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Journal of Cancer Therapy 2017年第13期8卷 1160-1168页

作者： May G. Ashour Tarek H. Shouman Ashraf H. Hassouna Reem M. Emad El din Maha H. Mokhtar mohamed A. Khalil Radiation Oncology department National Cancer Institute Cairo University Cairo Egypt Physics Unit Radiation Oncology Department National Cancer Institute Cairo University Cairo Egypt

Objective: We aim to quantify the magnitude of setup errors in intensity-modulated radiotherapy (IMRT) treated Head and Neck cancer patients and recommend appropriate PTV margin. Methods: 60 patients with head and neck cancer required bilateral neck irradiation were planned and treated by simultaneous integrated boost IMRT technique either treated radically or postoperative. Patients undergoing image-guided radiotherapy (IGRT) each with once weekly scheduled cone beam computed tomography (CBCT). The 3d displacements, systematic and random errors were calculated. The appropriate PTV expansion was determined using Van Herk’s formula. Results: Mean 3d displacement was 0.16 cm in the vertical direction, 0.14 cm in the horizontal direction and 0.16 cm in the longitudinal direction. Conclusion: Use of weekly CBCT allows the planning target volume (PTV) expansion to be reduced according to our setup. The appropriate clinical target volume (CTV)-PTV margin for our institute is 0.30 cm, 0.38 cm, and 0.33 cm in the horizontal, vertical, and longitudinal directions, respectively.

关键词： IMRT CBCT Setup Errors Head and Neck

Etiologies of Bone Metastases at the Rheumatology department (UTH) of Abidjan

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Open Journal of Rheumatology and Autoimmune diseases 2020年第1期10卷 1-7页

作者： Mariam Gbané Jean Claude Soglo mohamed diomandé Guy Léopold Kengni Baly Ouattara Jean Mermoz djaha Kouassi You Nina Carmelle Kpami Yaya Coulibaly Edmond Eti Rheumatology department University Teaching Hospital (UTH) of Cocody Abidjan C&#244 te d'Ivoire

Objectives: The aim of this study was to describe the diagnostic and etiological aspects of bone metastases in the Rheumatology department of Cocody’s University Teaching Hospital (UTH). Methodology: This was a descriptive, 11-year retrospective study (January 1, 2006 to december 31, 2016) of inpatient records of bone metastases. The diagnosis was made on clinical (bone signs), radiological (osteolysis, bone condensation) and sometimes histological basis. Result: Eighty out of 6, 1111 inpatients suffered from bone metastasis with a hospital frequency of 1.30%. The average age was 60.74 years (range 26 to 81 years). Men were predominant (53 men for 27 women) with a sex ratio of 1.96. The main complaints were pain (97.6%). chronic (90%), severe (73.8%), inflammatory (93.8%). There was sometimes a neurological complication: a motor deficit (21.3%), sensitive (13.8%). These symptoms were associated with fever (56.3%) and altered general state (85%). Bone metastases have been revealing in the vast majority of cases (93.75%);the primary cancer was known only in 5 patients (prostate = 2, breast = 2 and cervix = 1). Bone condensation (61.3%), osteolysis (50%) and mixed lesions (7.5%) where the main radiological lesions observed. The primary tumors were: prostatic (50%), pulmonary (18.8%), mammary (11.3%), uterine (5%), renal (2.5%), hepatic (2.5%), bladder (1.3%) and adrenal (1.3%). Conclusion: Bone metastases affect mostly the elderly;inflammatory spinal pain is the main symptom. Bone condensation is the most common radiologic lesion. The prostate, breast and lungs are the main primary tumors.

