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Common Prothrombotic Gene Mutations in Cerebral Venous Sinus Thrombosis in North-West of Iran

Neuroscience & Medicine 2017年第4期8卷 68-76页

作者： Elyar Sadeghi-Hokmabadi Ebrahim Sakhinia Mehdi Farhoudi Somayyeh Hasaneh Morteza Ghojazadeh mohammad amin farzi Sasan Andalib Masoumeh Nemati Omid Abbaszadeh Reza Rikhtegar Reshad Mirnour Neurosciences Research Center Department of Neurology Imam-Reza Hospital School of Medicine Tabriz University of Medical Sciences Tabriz Iran Connective Tissue Research Center Department of Medical Genetics Faculty of Medicine and Tabriz Genetic Analysis Centre (TGAC) Tabriz University of Medical Sciences Tabriz Iran Liver and Gastrointestinal Disease Research Center Tabriz University of Medical Sciences Tabriz Iran Department of Neurosurgery Poursina Hospital School of Medicine Guilan University of Medical Sciences Rasht Iran

Objective: Cerebral venous sinus thrombosis (CVST) is a life-threatening cerebrovascular disease which has high prevalence and mortality rate in Iran. Thrombophilia caused by gene mutation is a common cause of CVST. The present study aimed at assessing the prevalence of thrombophilic gene mutations in Iranian CVST patients and then comparing it with normal population. Materials and methods: In a case-control study, polymerase chain reaction-restriction fragment length polymorphism (PCR_RFLP) and amplification-refractory mutation system (ARMS-PCR) were carried out to detect common thrombophilic mutations in 70 CVST patients. Next, it was compared with 82 sex- and age-matched healthy controls. Results: Factor-V-Leiden, Factor-V-Leiden HR2, Factor prothrombin II, MTHFR (667C/T) and MTHFR (1298A/C) prevalence were significantly high in cases of CVST as compared to the controls (P values: 0.012, 0.019, 0.007 and 0.036, respectively). However, there was no significant difference between the two groups in plasminogen activator inhibitor (PAI), angiotensin-converting enzyme (ACE), beta-fibrinogen (FGB), Factor VIII, Factor XIII, and tissue plasminogen activator (tPA) mutations. Conclusion: The findings of the present study suggest that Factor V-Leiden, Factor-V-Leiden HR2, prothrombin II (G20210A), and MTHFR (667C/T & 1298A/C) mutations are more frequent in CVST. Detection of these mutations may help clinicians to decide on the duration of treatment and referral to genetic counseling for valuable prevention.

关键词： Gene Mutation Cerebral Venous Sinus Thrombosis Thrombophilia

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Geometrically Nonlinear Bending Analysis of Metal-Ceramic Composite Beams under Thermomechanical Loading

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Chinese Journal of Mechanical Engineering 2013年第4期26卷 701-713页

作者： TORABIZADEH mohammad amin Department of Industrial Design Engineering University of Applied Science and Technology

A new method is developed to derive equilibrium equations of Metal-Ceramic beams based on first order shear deformation plate theory which is named first order shear deformation beam theory2(FSDBT2). Equilibrium equations obtained from conventional method (FSDBT1) is compared with FSDBT2 and the case of cylindrical bending of Metal-Ceramic composite plates for non-linear thermomechanical deformations and various loadings and boundary conditions. These equations are solved by using three different methods (analytical, perturbation technique and finite element solution). The through-thickness variation of the volume fraction of the ceramic phase in a Metal-Ceramic beam is assumed to be given by a power-law type function. The non-linear strain-displacement relations in the von-Kármán sense are used to study the effect of geometric non-linearity. Also, four other representative averaging estimation methods, the linear rule, Mori-Tanaka, Self-Consistent and Wakashima-Tsukamoto schemes, by comparing with the power-law type function are also investigated. Temperature distribution through the thickness of the beams in thermal loadings is obtained by solving the one-dimensional heat transfer equation. Finally it is concluded that for Metal-Ceramic composites, these two theories result in identical static responses. Also the displacement field and equilibrium equations in the case of cylindrical bending of Metal-Ceramic plates are the same as those supposed in FSDBT2.

