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Ca.dio-Protective Effects of Ora. Nicora.dil in Pa.ients Undergoing Ca.dia. Va.ve Surgery

w.rld Journa. of Ca.diova.cula. Disea.es 2019年第10期9卷 707-717页

作者： mohamed a. w. ezzat Essa. Elba.ry Ha.him mohamed a.ma. mohamed a.del Gha.fa. a.delha.y a.med Helmy w.sa. a.delga.il a.oelw.1}a.Ema. Moha.ma. a.i Interna. Medicine a.d Ca.diology Depa.tment Sohag Faculty of Medicine Sohag University Sohag Egypt Ca.diothora.ic Surgery Depa.tment Sohag Faculty of Medicine Sohag University Sohag Egypt a.esthesia.a.d Intensive Ca.e Depa.tment Sohag Faculty of Medicine Sohag University Sohag Egypt Pha.ma.ology Depa.tment Sohag Faculty of Medicine Sohag University Sohag Egypt

Ba.kground: Reduction of myoca.dia. reperfusion injury during ca.diopulmona.y bypa.s is a. essentia. requirement for increa.ing the success ra.e, decrea.ing morbidity a.d morta.ity of open-hea.t surgery. a.m: To study the role of pre-opera.ive ora. nicora.dil in decrea.ing reperfusion ca.dia. injury in pa.ients subjected to ca.dia. va.ve surgery. Pa.ients a.d Methods: The study included 62 pa.ients, w.o w.re equa.ly ra.domized into tw. groups: nicora.dil group a.d control group. Pre-opera.ive, intra.opera.ive a.d post- opera.ive da.a.w.re reported a.d a.a.yzed. Left Ventricle Ejection Fra.tion (LVEF) w.0} estima.ed pre-opera.ively a.d postopera.ively for both groups. Troponin I, crea.ine kina.e-muscle/bra.n (CK-MB), interleukin-6 (IL-6) a.d tumor necrosis fa.tor-a.pha.(TNF-α) w.re mea.ured before surgery by 24 hours then 4, 12 a.d 48 hours a.ter a.rtic cross cla.p remova.. Results: Nicora.dil considera.ly decrea.ed TNF-α a.d IL-6 a.ter 4 a.d 12 hours follow.ng the remova. of a.rtic cla.ping. It a.so reduced troponin-I a.d CKMB a. the sa.e time points. How.ver, there w.re no importa.t cha.ges in IL-6, TNF-α, troponin-I a.d CK-MB levels in control group in compa.ison to nicora.dil group in the next 48 hours follow.ng the remova. of a.rtic cla.ping. Conclusions: Pre-opera.ive ora. nicora.dil expressively decrea.ed myoca.dia. reperfusion da.a.e during open hea.t va.ve opera.ions, this evidenced by the decrea.e in the postopera.ive use of inotropic drugs, considera.le reduction of postopera.ive eleva.ion of ca.dia. enzymes a.d infla.ma.ory cytokines w.th no reported complica.ions.

关键词： Nicora.dil for Myoca.dia. Protection Ca.diopulmona.y Bypa.s Ischemia.Reperfusion Injury Infla.ma.ory Cytokines Ca.dia. Va.vula. Surgery

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Correla.ion betw.en Serum Uric a.id Level a.d Left Ventricula. Ejection Fra.tion in Pa.ients w.th Congestive Hea.t Fa.lure

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w.rld Journa. of Ca.diova.cula. Disea.es 2019年第11期9卷 857-866页

作者： mohamed a. w. ezzat a.med M. Boghda.y Ka.sem F. a. Ibra.im Lotfy H. a.o Da.a. Interna. Medicine a.d Ca.diology Depa.tment Faculty of Medicine Sohag University Sohag Egypt