关键词： Bone Metastases Bone Condensation Prostate Cancer Africa

Frequency of Epidermal Growth Factor Mutation Status and Its Effect on Outcome of Patients with Adenocarcinoma of the Lung

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Journal of Cancer Therapy 2014年第11期5卷 1012-1020页

作者： Hanan E. Shafik[1 Salem H. Al-Shemarri[1 Fahed Al-Enezi mohamed Ashour[1 Eman Khalaf Ahmed I. Al-Khodary[1 Kuwait Cancer Control Center Kuwait City Kuwait department of Medical Oncology National Cancer Institute (NCI) Cairo Egypt department of Medicine Faculty of Medicine Kuwait University Kuwait City Kuwait department of Clinical Oncology AL-Azhar University Cairo Egypt

he frequency of EGFR mutations is ethnicity-dependent, with a higher proportion in Asian population than in whites. The prevalence of these mutations among Arab patients is unknown. The objective of this study was to report the frequency and spectrum of EGFR mutations in our population with lung adenocarcinoma, and the effect of this mutation on treatment outcome. Tumor specimens from 81 patients histological diagnosed as NSCLC adenocarcinoma were reviewed by our local pathologist and then sent to Lab 21 London, UK. Samples were tested for 28 mutations in EGFR gene. Positive patients received TKI and negative patients received chemotherapy. data were collected and retrospectively analyzed to determine frequency and spectrum of EGFR positivity. Patients were followed for time to progression (TTP) and overall survival (OS). Overall frequency of EGFR mutation was 37%;del 19 (46.6%), L858R (40%), d719x and insertion 20 (6.7%) for each. Females and nonsmokers exhibited a statistically significant higher EGFR positivity (P = 0.003, 0.059) respectively. Overall response rate (ORR) was 76.6% and 43% in EGFR positive and negative cases respectively (P = 0.002). There was a statistically significant difference in TTP and OS between EGFR positive and negative patients (P = 0.035 and 0.039 respectively). Arab patients exhibit an EGFR mutation pattern that is closer to Asian population. EGFR gene mutation subtypes are the same as that reported worldwide. A statistically significant TTP and OS benefit was noticed in EGFR positive patients compared to EGFR negative cases.

关键词： Adenocarcinoma EGFR NSCLC Outcome

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一株暗褐网柄牛肝菌的分离与培养基优化

浙江农业科学 2021年第1期62卷 83-86,94页

作者： HASSAN Sidik mohamed 郭旭新吴峥妍潘晨晨徐孟涛柳永浙江科技学院生物与化学工程学院浙江杭州310023 浙江省农产品化学与生物加工技术重点实验室浙江杭州310023 浙江省农业生物资源生化制造协同创新中心浙江杭州310023

暗褐网柄牛肝菌是新近获得工厂化栽培的珍稀食用菌。为获得长势旺盛菌株并配套开发适用培养基,本文开展了暗褐网柄牛肝菌菌种分离鉴定和培养基优化研究,并在分离株对植物生长调节剂的响应性方面进行了探索。结果表明,获得长势健壮的暗... 详细信息

暗褐网柄牛肝菌是新近获得工厂化栽培的珍稀食用菌。为获得长势旺盛菌株并配套开发适用培养基,本文开展了暗褐网柄牛肝菌菌种分离鉴定和培养基优化研究,并在分离株对植物生长调节剂的响应性方面进行了探索。结果表明,获得长势健壮的暗褐网柄牛肝菌分离株dN18,在分别添加花生秸秆粉和杨木粉的改良PdA培养基上生长较快速,并对植物生长调节剂具有响应性。在6-BA、2,4-d质量比1∶1和5 mg·L^-12,4-d下,dN18生长速度较无激素组提高37.3%。推测花生秸秆粉、杨木粉、6-BA和2,4-d等在dN18生产菌棒制备中可能有应用潜力。

关键词：暗褐网柄牛肝菌组织分离 6-BA 脱落酸 2,4-d

Endocranial Suppurations of Sinus Origin: Ratio of 3 Cases in Children at the Hospital in Mali

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Open Journal of Pediatrics 2021年第3期11卷 517-531页

作者： Bourama Kané Korotoumou Wélé diallo mohamed Maba Traoré Boubacar Mami Touré Mahamadou dama Mody Abdoulaye Camara Guédiouma dembélé daouda Sissoko Oumar Coulibaly Mamadou Traoré Pediatrics department of Mali Hospital Bamako Mali Medical Imaging Service Bamako Mali Neurosurgery department of the Mali Hospital Bamako Mali Pediatric Service of the Commune Reference Health Center V Bamako Mali

