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Investigations of Ion Confinement by Direct Current Coaxial Glow Discharge

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Journal of Modern Physics 2012年第1期3卷 48-56页

作者： Alaa Abu-Hashem mohamed ali hassouba mohamed Mahmoud Masoud 不详

A cylindrical dc coaxial glow discharge system with inner grid cathode was designed for ion confinement, and success- fully operated with low discharge current. The plasma is formed inside the cylindrical grid cathode. The discharge cur- rentvoltage characteristic curves and Paschen curve are obtained at different gas pressures. Langmuir probes are used to determine the electron temperature and the plasma density. The electron energy distribution functions indicated that, two groups of electrons, appear in radial interval from r = 12 mm up to r = 5 mm. One group of electrons with most probable energy around 1 eV appeared from r = 5 mm up to r = 0. The electron temperature Te is increased with increasing the current and also with moving from the center toward the grid cathode. Poisson’s equation is used to calculate the plasma density at different radial positions. The plasma density measured by the single probe is around 1015 m-3. A comparison is obtained between calculated plasma density and that measured by Langmuir probes. Experimental and calculated results have the same profile.

关键词： Inertial Electrostatic Confinement Virtual Anode Coaxial Glow Discharge

Small heat shock protein B8:from cell functions to its involvement in diseases and potential therapeutic applications

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Neural Regeneration Research 2025年第10期20卷 2872-2886页

作者： Marta Chierichetti Riccardo Cristofani Valeria Crippa Veronica Ferrari Marta Cozzi Elena Casarotto Paola Pramaggiore Laura Cornaggia Guglielmo Patelli ali mohamed Margherita Piccolella Mariarita Galbiati Paola Rusmini Barbara Tedesco Angelo Poletti Laboratory of Experimental Biology Dipartimento di Scienze Farmacologiche e Biomolecolari“Rodolfo Paoletti”(DiSFeB)Universitàdegli Studi di MilanoMilanItaly

Heat shock protein family B(small)member 8(HSPB8)is a 22 kDa ubiquitously expressed protein belonging to the family of small heat shock ***8 is involved in various cellular mechanisms mainly related to proteotoxic stress response and in other processes such as inflammation,cell division,and ***8 binds misfolded clients to prevent their aggregation by assisting protein refolding or degradation through chaperone-assisted selective *** line with this function,the pro-degradative activity of HSPB8 has been found protective in several neurodegenerative and neuromuscular diseases characterized by protein misfolding and *** cancer,HSPB8 has a dual role being capable of exerting either a pro-or an anti-tumoral activity depending on the pathways and factors expressed by the model of cancer under ***,HSPB8 exerts a protective function in different diseases by modulating the inflammatory response,which characterizes not only neurodegenerative diseases,but also other chronic or acute conditions affecting the nervous system,such as multiple sclerosis and intracerebellar *** note,HSPB8 modulation may represent a therapeutic approach in other neurological conditions that develop as a secondary consequence of other *** is the case of cognitive impairment related to diabetes mellitus,in which HSPB8 exerts a protective activity by assuring mitochondrial *** review aims to summarize the diverse and multiple functions of HSPB8 in different pathological conditions,focusing on the beneficial effects of its ***-based and alternative therapeutic approaches targeting HSPB8 and its regulated pathways will be discussed,emphasizing how new strategies for cell and tissue-specific delivery represent an avenue to advance in disease treatments.

关键词： aggregation autophagy cancer chaperone chaperone-assisted selective autophagy cognitive impairment HSPB8 neuroinflammation neuromuscular diseases therapy

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： mohamed Aghyad Al Kabbani Christoph Köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-KO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Dynamic Interaction Analysis of Coupled Axial-Torsional-Lateral Mechanical Vibrations in Rotary Drilling Systems

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Structural Durability & Health Monitoring 2025年第1期19卷 77-103页

作者： Sabrina Meddah Sid Ahmed Tadjer Abdelhakim Idir Kong Fah Tee mohamed Zinelabidine Doghmane Madjid Kidouche Applied Automation Laboratory Faculty of Hydrocarbons and ChemistryUniversity of BoumerdesBoumerdes35000Algeria Institute of Electrical and Electronic Engineering(IGEE) University of BoumerdesBoumerdes35000Algeria Laboratory of the Electrification of Industrial Enterprises University of BoumerdesBoumerdes35000Algeria Electrical Engineering Department Mohamed Boudiaf University of M’silaM’sila28000Algeria Department of Civil and Environmental Engineering King Fahd University of Petroleum&MineralsDhahran31261Saudi Arabia Interdisciplinary Research Center for Construction and Building Materials King Fahd University of Petroleum&Minerals(KFUPM)Dhahran31261Saudi Arabia

