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Late Neoproterozoic to early Cambrian high-grade metamorphism from Mikir Hills(Assam-Meghalaya gneissic Complex,northeast India):Implications for eastern Gondwana assembly

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Geoscience Frontiers 2024年第5期15卷 256-282页

作者： rahul nag H.Hrushikesh Nathan Cogné N.Prabhakar Department of Earth Sciences Indian Institute of Technology BombayPowaiMumbaiMaharastra 400076India Geological Survey of India Northeastern RegionGuwahatiAssam 781005India Géosciences rennes UMR6118CNRS Universitéde RennesFrance

Mikir Hills region,which represents the eastern segment of the Assam-Meghalaya Gneissic Complex(AMGC)in northeast India,constitutes part of the Eastern *** Mikir Hills preserves multiple metamorphic and magmatic events ranging from Early Mesoproterozoic to Early *** of these events,documenting the late Neoproterozoic to early Cambrian tectonothermal events is helpful in correlating the continental blocks of Eastern *** present an integrated study involving field relations,petrology,P-T history and zircon-monazite geochronology of hitherto poorly studied pelitic and quartzo-feldspathic gneisses from the Mikir Hills *** gneisses have experienced at least three deformation events(D_(1),D_(2) and D_(3))with dominant foliation indicated by ENE-WSW striking and shallow-moderately dipping(rphism in pelitic and quartzo-feldspathic gneisses is characterized by garnet(core)-K-feldspar-sillimanite-plagioclase-bio tite-rutile-quartz-ilmenite-melt and garnet-plagioclase-K-feldspar-biotite-quartz-ilmenite-melt assemblages,*** application of thermobarometric methods constrains the peak P-T conditions of 7.5-8.4 kbar at 674-778℃and 6.7-7.4 kbar at 601-618℃for pelitic and quartzofeldspathic gneisses,*** results are consistent with the values estimated using phase equilibria modelling and melt reintegration *** results of pseudosection modelling suggests a clockwise P-T path for pelitic gneisses involving migmatisation during peak metamorphism followed by near isothermal decompression from 8.0 to 8.6 kbar at 768-780℃to 4.0-5.0 kbar at 720-765℃.In contrast,quartzo-feldspathic gneisses preserved slightly lower peak P-T conditions at 3.8-4.6 kbar and 590-650℃.The U-Pb zircon dating of migmatised pelitic and quartzo-feldspathic gneisses yielded concordant ages of 1647±11 Ma and 1590±7 Ma,*** dates represent the inherited igneous protolith components,possibly

关键词： Gondwana Assam-Meghalaya Gneissic Complex Migmatisation Neoproterozoic Geochronology P-T-t history

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Evolution of a confined gravelly river to a braided-meandering river in the Late Cretaceous Khasi group, southern Shillong plateau, NE India

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Journal of Palaeogeography 2024年第4期13卷 754-774页

作者： Adrita Choudhuri Prem raj Uddandam Debarati nag Birbal Sahni Institute of Palaeosciences Savitribhai Phule Pune University

This paper intends to unravel the depositional condition of the Basal Conglomerate/Jadukata Formation and the Lower Mahadek Formation in southern Shillong Plateau, NE India deposited during the Late Cretaceous period. The studied succession is entirely siliciclastics in composition and was built up on the Precambrian basement rocks. State-of-art facies analysis and palaeocurrent evidence helped us to reconstruct the palaeogeography and palaeoenvironment. The facies tracts reveal that frequent hyperconcentrated mass flow deposits dominated the proximal part of the river channels. Gradually, the river evolved to a sandy braided and finally mud-dominated, meandering system. The river channel changed its pattern through onlapping and progressive elimination of the accommodation space created by the tectonic subsidence/upliftment. Major shifts in palaeocurrent direction at different stages of the river evolution confirm the role of tectonics on the river channel evolution. QFL detrital modes of the sandstones reflecting lithic wacke composition and the recycled orogeny corroborate the interpretation. rapid lateral and vertical facies transition suggests a pull-apart type basin due to ongoing rifting. Geochemical analyses also show signatures of the overlapping tectonic conditions supporting the pull-apart basin model.