Introduction: Intracranial suppurations are neoformed purulent collections including, in decreasing order, cerebral abscesses, subdural empyemas and extradural empyemas. Otorhinolaryngologic infections are one of the main causes, especially in older children and adolescents. We report 3 clinical cases of endocranial suppurations treated at the Mali Hospital. Clinical Cases:dana;"> 1) Observation 1. IK was a 14-year-old boy, who was hospitalized in our department for fever, headache and left hemiplegia. The emergency brain scan showed a right frontal and interhemispheric subdural empyema associated with multifocal sinusitis. Surgical drainage associated with ceftriaxone: 100 mg/Kg/d in direct intravenous (dI), metronidazole: 10 mg/Kgs/12hours in slow intravenous (SI) for 15 days, gentamycin: 3 mg/Kgs/d in SI for 3 days, paracetamol 15 mg/Kgs/6hours in SI, 10% glucose serum: 100 ml/Kg/d were given. The bacteriological analysis of the pus came back sterile. The postoperative period was calm. 2) Observation 2. This was a 14-year-old boy with a history of headaches who was admitted to our department for left hemiplegia. An emergency brain scan showed a right pre-suppurative encephalitis associated with a right fronto-ethmoidal and maxillary sinusitis. He was put on ceftriaxone 100 mg/kg/d in dI for 21 days, gentamycin: 3 mg/Kg/d in SI for 3 days;metronidazole: 10 mg/kg/12hours in SI for 21 days, paracetamol: 15 mg/kg/6hours in SI. After 3 weeks of medical treatment, a follow-up brain scan revealed an interhemispheric and right subdural empyema. Surgical drainage was associated with the triple antibiotic therapy initially instituted. The bacteriological analysis of the pus was sterile. The postoperative course was calm. 3) Observation 3. N.M was an 11-year-old boy, who was admitted with fever and left hemiplegi

关键词： Sinusitis Endocranial Suppurations Mali Hospital

果龄和生长调节剂对华脐果实外果皮蜡质数量和结构的影响

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东南园艺 1988年第2期 43-45页

作者： mohamed EL—Otmani Charles W.Coggins Jr. 王卫

材料和方法植株材料: 96株14年生华盛顿脐橙/特洛亚枳橙,栽植在一个含砂砾的,排水良好的,砂质壤土上,株行距为5.5×6m,装有低喷设备,用于本试验的所有果实来源于这些树上。试验果园位于加州大学Riverside（河边,译者注）分校附近。从983... 详细信息

材料和方法植株材料: 96株14年生华盛顿脐橙/特洛亚枳橙,栽植在一个含砂砾的,排水良好的,砂质壤土上,株行距为5.5×6m,装有低喷设备,用于本试验的所有果实来源于这些树上。试验果园位于加州大学Riverside（河边,译者注）分校附近。从983年5月25日1至1984年4月19日采集资料。试验设计和处理: 用10ppmGA3,16ppm2.4—d异丙酯液于果实着色时的1983年10月6日单独或组合整株喷布;对照树不处理。一种非离子可

关键词：蜡质累积速率气孔外果皮生长调节剂

青蒿素哌喹片联合伯氨喹治疗科摩罗无并发症恶性疟临床疗效观察(英文)

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广州中医药大学学报 2012年第2期29卷 197-201页

作者：邓长生宋健平谈博 Mariata Rahamatou Ali Silai Abobacar Soulaiman Moussa mohamed Ahamada MSA Mliva 李国桥广州中医药大学青蒿研究中心广东广州510405 科摩罗国家疟疾中心和国家中心医院科摩罗米察米乌利中心医院科摩罗义隆中心医院

【目的】评价青蒿素哌喹片联合伯氨喹治疗科摩罗恶性疟有效性和安全性,验证青蒿素哌喹片—伯氨喹治疗非洲恶性疟的有效临床剂量。【方法】共观察了无并发症恶性疟患者155例。成人口服青蒿素哌喹片—伯氨喹片1次/d,2片/次,连续2 d,1个疗... 详细信息

