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The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

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Cellular & Molecular Immunology 2011年第4期8卷 305-314页

作者： mitsuhiro Yamada Hiroshi Kubo Seiichi Kobayashi Kota Ishizawa Mei He Takaya Suzuki Naoya Fujino Hiroyuki Kunishima Masamitsu Hatta Katsushi Nishimaki Tetsuji Aoyagi Kouichi Tokuda Miho Kitagawa Hisakazu Yano Hirokazu Tamamura Nobutaka Fujii Mitsuo Kaku Department of Regional Cooperation for Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Advanced Preventive Medicine for Infectious Disease Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Respiratory Medicine Japanese Red-Cross Ishinomaki HospitalIshinomakiMiyagiJapan Department of Infection Control and Laboratory Diagnostics Tohoku University Graduate School of MedicineSendaiMiyagiJapan Department of Clinical Microbiology with Epidemiological Research&Management and Analysis of Infectious Diseases Tohoku University Graduate School of MedicineSendaiMiyagiJapan Institute of Biomaterials and Bioengineering Tokyo Medical and Dental UniversityChiyoda-kuTokyoJapan Graduate School of Pharmaceutical Sciences Kyoto UniversityKyotoJapan

Inflammatory stimuli,such as a microbes or lipopolysaccharides,induce a rapid release of neutrophils from the bone marrow and promote neutrophil migration into inflamed sites to promote host ***,an excess accumulation and retention of neutrophils in inflamed tissue can cause severe tissue injuries in the later stages of *** studies have reported that both CXCL12 levels in injured lungs and its receptor,CXCR4,on accumulated neutrophils in injured lungs,increased;furthermore,these studies showed that the CXCL12/CXCR4 signaling pathway participated in neutrophil accumulation in the later stages of lipopolysaccharide(LPS)-induced lung ***,the mechanisms underlying this increase in surface CXCR4 expression in neutrophils remain *** this study,we found that surface CXCR4 expression increased in extravascular,but not intravascular,neutrophils in the lungs of LPS-induced lung injury model ***,ex vivo studies revealed that CXCL12 acted not only as a chemoattractant,but also as a suppressor of cell death for the lung neutrophils expressing ***,one of the native ligands for L-selectin,induced the increase of surface CXCR4 expression on isolated circulating neutrophils,suggesting that the activation of L-selectin may be involved in the increase in surface *** findings show that surface CXCR4 levels on neutrophils increase after extravasation into injured lungs,possibly through the activation of *** CXCL12/CXCR4 signaling pathway plays an important role in the modulation of neutrophil activity during acute lung injury,not only by promoting chemotaxis but also by suppressing cell death.

关键词： CXCL12 CXCR4 lipopolysaccharides lung injury neutrophils

Accuracy of carbon dioxide insufflation for endoscopic retrograde cholangiopancreatography using double-balloon endoscopy

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World Journal of Gastroenterology 2020年第42期26卷 6669-6678页

作者： Yoshiki Niwa Masanao Nakamura Hiroki Kawashima Takeshi Yamamura Keiko Maeda Tsunaki Sawada Yasuyuki Mizutani Eri Ishikawa Takuya Ishikawa Naomi Kakushima Kazuhiro Furukawa Eizaburo Ohno Takashi Honda Masatoshi Ishigami mitsuhiro Fujishiro Department of Gastroenterology and Hepatology Nagoya University Graduate School of MedicineNagoya 466-8560Japan Department of Endoscopy Nagoya University HospitalNagoya 466-8560Japan

