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The comparison of the Wnt signaling pathway inhibitor delivered electrospun nanoyarn fabricated with two methods for the application of urethroplasty

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Frontiers of Materials Science 2016年第4期10卷 346-357页

作者： Xuran GUO Kaile ZHANG mohamed el-AASSAR Nanping WANG Hany el-HAMSHARY mohamed el-newehy Qiang FU Xiumei MO State Key Lab for Modification of Chemical Fibers & Polymer Materials College of Chemistry & Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Department of Urology Affiliated Sixth People's Hospital Shanghai Jiaotong University Shanghai 200030 China Polymer Materials Research Department Advanced Technology and New Material Institute City of Scientific Research and Technological Applications (SRTA-City) New Borg El-Arab City Alexandria 21934 Egypt Shanghai Aquatic Product Research Institute Shanghai 200030 China Department of Chemistry College of Science King Saud University Riyadh i 1451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt Shandong International Biotechnology Park Development Co. Ltd. Shanghai 200030 China

Urethral strictures were common disease caused by over-expression of extracellular matrix from fibroblast. In this study, we compare two nanoyarn scaffolds for improving fibroblasts infiltration without inhibition the over-expression of extracellular matrix. Collagenlpoly（L-lactide-co-caprolactone）（ColIP（LLA-CL）） nanoyarn scaffolds were prepared by conjugated electrospinning and dynamic liquid electrospinning, respectively, in addition, co-axial electrospinning technique was combined with the nanoyarn fabrication process to produce nanoyarn scaffolds loading Wntsignaling pathway inhibitor. The mechanical properties of the scaffolds were examined and morphology was observed by SEM. Cell morphology, proliferation and infiltration on the scaffolds were investigated by SEM, MTT assay and H＆E staining, respectively. The release profiles of different scaffolds were determined using HPLC. The results indicated that cells showed an organized morphology along the nanoyarns and considerable infiltration into the nanoyarn scaffolds prepared by dynamic liquid electrospinning （DLY）. It was also observed that the DLY significantly facilitate cell proliferation. The D-DLY could facilitate the infiltration of the fibroblasts and could be a promising scaffold for the treatment of urethra stricture while it may inhibit the collagen production.

关键词： biomaterials nanoyarn electrospinning inhibitor

Regulation of nerve cells using conductive nanofibrous scaffolds for controlled release of Lycium barbarum polysaccharides and nerve growth factor

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Regenerative Biomaterials 2023年第1期10卷 919-932页

作者： Jing Wang Yuan Liu Minmin Lv Xiaoli Zhao Kwok Fai So Hui Li mohamed el-newehy Hany el-Hamshary Yosry Morsi Xiumei Mo Research Center for Human Tissues and Organs Degeneration Institute of Biomedicine and BiotechnologyShenzhen Institutes of Advanced TechnologyChinese Academy of SciencesShenzhen518055P.R.China Department of Orthopedics Shanghai Sixth People’s HospitalShanghai201306P.R.China University of Hong Kong-Shenzhen Hospital Shenzhen518053P.R.China State Key Laboratory of Brain and Cognitive Sciences The University of Hong KongPokfulamHong KongP.R.China Department of Ophthalmology The University of Hong KongPokfulamHong KongP.R.China Guangdong-Hong Kong-Macao Institute of CNS Regeneration Jinan UniversityGuangzhouP.R.China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451P.O.Box 2455Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai201600P.R.China

Currently,more and more patients suffer from peripheral nerve injury due to trauma,tumor and other causes ***-based nerve conduits are increasingly recognized as a potential alternative to nerve autografts for the treatment of peripheral nerve ***,an ideal nerve conduit must offer topological guidance and biochemical and electrical signal transduction *** this work,aligned conductive nanofibrous scaffolds comprising polylactic-co-glycolic acid and multiwalled carbon nanotubes(MWCNTs)were fabricated via coaxial electrospinning,and nerve growth factor(NGF)and Lycium barbarum polysaccharides(LBP)purified from the wolfberry were loaded on the core and shell layers of the nanofibers,*** were confirmed to accelerate long-distance axon regeneration after severe peripheral nerve *** addition,the synergistic promotion of LBP and NGF on nerve cell proliferation and neurite outgrowth was *** were introduced into the aligned fibers to further increase the electrical conductivity,which promoted the directional growth and neurite extension of neurons in ***,the combination of conductive fibrous scaffolds with electrical stimulation that mimics endogenous electric fields significantly promoted the differentiation of PC12 cells and the axon outgrowth of *** on robust cell-induced behaviors,conductive composite fibers with optimized fiber alignment may be used for the promotion of nerve recovery.

