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Niosome-encapsulated auraptene reduced the mRNA expression of VEGF-A and PDGFs genes in human retinaderived RPE cell line

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International Journal of Ophthalmology(English edition) 2024年第6期17卷 1028-1035页

作者： Akram Vahidi Teymoor Khosravi Farzad Dastaviz Mehdi Sheikh arabi Ayyoob Khosravi Morteza Oladnabi Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To evaluate the effect of auraptene(AUR)treatment in forms of free and encapsulated in niosome nanoparticles by investigating the mRNA expression level of vascular endothelium growth factor(VEGF)-A and platelet-derived growth factors(PDGFs)in human retinal pigment epithelium(RPE)cell ***:Niosome nanocarriers were produced using two surfactants Span 60 and Tween *** cell line was treated with both free AUR and *** dosage of treatments was calculated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)*** of VEGF-A and PDGF-A,PDGF-B,PDGF-C,PDGF-D genes was measured after total RNA extraction and cDNA synthesis,using real-time polymerase chain reaction(RT-PCR).RESULTS:The highest entrapment efficiency(EE)was achieved by Span 60:cholesterol(1:1)with 64.3%.The half maximal inhibitory concentration(IC50)of free and niosome-encapsulated AUR were 38.5 and 27.78µg/mL,*** study revealed that niosomal AUR had more gradual delivery to the ***-PCR results showed reduced expression levels of VEGF-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D after treatment with both free and niosomal ***:Niosomal formulation of Span 60:cholesterol(1:1)is an effective drug delivery approach to transfer AUR to RPE ***-A,PDGF-A,PDGF-B,PDGF-C,and PDGF-D are four angiogenic factors,inhibiting which by niosomal AUR may be effective in age-related macular degeneration.

关键词： auraptene niosome age-related macular degeneration angiogenesis nanocarrier

Impact of umbelliprenin-containing niosome nanoparticles on VEGF-A and CTGF genes expression in retinal pigment epithelium cells

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 7-15页

作者： Farzad Dastaviz Akram Vahidi Teymoor Khosravi Ayyoob Khosravi Mehdi Sheikh arabi Abouzar Bagheri Mohsen Rashidi Morteza Oladnabi Stem Cell Research Center Golestan University of Medical SciencesGorgan ***Iran Department of Medical Genetics School of Advanced Technologies in MedicineGolestan University of Medical SciencesGorgan ***Iran Student Research Committee Golestan University of Medical SciencesGorgan ***Iran Department of Molecular Medicine Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Medical Nanotechnology Faculty of Advanced Medical TechnologiesGolestan University of Medical SciencesGorgan ***Iran Department of Clinical Biochemistry and Genetics Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Department Pharmacology Faculty of MedicineMazandaran University of Medical SciencesSari ***Iran Gorgan Congenital Malformations Research Center Golestan University of Medical SciencesGorgan ***Iran

AIM:To investigate the impact of niosome nanoparticles carrying umbelliprenin(UMB),an anti-angiogenic and anti-inflammatory plant compound,on the expression of vascular endothelial growth factor(VEGF-A)and connective tissue growth factor(CTGF)genes in a human retinal pigment epithelium(RPE)-like retina-derived cell ***:UMB-containing niosomes were created,optimized,and ***-like cells were treated with free UMB and UMB-containing *** IC_(50)values of the treatments were determined using an MTT *** expression of VEGF-A and CTGF was evaluated using real-time polymerase chain reaction after RNA extraction and cDNA ***’characteristics,including drug entrapment efficiency,size,dispersion index,and zeta potential were *** UMB had an IC_(50)of 96.2μg/mL,while UMB-containing niosomes had an IC_(50)of 25μg/***:Treatment with UMB-containing niosomes and free UMB resulted in a significant reduction in VEGF-A expression compared to control cells(P=0.001).Additionally,UMB-containing niosomes demonstrated a significant reduction in CTGF expression compared to control cells(P=0.05).However,there was no significant reduction in the expression of both genes in cells treated with free ***:Both free UMB and niosome-encapsulated UMB inhibits VEGF-A and CTGF genes ***,the latter demonstrates significantly greater efficacy,potentially due to the lower UMB dosage and gradual *** findings have implications for anti-angiogenesis therapeutic approaches targeting age-related macular degeneration.