Maintaining the integrity and longevity of structures is essential in many industries,such as aerospace,nuclear,and *** achieve the cost-effectiveness of large-scale systems in petroleum drilling,a strong emphasis on structural durability and monitoring is *** study focuses on the mechanical vibrations that occur in rotary drilling systems,which have a substantial impact on the structural integrity of drilling *** study speciﬁcally investigates axial,torsional,and lateral vibrations,which might lead to negative consequences such as bit-bounce,chaotic whirling,and high-frequency *** events not only hinder the efﬁciency of drilling but also lead to exhaustion and harm to the system’s components since they are difﬁcult to be detected and controlled in real *** study investigates the dynamic interactions of these vibrations,speciﬁcally in their high-frequency modes,usingﬁeld data obtained from measurement while ***ﬁndings have demonstrated the effect of strong coupling between the high-frequency modes of these vibrations on drilling sys-tem *** obtained results highlight the importance of considering the interconnected impacts of these vibrations when designing and implementing robust control ***,integrating these compo-nents can increase the durability of drill bits and drill strings,as well as improve the ability to monitor and detect ***,by exploiting theseﬁndings,the assessment of structural resilience in rotary drilling systems can be ***,the study demonstrates the capacity of structural health monitoring to improve the quality,dependability,and efﬁciency of rotary drilling systems in the petroleum industry.

关键词： Rotary drilling systems mechanical vibrations structural durability dynamic interaction analysis ﬁeld data analysis

The impact of alpha-fetoprotein (AFP), child-turcotte-pugh (CTP) score and disease staging on the survival of hepatocellular carcinoma (HCC) patients: a retrospective cohort from single oncology center

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Oncology research 2025年第1期33卷 149-160页

作者： Nasser Mulla Yousef Katib Asim M Almughamsi Duaa S Alkhayat mohamed Mosaad Samir T Alfotih Rawan Alaofi Department of Internal Medicine Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Radiology Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Surgery Faculty of Medicine Taibah University Madinah 42278 Saudi Arabia. Department of Endemic and Infectious Diseases Suez Canal University Ismailia 41522 Egypt. King Salman bin Abdulaziz Medical City Madinah 42311 Saudi Arabia. Prince Mohammed Bin Abdulaziz Hospital Madinah 41511 Saudi Arabia.

Background:Hepatocellular carcinoma (HCC) is the most common cause of cancer-related death in Saudi Arabia. Our study aimed to investigate the patterns of HCC and the effect of TNM staging, Alfa-fetoprotein (AFP), and Child-Turcotte Pugh (CTP) on patients' overall survival (OS).Methods:A retrospective analysis was conducted on 43 HCC patients at a single oncology center in Saudi Arabia from 2015 to 2020. All patients had to fulfill one of the following criteria: (a) a liver lesion reported as definitive HCC on dynamic imaging and/or (b) a biopsy-confirmed diagnosis.Results:The mean patient age of all HCC cases was 66.8 with a male-to-female ratio of 3.3:1. All patients were stratified into two groups: viral HCC (n = 22, 51%) and non-viral HCC (n = 21, 49%). Among viral-HCC patients, 55% were due to HBV and 45% due to HCV. Cirrhosis was diagnosed in 79% of cases. Age and sex did not significantly statistically differ in OS among viral and non-viral HCC patients (-value > 0.05). About 65% of patients had tumor size >5 cm during the diagnosis, with a significant statistical difference in OS (-value = 0.027). AFP was >400 ng/ml in 45% of the patients. There was a statistically significant difference in the OS in terms of AFP levels (-value = 0.021). A statistically significant difference was also observed between the CTP score and OS (-value = 0.02). CTP class B had the longest survival. BSC was the most common treatment provided to HCC patients followed by sorafenib therapy. There was a significant statistical difference in OS among viral and non-viral HCC patients (-value = 0.008).Conclusions:The most common predictors for OS were the underlying cause of HCC, AFP, and tumor size. Being having non-viral etiology, a tumor size >5 cm, an AFP > 400 ng/mL, and a CTP score class C were all negatively associated with OS.

关键词： Alpha-fetoprotein (AFP) Child-turcotte-pugh Hepatocellular carcinoma Pattern Progression free survival

Anti-wear properties evaluation of frictional sliding interfaces in automobile engines lubricated by copper/graphene nanolubricants

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Friction 2020年第5期8卷 905-916页

作者： mohamed Kamal Ahmed ali Xianjun HOU mohamed AAABDELKAREEM Hubei Key Laboratory of Advanced Technology for Automotive Components Wuhan University of TechnologyWuhan 430070China Automotive and Tractors Engineering Department Faculty of EngineeringMinia UniversityEl-Minia 61111Egypt Hubei Collaborative Innovation Center for Automotive Components Technology Wuhan 430070China

Owing to the significance of improving fuel economy, reducing emissions, and extending the durability of engine components, this study focused on the tribological performance of nano-additives. In this study, copper (Cu) and graphene (Gr) nanomaterials were dispersed in a fully formulated engine oil (5W-30) with different concentrations. The tribological trials were investigated under various speeds and loads, utilizing a reciprocating tribometer to mimic the ring/liner interfaces in the engine. The frictional surface morphologies were com-prehensively analyzed using electron probe X-ray microanalysis (EPMA), field emission scanning electron microscopy (FESEM), energy dispersive spectrometer (EDS), and three dimensional (3D) surface profilometry to explore the mechanisms responsible for improving the tribological performance of the frictional sliding parts in the engine. The tribological test results illustrated that lubrication by nano-additives reduced the wear rate (WR) and friction coefficient (COF) by 25%–30% and 26.5%–32.6%, respectively, as compared with 5W-30. The results showed that this is a promising approach for increasing the durability and lifespan of frictional sliding components and fuel economy in automobile engines.