【目的】评价青蒿素哌喹片联合伯氨喹治疗科摩罗恶性疟有效性和安全性,验证青蒿素哌喹片—伯氨喹治疗非洲恶性疟的有效临床剂量。【方法】共观察了无并发症恶性疟患者155例。成人口服青蒿素哌喹片—伯氨喹片1次/d,2片/次,连续2 d,1个疗程共4片(青蒿素320 mg,哌喹1 500 mg,伯氨喹16 mg);6岁以下儿童使用青蒿素哌喹片—伯氨喹颗粒剂。28 d后观察复燃率、平均原虫清除时间、平均退热时间、副作用等。【结果】服药后患者临床症状快速缓解。平均原虫清除时间(PCT)为(51.0±25.9)h,平均退热时间为(20.8±11.4)h。患者对青蒿素哌喹片—伯氨喹有良好的耐受性。只有少数患者出现恶心、呕吐和头晕等不良反应,副作用发生局限且能自愈。患者用药前及开始用药后的第7天观察血常规、生化检查未见明显毒副作用。【结论】青蒿素哌喹片—伯氨喹治疗无并发症恶性疟具有高效、速效、副作用低和疗程短等特点。

关键词：青蒿素哌喹片-伯氨喹片/治疗应用恶性疟科摩罗

Adherence Factors Affecting Kidney Transplant Recipient among Patients on Maintenance Haemodialysis in Cote d’Ivoire

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Open Journal of Nephrology 2017年第3期7卷 69-79页

作者： delphine Amelie Lagou Albert Pessa Coulibaly Luc Nigue Weu Melanie Tia Monlet Cyr Guei mohamed Ibrahim Alex Moudachirou Kan Clement Ackoundou-N’Guessan daze Apollinaire Gnionsahe Nephrology department University Teaching Hospital of YopougonAbidjanCote d’Ivoire Uro-Nephrology department Medical Science DepartmentFelix Houphouet Boigny UniversityAbidjanCote d’Ivoire department of Public Health and Medical Informatics Medical Science DepartmentFelix Houphouët Boigny UniversityAbidjanCote d’Ivoire

Background: Kidney Transplantation is the best treatment for patients in end stage renal disease. It’s a new therapeutic approach for such patients in Cote d’Ivoire which is expected to develop. Aim: determine the adherence factors affecting kidney transplant recipient among patients on maintenance haemodialysis in Cote d’Ivoire and point out possible obstacles to the development of this new practice in the country. Patients and Methods: This was a cross-sectional study carried out from May to June 2016 in the Haemodialysis Centres of Abidjan. Any patient aged ≥18 years, on haemodialysis for at least 6 months, who signed the inform consent were subjected to a questionnaire. None of the respondents had been transplanted. The subjects addressed in the document were sociocultural status, opinion related to kidney transplantation and willingness to be transplanted or not and the reasons. A statistical analysis was performed to determine factors associated with kidney transplantation desire. Results: We included 295 (71.53% males) patients, with a mean age of 44.53 ± 12.09 years. Among this population, 36.61% had a higher level of education, 70.85% were Christians, 66.44% lived with partners, 56.61% had no income and 74.92% were treated in Public Health Centres. The median duration on dialysis was 34 months. A total of 287 (97.29%) patients had already heard of kidney transplantation among which 149 (51.94%) for the first time after initiation of haemodialysis. There was 231 (78.31%) patients willing to be transplanted with only 91 (39.39%) of them having a potential living donors. The main motivations were the desire to stop dialysis (52.38%) and the search for a better quality of life (41.13%). Among the 64 (21.69%) patients unfavourable to renal transplantation, 45.31% raised its higher cost compared to haemodialysis. duration on haemodialysis (>34 months) was significantly higher in patients willing to be transplanted compare to non-applicants (51.95% versus 37.50%,

关键词： Kidney Transplantation Adherence Factors Haemodialysis Cote d’Ivoire

Mobilization of Cd34^+Cd38^- hematopoietic stem cells after priming in acute myeloid leukemia

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World Journal of Stem Cells 2013年第4期5卷 196-204页

作者： Adriana Plesa Eve Mattei Charles dumontet Youcef Chelghoum Hélène Labussière Giovanna Cannas Mauricette Michallet Xavier Thomas mohamed Elhamri Stéphane Morisset Inès Tagoug Laboratoire de Cytologie et d'Immunologie Centre Hospitalier Lyon-Sud Hospices Civils de Lyon department of Hematology Centre Hospitalier Lyon-SudHospices Civils de Lyon Unité de Recherche Clinique Service d'Hématologie Centre Hospitalier Lyon-SudHospices Civils de Lyon INSERM U590 Laboratoire de Cytologie Analy-tique Faculté de Médecine Rockefeller Université Lyon-I