BACKGROUND Retrograde cholangiopancreatography using double-balloon endoscopic retrograde cholangiography(DBERC)is a valuable technique to treat biliary stone and jejunobiliary anastomotic stenosis in patients with altered gastrointestinal *** accurate selection of the route at the anastomosis branch is one of the most important factors in reaching the target in a timely *** To determine the accuracy of carbon dioxide insufflation enterography(CDE)at the branch for selecting the correct route during *** We enrolled 52 consecutive patients scheduled for DBERC at our institution from June 2015 to November *** selection via two methods(visual observation and CDE)was performed in each *** determined the correct rate of route selection using *** Thirty-three patients had a jejunojejunal anastomosis and 19 patients had a gastrojejunal *** therapeutic target region was reached in 50 *** mean procedure times from the teeth to the target(total insertion time),from the teeth to the branch,and from the branch to the target,and the mean total examination time were 15.2,5.0,8.2,and 60.3 min,*** rate of correct route selection using visual observation and CDE were 36/52(69.2%)and 48/52(92.3%),respectively(P=0.002).The rate of correct route selection using CDE in patients with a jejunojejunal anastomosis was 29/33(87.8%),and the rate in patients with a gastrojejunal anastomosis was 19/19(100%).CONCLUSION CDE is helpful in selecting the route at the branch in the anastomosis for more timely access to the target in patients with altered gastrointestinal anatomy undergoing DBERC.

关键词： Retrograde cholangiopancreatography Double-balloon endoscopy Carbon dioxide insufflation Anastomosis Accuracy Prospective study

Efficacy of an Abduction Brace in Preventing Initial Dislocation in the Early Postoperative Period after Primary Total Hip Arthroplasty

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Surgical Science 2012年第3期3卷 131-135页

作者： Yoshinori Ishii Hideo Noguchi mitsuhiro Takeda Junko Sato Yoichiro Domae Department of Orthopaedic Surgery Shibata Prefectural Hospital Niigata Japan Ishii Orthopaedic and Rehabilitation Clinic Saitama Japan

We hypothesized that a hip brace may prevent the initial dislocation in the early postoperative period after total hip arthroplasty (THA). We performed a prospective evaluation of the efficacy of a brace in preventing dislocation in 54 primary THAs in 43 patients. All of the patients wore braces for 3 weeks postoperatively. The occurrence of dislocation was evaluated six months postoperatively. There were no cases of dislocation while wearing a brace, while two posterior dislocations occurred 8 and 12 days postoperatively while picking something up from the floor without a brace in so-called provocative positions. The results of this study suggest that a hip brace helps patients to recognize careless provocative positions and prevents the initial hip dislocation in this period instead of usual postoperative management for an average of 6 weeks after discharge, such as a high toilet seat, restricted hip flexion in the activities of daily living, use of a reacher or grabber, an abduction pillow, and a high chair.

关键词： Hip Brace Dislocation Total Hip Arthroplasty

Au Wire Bonding to Cu Alloy Substrate and Separation of Wire Bonding Area Assisted by Heat Treatment

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Au Wire Bonding to Cu Alloy Substrate and Separation of Wire...

Computer-Aided Design and Fabrication of Finger Prosthesis

第四届电子封装国际研讨会

作者： Masanori Onodera mitsuhiro Saito Hideki Ichinose Tadatomo Suga Research Center for Advance Science and Technology The University of Tokyo4-6-1KomabaMeguro-kuTokyo 153-8904Japan Department of Material Science Graduate School of EngineeringThe University of Tokyo7-3-1HongoBunkyo-kuTokyo 113-8656Japan

In this study,we examine the bonding conditions and the bonding mechanism of a Au wire onto a Cu alloy substrate in the ultrasonic thermo-compression method,using an existing wire bonder,and we discuss the possibility of separation of the wire bonded area,using heat treatment as a trigger for the *** Au wire bonding onto the Cu alloy substrate,the Au wire was verified to be directly connected to Cu oxide film,thereby not involving the formation process of a clean surface. In addition,the yield of separation in the wire bonding area was revealed to have increased due to the heat treatment after bonding,when the Cu alloy substrate was *** an examination of the results,the cause was found to be a fragile reaction layer grown at the bonding boundary on the Cu alloy *** results suggest that the flame retardant agent within the mold resin might have contributed to corrosion of this reaction layer.

