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Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami Hamid Reza mohammadi Hossein Mahmoudvand mohammad Nabi Moradi javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

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Oral lesions after COVID-19 vaccination:Immune mechanisms and clinical approach

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Infectious Medicine 2022年第3期1卷 171-179页

作者： mohammad Amin Khazeei Tabari Shaghayegh Najary Gita Khadivi mohammad javad Yousefi Noosha Samieefar Fahimeh Abdollahimajd Student Research Committee Mazandaran University of Medical SciencesSariIran USERN Office Mazandaran University of Medical SciencesSariIran School of Dentistry Shahid Beheshti University of Medical SciencesTehranIran USERN Office Shahid Beheshti University of Medical SciencesTehranIran Student Research Committee Babol University of Medical SciencesBabolIran USERN Office Babol University of Medical SciencesBabolIran Student Research Committee School of MedicineShahid Beheshti University of Medical SciencesTehranIran Clinical Research Development Unit Shohada-e Tajrish HospitalShahid Beheshti University of Medical SciencesTehranIran

COVID-19 vaccination,although is a promising tool to overcome the pandemic,has side *** are in-creasing reports of oral lesions after COVID-19 *** aim of this review is to identify the occurrence of some oral lesions after COVID-19 vaccination,and highlight the underlying immune mechanisms involved.A narrative literature review was performed by searching electronic databases including PubMed,Scopus and Web of Science to investigate the oral lesions after COVID-19 *** inclusion criteria were original stud-ies,including the case reports,case series,letter to the editor,and cross-sectional *** exclusion criteria included the studies which examined the oral lesions caused by COVID-19 *** information,including the number of participant(s)receiving vaccine,type of vaccine,dose number,side effect(s),time of onset fol-lowing vaccination,healing time,treatment strategies for the existing lesions,and related mechanisms were then summarized in a data extraction *** results of this review showed that some vaccines had side effects with oral involvement such as pemphigus vulgaris,bullous pemphigoid,herpes zoster,lichen planus,Stevens-Johnson syndrome and Behçet’s *** research needs to elucidate the physiopathology of oral manifestations after the COVID-19 vaccination,and better understand the risk factors associated with such *** vaccine’s side effects may be due to the nocebo effect,which means that the person expects some adverse events to occur following the vaccine administration.

关键词： COVID-19 SARS-CoV-2 Oral lesion Mucosal disease

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Improving the Cellular Characteristics of Aluminum Foam for Maximum Sound Absorption Coefficient Using Genetic Algorithm

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Sound & Vibration 2021年第2期55卷 117-130页

作者： mohammad javad Jafari Mohsen Niknam Sharak Ali Khavanin Touraj Ebadzadeh Mahmood Fazlali Rohollah Fallah Madvari Department of Occupational Health Engineering School of Public Health and SafetyShahid Beheshti University of Medical SciencesTehranIran Mechanical Engineering Department of Mechanical EngineeringUniversity of BirjandBirjandIran Department of Occupational Health Engineering Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Department of Ceramics Materials and Energy Research CenterAlborzIran Department of Data and Computer Science Faculty of Mathematical SciencesShahid Beheshti UniversityTehranIran Student Research Committee Department of Occupational Health EngineeringSchool of Public Health and SafetyShahid Beheshti University of Medical SciencesTehranIran Department of Occupational Health School of Public HealthShahid Sadoughi University of Medical SciencesYazdIran

Fabricating of metal foams with desired morphological parameters including pore size,porosity and pore opening is possible now using sintering ***,if it is possible to determine the morphology of metal foam to absorb sound at a given frequency,and then fabricate it through sintering,it is expected to have optimized metal foams for the best sound *** sound absorption models such as Lu model describe the relationship between morphological parameters and the sound absorption *** this study,the Lu model was used to optimize the morphological parameters of aluminum metal foam for the best sound absorption *** this purpose,the Lu model was numerically solved using written codes in MATLAB *** validating the proposed codes with benchmark data,the genetic algorithm(GA)was applied to optimize the affecting morphological parameters on the sound absorption *** optimization was carried out for the thicknesses of 5 mm to 40 mm at the sound frequency range of 250 Hz–8000 *** optimized parameters ranged from 50%to 95%for porosity,0.1 mm to 4.5 mm for pore size,and 0.07 mm to 0.6 mm for pore opening *** result of this study was applied to fabricate the desired aluminum metal foams for the best sound *** novel approach applied in this study,is expected to be successfully applied in for best sound absorption in desired frequencies.