AIM: To evaluate quantitatively and qualitatively the different Cd34+cell subsets after priming by chemotherapy granulocyte colony-stimulating factor(± G-CSF)in patients with acute myeloid ***: Peripheral blood and bone marrow sampleswere harvested in 8 acute myeloid leukemia patients during and after induction chemotherapy. The Cd34/Cd38 cell profile was analyzed by multi-parameter flow cytometry. Adhesion profile was made using CXC chemokine receptor 4(CXCR4)(Cd184), VLA-4(Cd49d/Cd29) and ***: Chemotherapy ± G-CSF mobilized immature cells(Cd34+Cd38 population), while the more mature cells(Cd34+Cd38lowand Cd34+Cd38+populations) decreased progressively after treatment. Circulating Cd34+cells tended to be more sensitive to chemotherapy after priming with G-CSF. Cd34+cell mobilization was correlated with a gradual increase in CXCR4 and Cd47expression, suggesting a role in cell protection and the capacity of homing back to the ***: Chemotherapy ± G-CSF mobilizes into the circulation Cd34+bone marrow cells, of which, the immature Cd34+Cd38-cell population. Further manipulations of these interactions may be a means with which to control the trafficking of leukemia stem cells to improve patients' outcomes.

关键词： Acute myeloid leukemia Leukemia stem cell Immunophenotype Priming Timed sequential chemotherapy

Prediction of permanent pacemaker implantation after transcatheter aortic valve replacement:The role of machine learning

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World Journal of Cardiology 2023年第3期15卷 95-105页

作者： Pradyumna Agasthi Hasan Ashraf Sai Harika Pujari Marlene Girardo Andrew Tseng Farouk Mookadam Nithin Venepally Matthew R Buras Bishoy Abraham Banveet K Khetarpal mohamed Allam Siva K Mulpuru Md Mackram F Eleid Kevin L Greason Nirat Beohar John Sweeney david Fortuin david R Jr Holmes Reza Arsanjani department of Cardiology Mayo ClinicPhoenixAZ 85054United States department of Internal Medicine The Brooklyn Hospital CenterBrooklynNY 11201United States department of Biostatistics Mayo ClinicPhoenixAZ 85054United States department of Cardiovascular diseases Mayo ClinicRochesterMN 55905United States department of Statistics Mayo ClinicPhoenixAZ 85054United States department of Cardiovascular Surgery Mayo ClinicRochesterMN 55905United States Mount Sinai Medical Center Columbia UniversityMiami BeachFL 33138United States

BACKGROUNd Atrioventricular block requiring permanent pacemaker(PPM)implantation is an important complication of transcatheter aortic valve replacement(TAVR).Application of machine learning could potentially be used to predict preprocedural risk for *** To apply machine learning to be used to predict pre-procedural risk for *** A retrospective study of 1200 patients who underwent TAVR(January 2014-december 2017)was performed.964 patients without prior PPM were included for a 30-d analysis and 657 patients without PPM requirement through 30 d were included for a 1-year *** the exclusion of variables with near-zero variance or≥50%missing data,167 variables were included in the random forest gradient boosting algorithm(GBM)optimized using 5-fold cross-validations repeated 10 *** receiver operator curve(ROC)for the GBM model and PPM risk score models were calculated to predict the risk of PPM at 30 d and 1 *** Of 964 patients included in the 30-d analysis without prior PPM,19.6%required PPM *** mean age of patients was 80.9±8.7 years.42.1%were *** 657 patients included in the 1-year analysis,the mean age of the patients was 80.7±*** those,42.6%of patients were female and 26.7%required PPM at 1-year *** area under ROC to predict 30-d and 1-year risk of PPM for the GBM model(0.66 and 0.72)was superior to that of the PPM risk score(0.55 and 0.54)with a P valuedel has good discrimination and calibration in identifying patients at high risk of PPM post-TAVR.

关键词： Transcatheter aortic valve replacement Permanent pacemaker implantation Machine learning