关键词： thermomechanical loading functionally graded beams monlinear analysis analytical solution

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Secure Channel Estimation Using Norm Estimation Model for 5G Next Generation Wireless Networks

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Computers, Materials & Continua 2025年第1期82卷 1151-1169页

作者： Khalil Ullah Song Jian Muhammad Naeem Ul Hassan Suliman Khan mohammad Babar Arshad Ahmad Shafiq Ahmad Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China Department of Computer Science Abbottabad University of Science and TechnologyHavelianAbbottabad22500Pakistan Department of Computing and Electronics Engineering Middle East CollegeMuscat124Oman Department of CS&IT Pak-Austria Fachhochschule Institute of Applied Sciences and Technology MangHaripur22621Pakistan Industrial Engineering Department College of EngineeringKing Saud UniversityRiyadh11421Saudi Arabia

The emergence of next generation networks(NextG),including 5G and beyond,is reshaping the technological landscape of cellular and mobile *** networks are sufficiently scaled to interconnect billions of users and *** in academia and industry are focusing on technological advancements to achieve highspeed transmission,cell planning,and latency reduction to facilitate emerging applications such as virtual reality,the metaverse,smart cities,smart health,and autonomous *** continuously improves its network functionality to support these *** input multiple output(MIMO)technology offers spectral efficiency,dependability,and overall performance in *** article proposes a secure channel estimation technique in MIMO topology using a norm-estimation model to provide comprehensive insights into protecting NextG network components against adversarial *** technique aims to create long-lasting and secure NextG networks using this extended *** viability of MIMO applications and modern AI-driven methodologies to combat cybersecurity threats are explored in this ***,the proposed model demonstrates high performance in terms of reliability and accuracy,with a 20%reduction in the MalOut-RealOut-Diff metric compared to existing state-of-the-art techniques.

关键词： Next generation networks massive mimo communication network artificial intelligence 5G adversarial attacks channel estimation information security

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Engendered nanoparticles for treatment of brain tumors

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Oncology Research 2025年第1期33卷 15-26页

作者： SOROUSH SOLEYMANI mohammad DOROUDIAN MAHDIEH SOEZI ALI BELADI KIARASH ASGARI ASO MOBARAKSHAHI ARYANA AGHAEIPOUR RONAN MACLOUGHLIN Department of Cell and Molecular Biology School of Biological SciencesUniversity of LeicesterLeicesterLE17RHUK Department of Cell and Molecular Biology Faculty of Biological SciencesKharazmi UniversityTehran15719-14911Iran Cancer Epidemiology Research Center Aja University of Medical SciencesTehran14117-18541Iran Medical Biotechnology Research Center Aja University of Medical SciencesTehran14117-18541Iran Department of Life Sciences Faculty of Natural SciencesImperial College LondonLondonSW72AZUK School of Pharmacy and Biomolecular Sciences Royal College of Surgeons in Ireland(RCSI)DublinD02 YN77Ireland Research and Development Science and Emerging TechnologiesAerogen Ltd.Galway Business ParkGalwayH91 HE94Ireland School of Pharmacy and Pharmaceutical Sciences Trinity CollegeDublinD02 PN40Ireland

Brain metastasis and primary glioblastoma multiforme represent the most common and lethal malignant brain *** median survival time is typically less than a year after *** of the major challenges in treating these cancers is the efficiency of the transport of drugs to the central nervous *** blood-brain barrier is cooperating with advanced stages of *** blood-brain barrier poses a significant challenge to delivering systemic medications to brain *** delivery systems have emerged as promising tools for effectively crossing this ***,the development of smart nanoparticles brings new hope for cancer diagnosis and *** nanoparticles improve drug delivery efficiency,allowing for the creation of targeted and stimuli-responsive delivery *** review highlights recent advancements in nanoparticle and smart nanoparticle technologies for brain cancer treatment,exploring the range of nanoparticles under development,their applications,targeting strategies,and the latest progress in enhancing transport across the blood-brain *** also addresses the ongoing challenges and potential benefits of these innovative approaches.

关键词： Nanoparticles Smart nanoparticles Stimuli responsive nanoparticles Targeted nanoparticles Blood-brain barrier(BBB) Brain cancer

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A novel method for the management of sulfone-rich waste produced in the oxidative desulfurization(ODS) process

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Chinese Journal of Chemical Engineering 2020年第9期28卷 2447-2456页

作者： Sobhan Farahani mohammad amin Sobati School of Chemical Engineering Iran University of Science and Technology(IUST)Tehran 16765-163Iran

The oxidative desulfurization(ODS) process is one of the new desulfurization processes for the production of clean fuels. Despite the benefits of the ODS process, this process faces several important challenges. One of the most important challenges of this process is the management of a waste which is rich of sulfone *** the present study, a new strategy which is the addition of waste to the bitumen with other solid waste such as high density polyethylene(HDPE) waste has been investigated. The experimental design method was applied to investigate the effect of addition of the sulfone and HDPE wastes to the properties of the bitumen blends including degree of penetration, softening point, and mass loss. It was found that the sulfone waste can be added to the bitumen as a softener. The results showed that several grades of bitumen including 50/60, 60/70, 85/100 can be produced through the addition of sulfone waste along with the HDPE waste to the base 60/70 *** general, the application of simple processes such as mixing the wastes with the bitumen can reduce the cost of waste management, considerably.

