检索结果-南通市图书馆

维普期刊数据库博看期刊

Hurdles of CAR-T cell-based cancer immunotherapy directed against solid tumors

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2016年第4期59卷 340-348页

作者： Bing-Lan Zhang Di-yuan Qin Ze-Ming mo yi Li Wei Wei Yong-Sheng Wang Wei Wang yu-Quan Wei State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Department of Emergency West China Hospital Sichuan University

Recent reports on the impressive efficacy of chimeric antigen receptor(CAR)-modified T cells against hematologic malignancies have inspired oncologists to extend these efforts for the treatment of solid tumors. Clinical trials of CAR-T-based cancer immunotherapy for solid tumors showed that the efficacies are not as remarkable as in the case of hematologic malignancies. There are several challenges that researchers must face when treating solid cancers with CAR-T cells, these include choosing an ideal target, promoting efficient trafficking and infiltration, overcoming the immunosuppressive microenvironment, and avoiding associated toxicity. In this review, we discuss the obstacles imposed by solid tumors on CAR-T cell-based immunotherapy and strategies adopted to improve the therapeutic potential of this approach. Continued investigations are necessary to improve therapeutic outcomes and decrease the adverse effects of CAR-T cell therapy in patients with solid malignancies in the future.

关键词： chimeric antigen receptor T cells solid tumors

Fractional anisotropy of the corticospinal tract in normal adults: Preliminary study using a diffusion tensor imaging technique

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2010年第3期5卷 232-235页

作者： Xuejin Sun Jihong Hu yin mo Qing Gu yi Liu yi Lu Conghui Ai Department of MRI First Affiliated Hospital of Kunming Medical College Kunming 650032 Yunnan Province China

BACKGROUND： The corticospinal tract is an important tract for conducting motor function. The majority of studies focus on lesions of the corticospinal tract on appearance and function, whereas observation of normal corticospinal pathways can also improve understanding of lesion outcomes. OBJECTIVE： To observe the normal adult corticospinal tract using a diffusion tensor imaging technique to analyze fractional anisotropy （FA） in different levels of the brain. DESIGN, TIME AND SETTING： Neuroimaging observation was performed in the MRI Department, First Affiliated Hospital of Kunming Medical College in China, from October 2005 to October 2008. PARTICIPANTS： A total of 30 healthy adults were selected from the Department of MRI, First Affiliated Hospital of Kunming Medical College in China, from October 2005 to October 2008, and people with nervous system symptoms and signs were excluded. METHODS： Participants with normal conventional MRI results underwent diffusion tensor imaging examination in a 1.5 T GE MRI （slice thickness 4-5 mm, slice gap 0） for gradient data acquisition from 15 directions. The scanning involved the entire brain from the inferior medulla oblongata to the inferior cranial plate. Imaging post-processing was performed to obtain FA values; a paired t-test was applied for statistical analysis. MAIN OUTCOME MEASURES： FA values of the bilateral corticospinal tract in the medulla oblongata, pons, cerebral peduncle, basal ganglia, corona radiata, and centrum semiovale. RESULTS： FA values in the medulla oblongata and centrum semiovale were similar （P 〉 0.01）. FA values of left corticospinal tract were significantly greater than the right side in the pons, cerebral peduncle, basal ganglia and corona radiata （P 〈 0.01）. CONCLUSION： FA values vary by brain levels, including pons, cerebral peduncle, basal ganglia, and corona radiata. moreover, FA values of the left corticospinal tract pathway were greater than the right side, which may relate to right handedness

关键词： corticospinal tract fractional anisotropy diffusion tensor imaging neuroimaging neural regeneration

Contrasting the Skills and Biases of Deterministic Predictions for the Two Types of El Nio

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2017年第12期34卷 1395-1403页

作者： Fei ZHENG Jin-yi yu International Center for Climate and Environment Science Institute of Atmospheric PhysicsChinese Academy of Sciences Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and Technology Department of Earth System Science University of California

The tropical Pacific has begun to experience a new type of El Nio, which has occurred particularly frequently during the last decade, referred to as the central Pacific(CP) El Nio. Various coupled models with different degrees of complexity have been used to make real-time El Nio predictions, but high uncertainty still exists in their forecasts. It remains unknown as to how much of this uncertainty is specifically related to the new CP-type El Nio and how much is common to both this type and the conventional Eastern Pacific(EP)-type El Nio. In this study, the deterministic performance of an El Nio–Southern Oscillation(ENSO) ensemble prediction system is examined for the two types of El Nio. Ensemble hindcasts are run for the nine EP El Nio events and twelve CP El Nio events that have occurred since 1950. The results show that(1) the skill scores for the EP events are significantly better than those for the CP events, at all lead times;(2) the systematic forecast biases come mostly from the prediction of the CP events; and(3) the systematic error is characterized by an overly warm eastern Pacific during the spring season, indicating a stronger spring prediction barrier for the CP El Nio. Further improvements to coupled atmosphere–ocean models in terms of CP El Nio prediction should be recognized as a key and high-priority task for the climate prediction community.