关键词： conductive nanofibrous scaffold LBP NGF nerve cells electrical stimulation

Fabrication and characterization of Antheraea pernyi silk fibroin-blended P（LLA-CL） nanofibrous scaffolds for peripheral nerve tissue engineering

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Frontiers of Materials Science 2017年第1期11卷 22-32页

作者： Juan WANG Binbin SUN Muhammad Aqeel BHUTTO Tonghe ZHU Kui YU Jiayu BAO Yosry MORSI Hany el-HAMSHARY mohamed el-newehy Xiumei MO State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Shandong International Biotechnology Park Development Co. Ltd. Yantai 264670 China College of Materials Science and Engineering Donghua University Shanghai 201620 China Faculty of Engineering and Industrial Sciences Swinburne University of Technology Hawthorn Vic 3122 Australia Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia Department of Chemistry Faculty of Science Tanta University Tanta 31527 Egypt

electrospun nanofibers have gained widespreading interest for tissue engineering application. In the present study, ApF/P（LLA-CL） nanofibrous scaffolds were fabricated via electrospinning. The feasibility of the material as tissue engineering nerve scaffold was investigated in vitro. The average diameter increased with decreasing the blend ratio of ApF to P（LLA-CL）. Characterization of 13C NMR and FTIR clarified that there is no obvious chemical bond reaction between ApF and P（LLA-CL）. The tensile strength and elongation at break increased with the content increase of P（LLA-CL）. The surface hydrophilic property of nanofibrous scaffolds enhanced with the increased content of ApF. Cell viability studies with Schwann cells demonstrated that ApFIP（LLA-CL） blended nanofibrous scaffolds significantly promoted cell growth as compare to P（LLA-CL）, especially when the weight ratio of ApF to P（LLA-CL） was 25：75. The present work provides a basis for further studies of this novel nanofibrous material （ApF/P（LLA-CL）） in peripheral nerve tissue repair or regeneration.

关键词： KEYWORDS: ApFIP(LLA-CL) electrospinning nanofibers scaffolds Schwann cells peripheral nerve tissue engineering

On the development of modular polyurethane-based bioelastomers for rapid hemostasis and wound healing

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Regenerative Biomaterials 2023年第1期10卷 640-654页

作者： Wanxin Guo Binan Zhao Muhammad Shafiq Xiao Yu Yihong Shen Jie Cui Yujie Chen Pengfei Cai Zhengchao Yuan mohamed el-newehy Hany el-Hamshary Yosry Morsi Binbin Sun Jianfeng Pan Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversitySongjiangShanghai 201620P.R.China Department of Orthopedics Shanghai Tongji HospitalSchool of MedicineTongji UniversityPutuoShanghai 200065China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819-0395Japan Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Department of Orthopedics Shanghai Tenth People’s HospitalSchool of MedicineTongji UniversityJinganShanghai 200072China

Massive hemorrhage may be detrimental to the patients,which necessitates the advent of new materials with high hemostatic efficiency and good *** objective of this research was to screen for the effect of the different types of bio-elastomers as hemostatic dressings.3D loose nanofiber sponges were prepared;PU-TA/Gel showed promising ***(PU)was synthesized and electrospun to afford porous sponges,which were crosslinked with glutaraldehyde(GA).FTIR and 1H-NMR evidenced the successful synthesis of *** prepared PU-TA/Gel sponge had the highest porosity and water absorption ***,PU-TA/Gel sponges exhibited cytocompatibility,negligible hemolysis and the shortest clotting ***-TA/Gel sponge rapidly induced stable blood clots with shorter hemostasis time and less bleeding volume in a liver injury model in ***,PU-TA/Gel sponges also induced good skin regeneration in a full-thickness excisional defect model as revealed by the histological *** results showed that the PU-TA/Gel-based sponges may offer an alternative platform for hemostasis and wound healing.

关键词： polyurethane electrospinning hemostasis material wound healing tissue regeneration regenerative medicine

electrospinning nanofiber scaffolds for soft and hard tissue regeneration

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Journal of Materials Science & Technology 2020年第24期59卷 243-261页

作者： Xianrui Xie Yujie Chen Xiaoyu Wang Xiaoqing Xu Yihong Shen Atta ur Rehman Khan Ali Aldalbahi Allison E.Fetz Gary L.Bowlin mohamed el-newehy Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials College of ChemistryChemical Engineering and BiotechnologyDonghua UniversityShanghai201620China Department of Chemistry College of ScienceKing Saud UniversityRiyadh 11451Saudi Arabia Department of Biomedical Engineering University of MemphisMemphisTN38152USA

Tissue engineering is an interdisciplinary field that integrates medical,biological,and engineering expertise to restore or regenerate the functionality of healthy tissues and *** three fundamental pillars of tissue engineering are scaffolds,cells,and *** nanofibers have been successfully used as scaffolds for a variety of tissue engineering applications because they are biomimetic of the natural,fibrous extracellular matrix(ECM)and contain a three-dimensional(3D)network of interconnected *** this review,we provide an overview of the electrospinning process,its principles,and the application of the resultant electrospun nanofibers for tissue *** first briefly introduce the electrospinning process and then cover its principles and standard equipment for biomaterial ***,we highlight the most important and recent advances related to the applications of electrospun nanofibers in tissue engineering,including skin,blood vessels,nerves,bone,cartilage,and tendon/ligament ***,we conclude with current advancements in the fabrication of electrospun nanofiber scaffolds and their biomedical applications in emerging areas.