关键词： Acoustic model Genetic Algorithm(GA) metal foam optimization Sound Absorption Coefficient(SAC)

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Drug resistance pattern of Mycobacterium tuberculosis isolates from patients of five provinces of Iran

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Asian Pacific Journal of Tropical Medicine 2014年第3期7卷 193-196页

作者： mohammad javad Nasiri Faranak Rezaei Samin Zamani Davod Darban-Sarokhalil Abbas Ali Imani Fooladi Hasan Shojaei mohammad Mehdi Feizabadi Department of Microbiology School of Medicine.Tehran University of Medical Sciences Department of Microbiology School of Medicine.Alborz University of Medical Sciemces Applied Microbiology Research Centre Baqiyatallah University of Medical Sciences Department of Microbiology School of Medicine.Isfahan University of Medical Sciences

Objective:To determine the patterns of resistance to first line anti-tuberculosis(TB)drugs among a collection of Mycobacterium tuberculosis(MTB)isolates from 5 provinces of ***:A total of the 6 426 clinical specimens from patients suspected of active TB were collected from March 2010 to June *** specimens were subjected for microscopy and culture tests in the TB centers of studies *** susceptibility testing to the first line anti-TB drugs for culture positive MTB was performed on Lwenstein-Jensen(LJ)medium using proportion ***:Of 6 426 clinical specimens,261 were culture positive for mycobacteria,of which 252 were MTB and 9 were MOTT(mycobacteria other than tuberculosis).Of 252 MTB isolates.211(83.7%)were pan-susceptible and 41(16.3%)were resistant to at least one *** was most common to streptomycin.30 isolates(12.0%),followed by isoniuzid,20isolates(8.0%),rifampin,15 isolates(6.0%)and ethambutol,14 isolates(5.5%).Sixteen(6.3%)MTB isolates were MDR.A clear evidence of heterogeneity amongst the 5 provinces in the proportions with resistance to one or more drugs was observed[χ~2=12.209(4 degrees of freedom),P values=0.015 9].Conclusions:The prevalence of drug resistance in this study area underscoring the need for further enforcement of TB control strategies in the *** susceptibility testing for all TB cases to provide optimal treatment,establishing advanced diagnostic facilities for rapid detection of MDR-TB and continuous monitoring of drug resistance are recommended for prevention and control of drug-resistant TB.

关键词： Mycobacterium tuberculosis MDR tuberculosis Drug resistance Iran

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Capacity-based performance measurements for loading equipment in open pit mines

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Journal of Central South University 2019年第6期26卷 1672-1686页

作者： Amin MONIRI-MORAD mohammad POURGOL-mohammad Hamid AGHABABAEI javad SATTARVAND Department of Mining Engineering Sahand University of TechnologyTabriz 51335-1996Iran Department of Mechanical Engineering Sahand University of TechnologyTabriz 51335-1996Iran Department of Mining and Metallurgical Engineering University of NevadaReno 89557United States

The purpose of this study is to develop an integrated framework for capacity analysis to address the influence of systematic hazardous factors on the haulage fleet nominal *** proposed model was made to capture unexpected risks for mining equipment based upon data-driven method considering different *** risk assessment(PRA)was employed to quantify the loss of production capacity by focusing on severity of failure incidents and maintainability ***-event simulation was configured to characterize the nominal capacity for mining ***,the system capacity was analyzed through the comparison of nominal and actual capacity.A case study was completed to validate the research *** past operation and maintenance field data were collected for shovel *** discrete-event simulation was developed to estimate the rate of shovel nominal ***,the effects of undesirable scenarios were assessed by developing the PRA *** research results provide significant insights into how to enhance the production capacity in *** analyst gets a well judgment for the crucial elements dealing with high risk levels.A holistic maintenance plan can be developed to mitigate and control the losses.