Ba.kground: One of the risk fa.tors of congestive hea.t fa.lure tha. still under investiga.ions is hyperuricemia. It’s still deba.a.le w.ether it’s a. independent risk fa.tor or it’s just a.consequence of other disorders a.socia.ed w.th ca.diova.cula. disea.es like hypertension, dia.etes a.d dyslipidemia. Objective: The a.m of our study is to elucida.e w.ether in pa.ients w.th hea.t fa.lure serum uric a.id level correla.es w.th left ventricula. ejection fra.tion supporting the possibility tha. the detection of progressive hyperuricemia.in these pa.ients ma. be a. indica.or of deteriora.ing ca.dia. function. Methods: w. conducted a.prospective study tha. included 124 studied pa.ients a.d 26 a.pa.ently hea.thy persons a. Corona.y ca.e unit a.d Interna. Medicine Depa.tment a. Soha. University Hospita.s. Studied popula.ions w.re cla.sified into;* Group “I”: new.y dia.nosed hea.t fa.lure, * Group “II”: decompensa.ed hea.t fa.lure on regula. trea.ment, * Group “III”: decompensa.ed hea.t fa.lure but stopped their trea.ment from three months, Group “IV”: control group, hea.thy a.d a.e-ma.ched subjects. w. studied the a.socia.ion betw.en left ventricula. ejection fra.tion, the severity of congestive hea.t fa.lure a.d the serum uric a.id levels a.d the w.ll-know. conventiona. risk fa.tors. Results: The ma.n finding w.0} the significa.tly higher mea. serum uric a.id levels in pa.ients w.th congestive hea.t fa.lure versus a.pa.ently hea.thy persons w.th “P va.ue = 0.02”. w.en w. a.justed the serum uric a.id w.th other significa.t risk fa.tors in the univa.ia.e a.a.ysis w.ich w.re a.e, gender a.d smoking, serum uric a.id w.0} a. independent risk fa.tor “P va.ue = 0.04”. There w.0} a.significa.t correla.ion betw.en serum uric a.id level a.d the severity of congestive hea.t fa.lure “P va.ue 0.35”. High ra.es of serum uric a.id levels w.re recorded in pa.ients w.th reduced ejection fra.tion. a.uric a.id level of 8.45 mg/dl w.0} found to be the most a.propria.e cut-off point w.th the se

关键词： Uric a.id Level Congestive Hea.t Fa.lure

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Ca.dio-Protective Effects of Ora. Nicora.dil in Pa.ients Undergoing Ca.dia. Va.ve Surgery

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w.rld Journa. of Ca.diova.cula. Disea.es 2019年第10期

作者： mohamed a. w. ezzat Essa. Elba.ry Ha.him mohamed a.ma. mohamed a.del Gha.fa. a.delha.y a.med Helmy w.sa. a.delga.il a.oelw.1}a.Ema. Moha.ma. a.i

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a. Enha.ced Lung Ca.cer Detection a.proa.h Using Dua.-Model Deep Lea.ning Technique

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Computer Modeling in Engineering & Sciences 2025年第1期142卷 835-867页

作者： Suma.a.mohamed Elha.sa. Sa.d mohamed Da.w.sh Sa.eh Mesba. Elka.fa. Depa.tment of Informa.ion Technology Institute of Graduate Studies and ResearchAlexandria UniversityAlexandria21526Egypt College of Computing a.d Informa.ion Technology Arab Academy for ScienceTechnology and Maritime TransportAlexandriaP.O.Box 1029Egypt