关键词： engine tribology nanomaterial nanolubricant friction wear tribofilm

Machine learning-based seismic assessment of framed structures with soil-structure interaction

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Frontiers of Structural and Civil Engineering 2023年第2期17卷 205-223页

作者： mohamed NOURELDIN Tabish ali Jinkoo KIM Department of Global Smart City Sungkyunkwan UniversitySuwon 16419Korea

The objective of the current study is to propose an expert system framework based on a supervised machine learning technique(MLT)to predict the seismic performance of low-to mid-rise frame structures considering soil-structure interaction(SSI).The methodology of the framework is based on examining different MLTs to obtain the highest possible accuracy for *** the MLT,a sensitivity analysis was conducted on the main SSI parameters to select the most effective input *** limit state criteria were used for the seismic evaluation within the process.A new global seismic assessment ratio was introduced that considers both serviceability and strength aspects by utilizing three different engineering demand parameters(EDPs).The proposed framework is novel because it enables the designer to seismically assess the structure,while simultaneously considering different EDPs and multiple limit ***,the framework provides recommendations for building component design based on the newly introduced global seismic assessment ratio,which considers different levels of seismic *** proposed framework was validated through comparison using non-linear time history(NLTH)*** results show that the proposed framework provides more accurate results than conventional ***,the generalization potential of the proposed framework was tested by investigating two different types of structural irregularities,namely,stiffness and mass *** results from the framework were in good agreement with the NLTH analysis results for the selected case studies,and peak ground acceleration(PGA)was found to be the most influential input parameter in the assessment process for the case study models *** proposed framework shows high generalization potential for low-to mid-rise structures.

关键词： seismic hazard artificial neural network soil-structure interaction seismic analysis

Robust Output Practical Stability of Time-Varying Nonlinear Control Systems via Indefinite Lyapunov Functions

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Journal of Systems Science & Complexity 2024年第6期37卷 2595-2613页

作者： DAMAK Hanen ABOTHHER Amal HAMMAMI mohamed ali Department of Mathematics University of SfacPreparatory Engineering Institute of SfaxSfax 3047Tunisia Department of Mathematics University of ZawiaFaculty of education Abu EssaZawia 16418Libya Department of Mathematics University of SfacFaculty of Sciences of SfaxSfax 3047Tunisia

This paper focuses on studying the problem of robust output practical stability of timevarying nonlinear control systems. The main innovation lies in the fact that the proposed approach for stability analysis allows for the computation of bounds that characterize the asymptotic convergence of solutions to a small ball centered at the origin using a Lyapunov method with a definite *** different conditions on the perturbation, the authors demonstrate that the system can be globally robustly asymptotically output stable by designing a candidate feedback controller. Finally, three examples are given to illustrate the practical implications and significance of the theoretical results.

关键词： Control theory global robust practical asymptotic output stability(GRPAOS) Lyapunov method time-varying control systems

A Multi-Level Selective Maintenance Strategy Combined to Data Mining Approach for Multi-Component System Subject to Propagated Failures

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Journal of Systems Science and Systems Engineering 2022年第3期31卷 313-337页

作者： mohamed ali Kammoun Zied Hajej Nidhal Rezg Universite de Lorraine LGIPMF-57000 MetzFrance Ecole poly technique du Groupe Honoris United Universities-Tunisia

In several industrial fields like air transport,energy industry and military domain,maintenance actions are carried out during downtimes in order to maintain the reliability and availability of production *** such a circumstance,selective maintenance strategy is considered the reliable solution for selecting the faulty components to achieve the next mission without *** this paper,a novel multi-level decision making approach based on data mining techniques is investigated to determine an optimal selective maintenance *** the first-level,the age acceleration factor and its impact on the component nominal age are used to establish the local *** first decision making employed K-means clustering algorithm that exploited the historical maintenance *** on the first-level intervention plan,the remaining-levels identify the stochastic dependence among components by relying upon Apriori association rules algorithm,which allows to discover of the failure occurrence *** addition,at each decision making level,an optimization model combined to a set of exclusion rules are called to supply the optimal selective maintenance plan within a reasonable time,minimizing the total maintenance cost under a required reliability *** illustrate the robustness of the proposed strategy,numerical examples and a FMS real study case have been solved.

关键词： Selective maintenance stochastic dependence age acceleration factor data mining flexible manufacturing system