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Elemental Concentrations in Biological Samples of Coronavirus Disease (COVID-19) and Other Pulmonary Disease Patients

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American Journal of Analytical Chemistry 2021年第5期12卷 162-187页

作者： hassan Imran Afridi Tasneem Gul Kazi farah Naz Talpur Jameel Ahmed Baig Ghulam Qadir Chanihoon Ayaz Lashari Ghulam Mustafa Channa National Center of Excellence in Analytical Chemistry University of Sindh Jamshoro Pakistan

Background: Recently, Coronavirus Disease 2019 (COVID-19) has been affected by the extreme acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has developed important global health anxiety. At this time, the treatment options for this disease are only moderately successful. Smoking has been related to COVID-19 and its mortality, and it has the potential to affect bacteriological and viral conversion, clinical effects, and treatment outcomes. Methods: The aim of this study was to determine the relationship between critical essential trace {zinc (Zn), iron (Fe), and copper (Cu)} and toxic {cadmium (Cd) and nickel (Ni)} elements in human biological samples such as scalp hair, serum, saliva, blood, nasal fluid, and sputum of smoking and nonsmoking male COVID-19 patients (n = 139, age range 25 - 38 years) from hyderabad, Pakistan. For comparative purposes, the biological specimens of referent persons (n = 83), pulmonary Tuberculosis (T.B) patients (n = 67), Pneumonia (n = 56) of the same age groups were also be analyzed. Microwave oven mediated digestion method was employed, and digestion of samples was carried out with the help of 2:1 mixture solution of hNO3 (65%) and h2O2 (30%). Atomic absorption spectrometry was employed for the determination of elemental concentrations from the microwave oven employed digested samples. Results: The found average of essential elements (Zn, Fe, and Cu) in biological specimens of smoker and nonsmoker male COVID-19, T.B, and Pneumonia patients was found to lower, whilst cadmium and nickel were found to be higher when compared with samples from referents (p Conclusions: Improved elemental (Cu, Fe, Zn) concentrations may also decrease the risk of bacterial co-infection by enhancing the mucociliary clearance and respiratory epithelial barrier function, in addition to providing direct antibacterial effects against S. pneum

关键词： COVID-19 Other Lung Infected Diseases Essential Trace Elements Toxic Elements Biological Samples Age Ranged 25 - 38 Years

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Systemic adverse effects and toxicities associated with immunotherapy:A review

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World Journal of Clinical Oncology 2021年第3期12卷 150-163页

作者： Asim Kichloo Michael Albosta Dushyant Dahiya Jean Claude Guidi Michael Aljadah Jagmeet Singh hafeez Shaka farah Wani Akshay Kumar Manidhar Lekkala Department of Internal Medicine Central Michigan UniversitySaginawMI 48603United States Department of Internal Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Internal Medicine Medical College of WisconsinMilwaukeeWI 53201United States Department of Nephrology Guthrie Robert Packer HospitalSayrePA 18840United States Department of Internal Medicine John H Stroger Jr.Hospital of Cook CountyChicagoIL 60612United States Department of Family Medicine Samaritan Medical CenterWatertownNY 13601United States Department of Surgery University of PittsburghPittsburghPA 15213United States Department of hematology and Oncology University of Rochester Medical CenterRochesterNY 14642United States

Immunotherapy is rapidly evolving secondary to the advent of newer immunotherapeutic agents and increasing approval of the current agents by the United States Food and Drug Administration to treat a wide spectrum of *** agents have gained immense popularity due to their tumorspecific *** is slowly transforming into a separate therapeutic entity,and the fifth pillar of management for cancers alongside surgery,radiotherapy,chemotherapy,and targeted ***,like any therapeutic entity it has its own adverse *** the increasing use of immunotherapeutic agents,it is vital for physicians to acquaint themselves with these adverse *** aim of this review is to investigate the common systemic adverse effects and toxicities associated with the use of different classes of immunotherapeutic *** provide an overview of potential adverse effects and toxicities associated with different classes of immunotherapeutic agents organized by organ systems,as well as an extensive discussion of the current recommendations for treatment and clinical trial *** we continue to see increasing usage of these agents in clinical practice,it is vital for physicians to familiarize themselves with these effects.

关键词： Immunotherapy Cancer Malignancy Adverse effects Immune checkpoint inhibitor Monoclonal antibody

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小鼠神经再生的检测(下)(英文)

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河南大学学报（医学版） 2013年第2期32卷 77-83页

作者：潘宝晗约翰W.格里芬迈克A.波里保罗N.霍夫曼默汗默德h.法拉约翰霍普金斯医学院神经科美国马里兰州巴尔的摩21205 约翰霍普金斯医学院神经科学系美国马里兰州巴尔的摩21205 约翰霍普金斯医学院病理科美国马里兰州巴尔的摩21205 约翰霍普金斯医学院眼科美国马里兰州巴尔的摩21205

神经系统疾病是人类疾病最复杂的一大类。由于神经系统的特殊发育和组织构造,从神经科学的基础科研到临床诊断治疗都极为困难。神经再生和神经退行性病变的研究是当代科学研究的最热门领域之一,但是实验研究进展缓慢,尤其是可转化为临... 详细信息