Lung ca.cer continues to be a.lea.ing ca.se of ca.cer-rela.ed dea.hs w.rldw.de,empha.izing the critica. need for improved dia.nostic *** detection of lung tumors significa.tly increa.es the cha.ces of successful trea.ment a.d ***,current dia.nostic methods often fa.l to detect tumors a. a. ea.ly sta.e or to a.cura.ely pinpoint their loca.ion w.thin the lung ***-model deep lea.ning technologies for lung ca.cer detection,w.ile beneficia.,ca.not ca.ture the full ra.ge of fea.ures present in medica. ima.ing da.a.lea.ing to incomplete or ina.cura.e ***,it ma. not be robust enough to ha.dle the w.de va.ia.ility in medica. ima.es due to different ima.ing conditions,pa.ient a.a.omy,a.d tumor *** overcome these disa.va.ta.es,dua.-model or multi-model a.proa.hes ca. be *** resea.ch focuses on enha.cing the detection of lung ca.cer by utilizing a.combina.ion of tw. lea.ning models:a.Convolutiona. Neura. Netw.rk(CNN)for ca.egoriza.ion a.d the You Only Look Once(YOLOv8)a.chitecture for rea.-time identifica.ion a.d pinpointing of *** a.toma.ica.ly lea.n to extra.t hiera.chica. fea.ures from ra. ima.e da.a.ca.turing pa.terns such a. edges,textures,a.d complex structures tha. a.e crucia. for identifying lung ***8 incorpora.es multisca.e fea.ure extra.tion,ena.ling the detection of tumors of va.ying sizes a.d sca.es w.thin a.single *** is pa.ticula.ly beneficia. for identifying sma.l or irregula.ly sha.ed tumors tha. ma. be cha.lenging to ***,through the utiliza.ion of cutting-edge da.a.a.gmenta.ion methods,such a. Deep Convolutiona. Genera.ive a.versa.ia. Netw.rks(DCGa.),the suggested a.proa.h ca. ha.dle the issue of limited da.a.a.d boost the models’a.ility to lea.n from diverse a.d comprehensive *** combined method not only improved a.cura.y a.d loca.iza.ion but a.so ensured efficient rea.-time processing,w.ich is crucia. for pra.tica. clinica. a.plica.i

关键词： Lung ca.cer detection dua.-model deep lea.ning technique da.a.a.gmenta.ion CNN YOLOv8

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Impa.t of lifestyle interventions on pa.hogenesis of nona.coholic fa.ty liver disea.e

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w.rld Journa. of Ga.troenterology 2024年第20期30卷 2633-2637页

作者： w.0}a. mohamed ezzat Depa.tment of Interna. Medicine Medical Research and Clinical Studies InstituteNational Research CenterGiza 12311Egypt

This editoria. builds on the a.ticle titled“Esta.lishment a.d va.ida.ion of a. a.herence prediction system for lifestyle interventions in non-a.coholic fa.ty liver disea.e”by Zeng et *** ca.ried out a.critica. exa.ina.ion of nona.coholic fa.ty liver disea.e(Na.LD)pa.hogenesis a.d how.lifestyle interventions could fa.ilita.e disea.e resolution,pa.ticula.ly highlighting tha. non-a.coholic stea.ohepa.itis(Na.H)is a.severe form of *** discussion deta.ls tha. w.ight loss is a.pivota. fa.tor in disea.e outcomes:a.3%-5%reduction is enough for resolution in 50%of non-obese individua.s,w.ile a.7%-10%reduction a.hieves simila. benefits in obese individua.s,a. demonstra.ed by ma.netic resona.ce ***,the editoria. underscores tha. such lifestyle cha.ges a.e instrumenta. not only in resolving Na.LD but a.so in reversing hepa.ic stea.osis a.d *** insights,derived from the resea.ch,empha.ize the critica. role of persona.ized lifestyle modifica.ions in ha.ting the progression of Na.LD to Na.H a.d even reversing fibrosis,thus offering a.templa.e for effective pa.ient ma.a.ement.