关键词： OXIDATIVE desulfurization Waste management Sulfone waste Bitumen Experimental design High density polyethylene(HDPE)waste

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Numerical analysis of confinement effect on crack propagation mechanism from a flaw in a pre-cracked rock under compression

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Acta Mechanica Sinica 2012年第5期28卷 1389-1397页

作者： amin Manouchehrian mohammad Fatehi Marji Mining and Metallurgical Engineering Department Yazd University

In many situations rocks are subjected to biaxial loading and the failure process is controlled by the lateral confinement stresses. The importance of confinement stresses has been recognized in the literature by many researchers, in particular, its influence on strength and on the angle of fracture, but still there is not a clear description for the influence of confining stress on the crack propagation mechanism of rocks. This paper presents a numerical pro- cedure for the analysis of crack propagation in rock-like ma- terials under compressive biaxial loads. Several numerical simulations of biaxial tests on the rock specimen have been carried out by a bonded particle model （BPM） and the influ- ence of confinement on the mechanism of crack propagation from a single flaw in rock specimens is studied. For this purpose, several biaxial compressive tests on rectangular spec- imens under different confinement stresses were modeled in （2 dimensional particle flow code） PFC2D. The results show that wing cracks initiate perpendicular to the flaw and trend toward the direction of major stress, however, when the lat- eral stresses increase, this initiation angle gets wider. Also it is concluded that in addition to the material type, the initiation direction of the secondary cracks depends on confine- ment stresses, too. Besides, it is understood that secondary cracks may be produced from both tensile and shear mechanisms.

关键词： Crack propagation Confinement Bonded par-ticle model - Rock Secondary cracks

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Development of a Colorimetric Loop-mediated Isothermal Amplification Assay for the Visual Detection of Fusarium oxysporum ***. melonis

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Horticultural Plant Journal 2019年第3期5卷 129-136页

作者： mohammad amin Almasi Young Researchers and Elites Club North Tehran Branch Islamic Azad University

Fusarium wilt of melon, Fusarium oxysporum ***. melonis is one of the most important diseases, causing tremendous losses in melon growing areas in Iran. There is a real need for a rapid and inexpensive assay to facilitate accurate disease diagnosis and surveillance for better management of Fusarium wilt outbreaks. One of the procedures designed for detection of this disease is loop-mediated isothermal amplification(LAMP)assay; its efficiency has been contrasted with polymerase chain reaction(PCR). The translation elongation factor 1-alpha gene is basically used for designing the LAMP(i.e. F3, B3, FIP, and BIP) together with PCR(F and B). Using hydroxynaphthol blue(HNB) dye, LAMP was placed in a water bath after the optimization was done. The results show LAMP is an advantageous method because it is highly sensitive(100-fold), quite cheap,user-friendly, and safe; in addition, it is performed quickly by visual detection and does not require DNA extraction(in direct-LAMP). The LAMP is believed to be a simple and reliable tool for laboratory purposes because it needs only very basic instruments and the results can be observed and contrasted visually.

关键词： Direct-LAMP assay Fusarium oxysporum f.sp. melonis Visual detection

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Regularity classification and corresponding analysis method requirements of horizontally curved bridges with unequal pier heights

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Earthquake Engineering and Engineering Vibration 2023年第2期22卷 549-571页

作者： mohammad Jalal Maleki-amin Shahrokh Maalek School of Civil Engineering Tehran UniversityTehran 11155-4563Iran Iranian Bridge Engineering Association Tehran 36481684Iran

The seismic behavior of horizontally curved bridges,particularly with unequal height piers,is more complicated than that of straight bridges due to their geometric *** this study,the seismic responses of several horizontally curved single-column-bent viaducts with various degrees of curvature and different pier heights have been investigated,employing three different analysis approaches:namely,modal pushover analysis,uniform load method,and nonlinear time history *** the investigated bridge configurations and utilizing the most common regularity indices,the results indicate that viaducts with 45-degree and 90-degree deck subtended angles can be categorized as regular and moderately irregular,respectively,while the bridges with 180-degree deck subtended angle are found to be highly ***,the viaducts whose pier heights are asymmetric may be considered as irregular for almost all ranges of the deck subtended *** effects of higher transverse and longitudinal modes are discussed and the minimum analysis requirements are identified to assess the seismic response of such bridge configurations for design *** the Regularity Indices used here are useful tools to distinguish between regular and irregular bridges,further studies are needed to improve their reliability.

