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Effects of Coronavirus Disease 2019 and Frailty on Delirium in the Intensive Care Unit: A Propensity Score Analysis

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Open Journal of Anesthesiology 2023年第2期13卷 23-31页

作者： Takayuki Yamanaka mitsuru ida Taich Kotani Masahiko Kawaguchi Department of Anesthesiology Nara Medical University Kashihara Nara Japan

Purpose: The association between frailty and delirium has emerged as a research topic. Neurological symptoms have been reported among patients with coronavirus disease 2019 (COVID-19), but its effects on delirium remain unclear. This study aimed to compare the incidence of delirium between patients with COVID-19 and those without COVID-19, and to evaluate the impact of COVID-19 and frailty on delirium. Methods: This retrospective study included patients aged ≥ 20 years who were admitted to our intensive care unit (ICU) between January 2020 and February 2022. An inverse probability of treatment weighting using stabilized inverse propensity scores was adopted to minimize bias. After patient demographics were adjusted, the incidence of delirium, assessed using the Confusion Assessment Method for ICU, was compared between patients with COVID-19 and those without COVID-19. The effects of COVID-19 and the Clinical Frailty Scale score on delirium were analyzed by adjusting some covariates, including the sequential organ failure assessment (SOFA) score, using a generalized estimating equation. Results: Among 260 eligible patients, 226 patients were included. The weighted incidence of delirium was 56.9% and 61.9% in patients with and without COVID-19, respectively (p = 0.67). The generalized estimating equation revealed that the odds ratios (95% confidence interval) for COVID-19, the CFS score, and the SOFA score were 1.49 (0.62 - 3.57), 1.46 (1.11 - 1.91), and 1.22 (1.10 - 1.36), respectively. Conclusion: CFS and SOFA scores on ICU admission may be associated with delirium, with no significant difference between patients with COVID-19 and those without COVID-19.

关键词： COVID-19 Delirium Frailty Intensive Care Unit SARS-CoV-2

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日本站前广场的建设特征及对我国的启示

都市快轨交通 2024年第3期37卷 170-177页

作者：马飞太田充徐畅日本筑波大学系统情报工学院日本筑波北京大学城市规划与设计学院广东深圳518055

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案... 详细信息

随着中国轨道交通和城市化进程的不断发展,单一功能的站前广场规划已无法满足当下多样化的城市建设需求。本研究通过对日本站前广场的建设历史和相关规划标准的梳理,针对日本多个不同级别城市的站前广场进行实地调研,并且分析代表性案例的空间规划和开发方式,总结出日本站前广场的规划经验:重视站前广场在站城一体化开发中的空间调节作用,根据规划需求调整广场的城市功能;广场建设要结合站点周边地区发展特点,注重广场的灵活布局和多样化利用;广场规划各阶段设立合作组织,注重广场各建设部门的相互沟通和责任划分以及制定持续的利用者参与机制和完善的广场运营制度等,以期为中国轨道交通可持续发展和合理的城市空间规划提供参考和借鉴。

关键词：日本铁路公共交通城市空间站点开发站前广场

Pulsed field magnetization of multiple bulks used as field pole of a high-temperature superconducting rotating machine

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Superconductivity 2023年第1期5卷 63-68页

作者： Antomne A.Caunes Mizuki Tsuchiya Hayato Imamichi Nagisa Kawasumi mitsuru Izumi Tetsuya ida Tokyo University of Marine Science and Technology 4-5-7KonanMinato-kuTokyo 108-8477Japan National Institute of Technology Toba College1-1Ikegami-choTobaMie 517-8501Japan

An array of three GdBa_(2)Cu_(3)O_(7‐δ)bulk high‐temperature superconductors(HTS)that mimic the field pole of a high‐power superconducting motor had been magnetized by pulsed field magnetization(PFM)while cooled by liquid *** bulk array was magnetized by a passive PFM technique using three vortex‐type coils placed over each individual bulk and connected in *** trapped magnetic flux density distribution was comparable to the distribution obtained with more traditional quasi‐static magnetization such as field‐*** suggests that the use of PFM technique on arrays of HTS bulks is *** has also been performed using each coil individually,to magnetize each bulk *** magnetization sequences showed a maximum reduction of the peak trapped magnetic flux density of 12%due to the demagnetization effect of the magnetization sequence,while the trapped magnetization distribution was improved.