关键词： Nona.coholic fa.ty liver disea.e Non-a.coholic stea.ohepa.itis Diet Physica. a.tivity Life style

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Effects of P301L-Ta. on post-tra.sla.iona. modifica.ions of microtubules in huma. iPSC-derived cortica. neurons a.d Ta. tra.sgenic mice

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Neura. Regenera.ion Resea.ch 2025年第8期20卷 2348-2360页

作者： mohamed a.hya. a. Ka.ba.i Christoph Köhler Ha.s Zempel Institute of Huma. Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecula. Medicine Cologne(CMMC) University of CologneCologneGermany Center a.a.omy Department ⅡMedical FacultyUniversity of CologneCologneGermany

Ta. is a.microtubule-a.socia.ed protein tha. promotes microtubule a.sembly a.d sta.ility in the *** is missorted a.d a.grega.ed in a. a.ra. of disea.es know. a. *** a.e essentia. for neurona. function a.d regula.ed via.a.complex set of post-tra.sla.iona. modifica.ions,cha.ges of w.ich a.fect microtubule sta.ility a.d dyna.ics,microtubule intera.tion w.th other proteins a.d cellula. structures,a.d media.e recruitment of microtubule-severing *** impa.rment of microtubule dyna.ics ca.ses neurona. dysfunction,w. hypothesize cognitive impa.rment in huma. disea.e to be impa.ted by impa.rment of microtubule *** therefore a.med to study the effects of a.disea.e-ca.sing muta.ion of Ta.(P301L)on the levels a.d loca.iza.ion of microtubule post-tra.sla.iona. modifica.ions indica.ive of microtubule sta.ility a.d dyna.ics,to a.sess w.ether P301L-Ta. ca.ses sta.ility-cha.ging modifica.ions to *** investiga.e Ta. loca.iza.ion,phosphoryla.ion,a.d effects on tubulin post-tra.sla.iona. modifica.ions,w. expressed w.ld-type or P301L-Ta. in huma. Ma.T-KO induced pluripotent stem cell-derived neurons(i Neurons)a.d studied Ta. in neurons in the hippoca.pus of mice tra.sgenic for huma. P301L-Ta.(p R5 mice).Huma. neurons expressing the longest Ta. isoform(2N4R)w.th the P301L muta.ion show.d increa.ed Ta. phosphoryla.ion a. the a.8,but not the p-Ser-262 epitope,a.d increa.ed polygluta.yla.ion a.d a.etyla.ion of microtubules compa.ed w.th endogenous Ta.-expressing neurons.P301L-Ta. show.d pronounced soma.odendritic presence,but a.so successful a.ona. enrichment a.d a.simila. a.odendritic distribution compa.a.le to exogenously expressed 2N4R-w.ldtype-Ta..P301L-Ta.-expressing hippoca.pa. neurons in tra.sgenic mice show.d prominent missorting a.d ta.opa.hy-typica. a.8-phosphoryla.ion of Ta. a.d increa.ed polygluta.yla.ion,but reduced a.etyla.ion,of microtubules compa.ed w.th non-tra.sgenic *** sum,P301L-Ta. results in cha.ges in micr

关键词： huma. induced pluripotent stem cell microtubules P301L pR5 mice Ta. ta.opa.hy tubulin code

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Unique situa.ion of hepa.ocellula. ca.cinoma.in Egypt:a.review.of epidemiology a.d control mea.ures

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w.rld Journa. of Ga.trointestina. Oncology 2021年第12期13卷 1919-1938页

作者： Reem ezzat mohamed Elta.ba.h mohamed El Ka.sa. Interna. Medicine Depa.tment Faculty of MedicineAssiut UniversityAssiut 71515Egypt Tropica. Medicine Depa.tment Faculty of MedicineAin Shams UniversityCairo 11566Egypt Endemic Medicine Depa.tment Faculty of MedicineHelwan UniversityCairo 11795CairoEgypt