关键词： capacity performance maintainability mining equipment risk assessment

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Immune checkpoints in targetedi-mmunotherapy of pancreatic cancer:New hope for clinical development

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Acta Pharmaceutica Sinica B 2021年第5期11卷 1083-1097页

作者： Seyed Hossein Kiaie mohammad javad Sanaei Masoud Heshmati Zahra Asadzadeh Iman Azimi Saleh Hadidi Reza Jafari Behzad Baradaran Immunology Research Center Tabriz University of Medical SciencesTabriz ***Iran Nano Drug Delivery Research Center Kermanshah University of Medical SciencesKermanshah ***Iran Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran School of Pharmacy and Pharmacology College of Health and MedicineUniversity of TasmaniaHobart 7001TasmaniaAustralia Clinical Biochemistry Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekord ***Iran Solid Tumor Research Center Cellular and Molecular Medicine InstituteUrmia University of Medical SciencesUrmia ***Iran Department of Immunology and Genetics School of MedicineUrmia University of Medical SciencesUrmia ***Iran

Immunotherapy has been recently considered as a promising alternative for cancer ***,targeting of immune checkpoint(ICP)strategies have shown significant success in human ***,despite remarkable success of cancer immunotherapy in pancreatic cancer(PCa),many of the developed immunotherapy methods show poor therapeutic outcomes in PCa with no or few effective treatment options thus *** this process,immunosuppression in the tumor microenvironment(TME)is found to be the main obstacle to the effectiveness of antitumor immune response induced by an immunotherapy *** this paper,the latest findings on the ICPs,which mediate immunosuppression in the TME have been *** addition,different approaches for targeting ICPs in the TME of PCa have been *** review has also synopsized the cutting-edge advances in the latest studies to clinical applications of ICP-targeted therapy in PCa.

关键词： Immune checkpoint Pancreatic cancer Tumor microenvironment Immunotherapy Clinical development

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Characteristics of the breakup and fragmentation of an electrohydrodynamic melt jet

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Particuology 2012年第3期10卷 255-265页

作者： Ahmad Khoshnevis Meisam Farzalipour Tabriz Morteza Hemayatkhah Ahmad Esmaielzadeh Kandjani javad Mollaei Milani Esmaeil Esmaeilzadeh Morteza Eslamian mohammad Reza Vaezi Department of Mechanical Engineering University of Tabriz Tabriz Iran School of Engineering and Computing Sciences Texas A&M University-Corpus Christi TX 78412 USA Materials and Energy Research Center (MERC) Karaj Iran

In this study, the breakup of a melt jet into a viscous medium is investigated in the presence of an intense electric field. Fragmentation of the melt jet occurs due to both hydrodynamic and electrohydrodynamic （EHD） forces within two kinds of silicone oil of different viscosities. The size and shape characteristics of the produced particles have been studied using SEM images, and the particle size distributions were found to exhibit considerable variations when a voltage was applied and when both the viscosity and temperature of the base fluid were changed. The morphologies of the particles were also affected by the same parameters. For instance, by applying EHD force, significant enhancements in size reduction and increased roundness of the particles occurred. The breakup process of the melt jet was found to be dominant by hydrodynamic or electrohydrodynamic instabilities, depending on the situation. Governing mechanisms （instability） in the cases of pure hydrodynamic and electrohydrodynamic fragmentations are discussed.

关键词： Electrohydrodynamic atomizationMelt jet breakupMelt fragmentationPowder productionElectrohydrodynamic instabilities

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Allele and haplotype frequencies for HLA-DQ in Iranian celiac disease patients

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World Journal of Gastroenterology 2014年第20期20卷 6302-6308页