神经系统疾病是人类疾病最复杂的一大类。由于神经系统的特殊发育和组织构造,从神经科学的基础科研到临床诊断治疗都极为困难。神经再生和神经退行性病变的研究是当代科学研究的最热门领域之一,但是实验研究进展缓慢,尤其是可转化为临床应用的知识更少。主要原因之一是我们一直缺乏直观易行的动物模型。我们课题组的努力方向之一是开发新的实验模型。最近几年我们已经取得了很多新进展,先将有关内容总结如下。

关键词：胸外侧神经皮大肌皮感觉神经神经再生神经变性神经即溶接头

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肾血管性高血压诱导代谢综合征猪的心肌线粒体损伤,导致心脏损伤和功能障碍

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中华高血压杂志 2022年第3期30卷 300-300页

作者： Nargesi AA farah MC Zhu XY Zhang L Tang h Jordan KL Saadiq IM Lerman A Lerman LO Eirin A 袁源(翻译) 周卫(翻译) 不详

肾血管性高血压(renovascular hypertension,RVh)患者常常也并发代谢综合征(metabolic syn-drome,Met S)。Met S和高血压并存增加心血管病的发病率和死亡率,但是心脏损伤的潜在机制仍不清楚。本研究假设合并Met S可引发RVh猪心肌线粒体... 详细信息

肾血管性高血压(renovascular hypertension,RVh)患者常常也并发代谢综合征(metabolic syn-drome,Met S)。Met S和高血压并存增加心血管病的发病率和死亡率,但是心脏损伤的潜在机制仍不清楚。本研究假设合并Met S可引发RVh猪心肌线粒体损伤,导致心脏损伤和功能障碍。方法:经过16周喂食诱导合并或不合并RVh(单侧肾动脉狭窄)的实验猪患MetS,瘦猪(Lean)作为对照组,每组6只。

关键词：肾血管性高血压心脏损伤肾动脉狭窄心肌线粒体损伤功能障碍心血管病代谢综合征 hypertension

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小鼠神经再生的检测(上)(英文)

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河南大学学报（医学版） 2013年第1期32卷 1-10页

神经系统疾病是人类疾病最复杂的一大类。由于神经系统的特殊发育和组织构造,从神经科学的基础科研到临床诊断治疗都极为困难。神经再生和神经退行性病变的研究是当代科学研究的最热门领域之一,但是试验研究进展缓慢,尤其是可转化为临... 详细信息

神经系统疾病是人类疾病最复杂的一大类。由于神经系统的特殊发育和组织构造,从神经科学的基础科研到临床诊断治疗都极为困难。神经再生和神经退行性病变的研究是当代科学研究的最热门领域之一,但是试验研究进展缓慢,尤其是可转化为临床应用的知识更少。主要原因之一是我们一直缺乏直观易行的动物模型。我们课题组的努力方向之一是开发新的试验模型。最近几年我们已经取得了很多新进展,先将有关内容总结如下。

关键词：胸外侧神经皮大肌皮感觉神经神经再生神经变性神经即溶接头

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Cd(Ⅱ)removal from phenols-bearing wastewater using magnetic carbon nanotubes

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Emerging Contaminants 2022年第1期8卷 400-410页

作者： Amjad h.El-Sheikh.farah A.Alahmad Mahmoud S.Sunjuk Nabil N.Al-hashimi Department of Chemistry Faculty of ScienceThe Hashemite UniversityP.O.Box 330127Zarqa13133Jordan Faculty of Pharmacy The Hashemite UniversityP.O.Box 330127Zarqa13133Jordan

This project studied Cd(Ⅱ)uptake from phenols-bearing wastewater using magnetic carbon nanotubes(MCNT)as ***,Cd(Ⅱ)complexation with various phenols was confirmed by FT-IR *** affecting Cd removal are:solution ph;type of phenol[phenol(Ph),2-chlorophenol(2-CP),2-nitrophenol(2-NP),and 2,4-dinitrophenol(2,4-DNP)];Mag:CNT mass ratio;Cd:phenolic compound molar ratio;and the effect of order of adding adsorption components(MCNT,Cd(Ⅱ),phenolic compound)to the extraction *** was found that the presence of phenols in the extraction medium caused a 10e50%decrease in Cd(Ⅱ)*** was probably due to a competition between phenols/surface functional groups towards Cd(Ⅱ);or phenols/Cd(Ⅱ)to occupy the surface functional groups.2,4-DNP was selected as a model phenolic *** optimum adsorption conditions[1:1 M ratio of(Cd(Ⅱ):2,4-DNP)at ph 6 using MCNT(1:1)adsorbent]resulted in adsorption capacity of 17.9 mg Cd g^(-1).The best order of adding reagents was(Cd(Ⅱ)þMCNT(1:1))and then 2,*** regeneration of the adsorbent was possible by using 0.5 M hNO_(3)where 90%of adsorption efficiency was reserved after three times of successive *** presence of co-existing ions,75%of the adsorption efficiency was *** applicability of the proposed adsorption method on real water samples was evaluated.

关键词： Adsorption of cadmium Magnetic carbon nanotubes Cadmium removal Phenols-bearing water Wastewater treatment

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