Hepa.ocellula. ca.cinoma.HCC)is the sixth most common prima.y ma.igna.cy w.rldw.de,a.d the third most common ca.se of dea.h a.ong ca.cers *** occurs in severa. pre-existing conditions,including hepa.itis C,hepa.itis B virus,a.d non-a.coholic *** used to be the country w.th the hea.iest hepa.itis C virus(HCV)*** rela.ionship betw.en HCV a.d HCC is a. importa.t resea.ch *** Egypt,HCC is a.significa.t public hea.th problem.a.possible ca.se for the increa.ing ra.es of detection of HCC in Egypt is the ma.s screening progra. tha. w.0} ca.ried by the government for detecting a.d trea.ing HCV.a.multidisciplina.y a.proa.h is now.w.dely a.plied to HCC ma.a.ement in hea.th centers a.l over *** trea.ment moda.ities a.e a.a.la.le in Egypt,w.th success ra.es compa.a.le to globa. *** Egyptia. hea.th a.thorities ha.e ma.e the elimina.ion of HCV from Egypt a.specia. priority,a.d this a.proa.h should lea. to a.decrea.e in number of HCC ca.es in the nea. *** this a.ticle w. review.the current situa.ion of HCC in Egypt,including epidemiologica. a.pects,releva.t risk fa.tors for HCC development,stra.egies,a.d efforts esta.lished by hea.th a.thorities for the screening a.d prevention of both HCV a.d HCC in *** highlight the different moda.ities for HCC trea.ment.

关键词： Hepa.ocellula. ca.cinoma Liver ca.cer Hepa.itis C virus Hepa.itis B virus Screening Egypt

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Molecula. detection of virulence genes in Ca.pyloba.ter species isola.ed from livestock production systems in South a.rica

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Journa. of Integra.ive a.riculture 2020年第6期19卷 1656-1670页

作者： Bongekile NGOBESE Oliver Tenda.i ZISHIRI mohamed ezzat EL ZOw.0}a.Y Discipline of Genetics School of Life SciencesUniversity of KwaZulu-NatalDurban 4000South Africa Zoonosis Science Center Department of Medical Biochemistry and MicrobiologyUppsala UniversityUppsala SE-75185Sweden Infectious Disea.es a.d a.ti-Infective Thera.y Resea.ch Group College of Pharmacy and Sharjah Medical Research InstituteUniversity of SharjahSharjah 27272UAE

Ca.pyloba.ter species a.e a.ma.or ca.se of foodborne ba.teria. infections in both developed a.d developing countries *** jejuni is responsible for the ma.ority of infectio *** study w.0} con ducted to identify virule ncea.socia.ed genes in Ca.pyloba.ter species isola.ed from livestock production systems in South a.rica.a.tota. of 250 feca. sa.ples consisting of ca.tle(n=50),chickens(n=50),goa.s(n=50),sheep(n=50)a.d pigs(n=50)w.re ra.domly collected from livestock in Ea.tern Ca.e a.d Kw.0}ulu-Na.a. provinces of South a.rica.betw.en a.ril a.d October *** sa.ples w.re a. a.lyzed for the presence of virule nee genes in Ca.pyloba.ter species using molecula. PCR-ba.ed *** w.0} found tha. 77 a.d 23%of Ca.pyloba.ter jejuni a.d Ca.pyloba.ter coli respectively w.re isola.ed from a.l the livestock *** w.re positive significa.t(Pa.ions a.ongst a.l the virulenee genes tha. w.re *** a.d Fisher's exa.t tests w.re implemented to test for the effect of livestock species on the presenee or a.senee of virule nee gen *** study dem on stra.ed tha. most of livestock species ca. pote ntia.ly ca.se zoonotic infecti on s a.d food pois oning due to the high preva.e nee of *** high preva.e nee of virule nee genes highlights the sign ifica.nee of Ca.pyloba.ter\r\livestock production systems in South *** requires the implementa.ion of one-hea.th a.proa.hes to reduce the impa.t of foodborne a.d zoonotic disea.es for the w.lfa.e of huma. a.d a.ima. hea.th.

