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国际眼科杂志 2007年第3期7卷 597-601页

作者： Heydar Siatiri Bahram Eshraghi mohammad Taher Rajabi Firoozeh Rahimi nasim Siatiri 伊朗德黑兰大学眼科研究中心 Farabi眼科医院

目的:研究重组组织型纤维蛋白酶原激活剂(tPA)对于治疗白内障手术后的纤维蛋白膜的作用。方法:选取白内障人工晶状体植入术后中度至重度纤维蛋白膜15例,行25μgtPA前房注射。同时给与持续的局部激素和睫状肌麻痹剂治疗,以及常规的裂隙... 详细信息

目的:研究重组组织型纤维蛋白酶原激活剂(tPA)对于治疗白内障手术后的纤维蛋白膜的作用。方法:选取白内障人工晶状体植入术后中度至重度纤维蛋白膜15例,行25μgtPA前房注射。同时给与持续的局部激素和睫状肌麻痹剂治疗,以及常规的裂隙灯检查和眼压监测。结果:在前房注射tPA的15眼中,其中9眼(60.0%)在2h后纤维蛋白膜完全溶解,11眼(73.3%)在1d内完全溶解。3眼内注射tPA几天后纤维蛋白膜复发。注射tPA24h后可观察到前房反应(P=0.54)和角膜水肿(P=0.083)增加。裂隙灯和眼压检查未发现明显的毒副作用。实验得到预期的稳定结果。结论:前房注射tPA用于治疗白内障手术后出现的纤维蛋白膜具有安全有效的作用。由于病例数量较少,需要进一步观察。

关键词：组织型纤维蛋白溶解酶原激活剂纤维蛋白膜白内障手术

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Post-traumatic thrombotic microangiopathy: What trauma surgeons need to know?

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Chinese Journal of Traumatology 2021年第2期24卷 69-74页

作者： mohammad A.Hossain nasim Ahmed Varsha Gupta Ravneet Bajwa Marjan Alidoost Arif Asif Tushar Vachharajani Department of Medicine Hackensack Meridian Health Jersey Shore University Medical CenterNeptuneNJ07753USA Department of Surgery Division of Trauma SurgeryHackensack Meridian Health Jersey Shore University Medical CenterNeptuneNJ07753USA Global Nephrology Glickman Urological&Kidney InstituteCleveland ClinicClevelandOH44103USA

Thrombotic microangiopathy(TMA)is characterized by systemic microvascular thrombosis,target organ injury,anemia and *** thrombocytopenic purpura,atypical hemolytic uremic syndrome and Shiga toxin E-coli-related hemolytic uremic syndrome are the three common forms of ***,TMA is encountered during pregnancy/postpartum period,malignant hypertension,systemic infections,malignancies,autoimmune disorders,***,the patients presenting with trauma have been reported to suffer from *** carries a high morbidity and mortality,and demands a prompt recognition and early intervention to limit the target organ *** trauma surgeons are the first line of defense for patients presenting with trauma,the prompt recognition of TMA for these experts is critically *** treatment of post-traumatic TMA can help improve the patient outcomes,if the diagnosis is made *** treatment of TMA is also different from acute blood loss anemia namely in that plasmapheresis is recommended rather than platelet *** article familiarizes trauma surgeons with TMA encountered in the context of ***,it provides a simplified approach to establishing the diagnosis of *** trauma patients can require multiple transfusions,the development of disseminated intravascular coagulation must be ***,the article also provides different features of disseminated intravascular coagulation and ***,the article suggests practical points that can be readily applied to the management of these patients.

关键词： Trauma Microangiopathy Complement amplifying condition

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A simple method for inducing nonalcoholic steatohepatitis with fibrosis

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Animal Models and Experimental Medicine 2019年第4期2卷 282-290页

作者： Leyla Yahaghi Azadeh Ebrahim-Habibi nasim Hayati-Roodbari Shiva Irani Parichehreh Yaghmaei Department of Biology Science and Research BranchIslamic Azad UniversityTehranIran Biosensor Research Center Endocrinology and Metabolism Molecular-Cellular Sciences InstituteTehran University of Medical SciencesTehranIran Endocrinology and Metabolism Research Center Tehran University of Medical SciencesTehranIran

Background: Nonalcoholic fatty liver disease(NAFLD) is increasingly occurring in sedentary people, and may progress to NASH and hepatocellular carcinoma. It is essential to design affordable animal models for the study of various diseases, including fatty liver, which was the aim of the study. In this study, a high-fat diet was devised that triggers NASH’s animal model quickly and easily. High-fat diet(HFD) was used both with intra-mouth oral gavage and in combination with animal ***: Twenty-four male C57 BL/6 J mice were divided into HFD and ND groups, which received a high-fat diet and a normal diet, respectively. At the end of the experiment(fourth week of treatment), body and liver weights, biochemical parameters, PPAR-α gene expression and histopathologic characteristics of the liver were ***: During 4 weeks, body weight of mice did not show a significant increase in the HFD group compared to the ND group, while weight gain of the liver was significant. Histological assessment of the HFD group’s liver confirmed NASH symptoms. In the HFD group, HDL-c, SOD, catalase, FRAP, adiponectin, and PPAR-α decreased significantly, and lipid profiles, hepatic enzymes, MDA, leptin, and TNF-α showed a significant increase compared to the ND ***: Our high-fat diet has successfully induced all aspects of NASH with fibrosis in 4 weeks, and with low cost.

关键词： animal model nonalcoholic fatty liver disease(NAFLD) nonalcoholic steatohepatitis(NASH) PPAR‐α

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TSC2 Deletions and Duplications: A Descriptive Study in Iranian Patients Affected with Tuberous Sclerosis

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American Journal of Molecular Biology 2014年第3期4卷 163-167页

作者： Hossein Ramandi Sayyed mohammad Hossein Ghaderian Parviz Toosi Seyyed Hassan Tonekaboni Ahmad Ebrahimi nasim Hatamnejadian Cellular and Molecular Research Center Research Institute for Endocrine Sciences Shahid Beheshti University of Medical Sciences Tehran Iran Medical Genetics Department Shahid Beheshti University of Medical Sciences Tehran Iran Pediatric Neurology Research Center Shahid Beheshti University of Medical Sciences (SBMU) Tehran Iran

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by formation of benign tumors called hamartomas. Although the TSC is diagnosed based on clinical findings but approximately 85% of individuals who meet diagnostic criteria for TSC a mutation can be identified in TSC2 (69%) and TSC1 (31%). A review of mutation type in TSC1 & TSC2 genes reveals that deletion/duplication assay could be a good screening strategy as a first step in TSC molecular diagnosis. All 41 exons and 5’ untranslated region of TSC2 gene in addition to adjacent PKD1 gene were screened for deletion/duplication in 81 patients DNA samples using multiplex ligation dependent probe amplification (MLPA) method. Deletion/duplication was found in 29 (35.8%) patients, including deletions in 26 (32.0%) patients and duplication in 3 (3.8%). Genotype/phenotype analysis, showed five patients with renal function impairment who have large deletions including PKD gene area. Approximately 65% of cases were sporadic, while the remaining have familial positive history. Deletions/duplications of TSC2 gene were seen in 35.8% of patients with TSC. So it could be concluded that MLPA is a useful testing strategy for molecular screening in sporadic forms of TSC patients. MLPA increased the detection of TSC mutations. MLPA is less expensive, quicker and more precise than direct sequencing and southern blot in the characterization of TSC deletions. This technique is recommended as a standard part of TSC clinical molecular diagnosis.

关键词： Tuberose Sclerosis Complex TSC2 MLPA Iran

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