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Journal of Biomedical Science and Engineering 2015年第2期8卷 98-103页

作者： Takeshi Murayama Kosei Oono Mitsunori Tada Toru Eguchi Misuzu Nagami mitsuhiro Tamamoto Graduate School of Biomedical and Health Sciences Hiroshima University Hiroshima Japan Digital Human Research Center Agency for Industrial Science and Technology (AIST) Tokyo Japan Graduate School of Engineering Hiroshima University Hiroshima Japan Hello Tomorrow Japan Co. Ltd. Tokyo Japan

Custom-made esthetic finger prostheses, which are used for rehabilitation of patients with missing or impaired fingers, have been fabricated manually. However, such fabrication is time-consuming and requires manual skill. Here we propose a computer-aided method for fabricating finger pros-theses to save time and allow fabrications that do not require considerable manual skill. In this method, the dimensions of a patient’s healthy finger on the contralateral hand are first measured using a caliper. Using these dimensions, a three-dimensional model is constructed for fabricating a prosthesis for the patient’s impaired finger. Using the 3D model, a mold is designed using 3D modeling tools and a computer-aided design system. The resulting mold is then fabricated using a 3D printer. A finger prosthesis is fabricated by pouring silicone resin into the mold. A finger prosthesis for a volunteer was experimentally fabricated according to the proposed method. To evaluate the size and shape of the finger prosthesis, the difference between the finger prosthesis and the original finger of the volunteer was analyzed. Because the average difference between them was 0.25 mm, it was concluded that the proposed method could be used to fabricate a finger prosthesis of adequate size and shape.

关键词： Finger Prostheses Esthetic Prostheses Computer-Aided Design 3D Printer Additive Manufacturing

Three-Component Coupling Catalyzed by Phosphine: Preparation of α-Amino γ-Oxo Acid Derivatives

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International Journal of Organic Chemistry 2012年第2期2卷 111-116页

作者： Yohei Oe Takeshi Inoue Hiroaki Kishimoto mitsuhiro Sasaki Tetsuo Ohta Isao Furukawa Department of Biomedical Information Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Biomedical Information Faculty of Life and Medical Sciences Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Molecular Science and Technology Faculty of Engineering Doshisha University Kyotanabe Kyoto 610-0394 Japan Department of Molecular Science and Technology Faculty of Engineering Doshisha University Kyotanabe Kyoto 610-0394 Japan

The three-component coupling reaction of ethyl propiolate (1), phthalimide (2), and aldehyde (3) catalyzed by tripheny- lphosphine, was developed. A solution of an equivalent amount of 1 and 2 in benzaldehyde (3a) in the presence of 30 mol% of PPh3 was heated at 100?C for 48 h to give N-(1-ethoxycarbonyl-3-oxo-3-phenylpropyl)phthalimide (4a) in 83% yield. This reaction was thought to proceed via vinylphosphonium salt formed from the reaction of ethyl propiolate (1) with triphenylphosphine in situ.

关键词： Three-Component Coupling Phosphine 2-Amino-4-Oxocarboxylic Acid

High-Speed Active Release End-Effector Motions for Precise Positioning of Adhered Micro-Objects

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World Journal of Engineering and Technology 2018年第1期6卷 81-103页

作者： Eunhye Kim Masaru Kojima Kazuto Kamiyama mitsuhiro Horade Yasushi Mae Tatsuo Arai Department of Systems Innovation Graduate School of Engineering Science Osaka University Osaka Japan Beijing Advanced Innovation Center for Intelligent Robot and Systems Beijing Institute of Technology Beijing China The University of Electro-Communications Tokyo Japan

This paper presents a release method for micro-objects. To improve position accuracy after release, we propose 3D high-speed end-effector motions. The classical release task focuses on the detachment of a micro-object from an end-effector. The technique utilizes merely the vibration of the end-effector regardless of the pattern of movement. To release different sizes of micro- objects and place them precisely at the desired locations in both air and liquid media, in this paper, we propose high-speed motions by analyzing the adhesion force and movement of micro-objects after separation. To generate high end-effector acceleration, many researchers have applied simple vibration by using an additional actuator. However, in our research, 3D high-speed motion with apt amplitude is accomplished by using only a compact parallel mechanism. To verify the advantages of the proposed motion, we compare five motions, 1D motions (in X-, Y-, and Z-directions) and circular motions (clockwise and counterclockwise directions), by changing the frequency and amplitude of the end-effector. Experiments are conducted with different sizes of microbeads and NIH3T3 cells. From these experiments, we conclude that a counterclockwise circular motion can release the objects precisely in air, while 1D motion in the Y direction and two circular motions can detach the objects at the desired positions after release in a liquid environment.