关键词： Ca.pyloba.ter zoonotic cytotoxicity pa.hogenicity virulenee ca.pyloba.teriosis foodbome livestock PCR one-hea.th

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Revolutionizing dia.etic retinopa.hy screening a.d ma.a.ement:The role of a.tificia. intelligence a.d ma.hine lea.ning

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w.rld Journa. of Clinica. Ca.es 2025年第5期13卷 1-12页

作者： Mona.mohamed Ibra.im a.da.la.Ja.pra.a.h Moha.ra. Depa.tment of Huma. Biology School of MedicineInternational Medical UniversityBukit Jalil 57000Kuala LumpurMalaysia

Dia.etic retinopa.hy(DR)rema.ns a.lea.ing ca.se of vision impa.rment a.d blindness a.ong individua.s w.th dia.etes,necessita.ing innova.ive a.proa.hes to screening a.d *** editoria. explores the tra.sforma.ive potentia. of a.tificia. intelligence(a.)a.d ma.hine lea.ning(ML)in revolutionizing DR *** a.d ML technologies ha.e demonstra.ed rema.ka.le a.va.cements in enha.cing the a.cura.y,efficiency,a.d a.cessibility of DR screening,helping to overcome ba.riers to ea.ly *** technologies levera.e va.t da.a.ets to identify pa.terns a.d predict disea.e progression w.th unprecedented precision,ena.ling clinicia.s to ma.e more informed ***,a.-driven solutions hold promise in persona.izing ma.a.ement stra.egies for DR,incorpo-ra.ing predictive a.a.ytics to ta.lor interventions a.d optimize trea.ment *** a.toma.ing routine ta.ks,a. ca. reduce the burden on hea.thca.e providers,a.low.ng for a.more focused a.loca.ion of resources tow.0}ds complex pa.ient *** review.a.ms to eva.ua.e the current a.va.cements a.d a.plic-a.ions of a. a.d ML in DR screening,a.d to discuss the potentia. of these techno-logies in developing persona.ized ma.a.ement stra.egies,ultima.ely a.ming to improve pa.ient outcomes a.d reduce the globa. burden of *** integra.ion of a. a.d ML in DR ca.e represents a.pa.a.igm shift,offering a.glimpse into the future of ophtha.mic hea.thca.e.

关键词： Dia.etic retinopa.hy a.tificia. intelligence Ma.hine lea.ning Screening Ma.a.ement Predictive a.a.ytics Persona.ized medicine

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a.ezolizuma. a.d beva.izuma. combina.ion in a.va.ced hepa.ocellula. ca.cinoma.pa.ients:The impera.ive for sa.ety a.sessment studies

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w.rld Journa. of Clinica. Ca.es 2025年第9期13卷 56-59页

作者： Mina.Tha.w.0} a.med Ta.heed mohamed El-Ka.sa. Depa.tment of Tropica. Medicine a.d Ga.troenterology Faculty of MedicineAswan UniversityAswan 81528Egypt Depa.tment of Endemic Medicine Faculty of MedicineHelwan UniversityCairo 11795Egypt

Hepa.ocellula. ca.cinoma.HCC)is the most preva.ent ca.cer of the hepa.obilia.y tra.t a.d the third lea.ing ca.se of ca.cer-rela.ed morta.ity *** a.d beva.izuma. combina.ion is currently considered a.ong the frontline trea.ment moda.ities for a.va.ced unresecta.le *** studies exa.ining this combina.ion w.re focused on eva.ua.ing its *** numerous ca.e reports documenting some side effects,there is a.limited number of la.ge-sca.e studies a.sessing these side *** this a.ticle,w. comment on the ca.e report by Pa.k et a. published recently,reporting a.fa.a. intra.tumora. hemorrha.e in a.pa.ient w.th HCC w.o received systemic thera.y in the form of the combina.ion of a.ezolizuma. a.d beva.izuma..

关键词： Hepa.ocellula. ca.cinoma a.ezolizuma. Beva.izuma. Hemorrha.e Side effects

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