关键词： Pulsed field magnetization HTS bulk Bulk HTS field pole Multiple bulks array Large field pole Superconducting rotating machines

Concept design of an HTS linear power generator for wave energy conversion

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Superconductivity 2023年第2期6卷 1-5页

作者： Petrus Kambo Yuhi Yamanouchi Antomne A.Caunes Kota Yamaguchi mitsuru Izumi Tetsuya ida Tokyo University of Marine Science and Technology 4-5-7KonanMinato-kuTokyo 108-8477Japan National Institute of Technology Oshima College1091-1Suo-Oshima-choOshima-gunYamaguchi 742-2193Japan National Institute of Technology Toba College1-1Ikegami-choTobaMie 517-8501Japan

We show a conceptual structure for a wave energy converter,which features a direct‐drive linear power generator with REBaCuO high‐temperature superconducting(HTS)bulk field poles and driven by a heaving buoy.A dual translator power generation system of the proposed concept structure is a linear generator in which both the HTS bulks and armature copper coils move in opposite directions simultaneously.A performance analysis of our linear generator was conducted using a finite‐element electromagnetic field analysis *** results of the analysis were compared between the HTS dual translator linear power generator and the HTS single translator linear power *** maximum electromagnetic force and the average output power of the HTS dual translator are around 5%and 11%higher than that of the HTS single *** further present the results of the analysis regarding the influence of reducing the stroke length of the linear generator translator on the output power,where the output power for the HTS dual translator system increased up to a factor of two,in comparison to the HTS single translator counterpart,for the same reduction of stroke length.

关键词： High‐temperature superconducting bulk Ocean energy Wave energy converter Linear power generator Dual translator

Advances in traction methods for endoscopic submucosal dissection:What is the best traction method and traction direction?

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World Journal of Gastroenterology 2022年第1期28卷 1-22页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalKanagawa 251-0041Japan

Endoscopic submucosal dissection(ESD)has been developed as a treatment for superficial gastrointestinal neoplasms,which can achieve en bloc resection regardless of the lesion ***,ESD is technically difficult because endoscopists cannot bring their hand into the gastrointestinal tract,unlike surgeons in regular *** is difficult to obtain sufficient tension in the dissection plane and a good field of ***,ESD is associated with a long procedure time and a high risk of adverse events in comparison with endoscopic mucosal *** methods have been developed to provide sufficient tension for the dissection plane and a good field of vision during the ESD ***,traction direction is limited in most traction methods,resulting in insufficient effect in some *** traction direction is considered important,there have been few investigations of its *** the first half of this review,important traction methods are discussed,including traction *** second half,appropriate traction methods for each organ are *** important considerations for traction method,such as ability to adjust traction strength,interference between traction device and endoscope,and the need for specialized devices are also discussed.

关键词： Endoscopic submucosal dissection Traction method Countertraction Traction direction Vertical traction

Evaluation of dry-in-place lubricants for cold forging by using an optimal steady combined forward and backward extrusion testing method

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Friction 2023年第10期11卷 1862-1876页

作者： Chengliang HU Shogo OSAKI Baixuan CAI mitsuru AOYAMA Kuniaki DOHDA Institute of Forming Technology&Equipment School of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200030China Central Research Laboratories Nihon Parkerizing Co.Ltd.Hiratsuka-shi 254-0012Japan Department of Mechanical Engineering Northwestern UniversityEvanston 60208-3111USA

This study evaluated dry-in-place lubricants used for cold forging.A group of isothermal compression tests with a strain rate(ε)e&range of 0.001–1 s^(−1) and temperature(T)range of 30–400℃ were *** flow stress(σ)curves of annealed steel S45C were obtained,and a corresponding Hensel–Spittel model was developed to support finite element(FE)*** sensitivity of the steady combined forward and backward extrusion(SCFBE)test proposed in another study was improved by approximately 20%after it was optimized using the results of the FE *** parameters were identified,and the calibration curves after optimization were *** the basis of the optimized test,a friction testing setup with a heating system was developed,in which the die temperature could be adjusted from room temperature(RT)to 230℃.Three dry-in-place lubricants and conventional phosphating lubricant were tested,and the friction factors(m),forming loads,and ejection loads were *** surface features of the specimens after testing were also *** to the testing results,of the three tested dry-in-place lubricants,the mica type was the *** addition,the optimized friction testing design was verified as effective.