关键词： Adhesion Force Vibration Generation Releasing Strategy Micro-Manipulation

Influence of Leakage from Non-Invasive Positive Pressure Ventilation Mask on FiO<sub>2</sub>Value Delivered by Home Oxygen Therapy Concentrator: A Bench Study on Simulating Patients with Chronic Obstructive Pulmonary Disease

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Health 2018年第7期10卷 919-927页

作者： Kazuto Doi mitsuhiro Nishitani Mayumi Doi Yukoh Yaegashi Masaru Ando Junichi Kadota Department of Pathophysiology Faculty of Medicine Oita University Oita Japan Department of Medical Engineering Faculty of Allied Health Sciences University of East Asia Yamaguchi Japan Daimon Clinic for Internal Medicine Nephrology and Dialysis Ishikawa Japan Department of Clinical Pharmacology & Therapeutics Faculty of Medicine Oita University Oita Japan Department of Medical Engineering Faculty of Health Sciences Junshin Gakuen University Fukuoka Japan Department of Respiratory Medicine & Infectious Diseases Faculty of Medicine Oita University Oita Japan

Introduction: During the application of non-invasive positive pressure ventilation (NPPV) therapy in home mechanical ventilation (HMV), leaks in the NPPV mask may occur owing to the position of the mask due to conditions such as skin disorders. Methods: To investigate whether such a leak affects FiO2 supplied to the alveoli, we simulated a patient with chronic obstructive pulmonary disorder during NPPV in HMV. In addition, FiO2 was measured in the portion assumed to be the mouth and lungs while setting the flow of the oxygen concentrator and leak amount based on a previous study. Results: FiO2 supplied to the lungs increased statistically significantly upon increasing the amount of leak (P Conclusions: We observed that FiO2 supplied to alveoli can be reduced by a leak in the NPPV mask. Because our results differ from those previously reported, we believe that further studies should reassess the selection of respirators and oxygen concentrators.

关键词： Mask Oxygen Ventilation Positive-Pressure Ventilation Chronic Obstructive Pulmonary Disorder

Evaluation of Fever and Its Related Factors during 4 Weeks after Primary Total Hip Arthroplasty

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Surgical Science 2013年第1期4卷 1-6页

作者： Yoshinori Ishii Hideo Noguchi mitsuhiro Takeda Junko Sato Takeshi Yamamoto Yo-Ichiro Domae Department of Orthopaedic Surgery Shibata Prefectural Hospital Shibata Japan Ishii Orthopaedic and Rehabilitation Clinic Gyoda Japan

The purpose of this study was to describe the incidence and characteristics of postoperative fever (POF;≥38℃) and clarify the correlation between POF and febrile-related factors during 4 weeks after primary total hip arthroplasty (THA). A total of 56 patients were included in the study (67 THAs). The preoperative diagnosis for all patients was osteoarthritis. The average follow-up period was 90 months. No patients developed deep infection during the follow-up period. The maximum mean peak daily temperature was 37.7℃ on the day of the surgery and the next day. Fifty-two percent of patients experienced POF, with most developing a maximum temperature (MT) on the day of surgery and the latest occurring by postoperative day (POD) 3. Only C-reactive protein (R = 0.384, p = 0.001) among the febrile-related factors had a weak correlation with MT. Four hips showed a POF of >38℃ later than POD 7;all four of these patients were diagnosed with a urinary tract infection. POF is common and may be part of a normal inflammatory response to tissue injury after THA. More than half of patients may develop POF within 1 week, with most developing MT on POD 0 and the latest occurring by POD 3. In addition, urinary tract infections might be an initial reason for POF in the subsequent 3 weeks.

关键词： Total Hip Arthroplasty Post-Operative Fever Maximum Temperature C-Reactive Protein Urinary Tract Infection