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Datura metelAdministration Distorts Medial Prefrontal Cortex Histology of Wistar Rats

World Journal of Neuroscience 2015年第4期5卷 282-291页

作者： Temitope Akhigbe Etibor Musa Iyiola Ajibola mohammad olanrewaju buhari Abass Alao Safiriyu Oluwole Busayo Akinola Ezekiel A. Caxton-Martins Department of Human Anatomy Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Physiology Kampala International University Western Campus Ishaka Bushenyi Uganda Department of Anatomy University of Ilorin Ilorin Nigeria

Datura metel is one of psychoactive substances of great ethno-pharmacological significance often abused because of its unrestricted availability, yet, little is known about its mechanisms of action. This work was therefore aimed at assessing the activity of ethanolic seed extract of D. metel on Nissl substances, astrocytes, axonal and neuronal integrity of the medial prefrontal cortex (mPFC) of Wistar rats. Eighteen Wistar rats averaging 175 g were used and randomly assigned to three groups: group A rats (n = 6) were administered extract of 100 mg/kg bw, group B rats (n = 6) received extract of 200 mg/kg bw, and group C-control (n = 6) took distilled water only for 14 days. The results revealed that D. metel is deleterious to the health of Wistar rats at a dose-dependent rate as observed in its actions on the medial prefrontal cortex at 100 mg/kg bw and 200 mg/kg bw. The histological study of the treated Wistar rats exhibited features of disoriented neuronal integrity such as, chromatolysis, reduced protein synthesis due to loss of Nissl substances and nuclei, neuronal loss as well as axonal injuries.

关键词： D. metel Nissl Substance Prefrontal Cortex Chromatolysis

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(Ventrodorsal) Symmetrical Bicornuate Uterus Mimicking a Pedunculated Myoma—A Case Report

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Forensic Medicine and Anatomy Research 2017年第4期5卷 33-38页

作者： Adam Moyosore Afodun Khadijah Kofoworola Quadri Mustapha Akajewole Masud Muhammad olanrewaju buhari Sodiq Kolawole Lawal Department of Anatomy Faculty of Biomedical Science Kampala International University Kampala Uganda Department of Radiology Ultrasound and Doppler Unit Crystal Specialist Hospital Lagos Nigeria Department of Physiology College of Medicine University of Lagos Lagos Nigeria Department of Anatomy State University of Zanzibar Zanzibar Tanzania

Uterine anomalies account for about 4% in the most sampled population. Here we report a case of a 35 years old woman with occasional complaint of suprapelvic “heaviness”. She had an abnormal menstrual circle for the last 6 years. Manual palpitations were unrevealing and she appeared externally healthy. HSG was earlier performed as part of a fertility intervention (wrongly concluding on a detached form of pedunculated-myoma). Ultrasound revealed 2 separated fundal-cones, uterine cavities and a single inferior cervix. Cyesis in the bicornuate uterus is usually high-risk, making patients with uterine anomalies prone to proven misdiagnosis (e.g. appendicitis) and infertility. In addition, sonar further showed bilateral ovarian torsion. Corrective surgery was done in a hospital;post surgical healing was normal and uneventful.

关键词： Bicornuate Ultrasound Fertility Population

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Comparative Study of the Effects of Metformin and Garlic Extract on Hippocampal Na+/K+ATPase, Ca2+ATPase and Glutamine Synthetase Activities in Type II Diabetic Wistar Rat

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Journal of Biomedical Science and Engineering 2018年第9期11卷 254-262页

作者： Abass Alao Safiriyu Ibrahim Semuyaba Sodiq Kolawole Lawal Muhammad olanrewaju buhari Emmanuel Ayikobua Tiyo Muhamudu Kalange Alfred Omachonu Okpanachi Miriam Nansunga Department of Physiology Faculty of Biomedical SciencesKampala International UniversityIshakaUganda Department of Anatomy St.Francis University College of Health and Applied SciencesIfakaraTanzania Department of Anatomy Faculty of Biomedical SciencesKampala International UniversityIshakaUganda Department of Physiology Faculty of Biomedical SciencesSt.Augustine International UniversityKampalaUganda

Diabetes mellitus has not ceased to be on rise in spite of the continuous research on its management. Brain dysfunction associated with Diabetes mellitus especially Type II has been the great concern. The aim of this study was to investigate the effect of insulin sensitizing drug metformin and ethanolic extract of garlic on membrane bound enzymes Na+/K+ ATPase, Ca2+ ATPase and glutamate-glutamine cycle enzyme, Glutamine Synthetase activities in the hippocampus of streptozotocin-Nicotinamide induced Type II Diabetic rats. Twenty four male wistar rats weighted 120 - 150 g were used and divided into four groups with six rats in each group. Group A was non-diabetic (Control) and Groups B, C and D were diabetic. Group B received no treatment (DNT) while Groups C and D were treated with 1000 mg/kg of ethanolic garlic extract (EGE) and 50 mg/kg of metformin (MET) respectively orally for three weeks. All the groups were fed on standard rat chow with water ad libitum. Blood glucose was monitored weekly. Animals were sacrificed and the brains were removed and hippocampi were carefully excised and homogenate were obtained. Homogenate was analyzed for Na+/K+ ATPase, Ca2+ ATPase and Glutamine Synthetase (GS) activities. MET and EGE significantly reduced the blood glucose levels. There was a significant increase in the activities of hippocampal Na+/K+ ATPase, Ca2+ ATPase and GS in MET and EGE when compared to DNT. The results suggest that both MET and EGE increase the activities of hippocampal Na+/K+ ATPase, Ca2+ ATPase and GS which were reduced by diabetes mellitus, thus garlic and metformin administration exhibiting neuroprotective effect during hippocampal-related disorders associated with diabetes mellitus.

关键词： ATPase Diabetic Mellitus Garlic Glutamine Synthetase Hippocampus Metformin Na+/K+ ATPase

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Studies on Cardiac Cytoarchitectonic and Biochemical Indices in Pregnant Streptozotocin-lnduced Diabetic Rats Treated with Gliclazide and Insulin

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Journal of Pharmacy and Pharmacology 2018年第1期6卷 38-51页

作者： Olojede Samuel Oluwaseun Lawal Sodiq Kolawole Medubi Leke Jacob Adekoya Abimbola Julius Esubi Juan Uche Dauda Feyikemi Funmilayo buhari Muhammed olanrewaju Osinubi Abraham Adewale Department of Anatomy College of Medicine of the University of Lagos Lagos100254 Nigeria Department of Anatomy St. Francis University College of Health and Allied Sciences Ifakara-Morogoro 67501 Tanzania Department of Human Anatomy Western Campus Kampala International University Ishaka-Bushenyi 25647 Uganda

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