关键词： Nanofibers electrospinning Tissue engineering Regeneration Biomedical application

Hierarchical TiO_2/ZnO Nanostructure as Novel Non-precious electrocatalyst for Ethanol electrooxidation

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Journal of Materials Science & Technology 2015年第1期31卷 97-105页

作者： Gehan M.K.Tolba Nasser A.M.Barakat A.M.Bastaweesy E.A.Ashour Wael Abdelmoez mohamed H.el-newehy Salem S.Al-Deyab Hak Yong Kim Organic Materials and Fiber Engineering Department Chonbuk National University Chemical Engineering Department Faculty of EngineeringMinia University BioNanosystem Department Chonbuk National University Department of Chemistry College of ScienceKing Saud University

Metal oxides have a higher chemical stability in comparison to metals,so they can be utilized as electrocatalysts if the activity could be *** the composition,the morphology of the nanostructures has a considerable impact on the electrocatalytic *** this work,zinc oxide nano branches-attached titanium dioxide nanofibers were investigated as an economic and stable catalyst for ethanol electrooxidation in the alkaline *** introduced material has been synthesized by electrospinning process followed by hydrothermal ***,electrospinning of colloidal solution consisting of titanium isopropoxide,poly（vinyl acetate） and zinc nanoparticles was performed to produce nanofibers embedding solid *** order to produce TiO2nanofibers containing ZnO nanoparticles,the obtained electrospun nanofiber mats were calcined in air at 600 °*** formed ZnO nanoparticles were exploited as seeds to outgrow ZnO branches around the TiO2nanofibers using the hydrothermal technique at sub-critical water conditions in the presence of zinc nitrate and bis-hexamethylene *** morphology of the final product,as well as the electrochemical measurements indicated that zinc nanoparticles content in the original electrospun nanofibers has a significant influence on the electrocatalytic activity as the best performance was observed with the nanofibers synthesized from electrospun solution containing 0.1 g Zn,and the corresponding current density was 37 mA/***,this study paves a way to titanium dioxide to be exploited to synthesize effective and stable metal oxide-based electrocatalysts.

关键词： Direct ethanol fuel cells electrospinning Nanofibe

Multi‑Functional Fibrous Dressings for Burn Injury Treatment with Pain and Swelling Relief and Scarless Wound Healing

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Advanced Fiber Materials 2023年第6期5卷 1963-1985页

作者： Zhengchao Yuan Yue Zhao Muhammad Shafiq Jiahui Song Jing Hou Yuqing Liang Xiao Yu Yujie Chen Fan Yu mohamed el‑newehy Hany el‑Hamshary Yosry Morsi Shichao Jiang Hui Zheng Xiumei Mo State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Shanghai Engineering Research Center of Nano‑Biomaterials and Regenerative MedicineCollege of Biological Science and Medical EngineeringDonghua UniversityShanghai 201620People’s Republic of China Department of Chemical Engineering Faculty of EngineeringGraduate SchoolKyushu UniversityFukuoka 819‑0395Japan United Graduate School of Drug Discovery and Medical Information Sciences Gifu University1‑1 YanagidoGifu 501‑1193Japan Department of Orthopedics Shandong Provincial Hospital Affiliated to Shandong First Medical UniversityJinan 250021People’s Republic of China Department of Chemistry College of ScienceKing Saud UniversityP.O.Box 245511451 RiyadhSaudi Arabia Faculty of Engineering and Industrial Sciences Swinburne University of TechnologyBoroondaraVIC 3122Australia Medical Science and Technology Innovation Center Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary HospitalTongji University School of MedicineShanghai 200443People’s Republic of China