关键词： ENSO EP El Nio CP El Nio prediction skill systematic bias spring prediction barrier

Joint and supremum distributions in the compound binomial model with Markovian environment

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2011年第3期26卷 265-279页

作者： yu yi-bin ZHANG Li-xin ZHANG yi Department of Mathematics Zhejiang University Hangzhou 310027 China.

In this paper, we study the compound binomial model in Markovian environment, which is proposed by Cossette, et al. （2003）. We obtain the recursive formula of the joint distributions of T, X（T - 1） and ｜X（T）｜（i.e., the time of ruin, the surplus before ruin and the deficit at ruin） by the method of mass function of up-crossing zero points, as given by Liu and Zhao （2007）. By using the same method, the recursive formula of supremum distribution is obtained. An example is included to illustrate the results of the model.

关键词： Compound binomial model Markovian environment joint distribution mass function recursive formula supremum distribution.

Recurrence of Transitive Points in Dynamical Systems with the Specification Property

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2018年第12期34卷 1879-1891页

作者： Xiao yi WANG yu HUANG School of Mathematics and Statistics Zhaoqing University Zhaoqing 526061 P. R. China Department of Mathematics Sun Yat-sen University Guangzhou 510275 P. R. China

Let T ： X →X be a continuous map of a compact metric space X. A point x E X is called Banach recurrent point if for all neighborhood V of x, （n ∈ N ： T^n（x） ∈ V} has positive upper Banach density. Denote by Tr（T）, W（T）, QW（T） and BR（T） the sets of transitive points, weakly almost periodic points, quasi-weakly almost periodic points and Banach recurrent points of （X, T）. If （X, T） has the specification property, then we show that every transitive point is Banach recurrent and O≠ W（T） n Tr（T） ≠ W＊（T） ∩ Tr（T） ≠ QW（T） ∩ Tr（T） ≠ BR（T） ∩ Tr（T）, in which W＊（T） is a recurrent points set related to an open question posed by Zhou and Feng. Specifically the set Tr（T） M W＊（T）／ W（T） is residual in X. moreover, we construct a point x E BR ／ QW in symbol dynamical system, and demonstrate that the sets W（T）, QW（T） and BR（T） of a dynamical system are all Borel sets.

关键词： Specification property invariant measures recurrent points measure center

紫外荧光法测定航天煤油硫含量的影响因素研究

在线全文

学校读者我要写书评

暂无评论

石油炼制与化工 2025年第1期56卷 181-186页

作者：周建臣俞少行唐毅吴奖君西昌卫星发射中心海南文昌571300 航天发射场可靠性技术重点实验室

系统地研究了紫外荧光法各参数对航天煤油硫含量测试结果的影响,分析了硫信号积分值随进样速率、进样量、负高压、裂解氧流量、氩气流量、进口氧流量和裂解温度的变化规律,得到了最佳测试条件。结果表明:进样速率、裂解氧流量、氩气流... 详细信息

系统地研究了紫外荧光法各参数对航天煤油硫含量测试结果的影响,分析了硫信号积分值随进样速率、进样量、负高压、裂解氧流量、氩气流量、进口氧流量和裂解温度的变化规律,得到了最佳测试条件。结果表明:进样速率、裂解氧流量、氩气流量、负高压是紫外荧光法精确测定硫含量的主要影响因素;最佳进样速率和最佳氩气流量会受航天煤油热裂解反应的影响,最佳裂解氧流量与进样速率有关,负高压范围由基线噪声情况确定,最佳进样量可根据负高压对最小进样量的影响来确定。本研究为紫外荧光法准确、高效地测定航天煤油硫含量提供了测试参数参考,也给探究最佳测试条件提供了试验方法。

关键词：航天煤油硫含量紫外荧光法热裂解

Metal-organic frameworks as photocatalysts for aerobic oxidation reactions

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2023年第6期66卷 1634-1653页

作者： Kun Wu Xin-yi Liu Pei-Wen Cheng mo Xie Weigang Lu Dan Li College of Chemistry and Materials Science Guangdong Provincial Key Laboratory of Functional Supramolecular Coordination Materials and ApplicationsJinan UniversityGuangzhou 510632China