关键词： Tectonics hyperconcentrated flows braided-meandering system pull-apart rift basin Late Cretaceous South Shillong Plateau

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Multidisciplinary approach toward enhanced recovery after surgery for total knee arthroplasty improves outcomes

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World Journal of Clinical Cases 2024年第9期12卷 1549-1554页

作者： Deb Sanjay nag Amlan Swain Seelora Sahu Ayaskant Sahoo Gunjan Wadhwa Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831001India

Knee osteoarthritis is a degenerative disorder of the knee,which leads to joint pain,stiffness,and inactivity and significantly affects the quality of *** an increased prevalence of obesity and greater life expectancies,total knee arthroplasty(TKA)is now one of the major arthroplasty surgeries performed for knee *** enhanced recovery after surgery(ErAS)was introduced in TKA,clinical outcomes were enhanced and the economic burden on the healthcare system was *** is an evidence-based scientific protocol aimed at ameliorating the surgical stress *** aims to enhance the recovery phase,which encompasses multidisciplinary strategies at every step of perioperative care,including the rehabilitation *** of ErAS in TKA aids in reducing the length of hospital stay,improving pain management,reducing perioperative complications,and enhancing patient *** collaboration,integrating the expertise of anesthesiologists,orthopedic surgeons,nursing personnel,and other healthcare professionals,is the cornerstone of ErAS in patients undergoing TKA.

关键词： Arthroplasty replacement Knee recovery of function Anesthesia Care Nursing

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Pain management in chronic pancreatitis

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World Journal of Clinical Cases 2024年第12期12卷 2016-2022页

作者： Deb Sanjay nag Bhanu Pratap Swain rishi Anand Tapas Kumar Barman Vatsala Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India

Pain in chronic pancreatitis(CP)is difficult to *** patients suffer from inadequate pain relief,completely incapacitating them in their daily ***,despite their well-known adverse effects,opioids have been the pillar of treatment regimens in painful *** management is now gradually evolving with a better understanding of the underlying pathophysiology of CP-related *** should follow a holistic approach to the management of CPassociated pain,which must involve lifestyle changes that are coupled with analgesic medications and other pain-relieving ***,there is no easy cure for vanquishing CP-associated *** patient must be evaluated on a case-by-case basis by a multidisciplinary team to decide which treatment option is best suited for that individual.

关键词： Pancreatitis Abdominal pain Palliative care Analgesics Life style Psychology

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Pitfalls in internal jugular vein cannulation

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World Journal of Clinical Cases 2024年第10期12卷 1714-1717页

作者： Deb Sanjay nag Amlan Swain Seelora Sahu Bhanu Pratap Swain Merina Sam Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

Central venous catheter insertion in the internal jugular vein(IJV)is frequently performed in acute care settings,facilitated by its easy availability and increased use of ultrasound in healthcare *** the increased safety profile and insertion convenience,it has ***,we aim to inform readers about the existing literature on the plethora of complications with potentially disastrous consequences for patients undergoing IJV cannulation.

关键词： Catheterization Central venous Complications Thoracic duct Arteriovenous fistula Vocal cord paralysis Pneumothorax Cardiac tamponade

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Perioperative cardiac risks in myasthenia gravis

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World Journal of Clinical Cases 2024年第13期12卷 2147-2150页

作者： Deb Sanjay nag Abhishek Chatterjee Pratap rudra Mahanty Merina Sam Murari Kumar Bharadwaj Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular *** primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChrs),which results in qualitative and quantitative reductions in the availability of functional *** muscles are also affected,resulting in various perioperative cardiac *** antibodies are commonly reported in MG cases with cardiac *** the presence of thymoma,the prevalence of cardiac manifestations in patients with MG increases to approximately 10%-15%.Cardiac involvement in MG may range from asymptomatic electrocardiogram changes to ventricular tachycardia,myocarditis,conduction disorders,heart failure,and sudden *** incidence of atrial fibrillation,ventricular and supraventricular extra systoles,and prolonged QTc have also been reported in patients with *** should consider the evaluation of autonomic dysfunction and risk of cardiovascular disease in patients with MG.

关键词： Myasthenia Gravis Perioperative period receptors Cholinergic Anesthesia

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relevance of sleep for wellness:New trends in using artificial intelligence and machine learning

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World Journal of Clinical Cases 2024年第7期12卷 1196-1199页

作者： Deb Sanjay nag Amlan Swain Seelora Sahu Abhishek Chatterjee Bhanu Pratap Swain Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

Sleep and well-being have been intricately linked,and sleep hygiene is paramount for developing mental well-being and *** widespread,sleep disorders require elaborate polysomnography laboratory and patient-stay with sleep in unfamiliar *** technologies have allowed various devices to diagnose sleep disorders at ***,these devices are in various validation stages,with many already receiving approvals from competent *** has captured vast patient-related physiologic data for advanced analytics using artificial intelligence through machine and deep learning *** is expected to be integrated with patients’Electronic Health records and provide individualized prescriptive therapy for sleep disorders in the future.

