L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices
L-Serine Decreases Taurine Concentration in the Extracellular Fluid of Brain Slices作者机构：不详
出 版 物：《Neuroscience & Medicine》 (神经系统科学与医药（英文）)
年 卷 期：2011年第2卷第3期
页 面：268-274页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：L-Serine Chick Brain Slice Taurine L-Alanine
摘 要：L-Serine is considered a functional amino acid in the central nervous system, and induces sedation and hypnotic effects in some animal models of acute and chronic stress. Accordingly, while L-serine is a candidate anti-stress factor, the central mechanism of L-serine is not clear. The present study clarifies the action of L-serine using acute chick brain slices. We investigated the changes in some extracellular fluid amino acid concentrations in response to L-serine perfusion. Taurine concentration decreased while L-alanine concentration increased following L-serine perfusion. To examine the involvement of the taurine transporter, the effect of L-serine on the taurine concentration in the presence and absence of Na+ was also investigated. Na+ had no effect on taurine concentration induced by L-serine perfusion. These results suggest that L-serine has an ability to promote L-alanine synthesis facilitating the catabolism of taurine. In conclusion, L-serine modifies the metabolism of taurine and L-alanine in the extracellular space in chick brain.
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