关键词： horizontally curved bridges unequal height piers pushover analysis regularity index seismic analysis and response

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Enhanced removal of nitrate and phosphate from wastewater by Chlorella vulgaris: Multi-objective optimization and CFD simulation

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Chinese Journal of Chemical Engineering 2019年第3期27卷 639-648页

作者： mohammad Bagher Sabeti mohammad amin Hejazi Afzal Karimi Faculty of Chemical and Petroleum Engineering University of Tabriz Department of Food Biotechnology Branch for Northwest & West Region Agricultural Biotechnology Research Institute of Iran Agricultural Education and Extension Organization (AREEO) Department of Biotechnology Faculty of Advanced Technologies in Medicine Iran University of Medical Sciences

To enhance the efficiency of wastewater biotreatment with microalgae, the effects of physical parameters need to be investigated and optimized. In this regard, the individual and interactive effects of temperature, p H and aeration rate on the performance of biological removal of nitrate and phosphate by Chlorella vulgaris were studied by response surface methodology(RSM). Furthermore, a multi-objective optimization technique was applied to the response equations to simultaneously find optimal combinations of input parameters capable of removing the highest possible amount of nitrate and phosphate. The optimal calculated values were temperature of 26.3 °C, pH of 8 and aeration rate of 4.7 L·min^(-1). Interestingly, under the optimum condition, approximately 85% of total nitrate and 77% of whole phosphate were removed after 48 h and 24 h, respectively, which were in excellent agreement with the predicted values. Finally, the effect of baffle on mixing performance and, as a result, on bioremoval efficiency was investigated in Stirred Tank Photobioreactor(STP) by means of Computational Fluid Dynamics(CFD). Flow behavior indicated substantial enhancement in mixing performance when the baffle was inserted into the tank. Obtained simulation results were validated experimentally. Under the optimum condition, due to proper mixing in baffled STP, nitrate and phosphate removal increased up to 93% and 86%,respectively, compared to unbaffled one.

关键词： Nitrate Phosphate Nutrient removal Response surface methodology Stirred Tank Photobioreactor Computational Fluid Dynamics

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Optimization of a continuous ultrasound assisted oxidative desulfurization(UAOD) process of diesel using response surface methodology(RSM) considering operating cost

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Chinese Journal of Chemical Engineering 2020年第5期28卷 1384-1396页

作者： mohammad Dana mohammad amin Sobati Shahrokh Shahhosseini aminreza Ansari School of Chemical Engineering Iran University of Science and Technology(IUST)TehranIran

A continuous-flow ultrasound-assisted oxidative desulfurization(UAOD)of partially hydro-treated diesel has been investigated using hydrogen peroxide-formic acid as simple and easy to apply oxidation *** effects of different operating parameters of oxidation stage including residence time(2–24 min),formic acid to sulfur molar ratio(10–150),and oxidant to sulfur molar ratio(5–35)on the sulfur removal have been studied using response surface methodology(RSM)based on Box–Behnken *** the operating costs of the continuous-flow oxidation stage including chemical and electrical energy consumption,the appropriate values of operating parameters were selected as follows:residence time of 16 min,the formic acid to sulfur molar ratio of 54.47,and the oxidant to sulfur molar ratio of *** these conditions,the sulfur removal and the volume ratio of the hydrocarbon phase to the aqueous phase were 86.90%and 4.34,*** drastic reduction in the chemical consumption in the oxidation stage,the volume ratio of the hydrocarbon phase to the aqueous phase was increased up to ***,the formic acid to sulfur molar ratio and the oxidant to sulfur molar ratio were obtained 23.64 and 3.58,respectively,which lead to sulfur removal of 84.38%with considerable improvements on the operating cost of oxidation stage in comparison with the previous works.

关键词： Ultrasound-Assisted Oxidative Desulfurization(UAOD) Continuous-flow system Sulfur removal Response Surface Methodology(RSM) Operating cost

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