关键词： umbelliprenin niosome age-related macular degeneration vascular endothelial growth factor-A connective tissue growth factor

Unroofed coronary sinus,left-sided superior vena cava and mitral insufficiency:A case report and review of the literature

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World Journal of Cardiology 2024年第10期16卷 595-603页

作者： Fouad Bitar Ziad Bulbul Yehya Jassar Rana Zareef Jennifer Abboud Mariam arabi Fadi Fouad Bitar Department of Pediatric and Adolescent American University of Beirut Medical CenterBeirut 1103Lebanon Department of Surgery American University of Beirut Medical CenterBeirut 1103Lebanon

BACKGROUND Unroofed coronary sinus(UCS)is a rare subtype of atrial septal *** is frequently associated with a persistent left superior vena cava and is often part of a more intricate cardiac *** SUMMARY This report describes a rare case of an adolescent patient with UCS featuring atrial situs solitus,absence of the right superior vena cava and a persistent left superior vena cava draining into the left atrium consistent with total unroofing of the coronary *** was associated with concurrent severe mitral insufficiency secondary to redundant and prolapsing leaflets,and a substantial left-to-right shunt across the coronary sinus orifice.A comprehensive examination of the existing literature is included,shedding light on the diagnostic challenges of UCS and describing the available surgical options within the context of mitral valve *** UCS is a complex condition requiring careful consideration of associated anomalies and a tailored surgical approach.

关键词： Unroofed coronary sinus Mitral insufficiency Single left superior vena cava Surgical options Absent right superior vena cava Case report

分子印迹表面增强拉曼散射传感器的构建与应用

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科学通报 2024年第11期69卷 1429-1446页

作者：陈璇温宇浩周娜曹晓林 Maryam arabi 纪灵张志阳陈令新李金花中国科学院烟台海岸带研究所山东省海岸带环境工程技术研究中心中国科学院海岸带环境过程与生态修复重点实验室山东省海岸带环境过程重点实验室烟台264003 烟台大学生命科学学院烟台264006 中国科学院大学海洋学院北京100049 国家海洋局烟台海洋环境监测中心站烟台264006 滨州医学院药学院烟台264003

分子印迹表面增强拉曼散射(MI-SERS)传感器,将具有构效预定性、识别特异性和应用普遍性的分子印迹聚合物(MIPs)作为识别元件,结合表面增强拉曼散射(SERS)光谱检测技术的指纹识别、无损、高灵敏和快速的优良特性,提高了传感器的分析性能... 详细信息

分子印迹表面增强拉曼散射(MI-SERS)传感器,将具有构效预定性、识别特异性和应用普遍性的分子印迹聚合物(MIPs)作为识别元件,结合表面增强拉曼散射(SERS)光谱检测技术的指纹识别、无损、高灵敏和快速的优良特性,提高了传感器的分析性能,为复杂基质痕量分析提供了新方法.MI-SERS传感器凭借高效、精确、无损等成为新兴的研究热点,在环境监测、食品安全、生物医药等领域显示了广阔的发展前景.本文综述了MI-SERS传感器构建与应用的新进展.首先,介绍了基本的传感机理,以及根据使用场景、操作过程和检测模式进行的结构分类.然后,从MIPs制备策略和SERS基底改良入手,阐述了提高传感器性能的印迹策略和条件优化方法,并探讨了传感器的即时检验应用.最后,提出了MI-SERS传感器在稳定性、增强机理、普适性、绿色可持续性方面可能面临的挑战,展望了其构建和应用前景.

关键词：分子印迹表面增强拉曼散射传感器构建策略

Variations in radioactivity of phosphate rocks from different sites in Central Eastern Desert of Upper Egypt

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Nuclear Science and Techniques 2002年第4期13卷 193-201页

作者： AMEl-arabi AMMYousef Physics Department Faculty of Science South Valley University 埃及 Qena

Natural radionuclides in the phosphate rock samples collected from Wadi Batur,Wadi Hegaza and Gabal Abu Had at Eastern Desert were determined using a high resolution γ-ray *** experimental results concerning ^226Ra,232Th and their daughters are *** of the measured spectra show that ^226Ra is distinguished with remarkable activities with average values ranging from 22.4 to 558Bq/kg,while ^232Th activity concentration is in the range of 9.7 to 92.8Bq/*** results of the analyses were found to be in a good agreement with the data obtained by others.

关键词：磷酸岩天然放射性核素 226Ra ^232Th

Improve regression-based models for prediction of internal-bond strength of particleboard using Buckingham's pi-theorem

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Journal of Forestry Research 2013年第4期24卷 735-740页

作者： Akbar Rostampour Haftkhani Mohammad arabi Department of Wood & Paper Science and Technology Faculty of Natural ResourcesUniversity of Tehran

Internal bond （IB） strength is one of the most important me- chanical properties that indicate particleboard quality. The aim of this study was to find a simple regression model that considers the most important parameters that can influence on IB strength. In this study, IB strength was predicted by three kinds of equations （linear, quadratic, and exponential） that were based on the percentage of adhesive （8%, 9.5%, and 11%）, particle size （＋5, -5 ＋8, -8 12, and -12 mesh）, and density （0.65, 0.7, and 0.75 g/cm3）. Our analysis of the results （using SHAZAM 9 software） showed that the exponential function best fitted the experi- mental data and predicted the IB strength with 18~,/0 error. In order de- crease the error percentage, the Buckingham Pi theorem was used to build regression models for predicting IB strength based on particle size,

关键词： Buckingham's Pi theorem intemal bond strength particle-board screw withdrawal resistance.

