosophila melanogaster)or MST kinases(mammalian)that activates the mammalian AGC kinase dmWts or LATS effector(MST and LATS).YAP in the nucleus work as a cofactor for a wide range of transcription factors involved in proliferation(TEA domain family,TEAD1-4),stem cells(Oct4 mononuclear factor and SMAD-related TGFb effector),differentiation(RUNX1),and Cell cycle/apoptosis control(p53,p63,and p73 family members).This is due to the diverse roles of YAP and may limit tumor progression and *** also coordinates various signal transduction pathways such as Hippo,WNT,TGFb and EGFR,and effects on lack of regulation of TEAD cancerous genes,such as KRAS,BRAF,LKB1,NF2 and MYC,which play essential roles in tumor progression,metastasis,cancer metabolism,immunity,and drug ***,RAS signaling is a pivotal factor in the inactivation of Hippo,which controls EGFR-RAS-RAF-MEK-ERKmediated interaction of Hippo ***,the loss of the Hippo pathway may have significant consequences on the targets of RAS-RAF mutations in cancer.

关键词： Cancer Hippo pathway Metastasis Signaling Tumor suppressor

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Enhanced empirical models for predicting the drift capacity of less ductile RC columns with flexural,shear,or axial failure modes

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Frontiers of Structural and Civil Engineering 2019年第5期13卷 1251-1270页

作者： mohammad reza AZADI KAKAVAND reza ALLAHVIRDIZADEH Unit of Strength of Materials and Structural Analysis Institute of Basic Sciences in Engineering SciencesUniversity of InnsbruckInnsbruck 6020Austria ISISE Department of Civil EngineeringUniversity of MinhoGuimaraes 4800-058Portugal

Capacity of components subjected to earthquake actions is still a widely interesting research topic. Hence, developing precise tools for predicting drift capacities of reinforced concrete (RC) columns is of great interest. RC columns are not only frequently constructed, but also their composite behavior makes the capacity prediction a task faced with many uncertainties. In the current article, novel empirical approaches are presented for predicting flexural, shear and axial failure modes in RC columns. To this aim, an extensive experimental database was created by collecting outcomes of previously conducted experimental tests since 1964, which are available in the literature. It serves as the basis for deriving the equations for predicting the drift capacity of RC columns by different regression analyses (both linear with different orders and nonlinear). Furthermore, fragility curves are determined for comparing the obtained results with the experimental results and with previously proposed models, like the ones of ASCE/SEI41-13. It is demonstrated that the proposed equations predict drift capacities, which are in better agreement with experimental results than those computed by previously published models. In addition, the reliability of the proposed equations is higher from a probabilistic point of view.

关键词： flexural-shear-axial failure drift capacity reinforced concrete columns statistical analysis fragility curves

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Prevalence of intestinal helminthes in owned dogs in Kerman city,Iran

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Asian Pacific Journal of Tropical Medicine 2012年第9期5卷 735-737页

作者： mohammad mirzaei Majid Fooladi Associate Professor Pathobiology DepartmentSchool of Veterinary MedicineShahid Bahonar University of KermanKermanIran Student of Veterinary Parasitology Pathobiology DepartmentSchool of Veterinary MedicineShahid Bahonar University of KermanKermanIran

ObjectiveTo survey the prevalence of canine gastrointestinal helminthes in dogs presented to the Veterinary faculty of the University of Kerman between May and November 2011.MethodsA total of 70 fecal samples were evaluated by the fecal sedimentation method.ResultsThe prevalence of gastrointestinal helminthes was 7.14%. The parasites most frequently detected were Toxocara canis (T. canis) (4.3%); Toxascaris leonina (T. leonina) (1.4%) and Teania spp. (1.4%). The age distribution of intestinal parasites in dogs showed that the dog less than 1 year old had a higher overall prevalence than those dogs over 12 months of age but there was not significant (P>0.05). Also there was no significant difference in the prevalence between male (7.7%) and female (6.5%) dogs (P>0.05).ConclusionsIt is thought that the reduction in the frequency of the dogs with those helminthes may be mainly a result of the improvement in breeding environment and the routine use of antihelmintics. The significance of zoonotic diseases caused by intestinal helminthes makes it necessary for us to know the infection status of domestic dogs and to take measures for further control. It is concluded that veterinarians have an important role in educating dog owners of these potential risks and means for preventing or minimizing zoonotic transmission.

关键词： Gastrointestinal helminthes Dog Kerman Iran

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The Role and Function of Ras-association domain family in Cancer:A Review

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Genes & Diseases 2019年第4期6卷 378-384页

作者： mohammad reza Zinatizadeh Seyed Ali Momeni Peyman Kheirandish Zarandi Ghanbar Mahmoodi Chalbatani Hassan Dana Hamid reza mirzaei mohammad Esmaeil Akbari Seyed Rouhollah Miri Cancer Research Center Shahid Beheshti University of Medical SciencesTehranIran Cancer Research Center Cancer Institute of IranTehran University of Medical ScienceTehranIran Uro-Oncology Research Center Tehran University of Medical SciencesTehranIRIran Cancer Research Center Shohadae Tajrish HospitalDepartment of Radiation OncologyShahid Beheshti University of Medical SciencesTehranIran

Ras gene mutation has been observed in more than 30%of cancers,and 90%of pancreatic,lung and colon *** proteins(K-Ras,H-Ras,N-Ras)act as molecular switches which are activated by binding to *** play a role in the cascade of cell process control(proliferation and cell division).In the inactive state,transforming GTP to GDP leads to the activation of GTpase in Ras ***,the mutation in Ras leads to the loss of internal GTPase activity and permanent activation of the *** activated Ras can promote the cell death or stop cell growth,which are facilitated by Ras-association domain *** studies have been conducted to determine the importance of losing RASSF proteins in Rasinduced *** paper examines the role of Ras and RASSF *** general,RASSF proteins can be used as a suitable means for targeting a large group of Ras-induced tumors.

关键词： Cancer Colon H-Ras K-Ras Lung N-Ras Pancreatic

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Evaluation of attraction terms in equations of state on the prediction of solubility of some biomolecules in supercritical carbon dioxide

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Chinese Chemical Letters 2009年第4期20卷 501-505页

作者： mohammad reza Bozorgmehr mohammad reza Housaindokht Department of Chemistry Faculty of Science.Islamic Azad UniversityMashad BranchMashhadIran Department of Chemistry Faculty of ScienceFerdowsi University of MashhadMashadIran

In the present work, effect of the attraction terms of four recently modified Peng-Robinson （MPR） equations of state on the prediction of solubility of caffeine, cholesterol, uracil and erythromycin was studied. The attraction terms of two of these equations are linear relative to the acentric factor and for the other two are exponential. It is found that the later show less deviation. Also interaction parameters for the studied systems are obtained and the percentage of average absolute relative deviation （%AARD） in each calculation is displayed.

关键词： Equation of state Solubility Supercritical carbon dioxide Biomolecules

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