关键词： Sleep initiation and maintenance disorders Sleep apnea Obstructive Machine learning Artificial intelligence Algorithms

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Autophagy and mitophagy as potential therapeutic targets in diabetic heart condition:Harnessing the power of nanotheranostics

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Asian Journal of Pharmaceutical Sciences 2024年第3期19卷 79-101页

作者： Sagnik nag Oishi Mitra Bhanu Maturi Simran Preet Kaur Ankita Saini Muskan Nama Soumik roy Souvik Samanta Leena Chacko rohan Dutta Suresh Babu Sayana Vetriselvan Subramaniyan Jasvinder Singh Bhatti ramesh Kandimalla Jeffrey Cheah School of Medicine and Health Sciences Monash University MalaysiaJalan Lagoon Selatan47500 Bandar SunwaySelangorMalaysia Department of Bio-Sciences School of Bio-Sciences&Technology(SBST)Vellore Institute of Technology(VIT)Tiruvalam RoadVellore 632014Tamil NaduIndia Department of Internal Medicine University of Alabama at BirminghamBirminghamALUSA Department of Microbiology University of Delhi(South Campus)Benito Juarez RoadNew Delhi 110021India Department of Biotechnology Indian Institute of TechnologyHyderabad(IIT-H)SangareddyTelangana 502284India BioAnalytical Lab Meso Scale Discovery1601 Research BlvdRockvilleMDUSA Department of Pharmacology Government Medical CollegeSuryapetTelanganaIndia Laboratory of Translational Medicine and Nanotherapeutics Department of Human Genetics and Molecular MedicineSchool of Health SciencesCentral University of PunjabBathindaIndia Department of Biochemistry Kakatiya Medical CollegeWarangal 506007India

Autophagy and mitophagy pose unresolved challenges in understanding the pathology of diabetic heart condition(DHC),which encompasses a complex range of cardiovascular issues linked to diabetes and associated *** significant progress in reducing mortality rates from cardiovascular diseases(CVDs),heart failure remains a major cause of increased morbidity among diabetic *** cellular processes are essential for maintaining cellular balance and removing damaged or dysfunctional components,and their involvement in the development of diabetic heart disease makes them attractive targets for diagnosis and *** a variety of conventional diagnostic and therapeutic strategies are available,DHC continues to present a significant ***-of-care diagnostics,supported by nanobiosensing techniques,offer a promising alternative for these complex *** conventional medications have been widely used in DHC patients,they raise several concerns regarding various physiological *** medicine places great emphasis on the application of nanotechnology to target autophagy and mitophagy in DHC,offering a promising approach to deliver drugs beyond the limitations of traditional *** article aims to explore the potential connections between autophagy,mitophagy and DHC,while also discussing the promise of nanotechnology-based theranostic interventions that specifically target these molecular pathways.

关键词： Autophagy Diabetes Diabetic heart condition Mitophagy Nanotheranostics Nanomedicine

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Stroke:Evolution of newer treatment modalities for acute ischemic stroke

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World Journal of Clinical Cases 2024年第28期12卷 6137-6147页

作者： Deb Sanjay nag Amlan Swain Seelora Sahu Biswajit Sen Vatsala Sadiya Parween Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Acute ischemic stroke is one of the leading causes of morbidity and mortality *** of cerebral blood flow to affected ischemic areas has been the cornerstone of therapy for patients for eligible patients as early diagnosis and treatment have shown improved ***,there has been a paradigm shift in the management approach over the last decade,and with the emphasis currently directed toward including newer modalities such as neuroprotection,stem cell treatment,magnetic stimulation,anti-apoptotic drugs,delayed recanali-zation,and utilization of artificial intelligence for early diagnosis and suggesting algorithm-based management protocols.

关键词： Acute ischemic stroke Neuroprotection Treatment Neurocritical care Thrombolytic therapy reperfusion injury Oxidative stress

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recent advances in managing obstructive sleep apnea

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World Journal of Clinical Cases 2024年第24期12卷 5456-5461页

作者： Deb Sanjay nag Abhishek Chatterjee roushan Patel Biswajit Sen Bappa Ditya Pal Gunjan Wadhwa Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Obstructive sleep apnea(OSA)is a rapidly increasing global *** it remains untreated,it can lead to cardiovascular,metabolic,and psychiatric complications and may result in premature *** efficient and effective management of OSA can have a beneficial effect and help reduce the financial burden on the health *** has been constant development in OSA management,and numerous options are *** mainstay of therapy is still the conventional measures and behavioral ***,in cases of failure of these modalities,surgical therapy is the only *** studies have shown that proper management of OSA has beneficial effects with good long-term outcomes.

关键词： Sleep apnea Obstructive Continuous positive airway pressure Concepts Pharmacological

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