关键词： lubrication optimization sensitivity friction factor(m) forming load cold forging

Eustachian tube involvement in a patient with relapsing polychondritis detected by magnetic resonance imaging:A case report

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World Journal of Clinical Cases 2022年第4期10卷 1441-1446页

作者： Daisuke Yunaiyama Akiko Aoki Hiroshi Kobayashi Miwako Someya mitsuru Okubo Kazuhiro Saito Department of Radiology Tokyo Medical University HospitalShinjuku-ku 160-0023TokyoJapan Department of Radiology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Rheumatology Tokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan Department of Otorhinolaryngology Head and Neck SurgeryTokyo Medical University Hachioji Medical CenterHachioji-shi 193-0998Japan

BACKGROUND Relapsing polychondritis(RP)is a rare inflammatory disease involving the systemic cartilage,such as the auricle,trachea,and bronchiole,among others.A patient with RP shows variable symptoms based on the involved *** SUMMARY A 72-year-old Japanese woman with a history of redness of the bilateral auricles for 3 d was referred to a *** clinician prescribed antibiotics to the patient;however,the symptoms worsened;thus,she was referred to our *** and neck magnetic resonance imaging(MRI)showed edematous auricle with remarkable contrast,fluid collection in the bilateral mastoid cells,suggesting otitis *** eustachian tube(ET)on the right side was also edematous with contrast *** patient was suspected of RP according to the diagnostic criteria.A biopsy of the auricular cartilage was performed by an otorhinolaryngologist,confirming pathological proof of *** with steroids were immediately administered *** We highlight a rare case of RP with radiologically confirmed involvement of ET in the MRI.

关键词： Relapsing polychondritis Magnetic resonance imaging Contrast enhancement Otitis media with effusion Eustachian tube Case report

Induction of adaptive response in utero by ionizing radiation:A radiation quality dependent phenomenon

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BIOCELL 2022年第10期46卷 2315-2325页

作者： BING WANG KAORU TANAKA KOUICHI MARUYAMA YASUHARA NINOMIYA TAKANORI KATSUBE mitsuru NENOI National Institutes for Quantum Science and Technology Chiba263-8555Japan

Investigation on possible induction of adaptive response(AR)by high-liner energy transfer(LET)particle radiation for protection against low-LET photon radiation-induced detrimental effects has not yet been performed in *** study verified if an AR could be induced by high-LET particle radiation from accelerated heavy ions against low-LET X-ray radiation-induced detrimental effects on fetal *** body irradiation of pregnant C57BL/6J mice were performed by delivering a priming dose ranging from 10 mGy to 320 mGy of particle radiation on gestation day 11 followed one day later by a challenge dose at 3500 mGy from X-ray *** monoenergetic beams of carbon,silicon and iron with the LET values of about 15,55,and 200 KeV/μm,respectively,were *** suppression by the priming radiation of the detrimental effects(fetal death,malformation,or low body weight)was used as the endpoints for judgment of a successful AR induction on gestation day *** of AR was not *** the other hand,the priming dose of high-LET particle radiation,in some cases,even increased the detrimental effects induced by the challenge dose from low-LET X-ray *** existence of AR induced by high-LET radiation in cultured mammalian cells in vitro and in certain tissues of laboratory mice in vivo was demonstrated,the present study did not suggest that low dose of high-LET particle radiation could induce an AR in fetal mice in utero under the setup of our experimental system.

关键词： Heavy particle radiation Adaptive response High liner energy transfer Teratogenesis Fetal mice

Device-assisted traction methods in colorectal endoscopic submucosal dissection and options for difficult cases

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World Journal of Gastrointestinal Endoscopy 2023年第4期15卷 265-272页

作者： mitsuru Nagata Department of Endoscopy Shonan Fujisawa Tokushukai HospitalFujisawa 251-0041KanagawaJapan

Endoscopic submucosal dissection(ESD)procedure has a longer procedure time and higher perforation rate than endoscopic mucosal resection owing to technical complications,including a poor field of vision and inadequate tension for the submucosal dissection *** traction devices were developed to secure the visual field and provide adequate tension for the dissection *** randomized controlled trials demonstrated that traction devices reduce colorectal ESD procedure time compared with conventional ESD(C-ESD),but they had limitations,including a single-center *** CONNECT-C trial was the first multicenter randomized controlled trial comparing the C-ESD and traction device-assisted ESD(T-ESD)for colorectal *** the T-ESD,one of the device-assisted traction methods(S-O clip,clip-with-line,and clip pulley)was chosen according to the operator’s *** median ESD procedure time(primary endpoint)was not significantly different between C-ESD and *** lesions≥30 mm in diameter or in cases treated by nonexpert operators,the median ESD procedure time tended to be shorter in T-ESD than in *** T-ESD did not reduce ESD procedure time,the CONNECT-C trial results suggest that T-ESD is effective for larger lesions and nonexpert operators in colorectal *** with esophageal and gastric ESD,colorectal ESD has some difficulties,including poor endoscope maneuverability,which may be associated with prolonged ESD procedure time.T-ESD may not effectively improve these issues,but a balloon-assisted endoscope and underwater ESD may be promising options and these methods can be combined with T-ESD.

关键词： Endoscopic submucosal dissection Traction Traction direction Balloonassisted endoscope Underwater endoscopic submucosal dissection