As one of the most common forms of skin injuries,skin burns are often accompanied by edema pain,suppuration of infection,slow tissue regeneration,and severe scar formation,which significantly delay wound healing as well as affect the quality of *** prepared multifunctional electrospun poly(L-lactide-co-glycolide)/gelatin(P/G)-based dressings to synergistically harness the therapeutic benefits of peppermint essential oil(T),burn ointment(B),and Oregano essential oil(O)(P/G@TBO)for skin regeneration in punch and burn injury *** P/G@TBO can afford the sustained release of bioactive cues for up to 72 h as well as remarkably promote cell migration(ca.P/G@TBO,89%*** group,51%)at 24 *** P/G@TBO membranes also showed significant angiogenic effect as well as antibacterial and anti-inflammatory properties than that of the control group in ***,P/G@TBO dressings enabled fast wound healing(ca.P/G@TBO,100%wound closure *** group,95%)in a full-thickness excisional defect model up to 14 days in *** evaluation of membranes in different animal models,including tail wagging model,facial itch model,and hot burn injury model showed significant pain relieve effect as well as itching and swelling relief functions during earlier stages of wound *** were next transplanted into a scalded wound model in rats and an ear punch wound model in rabbits,which manifested antibacterial and anti-inflammatory properties and promoted re-epithelialization to achieve scarless wound healing percentage wound closure at day 28:P/G@TBO,96%*** group 66%.Taken together our approach of simultaneously harnessing T,B,and O to enable multifunctionality to fibrous dressings may hold great promise for burn wound healing applications and other related disciplines.

关键词： Burn injury Wound healing Skin regeneration Pain and swelling relief Nanofiber membrane

Comparison between seismic analysis of twisting and regular 52-story towers considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2024年第3期23卷 663-675页

作者： mohamed Naguib Abouelsaad Mohammed Shaaban Salah el Bagalaty mohamed E.el Madawy Structural Engineering Department Faculty of EngineeringMansura UniversityMansoura 35511Egypt Faculty of Engineering Delta University for Science and TechnologyGamasa 35712Egypt

A dynamic analysis of both twisting and regular towers is carried out to determine the results of considering soil-structure interaction(SSI)on high-rise *** addition,the difference between the seismic performance of using twisting towers over regular ones is *** twisting tower is a simulation of the Evolution Tower(Moscow).The towers’skeletons consist of RC elements and rest on a reinforced concrete piled-raft *** soil model is considered as multi-layered with the same soil properties as the zone chosen for the analysis(New Mansoura City,Egypt).The only difference between both towers is their shape in *** whole system is modelled and analyzed in a single step as one full 3D model,which is known as the direct approach in *** analyses are carried out using finite-element software(Midas GTS NX).Dynamic output responses due to three records of seismic loads are proposed and presented in some *** on the results,it is concluded that SSI has a considerable effect on the dynamic response of tall buildings mainly because of the foundation flexibility,as it leads to lengthening the vibration period,increasing the story drift and the base shear for both cases.

关键词： soil-structure interaction seismic analysis twisting towers base shear story drift finite element method Midas GTS NX

In vivo study of conductive 3D printed PCL/MWCNTs scaffolds with electrical stimulation for bone tissue engineering

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Bio-Design and Manufacturing 2021年第2期4卷 190-202页

作者： Edney P.e Silva Boyang Huang Júlia V.Helaehil Paulo R.L.Nalesso Leonardo Bagne Maraiara A.de Oliveira Gabriela C.C.Albiazetti Ali Aldalbahi mohamed el-newehy Milton Santamaria-Jr Fernanda A.S.Mendonça Paulo Bártolo Guilherme F.Caetano Postgraduate Program in Biomedical Sciences University Center of Hermínio Ometto Foundation-FHOArarasSao PauloBrazil Department of Mechanical Aerospace and Civil EngineeringSchool of EngineeringUniversity of ManchesterManchester M139PLUK King Abdullah Institute for Nanotechnology King Saud UniversityRiyadh 11451Saudi Arabia

Critical bone defects are considered one of the major clinical challenges in reconstructive bone *** combination of 3D printed conductive scaffolds and exogenous electrical stimulation(ES)is a potential favorable approach for bone tissue *** this study,3D conductive scaffolds made with biocompatible and biodegradable polycaprolactone(PCL)and multi-walled carbon nanotubes(MWCNTs)were produced using the extrusion-based additive manufacturing to treat large calvary bone defects in *** results show that the use of PCL/MWCNTs scaffolds and ES contributes to thicker and increased bone tissue formation within the bone *** and mineralization are also significantly promoted using high concentration of MWCNTs(3 wt%)and ***,scaffolds favor the tartrate-resistant acid phosphatase(TRAP)positive cell formation,while the addition of MWCNTs seems to inhibit the osteoclastogenesis but present limited effects on the osteoclast functionalities(receptor activator of nuclear factor κβ ligand(RANKL)and osteoprotegerin(OPG)expressions).The use of ES promotes the osteoclastogenesis and RANKL expressions,showing a dominant effect in the bone remodeling *** results indicate that the combination of 3D printed conductive PCL/MWCNTs scaffold and ES is a promising strategy to treat critical bone defects and provide a cue to establish an optimal protocol to use conductive scaffolds and ES for bone tissue engineering.

关键词： Additive manufacturing Bone regeneration Bone remodeling Carbon nanotube Conductive scaffolds electrical stimulation