作者： mohammad Rostami-Nejad Jihane Romanos Kamran Rostami Azita Ganji mohammad javad Ehsani-Ardakani Ali-Reza Bakhshipour Homayoun Zojaji Seyed Reza Mohebbi mohammad-Reza Zali Cisca Wijmenga Department of Celiac Disease Gastroenterology and Liver Diseases Research Centers Shahid Beheshti University of Medical Sciences Tehran *** Iran Department of Genetics University of Groningen University Medical Centre of Groningen 9700 RB Groningen The Netherlands Department of Genetics Institute of Human Genetics Lebanese American University Byblos 36 Lebanon Department of Gastroenterology Worcestershire Royal Hospital Worcester WR5 1DD United Kingdom Department of Gastroenterology Imam Reza Hospital Mashhad University of Medical Sciences Mashhad 1351143 Iran Department of Gastroenterology Zahedan University of Medical Sciences Zahedan 2143453 Iran

AIM: To assess the distribution of human leukocyte antigen (HLA)-DQ2 and -DQ8 in Iranian celiac disease (CD) patients and compare them to healthy Iranian controls.

关键词： Human leukocyte antigen typing Validation Susceptibility Celiac disease Iran

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Seepage analysis of Upper Gotvand Dam concerning gypsum karstification(2D and 3D approaches)

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Frontiers of Structural and Civil Engineering 2011年第1期5卷 71-78页

作者： Jamshid SADREKARIMI Majid KIYANI Behnam FAKHRI mohammad javad VAHDATIRAD Amin BARARI Faculty of Civil Engineering University of TabrizTabrizIran Faculty of Civil Engineering University of MazandaranBabolIran Department of Cicil Engineering Aalborg UniversitySohngårdsholmsvej 57Aalborg 9000Denmark

Upper Gotvand Dam is constructed on the Karun River at the south west of *** this paper,2D and 3D models of the dam together with the foundation and abutments were established,and several seepage analyses were carried ***,the gypsum veins that are scattered throughout the foundation ground were included in the models,and the seepage pattern,considering the dissolution law of gypsum,was *** was disclosed that the discharge fluxes obtained from 2D and 3D analyses are not similar,and the discharge flux in 3D model is about four times that of the 2D ***,the 3D model locates the phreatic surface somewhat higher than the 2D *** means that the 2D model estimates lower pore water pressure pattern in comparison with the 3D *** may be attributed to the fact that with 2D model the lateral components of vectors of seepage velocity are *** the current case,the rate of increase of discharge flux due to dissolution of gypsum veins was obtained to be a thirdorder function of the aperture *** spite of the fact that the grout curtain is designed to be about 170 m deep,however,complete dissolve of gypsum will severely increase the discharge flux through the foundation ground.

关键词： Upper Gotvand Dam seepage analysis gypsum veins 3D model discharge flux

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多孔纳米结构Fe/Pt-Fe电极对碱性介质中甲醇电氧化的催化活性（英文）

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催化学报 2015年第7期36卷 1029-1034页

作者： javad Hosseini Mehdi Abdolmaleki Hamid Reza Pouretedal mohammad Hossein Keshavarz Department of Chemistry Malek-ashtar University of Technology Faculty of Science Department of ChemistrySayyed Jamaleddin Asadabadi University

An electrochemical approach to fabricate a nanostructured Fe/Pt-Fe catalyst through electrodeposition followed by galvanic replacement is presented. An Fe/Pt-Fe nanostructured electrode was prepared by deposition of Fe-Zn onto a Fe electrode surface, followed by replacement of the Zn by Pt at open-circuit potential in a Pt-containing alkaline solution. Scanning electron microscopy and energy-dispersive X-ray techniques reveal that the Fe/Pt-Fe electrode is porous and contains Pt. The electrocatalytic activity of the Fe/Pt-Fe electrode for oxidation of methanol was examined by cyclic voltammetry and chronoamperometry. The electrooxidation current on the Fe/Pt-Fe catalyst is much higher than that on flat Pt and smooth Fe catalysts. The onset potential and peak potential on the Fe/Pt-Fe catalyst are more negative than those on flat Pt and smooth Fe electrodes for methanol electrooxidation. All results show that this nanostructured Fe/Pt-Fe electrode is very attractive for integrated fuel cell applications in alkaline media.

关键词：电催化活性甲醇氧化纳米铁碱性介质铂电极多孔 Fe催化剂扫描电子显微镜

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