Metal-organic frameworks(moFs)are emerging as one of the most intriguing classes of heterogeneous photocatalysts owing to their abundant structures,tunable porosity,and versatile *** advantages of bottom-up design and reticular synthesis render moF materials with desired photocatalytic properties for targeted *** this review,we discussed the design and synthesis of moF-based photocatalysts as well as strategies for enhancing photocatalytic *** progress on moFs as platforms for photocatalytic aerobic oxidation reactions was summarized and categorized according to the types of bond *** hope this review will give an in-depth insight into moF-based photocatalytic systems for not only aerobic oxidation reactions but also other organic transformations.A brief outlook on the challenges and opportunities of moFs as heterogeneous photocatalysts is provided at the end of the review.

关键词： metal-organic frameworks heterogeneous photocatalyst reactive oxygen species aerobic oxidation organic synthesis

China's Aid in Higher Education Sector of Myanmar and Its Effects(2010-2020):A Case Study of Chinese Government Scholarship Program

在线全文

学校读者我要写书评

暂无评论

China's Aid in Higher Education Sector of Myanmar and Its Ef...

作者： yi mo n 山东大学

学位级别：硕士

The Sino-Myanmar relationship was symbolized as a "Pauk-Phaw"(kinsfolk)friendship.A turning point was brought about in the political atmosphere of Myanmar with a transition to democracy in 2010,and consequently,a large quantity of foreign aid started to set foot in Myanmar with different purposes under diverse *** also did not lag behind in implementing its own assistance programs like other countries,America's USAID,Korea's KOICA,and Japan's *** support for the Myanmar education sector,which is implementing educational reforms throughout the democracy period,has become one of China's key education aid strategies in *** China's aid to education in Myanmar may not have been as substantial as that of other countries,its activities in Myanmar have gained recognition in recent ***,the Chinese government offers a significant number of scholarships,surpassing even some powerful *** Myanmar's status as a developing countiy in dire need of human capital for its development,China's educational support has played a crucial role in shaping policies across various *** no studies have been conducted on how China uses higher education to project its soft power in Myanmar,this study aims to have a deeper understanding on China's education aid in Myanmar,with a specific focus on the Chinese Government Scholarship Programs,and analyze its potential impacts on Sino-Myanmar relations in terms of politics and people-to-people ***,the study explores the attitudes of Myanmar students who have been recipients of the Chinese Government Scholarship,providing valuable insights into their perspectives on Sino-Myanmar *** research serves as a practical endeavor to enhance understanding of China's education aid in Myanmar,especially at the tertiary *** paper further argues the underlying causes for being less popular scholarship and suggests to overcome that predicament.

关键词： Higher Education China's Education Aid Public Diplomacy Soft Power

Facile synthesis and in vivo bioimaging applications of porphyrin derivative-encapsulated polymer nanoparticles

同方学位论文库评论

在线全文

同方学位论文库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2022年第8期33卷 4101-4106页

作者： Mengfei Hou Wandi Chen Junkai Zhao Deshen Dai mo Yang Changqing yi Guangdong Provincial Engineering and Technology Center of Advanced and Portable Medical Devices School of Biomedical EngineeringSun Yat-sen UniversityShenzhen 518107China State Key Laboratory of Oncology in South China Collaborative Innovation Center For Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060China Department of Biomedical Engineering The Hong Kong Polytechnic UniversityHong KongChina

Fluorescence(FL)imaging guided photodynamic therapy(PDT)is becoming highly desirable for personalized therapy and precision *** this study,fluorescent polymer nanoparticles TCPP@PEI/PGA were facilely synthesized through electrostatic interaction-mediated self-assembly of porphyrins tetra(4-carboxyphenyl)porphine(TCPP)and polyethylenimine(PEI),and subsequent surface modification withγ-poly(glutamic acid)(γ-PGA).TCPP served a dual function as the FL imaging probe and the *** as-prepared TCPP@PEI/PGA nanoparticles showed excellent water-solubility and biocompatibility,while having outstanding capabilities of in vivo bioimaging and~1 O_(2) *** bioimaging of mice and effective killing of CT 26 cells as well as CT 26 tumor-bearing mice upon laser irradiation were successfully demonstrated when using TCPP@PEI/PGA as theranostic *** study provides a simple but robust method to design and synthesize porphyrin-based polymer nanoparticles for theranostics.

关键词： Porphyrins Fluorescence imaging Photodynamic therapy Theranostics