Characterizing incipient motion of low fines content soils with varying compositions, water contents, and relative densities

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International Journal of Sediment Research 2022年第6期37卷 847-856页

作者： Mahsa Ghazian arabi Ali Farhadzadeh Department of Civil Engineering College of Engineering and Applied Sciences Stony Brook University

Laboratory flume experiments were conducted to quantify the effects of the soil characteristics on the critical shear stress of low fines content soil samples collected from the Montauk shores in New York. The collected soils were reconstituted at five different fines contents, ranging between 0 and 20%. These soil mixtures were composed of two initial water contents, dry of optimum and optimum moistures, and two relative densities, one moderate dense and the other dense. The strength indices of the soils, including the effective cohesion and effective angle of internal friction, were measured using the consolidated undrained(CU) triaxial test. The initiation of erosion tests was conducted on the soil mixtures under a unidirectional steady current condition. The near-bed flow velocity, at the onset of erosion, was used to determine the critical velocity and shear stress for each soil sample. The results indicate that the critical shear stress increases with the fines content and effective cohesion. The soils with the optimum initial water contents demonstrate a higher erosion resistance than those with the initial water contents dry of optimum. The higher relative density appears to overshadow the effects of the fines content such that the critical shear stress of the denser soils remains relatively insensitive to the soil composition. The denser soils compacted at the optimum initial water content show the highest resistance against *** critical Shields parameter is modified to include the fines content, relative density, and initial water content.

关键词： Soil erodibility Sediment transport Critical shear stress Initiation of motion

Mechanical and microstructural variations in ECAP of Ti-6Al-4V alloy with equiaxed microstructure

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Rare Metals 2022年第8期41卷 2732-2738页

作者： Hamid arabi Mostafa Ketabchi S.H.N.Alhosseini Mining and Metallurgical Engineering Department Amirkabir University of TechnologyTehran***Iran University Complex of Material and Manufacturing Malek Ashtar University of TechnologyTehran***Iran

The aim of this study is to investigate mechanical and microstructural variations of Ti-6 Al-4 V acquired through various equal channel angular pressing(ECAP)*** ECAP of Ti-6 Al-4 V alloy with the first equiaxed micros tructure was carried out by an isothermal warm and isothermal die *** A pressing carried out on cylindrical samples at 650℃.Mechanical and microstructural investigations were performed concerning Ti-6 Al-4 V in the first state after 2,4,and 8 *** microscopy(OM)investigation shows that alpha grain size increases and beta grain size decreases with the pass numbers *** phase content initially decreases in the first two ECAP *** results show that more equiaxed alpha grains are achieved after four ECAP *** of X-ray diffraction(XRD)analysis show that crystallite size decreases with the number of passes *** two ECAP passes,a vivid increase in mechanical strength is observed;however,the increment dramatically slows down by the increasing number of passes.

关键词： Ti-6Al-4V alloy Equal channel angular pressing Equiaxed microstructure Mechanical properties

Effects of Multiple Strengthening Treatments on Mechanical Properties and Stability of Nanoscale Precipitated Phases in an Aluminum-Copper-Lithium Alloy

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Journal of Materials Science & Technology 2010年第12期26卷 1078-1082页

作者： S.Ahmadi H.arabi A.Shokuhfar Department of Material Science Faculty of EngineeringTarbiat Modares UniversityTehranIran Center of Excellence of Advanced Materials and Processing(CEAMP) Department of Metallurgy and Materials Science and EngineeringIran University of Science & Technology(IUST)NarmakTehranIran Department of Material Science Faculty of Mechanical EngineeringK.N.Toosi University of TechnologyTehranIran

Effects of multiple strengthening treatments （i.e. ag mechanical properties and stability of nanoscale prec in this research. Various tests such as hardness, tensi ng either at three or four consecutive temperatures） on pitated phases in an AA2090 alloy have been evaluated e, electrical resistance, differential scanning calorimetric （DSC）, and transmission electron microscopy （TEM） have been performed. The results show that the ultimate tensile strength （UTS） and the yield strength of the samples aged at four consecutive temperatures （i.e. natural aging＋190℃＋150℃＋100℃） can be increased approximately to 660 and 610 MPa, respectively. It is also found that precipitation of T1 phase occurs during multiple aging process of the alloy and the higher amounts of enthalpies shown in DSC charts are linked to higher volume fraction of this precipitate. Furthermore, TEM observations reveal that T1 phase has plate shape morphology and its crystal structure is in the form of hcp with lattice parameters of a=0.467 nm and c=0.878 nm.

关键词： Multiple strengthening Thermo mechanical treatment (TMT) Selected area electron diffraction (SAED) pattern Inter planar spacing (d)